#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9WYT9	uniprotkb:Q9WZV7	intact:EBI-2464826|uniprotkb:G4FE02|ensemblbacteria:AAD35552	intact:EBI-2464828|uniprotkb:G4FCX1|ensemblbacteria:AAD35935	psi-mi:q9wyt9_thema(display_long)|uniprotkb:TM_0468(locus name)	psi-mi:q9wzv7_thema(display_long)|uniprotkb:TM_0853(locus name)	psi-mi:"MI:0841"(phosphotransferase assay)	Podgornaia et al. (2013)	pubmed:23954504|doi:10.1016/j.str.2013.07.005|imex:IM-21905	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070175|imex:IM-21905-1|dip:DIP-136789E	-	-	psi-mi:"MI:0843"(phosphate acceptor)	psi-mi:"MI:0842"(phosphate donor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_228278.1|refseq:WP_004081498.1|dip:DIP-54543N|ensemblbacteria:AAD35552(transcript)|ensemblbacteria:TM_0468(gene)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0046872"(metal ion binding)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR011006(CheY-like)|rcsb pdb:3DGE|rcsb pdb:3DGF|rcsb pdb:3GL9|rcsb pdb:4JA2|rcsb pdb:4JAS|rcsb pdb:4JAV|rcsb pdb:5UHT|rcsb pdb:6AZR|rcsb pdb:6RFV|rcsb pdb:6RGY|rcsb pdb:6RGZ|rcsb pdb:6RH0|rcsb pdb:6RH1|rcsb pdb:6RH7|rcsb pdb:6RH8|rcsb pdb:6RH2	refseq:NP_228662.1|refseq:WP_004080773.1|dip:DIP-54544N|ensemblbacteria:AAD35935(transcript)|ensemblbacteria:TM_0853(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:2C2A|rcsb pdb:3DGE|rcsb pdb:4JAS|rcsb pdb:4JAU|rcsb pdb:4JAV|rcsb pdb:4KP4|rcsb pdb:5UHT|rcsb pdb:6AZR|rcsb pdb:6RFV|rcsb pdb:6RGY|rcsb pdb:6RGZ|rcsb pdb:6RH0|rcsb pdb:6RH1|rcsb pdb:6RH2|rcsb pdb:6RH7|rcsb pdb:6RH8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CP5OYhveeLzc1oa71/pfzAOfw9w243274	rogid:j+CHLIKfJUS5ZjDDg8REwHnTJDY243274	rigid:+/Jt8vvXHDBBGmkjcxxp1kyMSDI	false	-	sufficient binding region:232-489	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9WYT9	uniprotkb:Q9WZV7	intact:EBI-2464826|uniprotkb:G4FE02|ensemblbacteria:AAD35552	intact:EBI-2464828|uniprotkb:G4FCX1|ensemblbacteria:AAD35935	psi-mi:q9wyt9_thema(display_long)|uniprotkb:TM_0468(locus name)	psi-mi:q9wzv7_thema(display_long)|uniprotkb:TM_0853(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Podgornaia et al. (2013)	pubmed:23954504|doi:10.1016/j.str.2013.07.005|imex:IM-21905	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070225|imex:IM-21905-3|dip:DIP-136789E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_228278.1|refseq:WP_004081498.1|dip:DIP-54543N|ensemblbacteria:AAD35552(transcript)|ensemblbacteria:TM_0468(gene)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0046872"(metal ion binding)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR011006(CheY-like)|rcsb pdb:3DGE|rcsb pdb:3DGF|rcsb pdb:3GL9|rcsb pdb:4JA2|rcsb pdb:4JAS|rcsb pdb:4JAV|rcsb pdb:5UHT|rcsb pdb:6AZR|rcsb pdb:6RFV|rcsb pdb:6RGY|rcsb pdb:6RGZ|rcsb pdb:6RH0|rcsb pdb:6RH1|rcsb pdb:6RH7|rcsb pdb:6RH8|rcsb pdb:6RH2	refseq:NP_228662.1|refseq:WP_004080773.1|dip:DIP-54544N|ensemblbacteria:AAD35935(transcript)|ensemblbacteria:TM_0853(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:2C2A|rcsb pdb:3DGE|rcsb pdb:4JAS|rcsb pdb:4JAU|rcsb pdb:4JAV|rcsb pdb:4KP4|rcsb pdb:5UHT|rcsb pdb:6AZR|rcsb pdb:6RFV|rcsb pdb:6RGY|rcsb pdb:6RGZ|rcsb pdb:6RH0|rcsb pdb:6RH1|rcsb pdb:6RH2|rcsb pdb:6RH7|rcsb pdb:6RH8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CP5OYhveeLzc1oa71/pfzAOfw9w243274	rogid:j+CHLIKfJUS5ZjDDg8REwHnTJDY243274	rigid:+/Jt8vvXHDBBGmkjcxxp1kyMSDI	false	-	sufficient binding region:232-489	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WZV7	uniprotkb:Q9WZV7	intact:EBI-2464828|uniprotkb:G4FCX1|ensemblbacteria:AAD35935	intact:EBI-2464828|uniprotkb:G4FCX1|ensemblbacteria:AAD35935	psi-mi:q9wzv7_thema(display_long)|uniprotkb:TM_0853(locus name)	psi-mi:q9wzv7_thema(display_long)|uniprotkb:TM_0853(locus name)	psi-mi:"MI:0424"(protein kinase assay)	Podgornaia et al. (2013)	pubmed:23954504|doi:10.1016/j.str.2013.07.005|imex:IM-21905	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070244|imex:IM-21905-4|dip:DIP-136792E	-	-	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_228662.1|refseq:WP_004080773.1|dip:DIP-54544N|ensemblbacteria:AAD35935(transcript)|ensemblbacteria:TM_0853(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:2C2A|rcsb pdb:3DGE|rcsb pdb:4JAS|rcsb pdb:4JAU|rcsb pdb:4JAV|rcsb pdb:4KP4|rcsb pdb:5UHT|rcsb pdb:6AZR|rcsb pdb:6RFV|rcsb pdb:6RGY|rcsb pdb:6RGZ|rcsb pdb:6RH0|rcsb pdb:6RH1|rcsb pdb:6RH2|rcsb pdb:6RH7|rcsb pdb:6RH8	refseq:NP_228662.1|refseq:WP_004080773.1|dip:DIP-54544N|ensemblbacteria:AAD35935(transcript)|ensemblbacteria:TM_0853(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009927"(histidine phosphotransfer kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|rcsb pdb:2C2A|rcsb pdb:3DGE|rcsb pdb:4JAS|rcsb pdb:4JAU|rcsb pdb:4JAV|rcsb pdb:4KP4|rcsb pdb:5UHT|rcsb pdb:6AZR|rcsb pdb:6RFV|rcsb pdb:6RGY|rcsb pdb:6RGZ|rcsb pdb:6RH0|rcsb pdb:6RH1|rcsb pdb:6RH2|rcsb pdb:6RH7|rcsb pdb:6RH8	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:j+CHLIKfJUS5ZjDDg8REwHnTJDY243274	rogid:j+CHLIKfJUS5ZjDDg8REwHnTJDY243274	rigid:mZCkDz53RbqslS13T36zd5ggRsg	false	sufficient binding region:232-489	sufficient binding region:232-489	-	0	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:R4P0T2	uniprotkb:R4P0T2	intact:EBI-16070194|ensemblbacteria:AGL50187	intact:EBI-16070194|ensemblbacteria:AGL50187	psi-mi:r4p0t2_thema(display_long)|uniprotkb:Tmari_1263(orf name)	psi-mi:r4p0t2_thema(display_long)|uniprotkb:Tmari_1263(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Podgornaia et al. (2013)	pubmed:23954504|doi:10.1016/j.str.2013.07.005|imex:IM-21905	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070207|imex:IM-21905-2|dip:DIP-192475E	-	-	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AGL50187(transcript)|ensemblbacteria:Tmari_1263(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|dip:DIP-60578N	ensemblbacteria:AGL50187(transcript)|ensemblbacteria:Tmari_1263(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|dip:DIP-60578N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:BNcBJEzFCHDi/xGkcNxF97PSs/Y243274	rogid:BNcBJEzFCHDi/xGkcNxF97PSs/Y243274	rigid:LdCwY4FfC8VUKYA12Y1OV6IZ2BM	false	-	-	-	0	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9X0Y6	uniprotkb:R4P0T2	intact:EBI-16070262|ensemblbacteria:AAD36333	intact:EBI-16070194|ensemblbacteria:AGL50187	psi-mi:q9x0y6_thema(display_long)|uniprotkb:TM_1259(locus name)	psi-mi:r4p0t2_thema(display_long)|uniprotkb:Tmari_1263(orf name)	psi-mi:"MI:0841"(phosphotransferase assay)	Podgornaia et al. (2013)	pubmed:23954504|doi:10.1016/j.str.2013.07.005|imex:IM-21905	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	taxid:243274(thema)|taxid:243274("Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)")	psi-mi:"MI:0844"(phosphotransfer reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16070279|imex:IM-21905-5|dip:DIP-192474E	-	-	psi-mi:"MI:0843"(phosphate acceptor)	psi-mi:"MI:0842"(phosphate donor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:AAD36333(transcript)|ensemblbacteria:TM_1259(gene)|go:"GO:0000156"(phosphorelay response regulator activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0032993"(protein-DNA complex)|interpro:IPR001789(Signal transduction response regulator, receiver region)|interpro:IPR001867(Signal transduction response regulator, C-terminal)|interpro:IPR011006(CheY-like)|interpro:IPR036388|interpro:IPR039420|refseq:NP_229064.1|dip:DIP-60577N	ensemblbacteria:AGL50187(transcript)|ensemblbacteria:Tmari_1263(gene)|go:"GO:0000155"(phosphorelay sensor kinase activity)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR003661(Signal transduction histidine kinase, subgroup 1, dimerisation and phosphoacceptor region)|interpro:IPR004358(Signal transduction histidine kinase-related protein, C-terminal)|interpro:IPR005467(Signal transduction histidine kinase, core)|interpro:IPR036097|interpro:IPR036890|dip:DIP-60578N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:cqNp7T1tCbdzikxfGyRbwgUHjYE243274	rogid:BNcBJEzFCHDi/xGkcNxF97PSs/Y243274	rigid:H291NElaXIAZLJGM50NcGSDXlmM	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)