#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O54901	uniprotkb:Q6XJV4	intact:EBI-8328786|intact:MINT-4105943|uniprotkb:Q9JHD5|uniprotkb:O54816	intact:EBI-16045568|ensembl:ENSMUSP00000110273|ensembl:ENSMUSP00000135299	psi-mi:ox2g_mouse(display_long)|uniprotkb:Cd200(gene name)|psi-mi:Cd200(display_short)|uniprotkb:Mox2(gene name synonym)|uniprotkb:MRC OX-2 antigen(gene name synonym)	psi-mi:mo2r4_mouse(display_long)|uniprotkb:Cd200r4(gene name)|psi-mi:Cd200r4(display_short)|uniprotkb:CD200 cell surface glycoprotein receptor-like 4(gene name synonym)|uniprotkb:CD200 cell surface glycoprotein receptor-like a(gene name synonym)|uniprotkb:Cell surface glycoprotein OX2 receptor 4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hatherley et al. (2013)	pubmed:23602662|doi:10.1016/j.str.2013.03.008|imex:IM-21026	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16045596|imex:IM-21026-1|dip:DIP-190630E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60157N|mint:O54901|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0044297"(cell body)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150072"(positive regulation of arginase activity)|go:"GO:0150074"(positive regulation of protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033321|interpro:IPR036179|rcsb pdb:4BFI|reactome:R-MMU-198933	ensembl:ENSMUSG00000062082(gene)|ensembl:ENSMUST00000114626(transcript)|ensembl:ENSMUST00000176819(transcript)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040012|rcsb pdb:4BFE|refseq:NP_997127.1|refseq:XP_006522191.1|refseq:XP_006522192.1|refseq:XP_006522193.1|dip:DIP-60158N	psi-mi:"MI:0465"(dip)	comment:mint|function:Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:p6fhMxCILVMY6h6QQJ27g3kxKy410090	rogid:30ltMirk37grkCp4mTjejy6bvvI10090	rigid:FJdysDAvcgNSnJ9U9Ef7CTK6xAo	false	sufficient binding region:1-232	sufficient binding region:26-237|mutation increasing interaction strength:90-90,87-87,138-138|mutation increasing interaction strength:138-138|mutation increasing interaction strength:90-90,87-87	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54901	uniprotkb:Q9ES57	intact:EBI-8328786|intact:MINT-4105943|uniprotkb:Q9JHD5|uniprotkb:O54816	intact:EBI-16045630|ensembl:ENSMUSP00000053822	psi-mi:ox2g_mouse(display_long)|uniprotkb:Cd200(gene name)|psi-mi:Cd200(display_short)|uniprotkb:Mox2(gene name synonym)|uniprotkb:MRC OX-2 antigen(gene name synonym)	psi-mi:mo2r1_mouse(display_long)|uniprotkb:Cd200r1(gene name)|psi-mi:Cd200r1(display_short)|uniprotkb:Mox2r(gene name synonym)|uniprotkb:Ox2r(gene name synonym)|uniprotkb:CD200 cell surface glycoprotein receptor(gene name synonym)|uniprotkb:Cell surface glycoprotein OX2 receptor 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hatherley et al. (2013)	pubmed:23602662|doi:10.1016/j.str.2013.03.008|imex:IM-21026	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16045677|imex:IM-21026-3|dip:DIP-190629E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60157N|mint:O54901|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0044297"(cell body)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150072"(positive regulation of arginase activity)|go:"GO:0150074"(positive regulation of protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033321|interpro:IPR036179|rcsb pdb:4BFI|reactome:R-MMU-198933	ensembl:ENSMUSG00000022667(gene)|ensembl:ENSMUST00000057488(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040012|rcsb pdb:4BFG|rcsb pdb:4BFI|refseq:NP_067300.1|dip:DIP-60159N	psi-mi:"MI:0465"(dip)	comment:mint|function:Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:p6fhMxCILVMY6h6QQJ27g3kxKy410090	rogid:oHLZme7LPARTGmw1LHtnd57ouCI10090	rigid:3VbQHtrHQXH89q02fegwHG6+QQ0	false	sufficient binding region:31-232	sufficient binding region:26-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54901	uniprotkb:Q9ES57	intact:EBI-8328786|intact:MINT-4105943|uniprotkb:Q9JHD5|uniprotkb:O54816	intact:EBI-16045630|ensembl:ENSMUSP00000053822	psi-mi:ox2g_mouse(display_long)|uniprotkb:Cd200(gene name)|psi-mi:Cd200(display_short)|uniprotkb:Mox2(gene name synonym)|uniprotkb:MRC OX-2 antigen(gene name synonym)	psi-mi:mo2r1_mouse(display_long)|uniprotkb:Cd200r1(gene name)|psi-mi:Cd200r1(display_short)|uniprotkb:Mox2r(gene name synonym)|uniprotkb:Ox2r(gene name synonym)|uniprotkb:CD200 cell surface glycoprotein receptor(gene name synonym)|uniprotkb:Cell surface glycoprotein OX2 receptor 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hatherley et al. (2013)	pubmed:23602662|doi:10.1016/j.str.2013.03.008|imex:IM-21026	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16045656|imex:IM-21026-2|dip:DIP-190629E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60157N|mint:O54901|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0044297"(cell body)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150072"(positive regulation of arginase activity)|go:"GO:0150074"(positive regulation of protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033321|interpro:IPR036179|rcsb pdb:4BFI|reactome:R-MMU-198933	ensembl:ENSMUSG00000022667(gene)|ensembl:ENSMUST00000057488(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040012|rcsb pdb:4BFG|rcsb pdb:4BFI|refseq:NP_067300.1|dip:DIP-60159N	psi-mi:"MI:0465"(dip)	comment:mint|function:Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:p6fhMxCILVMY6h6QQJ27g3kxKy410090	rogid:oHLZme7LPARTGmw1LHtnd57ouCI10090	rigid:3VbQHtrHQXH89q02fegwHG6+QQ0	false	sufficient binding region:31-232	sufficient binding region:26-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O54901	uniprotkb:Q9ES57	intact:EBI-8328786|intact:MINT-4105943|uniprotkb:Q9JHD5|uniprotkb:O54816	intact:EBI-16045630|ensembl:ENSMUSP00000053822	psi-mi:ox2g_mouse(display_long)|uniprotkb:Cd200(gene name)|psi-mi:Cd200(display_short)|uniprotkb:Mox2(gene name synonym)|uniprotkb:MRC OX-2 antigen(gene name synonym)	psi-mi:mo2r1_mouse(display_long)|uniprotkb:Cd200r1(gene name)|psi-mi:Cd200r1(display_short)|uniprotkb:Mox2r(gene name synonym)|uniprotkb:Ox2r(gene name synonym)|uniprotkb:CD200 cell surface glycoprotein receptor(gene name synonym)|uniprotkb:Cell surface glycoprotein OX2 receptor 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Hatherley et al. (2013)	pubmed:23602662|doi:10.1016/j.str.2013.03.008|imex:IM-21026	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16045698|imex:IM-21026-4|dip:DIP-190629E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60157N|mint:O54901|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043031"(negative regulation of macrophage activation)|go:"GO:0044297"(cell body)|go:"GO:0050776"(regulation of immune response)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150072"(positive regulation of arginase activity)|go:"GO:0150074"(positive regulation of protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904465"(negative regulation of matrix metallopeptidase secretion)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033321|interpro:IPR036179|rcsb pdb:4BFI|reactome:R-MMU-198933	ensembl:ENSMUSG00000022667(gene)|ensembl:ENSMUST00000057488(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905522"(negative regulation of macrophage migration)|go:"GO:2000405"(negative regulation of T cell migration)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040012|rcsb pdb:4BFG|rcsb pdb:4BFI|refseq:NP_067300.1|dip:DIP-60159N	psi-mi:"MI:0465"(dip)	comment:mint|function:Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:p6fhMxCILVMY6h6QQJ27g3kxKy410090	rogid:oHLZme7LPARTGmw1LHtnd57ouCI10090	rigid:3VbQHtrHQXH89q02fegwHG6+QQ0	false	sufficient binding region:31-232|mutation disrupting interaction strength:74-74|mutation disrupting interaction strength:74-74|mutation disrupting interaction strength:60-60|mutation disrupting interaction strength:61-61|mutation disrupting interaction strength:122-122|mutation disrupting interaction strength:124-124|mutation disrupting interaction strength:126-126|mutation disrupting interaction strength:126-126|mutation disrupting interaction strength:130-130	sufficient binding region:26-232	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)