#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P35639 uniprotkb:Q06507 intact:EBI-10636142|uniprotkb:Q91YW9|ensembl:ENSMUSP00000026475 intact:EBI-77383|uniprotkb:Q5U4B2|uniprotkb:Q61906|ensembl:ENSMUSP00000105234 psi-mi:ddit3_mouse(display_long)|uniprotkb:Ddit3(gene name)|psi-mi:Ddit3(display_short)|uniprotkb:Chop(gene name synonym)|uniprotkb:Chop10(gene name synonym)|uniprotkb:Gadd153(gene name synonym)|uniprotkb:C/EBP zeta(gene name synonym)|uniprotkb:C/EBP-homologous protein(gene name synonym)|uniprotkb:C/EBP-homologous protein 10(gene name synonym)|uniprotkb:CCAAT/enhancer-binding protein homologous protein(gene name synonym)|uniprotkb:Growth arrest and DNA-damage-inducible protein GADD153(gene name synonym) psi-mi:atf4_mouse(display_long)|uniprotkb:Atf4(gene name)|psi-mi:Atf4(display_short)|uniprotkb:C/EBP-related ATF(gene name synonym)|uniprotkb:Activating transcription factor 4(gene name synonym)|uniprotkb:Creb2(gene name synonym)|uniprotkb:Cyclic AMP-responsive element-binding protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Han et al. (2013) pubmed:23624402|doi:"https://doi.org/10.1038/ncb2738"|imex:IM-22379 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16055632|imex:IM-22379-1|dip:DIP-195952E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277112.1|refseq:NP_031863.3|refseq:XP_006513260.1|ensembl:ENSMUSG00000025408(gene)|ensembl:ENSMUST00000026475(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990442"(intrinsic apoptotic signaling pathway in response to nitrosative stress)|go:"GO:1990617"(CHOP-ATF4 complex)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:2000016"(negative regulation of determination of dorsal identity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016670(DNA damage-inducible transcript 3)|dip:DIP-60705N refseq:NP_033846.2|refseq:NP_001274109.1|dip:DIP-30969N|ensembl:ENSMUSG00000042406(gene)|ensembl:ENSMUST00000109605(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070982"(L-asparagine metabolic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990037"(Lewy body core)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990590"(ATF1-ATF4 transcription factor complex)|go:"GO:1990617"(CHOP-ATF4 complex)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|interpro:IPR029811|rcsb pdb:6IRR|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor") psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:ltrRdLwc8dwkKYkmxIAmq4iuFfA10090 rogid:tNLuKEB2zKt5bpWuvhOVWJkkWNw10090 rigid:JS3/9HtKpsmhGW2000HaghRblIY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P35639 uniprotkb:Q06507 intact:EBI-10636142|uniprotkb:Q91YW9|ensembl:ENSMUSP00000026475 intact:EBI-77383|uniprotkb:Q5U4B2|uniprotkb:Q61906|ensembl:ENSMUSP00000105234 psi-mi:ddit3_mouse(display_long)|uniprotkb:Ddit3(gene name)|psi-mi:Ddit3(display_short)|uniprotkb:Chop(gene name synonym)|uniprotkb:Chop10(gene name synonym)|uniprotkb:Gadd153(gene name synonym)|uniprotkb:C/EBP zeta(gene name synonym)|uniprotkb:C/EBP-homologous protein(gene name synonym)|uniprotkb:C/EBP-homologous protein 10(gene name synonym)|uniprotkb:CCAAT/enhancer-binding protein homologous protein(gene name synonym)|uniprotkb:Growth arrest and DNA-damage-inducible protein GADD153(gene name synonym) psi-mi:atf4_mouse(display_long)|uniprotkb:Atf4(gene name)|psi-mi:Atf4(display_short)|uniprotkb:C/EBP-related ATF(gene name synonym)|uniprotkb:Activating transcription factor 4(gene name synonym)|uniprotkb:Creb2(gene name synonym)|uniprotkb:Cyclic AMP-responsive element-binding protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Han et al. (2013) pubmed:23624402|doi:"https://doi.org/10.1038/ncb2738"|imex:IM-22379 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16055649|imex:IM-22379-2|dip:DIP-195952E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277112.1|refseq:NP_031863.3|refseq:XP_006513260.1|ensembl:ENSMUSG00000025408(gene)|ensembl:ENSMUST00000026475(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990442"(intrinsic apoptotic signaling pathway in response to nitrosative stress)|go:"GO:1990617"(CHOP-ATF4 complex)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:2000016"(negative regulation of determination of dorsal identity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016670(DNA damage-inducible transcript 3)|dip:DIP-60705N refseq:NP_033846.2|refseq:NP_001274109.1|dip:DIP-30969N|ensembl:ENSMUSG00000042406(gene)|ensembl:ENSMUST00000109605(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070982"(L-asparagine metabolic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990037"(Lewy body core)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990590"(ATF1-ATF4 transcription factor complex)|go:"GO:1990617"(CHOP-ATF4 complex)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|interpro:IPR029811|rcsb pdb:6IRR|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor") psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:ltrRdLwc8dwkKYkmxIAmq4iuFfA10090 rogid:tNLuKEB2zKt5bpWuvhOVWJkkWNw10090 rigid:JS3/9HtKpsmhGW2000HaghRblIY false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P35639 uniprotkb:Q06507 intact:EBI-10636142|uniprotkb:Q91YW9|ensembl:ENSMUSP00000026475 intact:EBI-77383|uniprotkb:Q5U4B2|uniprotkb:Q61906|ensembl:ENSMUSP00000105234 psi-mi:ddit3_mouse(display_long)|uniprotkb:Ddit3(gene name)|psi-mi:Ddit3(display_short)|uniprotkb:Chop(gene name synonym)|uniprotkb:Chop10(gene name synonym)|uniprotkb:Gadd153(gene name synonym)|uniprotkb:C/EBP zeta(gene name synonym)|uniprotkb:C/EBP-homologous protein(gene name synonym)|uniprotkb:C/EBP-homologous protein 10(gene name synonym)|uniprotkb:CCAAT/enhancer-binding protein homologous protein(gene name synonym)|uniprotkb:Growth arrest and DNA-damage-inducible protein GADD153(gene name synonym) psi-mi:atf4_mouse(display_long)|uniprotkb:Atf4(gene name)|psi-mi:Atf4(display_short)|uniprotkb:C/EBP-related ATF(gene name synonym)|uniprotkb:Activating transcription factor 4(gene name synonym)|uniprotkb:Creb2(gene name synonym)|uniprotkb:Cyclic AMP-responsive element-binding protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Han et al. (2013) pubmed:23624402|doi:"https://doi.org/10.1038/ncb2738"|imex:IM-22379 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16055668|imex:IM-22379-3|dip:DIP-195952E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001277112.1|refseq:NP_031863.3|refseq:XP_006513260.1|ensembl:ENSMUSG00000025408(gene)|ensembl:ENSMUST00000026475(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006983"(ER overload response)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007049"(cell cycle)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032713"(negative regulation of interleukin-4 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036488"(CHOP-C/EBP complex)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140416"(transcription regulator inhibitor activity)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990442"(intrinsic apoptotic signaling pathway in response to nitrosative stress)|go:"GO:1990617"(CHOP-ATF4 complex)|go:"GO:1990622"(CHOP-ATF3 complex)|go:"GO:2000016"(negative regulation of determination of dorsal identity)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR016670(DNA damage-inducible transcript 3)|dip:DIP-60705N refseq:NP_033846.2|refseq:NP_001274109.1|dip:DIP-30969N|ensembl:ENSMUSG00000042406(gene)|ensembl:ENSMUST00000109605(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030282"(bone mineralization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043522"(leucine zipper domain binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070169"(positive regulation of biomineral tissue development)|go:"GO:0070309"(lens fiber cell morphogenesis)|go:"GO:0070982"(L-asparagine metabolic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1990037"(Lewy body core)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990589"(ATF4-CREB1 transcription factor complex)|go:"GO:1990590"(ATF1-ATF4 transcription factor complex)|go:"GO:1990617"(CHOP-ATF4 complex)|go:"GO:1990737"(response to manganese-induced endoplasmic reticulum stress)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000120"(positive regulation of sodium-dependent phosphate transport)|interpro:IPR029811|rcsb pdb:6IRR|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor") psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:ltrRdLwc8dwkKYkmxIAmq4iuFfA10090 rogid:tNLuKEB2zKt5bpWuvhOVWJkkWNw10090 rigid:JS3/9HtKpsmhGW2000HaghRblIY false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)