#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3U6Q4	uniprotkb:P48736	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063440|imex:IM-21055-1|dip:DIP-190684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:+Fex1ix5b/OSSIdnWBb09iEYpPI	false	ha tag:n-n	mutation decreasing interaction strength:582-582|mutation decreasing interaction strength:582-582	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U6Q4	uniprotkb:P48736	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0944"(mass spectrometry study of hydrogen/deuterium exchange)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063541|imex:IM-21055-5|dip:DIP-190684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/07	2017/08/10	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:+Fex1ix5b/OSSIdnWBb09iEYpPI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U6Q4	uniprotkb:P48736	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063518|imex:IM-21055-4|dip:DIP-190684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:+Fex1ix5b/OSSIdnWBb09iEYpPI	false	ha tag:n-n	mutation decreasing interaction strength:582-582|mutation decreasing interaction strength:582-582	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q3U6Q4	uniprotkb:P48736	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063495|imex:IM-21055-3|dip:DIP-190684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:+Fex1ix5b/OSSIdnWBb09iEYpPI	false	ha tag:n-n	necessary binding region:1-130|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P68404-2	uniprotkb:P48736	intact:EBI-16063464|ensembl:ENSMUSP00000070019|ensembl:ENSMUSP00000138788	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:p68404-2(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063472|imex:IM-21055-2|dip:DIP-190683E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064989(transcript)|ensembl:ENSMUST00000143692(transcript)|intact:EBI-397048(isoform-parent)	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 654. Contains a phosphoserine at position 660. Contains a phosphoserine at position 673. Contains a phosphoserine at position 664.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:6MHZMIMF95sbxmCnKRIL77Jgt1c10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:jGpQXQm+Mf26sQgt03692dTnYUc	false	sufficient binding region:302-673|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JHG7	uniprotkb:Q3U6Q4	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063558|imex:IM-21055-6|dip:DIP-190685E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rigid:iXuWtFw2q4pL5SxaNoJHwNc+u7k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P48736	uniprotkb:P48736	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063660|imex:IM-21055-11|dip:DIP-190686E	-	-	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:dqwnJ3/Fc5uo2DftGwRaP90QI7k	false	sufficient binding region:38-1102|mutation disrupting interaction rate:833-833	sufficient binding region:38-1102|mutation disrupting interaction rate:833-833	-	0	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P68404-2	uniprotkb:P48736	intact:EBI-16063464|ensembl:ENSMUSP00000070019|ensembl:ENSMUSP00000138788	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:p68404-2(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063637|imex:IM-21055-10|dip:DIP-190683E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064989(transcript)|ensembl:ENSMUST00000143692(transcript)|intact:EBI-397048(isoform-parent)	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 654. Contains a phosphoserine at position 660. Contains a phosphoserine at position 673. Contains a phosphoserine at position 664.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:6MHZMIMF95sbxmCnKRIL77Jgt1c10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:jGpQXQm+Mf26sQgt03692dTnYUc	false	sufficient binding region:302-673|ha tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9JHG7	uniprotkb:Q3U6Q4	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063620|imex:IM-21055-9|dip:DIP-190685E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rigid:iXuWtFw2q4pL5SxaNoJHwNc+u7k	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U6Q4	uniprotkb:P48736	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063597|imex:IM-21055-8|dip:DIP-190684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:+Fex1ix5b/OSSIdnWBb09iEYpPI	false	ha tag:n-n	mutation decreasing interaction strength:582-582|mutation decreasing interaction strength:582-582	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05771-2	uniprotkb:P48736	intact:EBI-5774511|intact:EBI-7750711|intact:MINT-241045|intact:EBI-7750580|intact:EBI-7750734|intact:EBI-7750836|intact:EBI-7750757|intact:EBI-7062973|intact:EBI-7063086|intact:EBI-7750664|intact:EBI-7750879|intact:EBI-7750925|ensembl:ENSP00000496129	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:p05771-2(display_long)|uniprotkb:PKCB(gene name synonym)|uniprotkb:PRKCB1(gene name synonym)|uniprotkb:PRKCB2(isoform synonym)|uniprotkb:PRKCB(gene name)|psi-mi:PRKCB(display_short)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063576|imex:IM-21055-7|dip:DIP-190687E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-706216(isoform-parent)|uniprotkb:P05771-2(isoform-parent)|ensembl:ENSG00000166501(gene)|ensembl:ENST00000643927(transcript)	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	isoform-comment:Contains a phosphothreonine at position 641. Contains a phosphoserine at position 660.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:quXWiIKrh2Fi30+QwgMfJlzPG2g9606	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:sd/bBEjOStQ48znezhF8fJGk2vg	false	-	sufficient binding region:38-1102|O-phospho-L-serine:582-582	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q3U6Q4	uniprotkb:P48736	intact:EBI-4303950|uniprotkb:Q3UAY4|uniprotkb:Q8K323|uniprotkb:Q3TBT5|ensembl:ENSMUSP00000052522	intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6	psi-mi:pi3r6_mouse(display_long)|uniprotkb:Pik3r6(gene name)|psi-mi:Pik3r6(display_short)|uniprotkb:Phosphoinositide 3-kinase gamma adapter protein of 87 kDa(gene name synonym)|uniprotkb:p87 PI3K adapter protein(gene name synonym)|uniprotkb:p84 PI3K adapter protein(gene name synonym)	psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Walser et al. (2012)	pubmed:23824069|doi:10.1371/journal.pbio.1001587|imex:IM-21055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16063681|imex:IM-21055-12|dip:DIP-190684E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004435.1|refseq:NP_001075035.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR019522|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|ensembl:ENSMUSG00000046207(gene)|ensembl:ENSMUST00000060441(transcript)|go:"GO:0001525"(angiogenesis)|dip:DIP-60179N	ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:poDoOV1PYQoviR5fRo/2ipnGjKs10090	rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606	rigid:+Fex1ix5b/OSSIdnWBb09iEYpPI	false	ha tag:n-n	necessary binding region:1-130|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)