#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q91YS4 uniprotkb:Q8IWE5 intact:EBI-6272135|ensembl:ENSMUSP00000112262 intact:EBI-726484|uniprotkb:O94928|uniprotkb:Q5VT65|uniprotkb:Q7L8G1|uniprotkb:Q8IVT7|uniprotkb:Q8N2T4|uniprotkb:Q96AY0|uniprotkb:Q9NTF7|uniprotkb:Q6NUH9|intact:EBI-28967282|ensembl:ENSP00000364956|intact:EBI-11039943|uniprotkb:Q5VVD7 psi-mi:q91ys4_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short) psi-mi:pkhm2_human(display_long)|uniprotkb:KIAA0842(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:Salmonella-induced filaments A and kinesin-interacting protein(gene name synonym)|uniprotkb:PLEKHM2(gene name)|psi-mi:PLEKHM2(display_short) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Pernigo et al. (2013) pubmed:23519214|doi:10.1126/science.1234264|imex:IM-24821 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16041456|imex:IM-24821-1|dip:DIP-199803E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024862(gene)|ensembl:ENSMUST00000116563(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0032418"(lysosome localization)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q91YS4|rcsb pdb:5OJF|rcsb pdb:6F9I|refseq:XP_011246905.1|refseq:NP_032477.2|dip:DIP-61735N ensembl:ENST00000375793|ensembl:ENSP00000364950|ensembl:ENSP00000364956|refseq:NP_055979.2|refseq:XP_005245847.1|ensembl:ENSG00000116786(gene)|ensembl:ENST00000375799(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR004012(RUN)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037213|rcsb pdb:3CXB|rcsb pdb:3HW2|rcsb pdb:3ZFW|dip:DIP-46410N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:MBs0600rW5+TjxDMoW/zbNUBHk010090 rogid:i7gH6BiDpQGSXReuHc81laPbWKo9606 rigid:t7rxccRR3du2895D33ergseVYdk false sufficient binding region:218-480|mutation decreasing interaction strength:251-251|mutation decreasing interaction strength:287-287|mutation decreasing interaction strength:312-312 sufficient binding region:202-212|tetramethyl rhodamine label:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91YS4 uniprotkb:Q8IWE5 intact:EBI-6272135|ensembl:ENSMUSP00000112262 intact:EBI-726484|uniprotkb:O94928|uniprotkb:Q5VT65|uniprotkb:Q7L8G1|uniprotkb:Q8IVT7|uniprotkb:Q8N2T4|uniprotkb:Q96AY0|uniprotkb:Q9NTF7|uniprotkb:Q6NUH9|intact:EBI-28967282|ensembl:ENSP00000364956|intact:EBI-11039943|uniprotkb:Q5VVD7 psi-mi:q91ys4_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short) psi-mi:pkhm2_human(display_long)|uniprotkb:KIAA0842(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:Salmonella-induced filaments A and kinesin-interacting protein(gene name synonym)|uniprotkb:PLEKHM2(gene name)|psi-mi:PLEKHM2(display_short) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Pernigo et al. (2013) pubmed:23519214|doi:10.1126/science.1234264|imex:IM-24821 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16041521|imex:IM-24821-3|dip:DIP-199803E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024862(gene)|ensembl:ENSMUST00000116563(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0032418"(lysosome localization)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q91YS4|rcsb pdb:5OJF|rcsb pdb:6F9I|refseq:XP_011246905.1|refseq:NP_032477.2|dip:DIP-61735N ensembl:ENST00000375793|ensembl:ENSP00000364950|ensembl:ENSP00000364956|refseq:NP_055979.2|refseq:XP_005245847.1|ensembl:ENSG00000116786(gene)|ensembl:ENST00000375799(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR004012(RUN)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037213|rcsb pdb:3CXB|rcsb pdb:3HW2|rcsb pdb:3ZFW|dip:DIP-46410N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:MBs0600rW5+TjxDMoW/zbNUBHk010090 rogid:i7gH6BiDpQGSXReuHc81laPbWKo9606 rigid:t7rxccRR3du2895D33ergseVYdk false sufficient binding region:218-480 sufficient binding region:202-212|sufficient binding region:231-241|tetramethyl rhodamine label:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q91YS4 uniprotkb:Q8IWE5 intact:EBI-6272135|ensembl:ENSMUSP00000112262 intact:EBI-726484|uniprotkb:O94928|uniprotkb:Q5VT65|uniprotkb:Q7L8G1|uniprotkb:Q8IVT7|uniprotkb:Q8N2T4|uniprotkb:Q96AY0|uniprotkb:Q9NTF7|uniprotkb:Q6NUH9|intact:EBI-28967282|ensembl:ENSP00000364956|intact:EBI-11039943|uniprotkb:Q5VVD7 psi-mi:q91ys4_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short) psi-mi:pkhm2_human(display_long)|uniprotkb:KIAA0842(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:Salmonella-induced filaments A and kinesin-interacting protein(gene name synonym)|uniprotkb:PLEKHM2(gene name)|psi-mi:PLEKHM2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pernigo et al. (2013) pubmed:23519214|doi:10.1126/science.1234264|imex:IM-24821 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041546|imex:IM-24821-4|dip:DIP-199803E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024862(gene)|ensembl:ENSMUST00000116563(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0032418"(lysosome localization)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q91YS4|rcsb pdb:5OJF|rcsb pdb:6F9I|refseq:XP_011246905.1|refseq:NP_032477.2|dip:DIP-61735N ensembl:ENST00000375793|ensembl:ENSP00000364950|ensembl:ENSP00000364956|refseq:NP_055979.2|refseq:XP_005245847.1|ensembl:ENSG00000116786(gene)|ensembl:ENST00000375799(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR004012(RUN)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037213|rcsb pdb:3CXB|rcsb pdb:3HW2|rcsb pdb:3ZFW|dip:DIP-46410N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:MBs0600rW5+TjxDMoW/zbNUBHk010090 rogid:i7gH6BiDpQGSXReuHc81laPbWKo9606 rigid:t7rxccRR3du2895D33ergseVYdk false ha tag:n-n|mutation decreasing interaction strength:251-251|mutation decreasing interaction strength:287-287|mutation decreasing interaction strength:290-290|mutation decreasing interaction strength:291-291|mutation decreasing interaction strength:312-312|mutation decreasing interaction strength:312-312|mutation decreasing interaction strength:325-325|mutation decreasing interaction strength:333-333 green fluorescent protein tag:n-n|sufficient binding region:1-310 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O94985-2 uniprotkb:Q91YS4 intact:EBI-16041593|ensembl:ENSP00000354997 intact:EBI-6272135|ensembl:ENSMUSP00000112262 psi-mi:o94985-2(display_long)|uniprotkb:CLSTN1(gene name)|psi-mi:CLSTN1(display_short)|uniprotkb:CS1(gene name synonym)|uniprotkb:KIAA0911(gene name synonym)|uniprotkb:Alcadein-alpha(gene name synonym)|uniprotkb:Alzheimer-related cadherin-like protein(gene name synonym)|uniprotkb:Non-classical cadherin XB31alpha(gene name synonym)|uniprotkb:Alcalpha1(isoform synonym) psi-mi:q91ys4_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pernigo et al. (2013) pubmed:23519214|doi:10.1126/science.1234264|imex:IM-24821 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041604|imex:IM-24821-5|dip:DIP-199804E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-522075(isoform-parent)|uniprotkb:O94985-2(isoform-parent)|ensembl:ENSG00000171603(gene)|ensembl:ENST00000361311(transcript) ensembl:ENSMUSG00000024862(gene)|ensembl:ENSMUST00000116563(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0032418"(lysosome localization)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q91YS4|rcsb pdb:5OJF|rcsb pdb:6F9I|refseq:XP_011246905.1|refseq:NP_032477.2|dip:DIP-61735N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:GCvEAhR3k+G0+rF8Xb6w03s+9+k9606 rogid:MBs0600rW5+TjxDMoW/zbNUBHk010090 rigid:Ryh6L1BJWjDCxdk450Y4H//LdBE false sufficient binding region:879-971|green fluorescent protein tag:?-? ha tag:n-n|mutation disrupting interaction strength:251-251|mutation disrupting interaction strength:287-287|mutation disrupting interaction strength:312-312 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q91YS4 uniprotkb:Q8IWE5 intact:EBI-6272135|ensembl:ENSMUSP00000112262 intact:EBI-726484|uniprotkb:O94928|uniprotkb:Q5VT65|uniprotkb:Q7L8G1|uniprotkb:Q8IVT7|uniprotkb:Q8N2T4|uniprotkb:Q96AY0|uniprotkb:Q9NTF7|uniprotkb:Q6NUH9|intact:EBI-28967282|ensembl:ENSP00000364956|intact:EBI-11039943|uniprotkb:Q5VVD7 psi-mi:q91ys4_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short) psi-mi:pkhm2_human(display_long)|uniprotkb:KIAA0842(gene name synonym)|uniprotkb:SKIP(gene name synonym)|uniprotkb:Salmonella-induced filaments A and kinesin-interacting protein(gene name synonym)|uniprotkb:PLEKHM2(gene name)|psi-mi:PLEKHM2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Pernigo et al. (2013) pubmed:23519214|doi:10.1126/science.1234264|imex:IM-24821 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041488|imex:IM-24821-2|dip:DIP-199803E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024862(gene)|ensembl:ENSMUST00000116563(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0032418"(lysosome localization)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q91YS4|rcsb pdb:5OJF|rcsb pdb:6F9I|refseq:XP_011246905.1|refseq:NP_032477.2|dip:DIP-61735N ensembl:ENST00000375793|ensembl:ENSP00000364950|ensembl:ENSP00000364956|refseq:NP_055979.2|refseq:XP_005245847.1|ensembl:ENSG00000116786(gene)|ensembl:ENST00000375799(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR004012(RUN)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR037213|rcsb pdb:3CXB|rcsb pdb:3HW2|rcsb pdb:3ZFW|dip:DIP-46410N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:MBs0600rW5+TjxDMoW/zbNUBHk010090 rogid:i7gH6BiDpQGSXReuHc81laPbWKo9606 rigid:t7rxccRR3du2895D33ergseVYdk false ha tag:n-n mutation disrupting interaction strength:208-208,207-207|mutation disrupting interaction strength:237-237,236-236,208-208,207-207|green fluorescent protein tag:n-n|sufficient binding region:1-310 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O94985-2 uniprotkb:Q91YS4 intact:EBI-16041593|ensembl:ENSP00000354997 intact:EBI-6272135|ensembl:ENSMUSP00000112262 psi-mi:o94985-2(display_long)|uniprotkb:CLSTN1(gene name)|psi-mi:CLSTN1(display_short)|uniprotkb:CS1(gene name synonym)|uniprotkb:KIAA0911(gene name synonym)|uniprotkb:Alcadein-alpha(gene name synonym)|uniprotkb:Alzheimer-related cadherin-like protein(gene name synonym)|uniprotkb:Non-classical cadherin XB31alpha(gene name synonym)|uniprotkb:Alcalpha1(isoform synonym) psi-mi:q91ys4_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Pernigo et al. (2013) pubmed:23519214|doi:10.1126/science.1234264|imex:IM-24821 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16041638|imex:IM-24821-6|dip:DIP-199804E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-522075(isoform-parent)|uniprotkb:O94985-2(isoform-parent)|ensembl:ENSG00000171603(gene)|ensembl:ENST00000361311(transcript) ensembl:ENSMUSG00000024862(gene)|ensembl:ENSMUST00000116563(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0032418"(lysosome localization)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|mint:Q91YS4|rcsb pdb:5OJF|rcsb pdb:6F9I|refseq:XP_011246905.1|refseq:NP_032477.2|dip:DIP-61735N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:GCvEAhR3k+G0+rF8Xb6w03s+9+k9606 rogid:MBs0600rW5+TjxDMoW/zbNUBHk010090 rigid:Ryh6L1BJWjDCxdk450Y4H//LdBE false sufficient binding region:888-898|tetramethyl rhodamine label:?-?|sufficient binding region:959-969 sufficient binding region:218-480|mutation decreasing interaction strength:251-251|mutation decreasing interaction strength:287-287|mutation decreasing interaction strength:312-312 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)