#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95140	intact:EBI-4399559	intact:EBI-3324756|uniprotkb:A8K1B3|uniprotkb:O95572|uniprotkb:Q5JXC3|uniprotkb:Q5JXC4|uniprotkb:Q9H131|uniprotkb:Q9NSX8|ensembl:ENSP00000235329|ensembl:ENSP00000416338|ensembl:ENSP00000502151|ensembl:ENSP00000502185|ensembl:ENSP00000502362|ensembl:ENSP00000502404|ensembl:ENSP00000502623|ensembl:ENSP00000501646|ensembl:ENSP00000501716|ensembl:ENSP00000501776	dip:DIP-24261N	psi-mi:mfn2_human(display_long)|uniprotkb:MFN2(gene name)|psi-mi:MFN2(display_short)|uniprotkb:CPRP1(gene name synonym)|uniprotkb:KIAA0214(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054685|imex:IM-24820-1|dip:DIP-199801E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121132.1|refseq:NP_055689.1|refseq:XP_005263600.1|refseq:XP_005263602.1|refseq:XP_005263604.1|refseq:XP_005263605.1|ensembl:ENSG00000116688(gene)|ensembl:ENST00000235329(transcript)|ensembl:ENST00000444836(transcript)|ensembl:ENST00000674548(transcript)|ensembl:ENST00000674817(transcript)|ensembl:ENST00000674910(transcript)|ensembl:ENST00000675053(transcript)|ensembl:ENST00000675113(transcript)|ensembl:ENST00000675231(transcript)|ensembl:ENST00000675919(transcript)|ensembl:ENST00000676293(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:O95140|rcsb pdb:6JFK|rcsb pdb:6JFL|rcsb pdb:6JFM|reactome:R-HSA-5205685|reactome:R-HSA-9013419|reactome:R-HSA-983231|dip:DIP-42832N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:E54l4ZR9fs6qvZJczOOibxVlJx49606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:lh0qGKrb+niOaYfMiS8yKdkdhHE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95140	uniprotkb:Q9BXM7-1	intact:EBI-3324756|uniprotkb:A8K1B3|uniprotkb:O95572|uniprotkb:Q5JXC3|uniprotkb:Q5JXC4|uniprotkb:Q9H131|uniprotkb:Q9NSX8|ensembl:ENSP00000235329|ensembl:ENSP00000416338|ensembl:ENSP00000502151|ensembl:ENSP00000502185|ensembl:ENSP00000502362|ensembl:ENSP00000502404|ensembl:ENSP00000502623|ensembl:ENSP00000501646|ensembl:ENSP00000501716|ensembl:ENSP00000501776	intact:EBI-15643376|ensembl:ENSP00000364204	psi-mi:mfn2_human(display_long)|uniprotkb:MFN2(gene name)|psi-mi:MFN2(display_short)|uniprotkb:CPRP1(gene name synonym)|uniprotkb:KIAA0214(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:q9bxm7-1(display_long)|uniprotkb:PINK1(gene name)|psi-mi:PINK1(display_short)|uniprotkb:BRPK(gene name synonym)|uniprotkb:PTEN-induced putative kinase protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054685|imex:IM-24820-1|dip:DIP-199801E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121132.1|refseq:NP_055689.1|refseq:XP_005263600.1|refseq:XP_005263602.1|refseq:XP_005263604.1|refseq:XP_005263605.1|ensembl:ENSG00000116688(gene)|ensembl:ENST00000235329(transcript)|ensembl:ENST00000444836(transcript)|ensembl:ENST00000674548(transcript)|ensembl:ENST00000674817(transcript)|ensembl:ENST00000674910(transcript)|ensembl:ENST00000675053(transcript)|ensembl:ENST00000675113(transcript)|ensembl:ENST00000675231(transcript)|ensembl:ENST00000675919(transcript)|ensembl:ENST00000676293(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:O95140|rcsb pdb:6JFK|rcsb pdb:6JFL|rcsb pdb:6JFM|reactome:R-HSA-5205685|reactome:R-HSA-9013419|reactome:R-HSA-983231|dip:DIP-42832N	intact:EBI-2846068(isoform-parent)|ensembl:ENSG00000158828(gene)|ensembl:ENST00000321556(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:E54l4ZR9fs6qvZJczOOibxVlJx49606	rogid:PL0FnTaDke9w5FQlThTKmye/phs9606	rigid:lh0qGKrb+niOaYfMiS8yKdkdhHE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95140	uniprotkb:O60260	intact:EBI-3324756|uniprotkb:A8K1B3|uniprotkb:O95572|uniprotkb:Q5JXC3|uniprotkb:Q5JXC4|uniprotkb:Q9H131|uniprotkb:Q9NSX8|ensembl:ENSP00000235329|ensembl:ENSP00000416338|ensembl:ENSP00000502151|ensembl:ENSP00000502185|ensembl:ENSP00000502362|ensembl:ENSP00000502404|ensembl:ENSP00000502623|ensembl:ENSP00000501646|ensembl:ENSP00000501716|ensembl:ENSP00000501776	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:mfn2_human(display_long)|uniprotkb:MFN2(gene name)|psi-mi:MFN2(display_short)|uniprotkb:CPRP1(gene name synonym)|uniprotkb:KIAA0214(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054685|imex:IM-24820-1|dip:DIP-199801E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121132.1|refseq:NP_055689.1|refseq:XP_005263600.1|refseq:XP_005263602.1|refseq:XP_005263604.1|refseq:XP_005263605.1|ensembl:ENSG00000116688(gene)|ensembl:ENST00000235329(transcript)|ensembl:ENST00000444836(transcript)|ensembl:ENST00000674548(transcript)|ensembl:ENST00000674817(transcript)|ensembl:ENST00000674910(transcript)|ensembl:ENST00000675053(transcript)|ensembl:ENST00000675113(transcript)|ensembl:ENST00000675231(transcript)|ensembl:ENST00000675919(transcript)|ensembl:ENST00000676293(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:O95140|rcsb pdb:6JFK|rcsb pdb:6JFL|rcsb pdb:6JFM|reactome:R-HSA-5205685|reactome:R-HSA-9013419|reactome:R-HSA-983231|dip:DIP-42832N	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:E54l4ZR9fs6qvZJczOOibxVlJx49606	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rigid:lh0qGKrb+niOaYfMiS8yKdkdhHE	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60260	uniprotkb:O95140	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-3324756|uniprotkb:A8K1B3|uniprotkb:O95572|uniprotkb:Q5JXC3|uniprotkb:Q5JXC4|uniprotkb:Q9H131|uniprotkb:Q9NSX8|ensembl:ENSP00000235329|ensembl:ENSP00000416338|ensembl:ENSP00000502151|ensembl:ENSP00000502185|ensembl:ENSP00000502362|ensembl:ENSP00000502404|ensembl:ENSP00000502623|ensembl:ENSP00000501646|ensembl:ENSP00000501716|ensembl:ENSP00000501776	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:mfn2_human(display_long)|uniprotkb:MFN2(gene name)|psi-mi:MFN2(display_short)|uniprotkb:CPRP1(gene name synonym)|uniprotkb:KIAA0214(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054708|imex:IM-24820-2|dip:DIP-199799E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001121132.1|refseq:NP_055689.1|refseq:XP_005263600.1|refseq:XP_005263602.1|refseq:XP_005263604.1|refseq:XP_005263605.1|ensembl:ENSG00000116688(gene)|ensembl:ENST00000235329(transcript)|ensembl:ENST00000444836(transcript)|ensembl:ENST00000674548(transcript)|ensembl:ENST00000674817(transcript)|ensembl:ENST00000674910(transcript)|ensembl:ENST00000675053(transcript)|ensembl:ENST00000675113(transcript)|ensembl:ENST00000675231(transcript)|ensembl:ENST00000675919(transcript)|ensembl:ENST00000676293(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:O95140|rcsb pdb:6JFK|rcsb pdb:6JFL|rcsb pdb:6JFM|reactome:R-HSA-5205685|reactome:R-HSA-9013419|reactome:R-HSA-983231|dip:DIP-42832N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:E54l4ZR9fs6qvZJczOOibxVlJx49606	rigid:D3RabD8Bu/Pg/i6tHhLNWymPfjo	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60260	uniprotkb:O95140	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-3324756|uniprotkb:A8K1B3|uniprotkb:O95572|uniprotkb:Q5JXC3|uniprotkb:Q5JXC4|uniprotkb:Q9H131|uniprotkb:Q9NSX8|ensembl:ENSP00000235329|ensembl:ENSP00000416338|ensembl:ENSP00000502151|ensembl:ENSP00000502185|ensembl:ENSP00000502362|ensembl:ENSP00000502404|ensembl:ENSP00000502623|ensembl:ENSP00000501646|ensembl:ENSP00000501716|ensembl:ENSP00000501776	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:mfn2_human(display_long)|uniprotkb:MFN2(gene name)|psi-mi:MFN2(display_short)|uniprotkb:CPRP1(gene name synonym)|uniprotkb:KIAA0214(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054729|imex:IM-24820-3|dip:DIP-199799E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001121132.1|refseq:NP_055689.1|refseq:XP_005263600.1|refseq:XP_005263602.1|refseq:XP_005263604.1|refseq:XP_005263605.1|ensembl:ENSG00000116688(gene)|ensembl:ENST00000235329(transcript)|ensembl:ENST00000444836(transcript)|ensembl:ENST00000674548(transcript)|ensembl:ENST00000674817(transcript)|ensembl:ENST00000674910(transcript)|ensembl:ENST00000675053(transcript)|ensembl:ENST00000675113(transcript)|ensembl:ENST00000675231(transcript)|ensembl:ENST00000675919(transcript)|ensembl:ENST00000676293(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:O95140|rcsb pdb:6JFK|rcsb pdb:6JFL|rcsb pdb:6JFM|reactome:R-HSA-5205685|reactome:R-HSA-9013419|reactome:R-HSA-983231|dip:DIP-42832N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:E54l4ZR9fs6qvZJczOOibxVlJx49606	rigid:D3RabD8Bu/Pg/i6tHhLNWymPfjo	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q80U63	uniprotkb:O60260	intact:EBI-8437663|intact:MINT-8057620|uniprotkb:Q8R535|uniprotkb:A2A7Y7|uniprotkb:Q80XK3|uniprotkb:Q8BHF0|uniprotkb:Q8BKV5|uniprotkb:A8Y5E4|uniprotkb:Q3V3B8|uniprotkb:Q923X2|uniprotkb:Q80WP4|ensembl:ENSMUSP00000030884|ensembl:ENSMUSP00000101340|ensembl:ENSMUSP00000101341	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	psi-mi:mfn2_mouse(display_long)|uniprotkb:Mfn2(gene name)|psi-mi:Mfn2(display_short)|uniprotkb:Kiaa0214(gene name synonym)|uniprotkb:Marf(gene name synonym)|uniprotkb:Hypertension-related protein 1(gene name synonym)|uniprotkb:Mitochondrial assembly regulatory factor(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054750|imex:IM-24820-4|dip:DIP-199800E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272849.1|refseq:NP_001272850.1|refseq:NP_001272851.1|refseq:NP_001272852.1|refseq:NP_573464.2|dip:DIP-60970N|refseq:XP_006538672.1|refseq:XP_006538673.1|refseq:XP_006538674.1|ensembl:ENSMUSG00000029020(gene)|ensembl:ENSMUST00000030884(transcript)|ensembl:ENSMUST00000105715(transcript)|ensembl:ENSMUST00000105716(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:Q80U63|reactome:R-MMU-5205685|reactome:R-MMU-9013419|reactome:R-MMU-983231	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:7jDQScOD9jxw/I3zBy5mnbjOF0M10090	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rigid:o2jjUPs0XIO6j8YDZE8nMd8wxyA	false	myc tag:c-c	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9WVS6	uniprotkb:Q80U63	intact:EBI-973635|ensembl:ENSMUSP00000140587|uniprotkb:Q9ES22|uniprotkb:Q9ES23|uniprotkb:Q2KHJ9	intact:EBI-8437663|intact:MINT-8057620|uniprotkb:Q8R535|uniprotkb:A2A7Y7|uniprotkb:Q80XK3|uniprotkb:Q8BHF0|uniprotkb:Q8BKV5|uniprotkb:A8Y5E4|uniprotkb:Q3V3B8|uniprotkb:Q923X2|uniprotkb:Q80WP4|ensembl:ENSMUSP00000030884|ensembl:ENSMUSP00000101340|ensembl:ENSMUSP00000101341	psi-mi:prkn_mouse(display_long)|uniprotkb:Prkn(gene name)|psi-mi:Prkn(display_short)|uniprotkb:Park2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)	psi-mi:mfn2_mouse(display_long)|uniprotkb:Mfn2(gene name)|psi-mi:Mfn2(display_short)|uniprotkb:Kiaa0214(gene name synonym)|uniprotkb:Marf(gene name synonym)|uniprotkb:Hypertension-related protein 1(gene name synonym)|uniprotkb:Mitochondrial assembly regulatory factor(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054771|imex:IM-24820-5|dip:DIP-199802E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0098793"(presynapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:Q9WVS6|rcsb pdb:1MG8|rcsb pdb:2ZEQ|rcsb pdb:3B1L|reactome:R-MMU-5205685|reactome:R-MMU-5689877|reactome:R-MMU-9646399|reactome:R-MMU-983168|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|ensembl:ENSMUSG00000023826(gene)|ensembl:ENSMUST00000191124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051646"(mitochondrion localization)|refseq:NP_001304655.1|refseq:NP_057903.1|dip:DIP-37657N	refseq:NP_001272849.1|refseq:NP_001272850.1|refseq:NP_001272851.1|refseq:NP_001272852.1|refseq:NP_573464.2|dip:DIP-60970N|refseq:XP_006538672.1|refseq:XP_006538673.1|refseq:XP_006538674.1|ensembl:ENSMUSG00000029020(gene)|ensembl:ENSMUST00000030884(transcript)|ensembl:ENSMUST00000105715(transcript)|ensembl:ENSMUST00000105716(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051020"(GTPase binding)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:Q80U63|reactome:R-MMU-5205685|reactome:R-MMU-9013419|reactome:R-MMU-983231	psi-mi:"MI:0465"(dip)	-	comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:RN1+PilwTUQahy76UEu+DIVq3QE10090	rogid:7jDQScOD9jxw/I3zBy5mnbjOF0M10090	rigid:siw1i13Ez30rYPATcnojpPHnSUg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WVS6	uniprotkb:P62991	intact:EBI-973635|ensembl:ENSMUSP00000140587|uniprotkb:Q9ES22|uniprotkb:Q9ES23|uniprotkb:Q2KHJ9	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:prkn_mouse(display_long)|uniprotkb:Prkn(gene name)|psi-mi:Prkn(display_short)|uniprotkb:Park2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054771|imex:IM-24820-5|dip:DIP-199802E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090258"(negative regulation of mitochondrial fission)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0098793"(presynapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901526"(positive regulation of mitophagy)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:Q9WVS6|rcsb pdb:1MG8|rcsb pdb:2ZEQ|rcsb pdb:3B1L|reactome:R-MMU-5205685|reactome:R-MMU-5689877|reactome:R-MMU-9646399|reactome:R-MMU-983168|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|ensembl:ENSMUSG00000023826(gene)|ensembl:ENSMUST00000191124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051646"(mitochondrion localization)|refseq:NP_001304655.1|refseq:NP_057903.1|dip:DIP-37657N	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/15	rogid:RN1+PilwTUQahy76UEu+DIVq3QE10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rigid:siw1i13Ez30rYPATcnojpPHnSUg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60260	uniprotkb:O95140	intact:EBI-716346|uniprotkb:A3FG77|uniprotkb:Q5TFV8|uniprotkb:Q6Q2I6|uniprotkb:Q8NI41|uniprotkb:Q8NI43|uniprotkb:Q8NI44|uniprotkb:D3JZW7|uniprotkb:D3K2X0|uniprotkb:Q5VVX4|uniprotkb:Q8WW07|uniprotkb:A8K975|ensembl:ENSP00000355865	intact:EBI-3324756|uniprotkb:A8K1B3|uniprotkb:O95572|uniprotkb:Q5JXC3|uniprotkb:Q5JXC4|uniprotkb:Q9H131|uniprotkb:Q9NSX8|ensembl:ENSP00000235329|ensembl:ENSP00000416338|ensembl:ENSP00000502151|ensembl:ENSP00000502185|ensembl:ENSP00000502362|ensembl:ENSP00000502404|ensembl:ENSP00000502623|ensembl:ENSP00000501646|ensembl:ENSP00000501716|ensembl:ENSP00000501776	psi-mi:prkn_human(display_long)|uniprotkb:PRKN(gene name)|psi-mi:PRKN(display_short)|uniprotkb:PARK2(gene name synonym)|uniprotkb:Parkin RBR E3 ubiquitin-protein ligase(gene name synonym)|uniprotkb:Parkinson juvenile disease protein 2(gene name synonym)	psi-mi:mfn2_human(display_long)|uniprotkb:MFN2(gene name)|psi-mi:MFN2(display_short)|uniprotkb:CPRP1(gene name synonym)|uniprotkb:KIAA0214(gene name synonym)|uniprotkb:Transmembrane GTPase MFN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Chen et al. (2013)	pubmed:23620051|doi:10.1126/science.1231031|imex:IM-24820	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16054789|imex:IM-24820-6|dip:DIP-199799E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004553.2|refseq:NP_054642.2|refseq:NP_054643.2|ensembl:ENSG00000185345(gene)|ensembl:ENST00000366898(transcript)|go:"GO:0097602"(cullin family protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0098793"(presynapse)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:1900407"(regulation of cellular response to oxidative stress)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902283"(negative regulation of primary amine oxidase activity)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1902803"(regulation of synaptic vesicle transport)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903214"(regulation of protein targeting to mitochondrion)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903382"(negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1905281"(positive regulation of retrograde transport, endosome to Golgi)|go:"GO:1905366"(negative regulation of intralumenal vesicle formation)|go:"GO:1905477"(positive regulation of protein localization to membrane)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR003977(Parkin)|interpro:IPR029071|interpro:IPR041170|interpro:IPR041565|interpro:IPR044066|mint:O60260|rcsb pdb:1IYF|rcsb pdb:2JMO|rcsb pdb:4BM9|rcsb pdb:4I1F|rcsb pdb:4I1H|rcsb pdb:5C1Z|rcsb pdb:5C23|rcsb pdb:5C9V|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5TR5|rcsb pdb:6GLC|rcsb pdb:6HUE|rcsb pdb:6N13|reactome:R-HSA-5205685|reactome:R-HSA-5689877|reactome:R-HSA-9646399|reactome:R-HSA-977225|reactome:R-HSA-983168|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001964"(startle response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0007612"(learning)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010636"(positive regulation of mitochondrial fusion)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032368"(regulation of lipid transport)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033132"(negative regulation of glucokinase activity)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0036503"(ERAD pathway)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051582"(positive regulation of neurotransmitter uptake)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070585"(protein localization to mitochondrion)|go:"GO:0070842"(aggresome assembly)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097413"(Lewy body)|dip:DIP-37655N	refseq:NP_001121132.1|refseq:NP_055689.1|refseq:XP_005263600.1|refseq:XP_005263602.1|refseq:XP_005263604.1|refseq:XP_005263605.1|ensembl:ENSG00000116688(gene)|ensembl:ENST00000235329(transcript)|ensembl:ENST00000444836(transcript)|ensembl:ENST00000674548(transcript)|ensembl:ENST00000674817(transcript)|ensembl:ENST00000674910(transcript)|ensembl:ENST00000675053(transcript)|ensembl:ENST00000675113(transcript)|ensembl:ENST00000675231(transcript)|ensembl:ENST00000675919(transcript)|ensembl:ENST00000676293(transcript)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031306"(intrinsic component of mitochondrial outer membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034497"(protein localization to phagophore assembly site)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|interpro:IPR006884(Fzo-like conserved region)|interpro:IPR022812|interpro:IPR027089|interpro:IPR027094|interpro:IPR027417|interpro:IPR030381|mint:O95140|rcsb pdb:6JFK|rcsb pdb:6JFL|rcsb pdb:6JFM|reactome:R-HSA-5205685|reactome:R-HSA-9013419|reactome:R-HSA-983231|dip:DIP-42832N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:KbbW8SMJIWwQvR4lvsKyi25NRUw9606	rogid:E54l4ZR9fs6qvZJczOOibxVlJx49606	rigid:D3RabD8Bu/Pg/i6tHhLNWymPfjo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)