#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P17813-1	uniprotkb:P02750	intact:EBI-16065304|ensembl:ENSP00000362299	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065310|imex:IM-21258-2|dip:DIP-191214E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:/Y7Ux8s05tYBJQRBhTGABUmhFiY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37023	uniprotkb:P02750	intact:EBI-8043559|uniprotkb:A6NGA8|intact:UNK-5840517|ensembl:ENSP00000373574	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:acvl1_human(display_long)|uniprotkb:ACVRL1(gene name)|psi-mi:ACVRL1(display_short)|uniprotkb:ACVRLK1(gene name synonym)|uniprotkb:ALK1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065287|imex:IM-21258-1|dip:DIP-191212E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005269292.1|refseq:NP_000011.2|refseq:NP_001070869.1|dip:DIP-5938N|ensembl:ENST00000388922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000139567(gene)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2LCR|rcsb pdb:3MY0|rcsb pdb:4FAO|rcsb pdb:6SF1|rcsb pdb:6SF2|rcsb pdb:6SF3|reactome:R-HSA-201451|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well|comment:mint|comment:homomint|function:"Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:0hUxx0V41Gm7SIQyaV3F/NoWiT49606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:W+NQF/R52hA9iZUu1XDzOTWRBYw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q91XL1	uniprotkb:Q62312	intact:EBI-16065327|ensembl:ENSMUSP00000038048	intact:EBI-2899332|ensembl:ENSMUSP00000062333|uniprotkb:Q63947	psi-mi:q91xl1_mouse(display_long)|uniprotkb:Lrg1(gene name)|psi-mi:Lrg1(display_short)|uniprotkb:Lrg(gene name synonym)|uniprotkb:lrhg(gene name synonym)	psi-mi:tgfr2_mouse(display_long)|uniprotkb:Tgfbr2(gene name)|psi-mi:Tgfbr2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065353|imex:IM-21258-3|dip:DIP-191216E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000037095(gene)|ensembl:ENSMUST00000041357(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|go:"GO:0050873"(brown fat cell differentiation)|refseq:NP_084072.1|dip:DIP-60318N	go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030324"(lung development)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003274"(endocardial cushion fusion)|ensembl:ENSMUSG00000032440(gene)|ensembl:ENSMUST00000061101(transcript)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62312|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:0048185"(activin binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0046872"(metal ion binding)|refseq:NP_033397.3|dip:DIP-44605N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:wavVhkhtdrXYMG/M2DMKli8EWuM10090	rogid:zO622M93E590ht8MhEJYcOigw2E10090	rigid:4jQb3f3msY6NooINEF25qaUCMBs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37173-2	uniprotkb:P02750	intact:EBI-16065370|ensembl:ENSP00000351905	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p37173-2(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:TGF-beta type II receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065377|imex:IM-21258-4|dip:DIP-191215E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163513(gene)|ensembl:ENST00000359013(transcript)|intact:EBI-296151(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:xSukId8q6IgvaxgQ8lLEHwGg2iU9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:SyqN+a5O4WOTvxSw7+DBsyrW0MM	false	sufficient binding region:23-184|myc tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q61288	uniprotkb:Q91XL1	intact:EBI-7845979|ensembl:ENSMUSP00000000542|ensembl:ENSMUSP00000112490|ensembl:ENSMUSP00000113297|ensembl:ENSMUSP00000113505|ensembl:ENSMUSP00000113536|ensembl:ENSMUSP00000114027|uniprotkb:Q61289|uniprotkb:Q91YR0|intact:MINT-4086807	intact:EBI-16065327|ensembl:ENSMUSP00000038048	psi-mi:acvl1_mouse(display_long)|uniprotkb:Acvrl1(gene name)|psi-mi:Acvrl1(display_short)|uniprotkb:Acvrlk1(gene name synonym)|uniprotkb:Alk-1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:q91xl1_mouse(display_long)|uniprotkb:Lrg1(gene name)|psi-mi:Lrg1(display_short)|uniprotkb:Lrg(gene name synonym)|uniprotkb:lrhg(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065400|imex:IM-21258-5|dip:DIP-191217E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000000530(gene)|ensembl:ENSMUST00000000542(transcript)|ensembl:ENSMUST00000117984(transcript)|ensembl:ENSMUST00000119063(transcript)|ensembl:ENSMUST00000120028(transcript)|ensembl:ENSMUST00000120754(transcript)|ensembl:ENSMUST00000121718(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0043235"(receptor complex)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q61288|reactome:R-MMU-201451|refseq:NP_001264186.1|refseq:NP_001264188.1|refseq:NP_033742.2|refseq:NP_001264187.1|dip:DIP-47635N	ensembl:ENSMUSG00000037095(gene)|ensembl:ENSMUST00000041357(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|go:"GO:0050873"(brown fat cell differentiation)|refseq:NP_084072.1|dip:DIP-60318N	psi-mi:"MI:0465"(dip)	comment:mint|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:qY0lykfwVlCN4HvDNTPPjDGAAl410090	rogid:wavVhkhtdrXYMG/M2DMKli8EWuM10090	rigid:blJ/InxoBjfb8IrgaAi2MNsLqt0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897-1	uniprotkb:P37173-2	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-16065370|ensembl:ENSP00000351905	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:p37173-2(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:TGF-beta type II receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065429|imex:IM-21258-6|dip:DIP-191222E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	ensembl:ENSG00000163513(gene)|ensembl:ENST00000359013(transcript)|intact:EBI-296151(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:xSukId8q6IgvaxgQ8lLEHwGg2iU9606	rigid:8ki57e0wIP08YOv0sp6HrbRyK04	false	sufficient binding region:34-126	sufficient binding region:23-184	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897-1	uniprotkb:P02750	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065429|imex:IM-21258-6|dip:DIP-191222E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:8ki57e0wIP08YOv0sp6HrbRyK04	false	sufficient binding region:34-126	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897	uniprotkb:P02750	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065451|imex:IM-21258-7|dip:DIP-191213E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:JTS3/7/0s+ghL2l5KV7C4XAaI9Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36897-1	uniprotkb:P37173-2	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-16065370|ensembl:ENSP00000351905	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:p37173-2(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:TGF-beta type II receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065468|imex:IM-21258-8|dip:DIP-191221E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	ensembl:ENSG00000163513(gene)|ensembl:ENST00000359013(transcript)|intact:EBI-296151(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:xSukId8q6IgvaxgQ8lLEHwGg2iU9606	rigid:m5uo62/VAHwUGcw1erxWPAEJYPY	false	sufficient binding region:34-126	sufficient binding region:23-184	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897-1	uniprotkb:P17813-1	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-16065304|ensembl:ENSP00000362299	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065468|imex:IM-21258-8|dip:DIP-191221E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rigid:m5uo62/VAHwUGcw1erxWPAEJYPY	false	sufficient binding region:34-126	sufficient binding region:26-586	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897-1	uniprotkb:P02750	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065468|imex:IM-21258-8|dip:DIP-191221E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:m5uo62/VAHwUGcw1erxWPAEJYPY	false	sufficient binding region:34-126	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897-1	uniprotkb:P02750	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065493|imex:IM-21258-9|dip:DIP-191213E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:JTS3/7/0s+ghL2l5KV7C4XAaI9Q	false	sufficient binding region:34-126	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37023	uniprotkb:P37173-2	intact:EBI-8043559|uniprotkb:A6NGA8|intact:UNK-5840517|ensembl:ENSP00000373574	intact:EBI-16065370|ensembl:ENSP00000351905	psi-mi:acvl1_human(display_long)|uniprotkb:ACVRL1(gene name)|psi-mi:ACVRL1(display_short)|uniprotkb:ACVRLK1(gene name synonym)|uniprotkb:ALK1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:p37173-2(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:TGF-beta type II receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065512|imex:IM-21258-10|dip:DIP-191224E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005269292.1|refseq:NP_000011.2|refseq:NP_001070869.1|dip:DIP-5938N|ensembl:ENST00000388922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000139567(gene)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2LCR|rcsb pdb:3MY0|rcsb pdb:4FAO|rcsb pdb:6SF1|rcsb pdb:6SF2|rcsb pdb:6SF3|reactome:R-HSA-201451|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)	ensembl:ENSG00000163513(gene)|ensembl:ENST00000359013(transcript)|intact:EBI-296151(isoform-parent)	psi-mi:"MI:0465"(dip)	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well|comment:mint|comment:homomint|function:"Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:0hUxx0V41Gm7SIQyaV3F/NoWiT49606	rogid:xSukId8q6IgvaxgQ8lLEHwGg2iU9606	rigid:nUU1SUNFFhMTcWxcJOD5ut4Wovs	false	sufficient binding region:22-118	sufficient binding region:23-184	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37023	uniprotkb:P17813-1	intact:EBI-8043559|uniprotkb:A6NGA8|intact:UNK-5840517|ensembl:ENSP00000373574	intact:EBI-16065304|ensembl:ENSP00000362299	psi-mi:acvl1_human(display_long)|uniprotkb:ACVRL1(gene name)|psi-mi:ACVRL1(display_short)|uniprotkb:ACVRLK1(gene name synonym)|uniprotkb:ALK1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065512|imex:IM-21258-10|dip:DIP-191224E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005269292.1|refseq:NP_000011.2|refseq:NP_001070869.1|dip:DIP-5938N|ensembl:ENST00000388922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000139567(gene)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2LCR|rcsb pdb:3MY0|rcsb pdb:4FAO|rcsb pdb:6SF1|rcsb pdb:6SF2|rcsb pdb:6SF3|reactome:R-HSA-201451|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	psi-mi:"MI:0465"(dip)	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well|comment:mint|comment:homomint|function:"Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:0hUxx0V41Gm7SIQyaV3F/NoWiT49606	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rigid:nUU1SUNFFhMTcWxcJOD5ut4Wovs	false	sufficient binding region:22-118	sufficient binding region:26-586	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37023	uniprotkb:P02750	intact:EBI-8043559|uniprotkb:A6NGA8|intact:UNK-5840517|ensembl:ENSP00000373574	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:acvl1_human(display_long)|uniprotkb:ACVRL1(gene name)|psi-mi:ACVRL1(display_short)|uniprotkb:ACVRLK1(gene name synonym)|uniprotkb:ALK1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065512|imex:IM-21258-10|dip:DIP-191224E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005269292.1|refseq:NP_000011.2|refseq:NP_001070869.1|dip:DIP-5938N|ensembl:ENST00000388922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000139567(gene)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2LCR|rcsb pdb:3MY0|rcsb pdb:4FAO|rcsb pdb:6SF1|rcsb pdb:6SF2|rcsb pdb:6SF3|reactome:R-HSA-201451|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well|comment:mint|comment:homomint|function:"Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:0hUxx0V41Gm7SIQyaV3F/NoWiT49606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:nUU1SUNFFhMTcWxcJOD5ut4Wovs	false	sufficient binding region:22-118	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q64729	uniprotkb:Q91XL1	intact:EBI-2899393|ensembl:ENSMUSP00000007757|uniprotkb:A2AJN0	intact:EBI-16065327|ensembl:ENSMUSP00000038048	psi-mi:tgfr1_mouse(display_long)|uniprotkb:Tgfbr1(gene name)|psi-mi:Tgfbr1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:ESK2(gene name synonym)	psi-mi:q91xl1_mouse(display_long)|uniprotkb:Lrg1(gene name)|psi-mi:Lrg1(display_short)|uniprotkb:Lrg(gene name synonym)|uniprotkb:lrhg(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065571|imex:IM-21258-13|dip:DIP-191218E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000007613(gene)|ensembl:ENSMUST00000007757(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007399"(nervous system development)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0007507"(heart development)|go:"GO:0005524"(ATP binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q64729|reactome:R-MMU-2173788|reactome:R-MMU-2173789|reactome:R-MMU-2173791|reactome:R-MMU-5689880|refseq:NP_033396.1|refseq:NP_001299797.1|refseq:NP_001299798.1|dip:DIP-42262N	ensembl:ENSMUSG00000037095(gene)|ensembl:ENSMUST00000041357(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|go:"GO:0050873"(brown fat cell differentiation)|refseq:NP_084072.1|dip:DIP-60318N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:FVbLT2jZx3h9oz+W89A7vrzJLGY10090	rogid:wavVhkhtdrXYMG/M2DMKli8EWuM10090	rigid:fNh+cWE5VyK+UCkFjN/tyytyKZo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17813	uniprotkb:P02750	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065554|imex:IM-21258-12|dip:DIP-191214E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:/Y7Ux8s05tYBJQRBhTGABUmhFiY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17813-1	uniprotkb:P02750	intact:EBI-16065304|ensembl:ENSP00000362299	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065537|imex:IM-21258-11|dip:DIP-191214E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:/Y7Ux8s05tYBJQRBhTGABUmhFiY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36897-1	uniprotkb:P17813-1	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-16065304|ensembl:ENSP00000362299	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065588|imex:IM-21258-14|dip:DIP-191220E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rigid:gHg5eGWU5ADoxAELtqdA9ObNHX4	false	sufficient binding region:34-126	sufficient binding region:26-586	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897-1	uniprotkb:P02750	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065588|imex:IM-21258-14|dip:DIP-191220E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:gHg5eGWU5ADoxAELtqdA9ObNHX4	false	sufficient binding region:34-126	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37023	uniprotkb:P17813-1	intact:EBI-8043559|uniprotkb:A6NGA8|intact:UNK-5840517|ensembl:ENSP00000373574	intact:EBI-16065304|ensembl:ENSP00000362299	psi-mi:acvl1_human(display_long)|uniprotkb:ACVRL1(gene name)|psi-mi:ACVRL1(display_short)|uniprotkb:ACVRLK1(gene name synonym)|uniprotkb:ALK1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065610|imex:IM-21258-15|dip:DIP-191223E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005269292.1|refseq:NP_000011.2|refseq:NP_001070869.1|dip:DIP-5938N|ensembl:ENST00000388922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000139567(gene)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2LCR|rcsb pdb:3MY0|rcsb pdb:4FAO|rcsb pdb:6SF1|rcsb pdb:6SF2|rcsb pdb:6SF3|reactome:R-HSA-201451|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	psi-mi:"MI:0465"(dip)	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well|comment:mint|comment:homomint|function:"Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:0hUxx0V41Gm7SIQyaV3F/NoWiT49606	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rigid:gYeb2WIVaTWzzycq+VRLmK1wSn0	false	sufficient binding region:22-118	sufficient binding region:26-586	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37023	uniprotkb:P02750	intact:EBI-8043559|uniprotkb:A6NGA8|intact:UNK-5840517|ensembl:ENSP00000373574	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:acvl1_human(display_long)|uniprotkb:ACVRL1(gene name)|psi-mi:ACVRL1(display_short)|uniprotkb:ACVRLK1(gene name synonym)|uniprotkb:ALK1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065610|imex:IM-21258-15|dip:DIP-191223E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005269292.1|refseq:NP_000011.2|refseq:NP_001070869.1|dip:DIP-5938N|ensembl:ENST00000388922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000139567(gene)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2LCR|rcsb pdb:3MY0|rcsb pdb:4FAO|rcsb pdb:6SF1|rcsb pdb:6SF2|rcsb pdb:6SF3|reactome:R-HSA-201451|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well|comment:mint|comment:homomint|function:"Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:0hUxx0V41Gm7SIQyaV3F/NoWiT49606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:gYeb2WIVaTWzzycq+VRLmK1wSn0	false	sufficient binding region:22-118	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q63961	uniprotkb:Q91XL1	intact:EBI-7846091|ensembl:ENSMUSP00000009705|uniprotkb:Q61520|intact:UNK-5465340|intact:MINT-4116867|uniprotkb:Q8K100	intact:EBI-16065327|ensembl:ENSMUSP00000038048	psi-mi:egln_mouse(display_long)|uniprotkb:Eng(gene name)|psi-mi:Eng(display_short)|uniprotkb:Cell surface MJ7/18 antigen(gene name synonym)|uniprotkb:Edg(gene name synonym)	psi-mi:q91xl1_mouse(display_long)|uniprotkb:Lrg1(gene name)|psi-mi:Lrg1(display_short)|uniprotkb:Lrg(gene name synonym)|uniprotkb:lrhg(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065632|imex:IM-21258-16|dip:DIP-191219E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0036122"(BMP binding)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:Q63961|ensembl:ENSMUST00000009705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|ensembl:ENSMUSG00000026814(gene)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|refseq:NP_031958.2|dip:DIP-47636N	ensembl:ENSMUSG00000037095(gene)|ensembl:ENSMUST00000041357(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|go:"GO:0050873"(brown fat cell differentiation)|refseq:NP_084072.1|dip:DIP-60318N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:Hbop7m12Up7X+y+EN/NSBgMe8nI10090	rogid:wavVhkhtdrXYMG/M2DMKli8EWuM10090	rigid:yDIsFq9uK9iGqZBMSOzg1Hebk/Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37173	uniprotkb:P02750	intact:EBI-296151|uniprotkb:Q15580|uniprotkb:Q6DKT6|uniprotkb:Q99474|ensembl:ENSP00000295754|uniprotkb:B4DTV5	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:tgfr2_human(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)|uniprotkb:TGF-beta type II receptor(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065649|imex:IM-21258-17|dip:DIP-191215E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007566"(embryo implantation)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017002"(activin-activated receptor activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043415"(positive regulation of skeletal muscle tissue regeneration)|go:"GO:0043627"(response to estrogen)|go:"GO:0045121"(membrane raft)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0060440"(trachea formation)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0060463"(lung lobe morphogenesis)|go:"GO:0062009"(secondary palate development)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048565"(digestive tract development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:1905317"(inferior endocardial cushion morphogenesis)|go:"GO:0060434"(bronchus morphogenesis)|go:"GO:1990086"(lens fiber cell apoptotic process)|go:"GO:1990428"(miRNA transport)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015013(Transforming growth factor beta receptor 2 ectodomain)|interpro:IPR017194(Transforming growth factor-beta receptor, type II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1KTZ|rcsb pdb:1PLO|rcsb pdb:2PJY|rcsb pdb:1M9Z|rcsb pdb:3KFD|rcsb pdb:4P7U|rcsb pdb:4XJJ|rcsb pdb:5E8V|rcsb pdb:5E8Y|rcsb pdb:5E91|rcsb pdb:5E92|rcsb pdb:5QIN|rcsb pdb:5TX4|rcsb pdb:5TY4|rcsb pdb:7DV6|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-5689603|ensembl:ENSG00000163513(gene)|ensembl:ENST00000295754(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002651"(positive regulation of tolerance induction to self antigen)|go:"GO:0002663"(positive regulation of B cell tolerance induction)|go:"GO:0002666"(positive regulation of T cell tolerance induction)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003430"(growth plate cartilage chondrocyte growth)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005026"(transforming growth factor beta receptor activity, type II)|go:"GO:0005524"(ATP binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0003274"(endocardial cushion fusion)|refseq:NP_001020018.1|refseq:NP_003233.4|dip:DIP-5939N	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BhAUE/hzn1B/qAW63HhmI8ST21I9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:DVWf4sGzfTgJUF+vcZe1WNmHJOI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17813-1	uniprotkb:P02750	intact:EBI-16065304|ensembl:ENSP00000362299	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065689|imex:IM-21258-19|dip:DIP-191214E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:/Y7Ux8s05tYBJQRBhTGABUmhFiY	false	v5 tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P36897-1	uniprotkb:P02750	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065666|imex:IM-21258-18|dip:DIP-191213E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:JTS3/7/0s+ghL2l5KV7C4XAaI9Q	false	sufficient binding region:34-126|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P17813-1	uniprotkb:P02750	intact:EBI-16065304|ensembl:ENSP00000362299	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p17813-1(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065710|imex:IM-21258-20|dip:DIP-191214E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2834630(isoform-parent)|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:/Y7Ux8s05tYBJQRBhTGABUmhFiY	false	sufficient binding region:26-586	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37173-2	uniprotkb:P02750	intact:EBI-16065370|ensembl:ENSP00000351905	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p37173-2(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:TGF-beta type II receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065748|imex:IM-21258-22|dip:DIP-191215E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163513(gene)|ensembl:ENST00000359013(transcript)|intact:EBI-296151(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:xSukId8q6IgvaxgQ8lLEHwGg2iU9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:SyqN+a5O4WOTvxSw7+DBsyrW0MM	false	sufficient binding region:23-184	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36897-1	uniprotkb:P02750	intact:EBI-16065417|ensembl:ENSP00000364133	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p36897-1(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065729|imex:IM-21258-21|dip:DIP-191213E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|intact:EBI-1027557(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:JTS3/7/0s+ghL2l5KV7C4XAaI9Q	false	sufficient binding region:34-126	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P37173-2	uniprotkb:P02750	intact:EBI-16065370|ensembl:ENSP00000351905	intact:EBI-9083443|uniprotkb:Q8N4F5|uniprotkb:Q96QZ4|ensembl:ENSP00000302621	psi-mi:p37173-2(display_long)|uniprotkb:TGFBR2(gene name)|psi-mi:TGFBR2(display_short)|uniprotkb:TGF-beta type II receptor(gene name synonym)|uniprotkb:Transforming growth factor-beta receptor type II(gene name synonym)	psi-mi:a2gl_human(display_long)|uniprotkb:LRG1(gene name)|psi-mi:LRG1(display_short)|uniprotkb:LRG(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23868260|doi:"https://doi.org/10.1038/nature12345"|imex:IM-21258	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16065767|imex:IM-21258-23|dip:DIP-191215E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163513(gene)|ensembl:ENST00000359013(transcript)|intact:EBI-296151(isoform-parent)	refseq:NP_443204.1|dip:DIP-60317N|ensembl:ENSG00000171236(gene)|ensembl:ENST00000306390(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|reactome:R-HSA-6798695|go:"GO:0035580"(specific granule lumen)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:xSukId8q6IgvaxgQ8lLEHwGg2iU9606	rogid:di653qGxwl+poYXeOOsZfNxESIw9606	rigid:SyqN+a5O4WOTvxSw7+DBsyrW0MM	false	sufficient binding region:23-184	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)