#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P16671 uniprotkb:P07996-PRO_0000035842 intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4 intact:EBI-13915509 psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short) psi-mi:p07996-pro_0000035842(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Klenotic et al. (2013) pubmed:23640500|imex:IM-25689 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13915493|imex:IM-25689-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1 intact:EBI-2530274(chain-parent) - - chain-seq-start:19|chain-seq-end:1170 figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/16 2017/02/16 rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606 rogid:XNUT5/qOf05T8Db2tAkuajNDYqk9606 rigid:gzJAXyHcOlMNFGxgy1dkFi0CnsA false sufficient binding region:81-117|tag:?-?|glutathione s tranferase tag:?-? glutathione s tranferase tag:?-?|sufficient binding region:429-469..472(IPR000884) - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P16671 uniprotkb:P07996-PRO_0000035842 intact:EBI-2808214|uniprotkb:D9IX66|uniprotkb:D9IX67|uniprotkb:D9IX68|uniprotkb:D9IX69|ensembl:ENSP00000308165|ensembl:ENSP00000378268|ensembl:ENSP00000399421|ensembl:ENSP00000411411|ensembl:ENSP00000415743|uniprotkb:Q9BQC2|uniprotkb:Q9BPZ8|uniprotkb:Q9BZN5|uniprotkb:Q9BZM8|uniprotkb:Q8TCV7|uniprotkb:Q9BZN3|uniprotkb:Q16093|uniprotkb:Q13966|uniprotkb:Q9BZN4 intact:EBI-13915509 psi-mi:cd36_human(display_long)|uniprotkb:GP3B(gene name synonym)|uniprotkb:GP4(gene name synonym)|uniprotkb:Platelet glycoprotein IV(gene name synonym)|uniprotkb:Glycoprotein IIIb(gene name synonym)|uniprotkb:Leukocyte differentiation antigen CD36(gene name synonym)|uniprotkb:PAS IV(gene name synonym)|uniprotkb:PAS-4(gene name synonym)|uniprotkb:Platelet collagen receptor(gene name synonym)|uniprotkb:Fatty acid translocase(gene name synonym)|uniprotkb:Thrombospondin receptor(gene name synonym)|uniprotkb:CD36(gene name)|psi-mi:CD36(display_short) psi-mi:p07996-pro_0000035842(display_long)|uniprotkb:THBS1(gene name)|psi-mi:THBS1(display_short)|uniprotkb:TSP(gene name synonym)|uniprotkb:TSP1(gene name synonym)|uniprotkb:Glycoprotein G(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Klenotic et al. (2013) pubmed:23640500|imex:IM-25689 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-13915546|imex:IM-25689-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:1901480"(oleate transmembrane transporter activity)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:0071726"(cellular response to diacyl bacterial lipopeptide)|go:"GO:1990379"(lipid transport across blood-brain barrier)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071944"(cell periphery)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098900"(regulation of action potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150024"(oxidised low-density lipoprotein particle clearance)|go:"GO:0150025"(oxidised low-density lipoprotein particle receptor activity)|go:"GO:2000334"(positive regulation of blood microparticle formation)|interpro:IPR002159(CD36 antigen)|interpro:IPR005428(Adhesion molecule CD36)|interpro:IPR033076|rcsb pdb:5LGD|reactome:R-HSA-114608|reactome:R-HSA-1236973|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-168188|reactome:R-HSA-1989781|reactome:R-HSA-3000471|reactome:R-HSA-381340|go:"GO:2000121"(regulation of removal of superoxide radicals)|reactome:R-HSA-434313|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-6785807|reactome:R-HSA-6798695|ensembl:ENST00000447544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007596"(blood coagulation)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009897"(external side of plasma membrane)|ensembl:ENSG00000135218(gene)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015636"(short-chain fatty acid transmembrane transporter activity)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0015912"(short-chain fatty acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030169"(low-density lipoprotein particle binding)|ensembl:ENST00000309881(transcript)|ensembl:ENST00000394788(transcript)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0030666"(endocytic vesicle membrane)|ensembl:ENST00000432207(transcript)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|ensembl:ENST00000435819(transcript)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033993"(response to lipid)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0034197"(triglyceride transport)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050892"(intestinal absorption)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055096"(low-density lipoprotein particle mediated signaling)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070508"(cholesterol import)|go:"GO:0070542"(response to fatty acid)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070892"(lipoteichoic acid immune receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0035634"(response to stilbenoid)|refseq:NP_000063.2|refseq:NP_001001547.1|refseq:NP_001001548.1|refseq:NP_001120915.1|refseq:NP_001120916.1|refseq:XP_005250770.1|refseq:XP_005250771.1|refseq:XP_005250772.1|refseq:NP_001276837.1|refseq:NP_001276838.1|refseq:NP_001276840.1 intact:EBI-2530274(chain-parent) - - chain-seq-start:19|chain-seq-end:1170 figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/16 2017/02/16 rogid:aYX4Uyq9gXqLN3pgTWyKWGQmL5w9606 rogid:XNUT5/qOf05T8Db2tAkuajNDYqk9606 rigid:gzJAXyHcOlMNFGxgy1dkFi0CnsA false sufficient binding region:81-117|tag:?-?|glutathione s tranferase tag:?-? glutathione s tranferase tag:?-?|sufficient binding region:429-469..472(IPR000884)|15n label:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)