#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H2X6	uniprotkb:O43318	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	intact:EBI-358684|uniprotkb:O43317|uniprotkb:O43319|uniprotkb:Q9NZ70|uniprotkb:Q9NTR3|uniprotkb:E1P523|uniprotkb:Q5TDN2|uniprotkb:Q5TDN3|uniprotkb:B2RE27|uniprotkb:Q5TDT7|ensembl:ENSP00000358335	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:m3k7_human(display_long)|uniprotkb:MAP3K7(gene name)|psi-mi:MAP3K7(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044551|imex:IM-21048-2|dip:DIP-190664E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N	refseq:NP_003179.1|refseq:NP_663304.1|refseq:NP_663305.1|refseq:NP_663306.1|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSG00000135341(gene)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|ensembl:ENST00000369329(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43318|rcsb pdb:2EVA|rcsb pdb:2YIY|rcsb pdb:4GS6|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5V5N|rcsb pdb:7NTH|rcsb pdb:7NTI|reactome:R-HSA-1169091|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-4086398|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27523N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	rogid:U/W3xH9XPl6BIdCcfrw1gG/+n7Y9606	rigid:5LDMnCeh+lwbObrZMpLETNXNf1E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9H2X6	uniprotkb:Q06413	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	intact:EBI-2684075|uniprotkb:D7F7N5|uniprotkb:F8W7V7|uniprotkb:C9JMZ0|ensembl:ENSP00000396219|ensembl:ENSP00000421925|ensembl:ENSP00000490473	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:mef2c_human(display_long)|uniprotkb:MEF2C(gene name)|psi-mi:MEF2C(display_short)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044551|imex:IM-21048-2|dip:DIP-190664E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N	refseq:XP_011541702.1|refseq:XP_011541698.1|refseq:NP_001294931.1|refseq:NP_001124477.1|refseq:NP_001180276.1|refseq:NP_001180277.1|refseq:NP_001180278.1|refseq:NP_001180279.1|refseq:NP_002388.2|refseq:XP_005248568.1|refseq:XP_006714682.1|refseq:XP_006714688.1|refseq:XP_016864967.1|refseq:XP_016864968.1|refseq:XP_016864969.1|refseq:XP_016864970.1|dip:DIP-40857N|refseq:XP_016864965.1|refseq:XP_016864966.1|ensembl:ENSG00000081189(gene)|ensembl:ENST00000437473(transcript)|ensembl:ENST00000504921(transcript)|ensembl:ENST00000636294(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0014902"(myotube differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q06413|reactome:R-HSA-198753|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-525793|reactome:R-HSA-9022707|reactome:R-HSA-9707616|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:0003700"(DNA-binding transcription factor activity)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	rogid:vZxaYdzMYwHDAZZItu8N7SWZPic9606	rigid:5LDMnCeh+lwbObrZMpLETNXNf1E	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFN5	uniprotkb:Q9QZR5	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	intact:EBI-366905|uniprotkb:O88905|uniprotkb:Q99P45|uniprotkb:Q99P46|uniprotkb:Q9D2E6|uniprotkb:Q9D474|uniprotkb:Q9EQL2|uniprotkb:Q9QZR4|ensembl:ENSMUSP00000124133	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:hipk2_mouse(display_long)|uniprotkb:Hipk2(gene name)|psi-mi:Hipk2(display_short)|uniprotkb:Nbak1(gene name synonym)|uniprotkb:Stank(gene name synonym)|uniprotkb:Nuclear body-associated kinase 1(gene name synonym)|uniprotkb:Sialophorin tail-associated nuclear serine/threonine-protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044532|imex:IM-21048-1|dip:DIP-190666E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	refseq:NP_001129537.1|refseq:NP_034563.2|ensembl:ENSMUSG00000061436|ensembl:ENSMUSG00000061436(gene)|ensembl:ENSMUST00000161779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9QZR5|reactome:R-MMU-3899300|reactome:R-MMU-6804756|reactome:R-MMU-8939243|reactome:R-MMU-9022692|refseq:NP_001281072.1|refseq:NP_001281073.1|dip:DIP-31712N	psi-mi:"MI:0465"(dip)	-	crc64:5C863BE377F3AAEF	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rogid:QuwURfphVnnlJdiKOk6l4fDgtQM10090	rigid:fp6r7/gFi4Rq7f5WfMmNf+CiR5I	false	-	mutation decreasing interaction strength:228-228	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QZR5	uniprotkb:Q62073	intact:EBI-366905|uniprotkb:O88905|uniprotkb:Q99P45|uniprotkb:Q99P46|uniprotkb:Q9D2E6|uniprotkb:Q9D474|uniprotkb:Q9EQL2|uniprotkb:Q9QZR4|ensembl:ENSMUSP00000124133	intact:EBI-1775345|ensembl:ENSMUSP00000079734	psi-mi:hipk2_mouse(display_long)|uniprotkb:Hipk2(gene name)|psi-mi:Hipk2(display_short)|uniprotkb:Nbak1(gene name synonym)|uniprotkb:Stank(gene name synonym)|uniprotkb:Nuclear body-associated kinase 1(gene name synonym)|uniprotkb:Sialophorin tail-associated nuclear serine/threonine-protein kinase(gene name synonym)	psi-mi:m3k7_mouse(display_long)|uniprotkb:Map3k7(gene name)|psi-mi:Map3k7(display_short)|uniprotkb:Tak1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044604|imex:IM-21048-5|dip:DIP-190665E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129537.1|refseq:NP_034563.2|ensembl:ENSMUSG00000061436|ensembl:ENSMUSG00000061436(gene)|ensembl:ENSMUST00000161779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9QZR5|reactome:R-MMU-3899300|reactome:R-MMU-6804756|reactome:R-MMU-8939243|reactome:R-MMU-9022692|refseq:NP_001281072.1|refseq:NP_001281073.1|dip:DIP-31712N	refseq:NP_766276.1|dip:DIP-40666N|ensembl:ENSMUSG00000028284(gene)|ensembl:ENSMUST00000080933(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001841"(neural tube formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060348"(bone development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62073|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-4086398|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163	psi-mi:"MI:0465"(dip)	crc64:5C863BE377F3AAEF	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:QuwURfphVnnlJdiKOk6l4fDgtQM10090	rogid:2S6IUyXZT5QqsQ4SAIpIJszQuPE10090	rigid:mxBL0vhhQoOYzEq6qfh36whzewA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9QZR5	uniprotkb:Q8CFN5	intact:EBI-366905|uniprotkb:O88905|uniprotkb:Q99P45|uniprotkb:Q99P46|uniprotkb:Q9D2E6|uniprotkb:Q9D474|uniprotkb:Q9EQL2|uniprotkb:Q9QZR4|ensembl:ENSMUSP00000124133	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	psi-mi:hipk2_mouse(display_long)|uniprotkb:Hipk2(gene name)|psi-mi:Hipk2(display_short)|uniprotkb:Nbak1(gene name synonym)|uniprotkb:Stank(gene name synonym)|uniprotkb:Nuclear body-associated kinase 1(gene name synonym)|uniprotkb:Sialophorin tail-associated nuclear serine/threonine-protein kinase(gene name synonym)	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044604|imex:IM-21048-5|dip:DIP-190665E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129537.1|refseq:NP_034563.2|ensembl:ENSMUSG00000061436|ensembl:ENSMUSG00000061436(gene)|ensembl:ENSMUST00000161779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9QZR5|reactome:R-MMU-3899300|reactome:R-MMU-6804756|reactome:R-MMU-8939243|reactome:R-MMU-9022692|refseq:NP_001281072.1|refseq:NP_001281073.1|dip:DIP-31712N	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	psi-mi:"MI:0465"(dip)	crc64:5C863BE377F3AAEF	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:QuwURfphVnnlJdiKOk6l4fDgtQM10090	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rigid:mxBL0vhhQoOYzEq6qfh36whzewA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUI4	uniprotkb:Q8CFN5	intact:EBI-1048378|uniprotkb:Q7Z5I1|uniprotkb:Q96K01|uniprotkb:Q9BR73|uniprotkb:Q9H7L0|uniprotkb:Q9NW41|uniprotkb:Q9NWA9|uniprotkb:Q9NYK9|uniprotkb:Q9UFU7|uniprotkb:B3KY08|uniprotkb:B4DWI0|uniprotkb:B4E0Q5|uniprotkb:Q6P1W9|uniprotkb:Q6W9G7|uniprotkb:Q7Z4K2|ensembl:ENSP00000404394	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	psi-mi:hdac7_human(display_long)|uniprotkb:Histone deacetylase 7A(gene name synonym)|uniprotkb:HDAC7(gene name)|psi-mi:HDAC7(display_short)|uniprotkb:HDAC7A(gene name synonym)	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044622|imex:IM-21048-6|dip:DIP-190668E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536783.1|refseq:XP_011536784.1|refseq:NP_001295019.1|refseq:NP_001091886.1|refseq:NP_056216.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|ensembl:ENSG00000061273(gene)|ensembl:ENST00000427332(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR023801|interpro:IPR037138|mint:Q8WUI4|rcsb pdb:3C0Y|rcsb pdb:3C0Z|rcsb pdb:3C10|rcsb pdb:3ZNR|rcsb pdb:3ZNS|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3108214|reactome:R-HSA-350054|reactome:R-HSA-8943724|dip:DIP-29860N	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:lRG/KaW9IIP1O9X26GT+ho94JDg9606	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rigid:NQ349O087+Uy86Wz7ePCnGhYIQk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CFN5	uniprotkb:Q9QZR5	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	intact:EBI-366905|uniprotkb:O88905|uniprotkb:Q99P45|uniprotkb:Q99P46|uniprotkb:Q9D2E6|uniprotkb:Q9D474|uniprotkb:Q9EQL2|uniprotkb:Q9QZR4|ensembl:ENSMUSP00000124133	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:hipk2_mouse(display_long)|uniprotkb:Hipk2(gene name)|psi-mi:Hipk2(display_short)|uniprotkb:Nbak1(gene name synonym)|uniprotkb:Stank(gene name synonym)|uniprotkb:Nuclear body-associated kinase 1(gene name synonym)|uniprotkb:Sialophorin tail-associated nuclear serine/threonine-protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044587|imex:IM-21048-4|dip:DIP-190666E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	refseq:NP_001129537.1|refseq:NP_034563.2|ensembl:ENSMUSG00000061436|ensembl:ENSMUSG00000061436(gene)|ensembl:ENSMUST00000161779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9QZR5|reactome:R-MMU-3899300|reactome:R-MMU-6804756|reactome:R-MMU-8939243|reactome:R-MMU-9022692|refseq:NP_001281072.1|refseq:NP_001281073.1|dip:DIP-31712N	psi-mi:"MI:0465"(dip)	-	crc64:5C863BE377F3AAEF	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rogid:QuwURfphVnnlJdiKOk6l4fDgtQM10090	rigid:fp6r7/gFi4Rq7f5WfMmNf+CiR5I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CFN5	uniprotkb:Q8WUI4	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	intact:EBI-1048378|uniprotkb:Q7Z5I1|uniprotkb:Q96K01|uniprotkb:Q9BR73|uniprotkb:Q9H7L0|uniprotkb:Q9NW41|uniprotkb:Q9NWA9|uniprotkb:Q9NYK9|uniprotkb:Q9UFU7|uniprotkb:B3KY08|uniprotkb:B4DWI0|uniprotkb:B4E0Q5|uniprotkb:Q6P1W9|uniprotkb:Q6W9G7|uniprotkb:Q7Z4K2|ensembl:ENSP00000404394	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:hdac7_human(display_long)|uniprotkb:Histone deacetylase 7A(gene name synonym)|uniprotkb:HDAC7(gene name)|psi-mi:HDAC7(display_short)|uniprotkb:HDAC7A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044569|imex:IM-21048-3|dip:DIP-190667E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	refseq:XP_011536783.1|refseq:XP_011536784.1|refseq:NP_001295019.1|refseq:NP_001091886.1|refseq:NP_056216.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|ensembl:ENSG00000061273(gene)|ensembl:ENST00000427332(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR023801|interpro:IPR037138|mint:Q8WUI4|rcsb pdb:3C0Y|rcsb pdb:3C0Z|rcsb pdb:3C10|rcsb pdb:3ZNR|rcsb pdb:3ZNS|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3108214|reactome:R-HSA-350054|reactome:R-HSA-8943724|dip:DIP-29860N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rogid:lRG/KaW9IIP1O9X26GT+ho94JDg9606	rigid:6cDH7n+2tXezzXw6Bmrl0psVY5M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CFN5	uniprotkb:Q9QZR5	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	intact:EBI-366905|uniprotkb:O88905|uniprotkb:Q99P45|uniprotkb:Q99P46|uniprotkb:Q9D2E6|uniprotkb:Q9D474|uniprotkb:Q9EQL2|uniprotkb:Q9QZR4|ensembl:ENSMUSP00000124133	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:hipk2_mouse(display_long)|uniprotkb:Hipk2(gene name)|psi-mi:Hipk2(display_short)|uniprotkb:Nbak1(gene name synonym)|uniprotkb:Stank(gene name synonym)|uniprotkb:Nuclear body-associated kinase 1(gene name synonym)|uniprotkb:Sialophorin tail-associated nuclear serine/threonine-protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044569|imex:IM-21048-3|dip:DIP-190667E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	refseq:NP_001129537.1|refseq:NP_034563.2|ensembl:ENSMUSG00000061436|ensembl:ENSMUSG00000061436(gene)|ensembl:ENSMUST00000161779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9QZR5|reactome:R-MMU-3899300|reactome:R-MMU-6804756|reactome:R-MMU-8939243|reactome:R-MMU-9022692|refseq:NP_001281072.1|refseq:NP_001281073.1|dip:DIP-31712N	psi-mi:"MI:0465"(dip)	-	crc64:5C863BE377F3AAEF	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rogid:QuwURfphVnnlJdiKOk6l4fDgtQM10090	rigid:6cDH7n+2tXezzXw6Bmrl0psVY5M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CFN5	uniprotkb:Q9QZR5	intact:EBI-643797|uniprotkb:Q8R0H1|uniprotkb:Q9D7L0|uniprotkb:Q9QW20|ensembl:ENSMUSP00000143212|ensembl:ENSMUSP00000143401	intact:EBI-366905|uniprotkb:O88905|uniprotkb:Q99P45|uniprotkb:Q99P46|uniprotkb:Q9D2E6|uniprotkb:Q9D474|uniprotkb:Q9EQL2|uniprotkb:Q9QZR4|ensembl:ENSMUSP00000124133	psi-mi:mef2c_mouse(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:hipk2_mouse(display_long)|uniprotkb:Hipk2(gene name)|psi-mi:Hipk2(display_short)|uniprotkb:Nbak1(gene name synonym)|uniprotkb:Stank(gene name synonym)|uniprotkb:Nuclear body-associated kinase 1(gene name synonym)|uniprotkb:Sialophorin tail-associated nuclear serine/threonine-protein kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shang et al. (2012)	pubmed:23565059|doi:10.1371/journal.pbio.1001527|imex:IM-21048	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16044639|imex:IM-21048-7|dip:DIP-190666E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079558.1|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000199019(transcript)|ensembl:ENSMUST00000199105(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001764"(neuron migration)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001947"(heart looping)|go:"GO:0001958"(endochondral ossification)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002467"(germinal center formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003138"(primary heart field specification)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003185"(sinoatrial valve morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007521"(muscle cell fate determination)|go:"GO:0007611"(learning or memory)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035690"|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048666"(neuron development)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055012"(ventricular cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060025"(regulation of synaptic activity)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0072102"(glomerulus morphogenesis)|go:"GO:0072160"(nephron tubule epithelial cell differentiation)|go:"GO:0098794"(postsynapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2000987"(positive regulation of behavioral fear response)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|rcsb pdb:5F28|reactome:R-MMU-525793|refseq:XP_006517186.1|refseq:XP_006517187.1|refseq:XP_006517189.1|refseq:XP_006517195.1|refseq:XP_011242794.1|refseq:XP_017170894.1|refseq:NP_001334504.1|refseq:NP_001334505.1|refseq:NP_001334506.1|refseq:NP_001334493.1|refseq:NP_001334495.1|refseq:NP_001334496.1|refseq:NP_001334497.1|refseq:NP_001334498.1|refseq:NP_001334500.1|refseq:NP_001334501.1|refseq:NP_001334502.1|refseq:NP_001334503.1|dip:DIP-49524N	refseq:NP_001129537.1|refseq:NP_034563.2|ensembl:ENSMUSG00000061436|ensembl:ENSMUSG00000061436(gene)|ensembl:ENSMUST00000161779(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9QZR5|reactome:R-MMU-3899300|reactome:R-MMU-6804756|reactome:R-MMU-8939243|reactome:R-MMU-9022692|refseq:NP_001281072.1|refseq:NP_001281073.1|dip:DIP-31712N	psi-mi:"MI:0465"(dip)	-	crc64:5C863BE377F3AAEF	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:Wpir/aP9UI1pA7jZYsB2aMJWTrQ10090	rogid:QuwURfphVnnlJdiKOk6l4fDgtQM10090	rigid:fp6r7/gFi4Rq7f5WfMmNf+CiR5I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)