#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31129	uniprotkb:P31129	intact:EBI-1124405|uniprotkb:P76152|uniprotkb:P77452|ensemblbacteria:AAC74608|ensemblbacteria:BAA18882	intact:EBI-1124405|uniprotkb:P76152|uniprotkb:P77452|ensemblbacteria:AAC74608|ensemblbacteria:BAA18882	psi-mi:dgcz_ecoli(display_long)|uniprotkb:dgcZ(gene name)|psi-mi:dgcZ(display_short)|uniprotkb:Zinc-sensory diguanylate cyclase(gene name synonym)|uniprotkb:ydeG(gene name synonym)|uniprotkb:ydeH(gene name synonym)|uniprotkb:JW1528(locus name)|uniprotkb:b1535(locus name)	psi-mi:dgcz_ecoli(display_long)|uniprotkb:dgcZ(gene name)|psi-mi:dgcZ(display_short)|uniprotkb:Zinc-sensory diguanylate cyclase(gene name synonym)|uniprotkb:ydeG(gene name synonym)|uniprotkb:ydeH(gene name synonym)|uniprotkb:JW1528(locus name)|uniprotkb:b1535(locus name)	psi-mi:"MI:0071"(molecular sieving)	Zähringer et al. (2013)	pubmed:23769666|doi:"https://doi.org/10.1016/j.str.2013.04.026"|imex:IM-21375	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16061174|imex:IM-21375-1|dip:DIP-191579E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416052.1|refseq:WP_000592814.1|ensemblbacteria:AAC74608(transcript)|ensemblbacteria:b1535(gene)|ensemblbacteria:BAA18882(gene)|ensemblbacteria:BAA18882(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008152"(metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0052621"(diguanylate cyclase activity)|go:"GO:0060187"(cell pole)|go:"GO:1900233"(positive regulation of single-species biofilm formation on inanimate substrate)|go:"GO:1902201"(negative regulation of bacterial-type flagellum-dependent cell motility)|go:"GO:1902209"(negative regulation of bacterial-type flagellum assembly)|interpro:IPR000160(GGDEF)|interpro:IPR029787|interpro:IPR043128|rcsb pdb:3T9O|rcsb pdb:3TVK|rcsb pdb:4H54|dip:DIP-11677N	refseq:NP_416052.1|refseq:WP_000592814.1|ensemblbacteria:AAC74608(transcript)|ensemblbacteria:b1535(gene)|ensemblbacteria:BAA18882(gene)|ensemblbacteria:BAA18882(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008152"(metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0052621"(diguanylate cyclase activity)|go:"GO:0060187"(cell pole)|go:"GO:1900233"(positive regulation of single-species biofilm formation on inanimate substrate)|go:"GO:1902201"(negative regulation of bacterial-type flagellum-dependent cell motility)|go:"GO:1902209"(negative regulation of bacterial-type flagellum assembly)|interpro:IPR000160(GGDEF)|interpro:IPR029787|interpro:IPR043128|rcsb pdb:3T9O|rcsb pdb:3TVK|rcsb pdb:4H54|dip:DIP-11677N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:LrxetHCdXLa32eyguE9/WGQ0NWs83333	rogid:LrxetHCdXLa32eyguE9/WGQ0NWs83333	rigid:TSQdY3lvEOQyfr3m+tWmon2n4V0	false	sufficient binding region:1-126	sufficient binding region:1-126	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31129	uniprotkb:P31129	intact:EBI-1124405|uniprotkb:P76152|uniprotkb:P77452|ensemblbacteria:AAC74608|ensemblbacteria:BAA18882	intact:EBI-1124405|uniprotkb:P76152|uniprotkb:P77452|ensemblbacteria:AAC74608|ensemblbacteria:BAA18882	psi-mi:dgcz_ecoli(display_long)|uniprotkb:dgcZ(gene name)|psi-mi:dgcZ(display_short)|uniprotkb:Zinc-sensory diguanylate cyclase(gene name synonym)|uniprotkb:ydeG(gene name synonym)|uniprotkb:ydeH(gene name synonym)|uniprotkb:JW1528(locus name)|uniprotkb:b1535(locus name)	psi-mi:dgcz_ecoli(display_long)|uniprotkb:dgcZ(gene name)|psi-mi:dgcZ(display_short)|uniprotkb:Zinc-sensory diguanylate cyclase(gene name synonym)|uniprotkb:ydeG(gene name synonym)|uniprotkb:ydeH(gene name synonym)|uniprotkb:JW1528(locus name)|uniprotkb:b1535(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Zähringer et al. (2013)	pubmed:23769666|doi:"https://doi.org/10.1016/j.str.2013.04.026"|imex:IM-21375	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16061193|imex:IM-21375-2|dip:DIP-191579E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416052.1|refseq:WP_000592814.1|ensemblbacteria:AAC74608(transcript)|ensemblbacteria:b1535(gene)|ensemblbacteria:BAA18882(gene)|ensemblbacteria:BAA18882(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008152"(metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0052621"(diguanylate cyclase activity)|go:"GO:0060187"(cell pole)|go:"GO:1900233"(positive regulation of single-species biofilm formation on inanimate substrate)|go:"GO:1902201"(negative regulation of bacterial-type flagellum-dependent cell motility)|go:"GO:1902209"(negative regulation of bacterial-type flagellum assembly)|interpro:IPR000160(GGDEF)|interpro:IPR029787|interpro:IPR043128|rcsb pdb:3T9O|rcsb pdb:3TVK|rcsb pdb:4H54|dip:DIP-11677N	refseq:NP_416052.1|refseq:WP_000592814.1|ensemblbacteria:AAC74608(transcript)|ensemblbacteria:b1535(gene)|ensemblbacteria:BAA18882(gene)|ensemblbacteria:BAA18882(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008152"(metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0052621"(diguanylate cyclase activity)|go:"GO:0060187"(cell pole)|go:"GO:1900233"(positive regulation of single-species biofilm formation on inanimate substrate)|go:"GO:1902201"(negative regulation of bacterial-type flagellum-dependent cell motility)|go:"GO:1902209"(negative regulation of bacterial-type flagellum assembly)|interpro:IPR000160(GGDEF)|interpro:IPR029787|interpro:IPR043128|rcsb pdb:3T9O|rcsb pdb:3TVK|rcsb pdb:4H54|dip:DIP-11677N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:LrxetHCdXLa32eyguE9/WGQ0NWs83333	rogid:LrxetHCdXLa32eyguE9/WGQ0NWs83333	rigid:TSQdY3lvEOQyfr3m+tWmon2n4V0	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31129	uniprotkb:P31129	intact:EBI-1124405|uniprotkb:P76152|uniprotkb:P77452|ensemblbacteria:AAC74608|ensemblbacteria:BAA18882	intact:EBI-1124405|uniprotkb:P76152|uniprotkb:P77452|ensemblbacteria:AAC74608|ensemblbacteria:BAA18882	psi-mi:dgcz_ecoli(display_long)|uniprotkb:dgcZ(gene name)|psi-mi:dgcZ(display_short)|uniprotkb:Zinc-sensory diguanylate cyclase(gene name synonym)|uniprotkb:ydeG(gene name synonym)|uniprotkb:ydeH(gene name synonym)|uniprotkb:JW1528(locus name)|uniprotkb:b1535(locus name)	psi-mi:dgcz_ecoli(display_long)|uniprotkb:dgcZ(gene name)|psi-mi:dgcZ(display_short)|uniprotkb:Zinc-sensory diguanylate cyclase(gene name synonym)|uniprotkb:ydeG(gene name synonym)|uniprotkb:ydeH(gene name synonym)|uniprotkb:JW1528(locus name)|uniprotkb:b1535(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Zähringer et al. (2013)	pubmed:23769666|doi:"https://doi.org/10.1016/j.str.2013.04.026"|imex:IM-21375	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16061210|imex:IM-21375-3|dip:DIP-191579E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_416052.1|refseq:WP_000592814.1|ensemblbacteria:AAC74608(transcript)|ensemblbacteria:b1535(gene)|ensemblbacteria:BAA18882(gene)|ensemblbacteria:BAA18882(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008152"(metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0052621"(diguanylate cyclase activity)|go:"GO:0060187"(cell pole)|go:"GO:1900233"(positive regulation of single-species biofilm formation on inanimate substrate)|go:"GO:1902201"(negative regulation of bacterial-type flagellum-dependent cell motility)|go:"GO:1902209"(negative regulation of bacterial-type flagellum assembly)|interpro:IPR000160(GGDEF)|interpro:IPR029787|interpro:IPR043128|rcsb pdb:3T9O|rcsb pdb:3TVK|rcsb pdb:4H54|dip:DIP-11677N	refseq:NP_416052.1|refseq:WP_000592814.1|ensemblbacteria:AAC74608(transcript)|ensemblbacteria:b1535(gene)|ensemblbacteria:BAA18882(gene)|ensemblbacteria:BAA18882(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0008152"(metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043709"(cell adhesion involved in single-species biofilm formation)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0052621"(diguanylate cyclase activity)|go:"GO:0060187"(cell pole)|go:"GO:1900233"(positive regulation of single-species biofilm formation on inanimate substrate)|go:"GO:1902201"(negative regulation of bacterial-type flagellum-dependent cell motility)|go:"GO:1902209"(negative regulation of bacterial-type flagellum assembly)|interpro:IPR000160(GGDEF)|interpro:IPR029787|interpro:IPR043128|rcsb pdb:3T9O|rcsb pdb:3TVK|rcsb pdb:4H54|dip:DIP-11677N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:LrxetHCdXLa32eyguE9/WGQ0NWs83333	rogid:LrxetHCdXLa32eyguE9/WGQ0NWs83333	rigid:TSQdY3lvEOQyfr3m+tWmon2n4V0	false	sufficient binding region:1-126	sufficient binding region:1-126	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)