#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O60499-1 uniprotkb:Q9UID3-1 intact:EBI-16067850|ensembl:ENSP00000466298 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:o60499-1(display_long)|uniprotkb:STX10(gene name)|psi-mi:STX10(display_short)|uniprotkb:SYN10(gene name synonym) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0018"(two hybrid) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16067856|imex:IM-21901-1|dip:DIP-192447E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104915(gene)|ensembl:ENST00000587230(transcript)|intact:EBI-11343362(isoform-parent) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:PV1m5+whDK+Af3FGLEts82P1EyM9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:3Pn13V1OXSKsAuCf+faHOZWhang false sufficient binding region:1-103 sufficient binding region:1-299 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43752 uniprotkb:Q9UID3-1 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0065"(isothermal titration calorimetry) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16067896|imex:IM-21901-3|dip:DIP-192446E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:r/3JR0hmadmt76Jr4SVIghmFyHs false sufficient binding region:3-110 sufficient binding region:1-69|mutation disrupting interaction strength:40-40|mutation disrupting interaction strength:41-41|mutation disrupting interaction strength:37-37 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60499-1 uniprotkb:Q9UID3-1 intact:EBI-16067850|ensembl:ENSP00000466298 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:o60499-1(display_long)|uniprotkb:STX10(gene name)|psi-mi:STX10(display_short)|uniprotkb:SYN10(gene name synonym) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0065"(isothermal titration calorimetry) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16067926|imex:IM-21901-4|dip:DIP-192447E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104915(gene)|ensembl:ENST00000587230(transcript)|intact:EBI-11343362(isoform-parent) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:PV1m5+whDK+Af3FGLEts82P1EyM9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:3Pn13V1OXSKsAuCf+faHOZWhang false sufficient binding region:1-110|mutation disrupting interaction strength:5-5|mutation disrupting interaction strength:6-6|mutation disrupting interaction strength:7-7|mutation disrupting interaction strength:88-88 sufficient binding region:1-69 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N1B4 uniprotkb:Q9UID3-1 intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16067959|imex:IM-21901-5|dip:DIP-192450E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:zilcAdWn+ss1T2gbvbctCUGljZs false - sufficient binding region:1-299|flag tag:c-c|strep tag:c-c|mutation:41-41,40-40 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O43752 uniprotkb:Q9UID3-1 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0018"(two hybrid) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16067987|imex:IM-21901-6|dip:DIP-192446E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:r/3JR0hmadmt76Jr4SVIghmFyHs false sufficient binding region:1-103 sufficient binding region:1-50|mutation disrupting interaction strength:41-41,40-40 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75379 uniprotkb:Q9UID3-1 intact:EBI-744953|uniprotkb:Q96IY9|uniprotkb:Q96J20|uniprotkb:Q9UEL7|uniprotkb:A2IDD8|ensembl:ENSP00000236192|ensembl:ENSP00000435933 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:vamp4_human(display_long)|uniprotkb:VAMP4(gene name)|psi-mi:VAMP4(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0018"(two hybrid) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16067877|imex:IM-21901-2|dip:DIP-192445E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001172056.1|refseq:NP_003753.2|ensembl:ENSG00000117533(gene)|ensembl:ENST00000236192(transcript)|ensembl:ENST00000474047(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030133"(transport vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR001388(Synaptobrevin)|interpro:IPR042855|interpro:IPR042887|mint:O75379|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-44226N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:tITvmst+UYk596iJSowMT+R0U/89606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:51mS3A+Yj1u6KU4ZZVCZxlXZ/1E false sufficient binding region:1-114 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43752 uniprotkb:Q9UID3-1 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16068012|imex:IM-21901-7|dip:DIP-192446E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:r/3JR0hmadmt76Jr4SVIghmFyHs false sufficient binding region:1-103|glutathione s tranferase tag:n-n sufficient binding region:1-299|flag tag:c-c|mutation disrupting interaction strength:41-41,40-40 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43752 uniprotkb:Q9UID3-1 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0114"(x-ray crystallography) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16068042|imex:IM-21901-8|dip:DIP-192446E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:r/3JR0hmadmt76Jr4SVIghmFyHs false sufficient binding region:3-110 sufficient binding region:33-49 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UID3-1 uniprotkb:Q96AJ9 intact:EBI-16067837|ensembl:ENSP00000279281 intact:EBI-3923262|uniprotkb:B4E137|uniprotkb:A2A307|ensembl:ENSP00000376792|uniprotkb:Q5W0D7 psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:vti1a_human(display_long)|uniprotkb:VTI1A(gene name)|psi-mi:VTI1A(display_short)|uniprotkb:Vesicle transport v-SNARE protein Vti1-like 2(gene name synonym)|uniprotkb:Vti1-rp2(gene name synonym) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16068063|imex:IM-21901-9|dip:DIP-192449E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) refseq:NP_660207.2|ensembl:ENSG00000151532(gene)|ensembl:ENST00000393077(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR007705(Vesicle transport v-SNARE)|interpro:IPR010989(t-SNARE)|interpro:IPR027027|interpro:IPR038407|mint:Q96AJ9|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001305132.1|refseq:NP_001305134.1|refseq:XP_005269601.1|dip:DIP-44223N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rogid:MZOfyoq6Oe9cFxPKa3ZxWTuPTrI9606 rigid:D82fP9y//dtGrgrwxNMugkTsNj4 false sufficient binding region:1-299|flag tag:c-c|strep tag:c-c|mutation disrupting interaction strength:41-41,40-40 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UID3-1 uniprotkb:O43752 intact:EBI-16067837|ensembl:ENSP00000279281 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16068063|imex:IM-21901-9|dip:DIP-192449E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rigid:D82fP9y//dtGrgrwxNMugkTsNj4 false sufficient binding region:1-299|flag tag:c-c|strep tag:c-c|mutation disrupting interaction strength:41-41,40-40 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O43752 uniprotkb:Q9UID3-1 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0065"(isothermal titration calorimetry) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16068092|imex:IM-21901-10|dip:DIP-192446E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:r/3JR0hmadmt76Jr4SVIghmFyHs false sufficient binding region:3-110|mutation disrupting interaction strength:5-5|mutation disrupting interaction strength:6-6|mutation disrupting interaction strength:7-7|mutation disrupting interaction strength:88-88 sufficient binding region:1-69 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60499-1 uniprotkb:Q9UID3-1 intact:EBI-16067850|ensembl:ENSP00000466298 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:o60499-1(display_long)|uniprotkb:STX10(gene name)|psi-mi:STX10(display_short)|uniprotkb:SYN10(gene name synonym) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0018"(two hybrid) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16068125|imex:IM-21901-11|dip:DIP-192447E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104915(gene)|ensembl:ENST00000587230(transcript)|intact:EBI-11343362(isoform-parent) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:PV1m5+whDK+Af3FGLEts82P1EyM9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:3Pn13V1OXSKsAuCf+faHOZWhang false sufficient binding region:1-103 sufficient binding region:1-50|mutation disrupting interaction strength:41-41,40-40 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UID3-1 uniprotkb:Q8N1B4 intact:EBI-16067837|ensembl:ENSP00000279281 intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38 psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16068150|imex:IM-21901-12|dip:DIP-192448E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606 rigid:r98My/7YrOlrWzkHquA0EnRC4Ls false sufficient binding region:1-299|flag tag:c-c|strep tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UID3-1 uniprotkb:Q96AJ9 intact:EBI-16067837|ensembl:ENSP00000279281 intact:EBI-3923262|uniprotkb:B4E137|uniprotkb:A2A307|ensembl:ENSP00000376792|uniprotkb:Q5W0D7 psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:vti1a_human(display_long)|uniprotkb:VTI1A(gene name)|psi-mi:VTI1A(display_short)|uniprotkb:Vesicle transport v-SNARE protein Vti1-like 2(gene name synonym)|uniprotkb:Vti1-rp2(gene name synonym) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16068150|imex:IM-21901-12|dip:DIP-192448E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) refseq:NP_660207.2|ensembl:ENSG00000151532(gene)|ensembl:ENST00000393077(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR007705(Vesicle transport v-SNARE)|interpro:IPR010989(t-SNARE)|interpro:IPR027027|interpro:IPR038407|mint:Q96AJ9|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001305132.1|refseq:NP_001305134.1|refseq:XP_005269601.1|dip:DIP-44223N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rogid:MZOfyoq6Oe9cFxPKa3ZxWTuPTrI9606 rigid:r98My/7YrOlrWzkHquA0EnRC4Ls false sufficient binding region:1-299|flag tag:c-c|strep tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UID3-1 uniprotkb:O43752 intact:EBI-16067837|ensembl:ENSP00000279281 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16068150|imex:IM-21901-12|dip:DIP-192448E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rigid:r98My/7YrOlrWzkHquA0EnRC4Ls false sufficient binding region:1-299|flag tag:c-c|strep tag:c-c - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O60499-1 uniprotkb:Q9UID3-1 intact:EBI-16067850|ensembl:ENSP00000466298 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:o60499-1(display_long)|uniprotkb:STX10(gene name)|psi-mi:STX10(display_short)|uniprotkb:SYN10(gene name synonym) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0065"(isothermal titration calorimetry) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16068176|imex:IM-21901-13|dip:DIP-192447E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104915(gene)|ensembl:ENST00000587230(transcript)|intact:EBI-11343362(isoform-parent) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:PV1m5+whDK+Af3FGLEts82P1EyM9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:3Pn13V1OXSKsAuCf+faHOZWhang false sufficient binding region:1-110 sufficient binding region:1-69|mutation disrupting interaction strength:40-40|mutation disrupting interaction strength:41-41|mutation disrupting interaction strength:37-37 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O60499-1 uniprotkb:Q9UID3-1 intact:EBI-16067850|ensembl:ENSP00000466298 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:o60499-1(display_long)|uniprotkb:STX10(gene name)|psi-mi:STX10(display_short)|uniprotkb:SYN10(gene name synonym) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0096"(pull down) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16068206|imex:IM-21901-14|dip:DIP-192447E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000104915(gene)|ensembl:ENST00000587230(transcript)|intact:EBI-11343362(isoform-parent) ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:PV1m5+whDK+Af3FGLEts82P1EyM9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:3Pn13V1OXSKsAuCf+faHOZWhang false sufficient binding region:1-232|glutathione s tranferase tag:?-? sufficient binding region:1-299|flag tag:c-c|mutation disrupting interaction strength:41-41,40-40 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O43752 uniprotkb:Q9UID3-1 intact:EBI-2695795|uniprotkb:Q5VY08|uniprotkb:B2R652|uniprotkb:Q6FH83|intact:EBI-28977663|ensembl:ENSP00000258301|uniprotkb:B4DR17 intact:EBI-16067837|ensembl:ENSP00000279281 psi-mi:stx6_human(display_long)|uniprotkb:STX6(gene name)|psi-mi:STX6(display_short) psi-mi:q9uid3-1(display_long)|uniprotkb:VPS51(gene name)|psi-mi:VPS51(display_short)|uniprotkb:ANG2(gene name synonym)|uniprotkb:C11orf2(gene name synonym)|uniprotkb:C11orf3(gene name synonym)|uniprotkb:FFR(gene name synonym)|uniprotkb:Another new gene 2 protein(gene name synonym)|uniprotkb:Protein fat-free homolog(gene name synonym)|uniprotkb:PP5382(orf name) psi-mi:"MI:0018"(two hybrid) Abascal-Palacios et al. (2013) pubmed:23932592|doi:10.1016/j.str.2013.06.025|imex:IM-21901 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16068237|imex:IM-21901-15|dip:DIP-192446E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000258301|ensembl:ENST00000542060|ensembl:ENSP00000440188|refseq:NP_005810.1|ensembl:ENSG00000135823(gene)|ensembl:ENST00000258301(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:O43752|rcsb pdb:2NPS|rcsb pdb:4J2C|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_001273139.1|refseq:XP_016855496.1|dip:DIP-44224N ensembl:ENSG00000149823(gene)|ensembl:ENST00000279281(transcript)|intact:EBI-2932923(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:g8/HcXvvEY2Pqv8NWy3V+T+jBTY9606 rogid:UGjZbNWrm7SCFNgZLmPRor03b+k9606 rigid:r/3JR0hmadmt76Jr4SVIghmFyHs false sufficient binding region:1-103 sufficient binding region:1-299 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)