#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02545-1	uniprotkb:O75844	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	intact:EBI-1056377|uniprotkb:Q8NDZ8|uniprotkb:Q9UBQ2|uniprotkb:B3KQI7|uniprotkb:D3DPU7|ensembl:ENSP00000361845	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:face1_human(display_long)|uniprotkb:ZMPSTE24(gene name)|psi-mi:ZMPSTE24(display_short)|uniprotkb:FACE1(gene name synonym)|uniprotkb:STE24(gene name synonym)|uniprotkb:Prenyl protein-specific endoprotease 1(gene name synonym)|uniprotkb:Farnesylated proteins-converting enzyme 1(gene name synonym)|uniprotkb:Zinc metalloproteinase Ste24 homolog(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Quigley et al. (2013)	pubmed:23539603|doi:10.1126/science.1231513|imex:IM-24822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16043055|imex:IM-24822-1|dip:DIP-199805E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	refseq:NP_005848.2|ensembl:ENSG00000084073(gene)|ensembl:ENST00000372759(transcript)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006508"(proteolysis)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030327"(prenylated protein catabolic process)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043007"(maintenance of rDNA)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043979"(histone H2B-K5 acetylation)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048538"(thymus development)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0050905"(neuromuscular process)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070302"(regulation of stress-activated protein kinase signaling cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903463"(regulation of mitotic cell cycle DNA replication)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990164"(histone H2A phosphorylation)|go:"GO:2000618"(regulation of histone H4-K16 acetylation)|go:"GO:2000730"(regulation of termination of RNA polymerase I transcription)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR001915(Peptidase M48, Ste24p)|interpro:IPR027057|interpro:IPR032456|rcsb pdb:2YPT|rcsb pdb:4AW6|rcsb pdb:5SYT|rcsb pdb:6BH8|dip:DIP-39641N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rogid:OPwBYiVhnltoUrmk2Jtj07QDSCg9606	rigid:GZwYHpGt0jTheM/zQAtM9IQqHB0	false	sufficient binding region:661-664	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02545-1	uniprotkb:O75844	intact:EBI-351949|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	intact:EBI-1056377|uniprotkb:Q8NDZ8|uniprotkb:Q9UBQ2|uniprotkb:B3KQI7|uniprotkb:D3DPU7|ensembl:ENSP00000361845	psi-mi:p02545-1(display_long)|uniprotkb:Lamin A(isoform synonym)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:face1_human(display_long)|uniprotkb:ZMPSTE24(gene name)|psi-mi:ZMPSTE24(display_short)|uniprotkb:FACE1(gene name synonym)|uniprotkb:STE24(gene name synonym)|uniprotkb:Prenyl protein-specific endoprotease 1(gene name synonym)|uniprotkb:Farnesylated proteins-converting enzyme 1(gene name synonym)|uniprotkb:Zinc metalloproteinase Ste24 homolog(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Quigley et al. (2013)	pubmed:23539603|doi:10.1126/science.1231513|imex:IM-24822	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-16043074|imex:IM-24822-2|dip:DIP-199805E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-351935(lmna_human)|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)	refseq:NP_005848.2|ensembl:ENSG00000084073(gene)|ensembl:ENST00000372759(transcript)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006508"(proteolysis)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030327"(prenylated protein catabolic process)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043007"(maintenance of rDNA)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043979"(histone H2B-K5 acetylation)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048538"(thymus development)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0050905"(neuromuscular process)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070302"(regulation of stress-activated protein kinase signaling cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903463"(regulation of mitotic cell cycle DNA replication)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990164"(histone H2A phosphorylation)|go:"GO:2000618"(regulation of histone H4-K16 acetylation)|go:"GO:2000730"(regulation of termination of RNA polymerase I transcription)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR001915(Peptidase M48, Ste24p)|interpro:IPR027057|interpro:IPR032456|rcsb pdb:2YPT|rcsb pdb:4AW6|rcsb pdb:5SYT|rcsb pdb:6BH8|dip:DIP-39641N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	rogid:OPwBYiVhnltoUrmk2Jtj07QDSCg9606	rigid:GZwYHpGt0jTheM/zQAtM9IQqHB0	false	sufficient binding region:643-656|sufficient binding region:656-664	mutation decreasing interaction rate:336-336	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)