#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P09167	uniprotkb:P09167	intact:EBI-8027669|intact:MINT-1958193	intact:EBI-8027669|intact:MINT-1958193	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:"MI:0410"(3D electron microscopy)	Degiacomi et al. (2013)	pubmed:23912165|doi:10.1038/nchembio.1312|imex:IM-24831	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16066928|imex:IM-24831-1|dip:DIP-199823E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW	psi-mi:"MI:0465"(dip)	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rigid:1lb/73QgtYLFngVkyxoGAugtW1Q	false	sufficient binding region:24-493	sufficient binding region:24-493	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09167	uniprotkb:P09167	intact:EBI-8027669|intact:MINT-1958193	intact:EBI-8027669|intact:MINT-1958193	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:"MI:0020"(transmission electron microscopy)	Degiacomi et al. (2013)	pubmed:23912165|doi:10.1038/nchembio.1312|imex:IM-24831	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16066946|imex:IM-24831-2|dip:DIP-199823E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW	psi-mi:"MI:0465"(dip)	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rigid:1lb/73QgtYLFngVkyxoGAugtW1Q	false	sufficient binding region:24-493	sufficient binding region:24-493	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09167	uniprotkb:P09167	intact:EBI-8027669|intact:MINT-1958193	intact:EBI-8027669|intact:MINT-1958193	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:aera_aerhy(display_long)|uniprotkb:aerA(gene name)|psi-mi:aerA(display_short)	psi-mi:"MI:0808"(comigration in sds page)	Degiacomi et al. (2013)	pubmed:23912165|doi:10.1038/nchembio.1312|imex:IM-24831	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	taxid:644(aerhy)|taxid:644(Aeromonas hydrophila)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16066964|imex:IM-24831-3|dip:DIP-199823E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW	mint:P09167|dip:DIP-42724N|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0090729"(toxin activity)|interpro:IPR005138(Aerolysin/Pertussis toxin APT)|interpro:IPR005830(Aerolysin/haemolysin/leukocidin toxin)|interpro:IPR005831(Aerolysin/haemolysin toxin, conserved site)|interpro:IPR016187(C-type lectin fold)|interpro:IPR037015|rcsb pdb:1PRE|rcsb pdb:1Z52|rcsb pdb:3C0M|rcsb pdb:3C0N|rcsb pdb:3C0O|rcsb pdb:3G4N|rcsb pdb:3G4O|rcsb pdb:5JZH|rcsb pdb:5JZT|rcsb pdb:5JZW	psi-mi:"MI:0465"(dip)	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis	comment:mint|function:Aerolysin is a cytolytic toxin exported by the Gram negative Aeromonas bacteria. The mature toxin binds to eukaryotic cells and aggregates to form holes approximatively 3 nm in diameter, leading to destruction of the membrane permeability barrier and osmotic lysis	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rogid:AyhML6xpBqNlwHtQuBxoqZzqvAk644	rigid:1lb/73QgtYLFngVkyxoGAugtW1Q	false	sufficient binding region:24-493	sufficient binding region:24-493	-	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)