#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9R194 uniprotkb:P63208-1 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041016|imex:IM-21071-1|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false flag tag:n-n|mutation disrupting interaction strength:428-428|mutation disrupting interaction strength:499-499 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041016|imex:IM-21071-1|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false flag tag:n-n|mutation disrupting interaction strength:428-428|mutation disrupting interaction strength:499-499 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041125|imex:IM-21071-5|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:P63208-1 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041125|imex:IM-21071-5|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041088|imex:IM-21071-4|dip:DIP-190914E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:Irg8THO2P2lSBATo4NOIpH45qMA false - flag tag:n-n|mutation disrupting interaction strength:336-336|mutation disrupting interaction strength:314-314|necessary binding region:424-428|mutation disrupting interaction strength:426-426|mutation decreasing interaction strength:428-428|mutation decreasing interaction strength:292-292 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:O00327 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-1794206|uniprotkb:O00313|uniprotkb:O00314|uniprotkb:O00315|uniprotkb:O00316|uniprotkb:O00317|uniprotkb:Q99631|uniprotkb:Q99649|uniprotkb:Q8IUT4|uniprotkb:D3DQW6|uniprotkb:A8K645|uniprotkb:B7WPG7|uniprotkb:B5ME11|uniprotkb:Q4G136|uniprotkb:A2I2N6|intact:EBI-28970920|ensembl:ENSP00000384517|ensembl:ENSP00000385581|ensembl:ENSP00000433571 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:bmal1_human(display_long)|uniprotkb:ARNTL(gene name)|psi-mi:ARNTL(display_short)|uniprotkb:BMAL1(gene name synonym)|uniprotkb:MOP3(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Member of PAS protein 3(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP3(gene name synonym)|uniprotkb:bHLH-PAS protein JAP3(gene name synonym)|uniprotkb:BHLHE5(gene name synonym)|uniprotkb:PASD3(gene name synonym)|uniprotkb:PAS domain-containing protein 3(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041063|imex:IM-21071-3|dip:DIP-190917E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENST00000389707|ensembl:ENSP00000374357|ensembl:ENST00000401424|ensembl:ENSP00000385915|ensembl:ENSP00000384517|ensembl:ENST00000403482|ensembl:ENSP00000385897|ensembl:ENSP00000385581|ensembl:ENSP00000433571|refseq:XP_011518414.1|refseq:XP_011518415.1|refseq:NP_001025443.1|refseq:NP_001025444.1|refseq:NP_001169.3|refseq:XP_016873232.1|refseq:NP_001284648.1|refseq:NP_001284651.1|refseq:NP_001284653.1|refseq:XP_016873231.1|refseq:XP_016873235.1|refseq:XP_016873236.1|refseq:XP_016873237.1|dip:DIP-46008N|ensembl:ENSG00000133794(gene)|ensembl:ENST00000403290(transcript)|ensembl:ENST00000403510(transcript)|ensembl:ENST00000529388(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4H10|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:UJwUJQAcLUT6aEBNSUZOF6YyvMA9606 rigid:toOX7dgR6J6yFPatwvSi3zetaUc false flag tag:n-n|mutation disrupting interaction strength:376-376 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:O15534 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557276|uniprotkb:B4DI49|uniprotkb:B2RPA8|uniprotkb:D3DTR3|ensembl:ENSP00000314420 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:per1_human(display_long)|uniprotkb:KIAA0482(gene name synonym)|uniprotkb:PER(gene name synonym)|uniprotkb:RIGUI(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)|uniprotkb:PER1(gene name)|psi-mi:PER1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041063|imex:IM-21071-3|dip:DIP-190917E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000179094(gene)|ensembl:ENST00000317276(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:1UL6|reactome:R-HSA-400253|refseq:NP_002607.2|refseq:XP_005256746.1|ensembl:ENSP00000314420|ensembl:ENST00000354903|ensembl:ENSP00000346979|dip:DIP-56603N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:pLY3Sbn659CD2bY07SU8ysJxSSg9606 rigid:toOX7dgR6J6yFPatwvSi3zetaUc false flag tag:n-n|mutation disrupting interaction strength:376-376 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:P63208-1 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041063|imex:IM-21071-3|dip:DIP-190917E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:toOX7dgR6J6yFPatwvSi3zetaUc false flag tag:n-n|mutation disrupting interaction strength:376-376 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041063|imex:IM-21071-3|dip:DIP-190917E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:toOX7dgR6J6yFPatwvSi3zetaUc false flag tag:n-n|mutation disrupting interaction strength:376-376 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0114"(x-ray crystallography) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041043|imex:IM-21071-2|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:P63208-1 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041043|imex:IM-21071-2|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O15534 uniprotkb:Q9R194 intact:EBI-2557276|uniprotkb:B4DI49|uniprotkb:B2RPA8|uniprotkb:D3DTR3|ensembl:ENSP00000314420 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 psi-mi:per1_human(display_long)|uniprotkb:KIAA0482(gene name synonym)|uniprotkb:PER(gene name synonym)|uniprotkb:RIGUI(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)|uniprotkb:PER1(gene name)|psi-mi:PER1(display_short) psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041145|imex:IM-21071-6|dip:DIP-190919E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000179094(gene)|ensembl:ENST00000317276(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:1UL6|reactome:R-HSA-400253|refseq:NP_002607.2|refseq:XP_005256746.1|ensembl:ENSP00000314420|ensembl:ENST00000354903|ensembl:ENSP00000346979|dip:DIP-56603N refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:pLY3Sbn659CD2bY07SU8ysJxSSg9606 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rigid:ldaL3noOiUsnhxNAQ+s42z+nxPs false - flag tag:n-n|mutation disrupting interaction strength:339-339 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKT7 uniprotkb:P63208-1 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0096"(pull down) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041167|imex:IM-21071-7|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT7 uniprotkb:Q9R194 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:"MI:0096"(pull down) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041167|imex:IM-21071-7|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rigid:W44esEn77QorQHjfdXSn/7BmQwY false glutathione s tranferase tag:n-n sufficient binding region:1-544 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT7 uniprotkb:Q9R194 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:"MI:0069"(mass spectrometry studies of complexes) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16041189|imex:IM-21071-8|dip:DIP-190914E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rigid:Irg8THO2P2lSBATo4NOIpH45qMA false - sufficient binding region:1-544 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0071"(molecular sieving) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041294|imex:IM-21071-14|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:P63208-1 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041294|imex:IM-21071-14|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UKT7 uniprotkb:Q9R194 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:"MI:0096"(pull down) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041273|imex:IM-21071-13|dip:DIP-190914E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rigid:Irg8THO2P2lSBATo4NOIpH45qMA false strep tag:n-n glutathione s tranferase tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:O54943 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-1266779|uniprotkb:O54954 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:per2_mouse(display_long)|uniprotkb:Per2(gene name)|psi-mi:Per2(display_short)|uniprotkb:Circadian clock protein PERIOD 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16041252|imex:IM-21071-12|dip:DIP-188164E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 refseq:NP_035196.2|mint:O54943|dip:DIP-38518N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051946"(regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0060567"(negative regulation of DNA-templated transcription, termination)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:3GDI|rcsb pdb:4CT0|rcsb pdb:4U8H psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:bA+e5kx1ZkqfPRHn3TDAuhmqAw410090 rigid:MrCq33ylc8KQ64VYwv538eatPg8 false flag tag:n-n myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0226"(ion exchange chromatography) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041232|imex:IM-21071-11|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:P63208-1 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041232|imex:IM-21071-11|dip:DIP-190913E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)") - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:W44esEn77QorQHjfdXSn/7BmQwY false sufficient binding region:1-544 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9R194 uniprotkb:O00327 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-1794206|uniprotkb:O00313|uniprotkb:O00314|uniprotkb:O00315|uniprotkb:O00316|uniprotkb:O00317|uniprotkb:Q99631|uniprotkb:Q99649|uniprotkb:Q8IUT4|uniprotkb:D3DQW6|uniprotkb:A8K645|uniprotkb:B7WPG7|uniprotkb:B5ME11|uniprotkb:Q4G136|uniprotkb:A2I2N6|intact:EBI-28970920|ensembl:ENSP00000384517|ensembl:ENSP00000385581|ensembl:ENSP00000433571 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:bmal1_human(display_long)|uniprotkb:ARNTL(gene name)|psi-mi:ARNTL(display_short)|uniprotkb:BMAL1(gene name synonym)|uniprotkb:MOP3(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Member of PAS protein 3(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP3(gene name synonym)|uniprotkb:bHLH-PAS protein JAP3(gene name synonym)|uniprotkb:BHLHE5(gene name synonym)|uniprotkb:PASD3(gene name synonym)|uniprotkb:PAS domain-containing protein 3(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041208|imex:IM-21071-10|dip:DIP-190918E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENST00000389707|ensembl:ENSP00000374357|ensembl:ENST00000401424|ensembl:ENSP00000385915|ensembl:ENSP00000384517|ensembl:ENST00000403482|ensembl:ENSP00000385897|ensembl:ENSP00000385581|ensembl:ENSP00000433571|refseq:XP_011518414.1|refseq:XP_011518415.1|refseq:NP_001025443.1|refseq:NP_001025444.1|refseq:NP_001169.3|refseq:XP_016873232.1|refseq:NP_001284648.1|refseq:NP_001284651.1|refseq:NP_001284653.1|refseq:XP_016873231.1|refseq:XP_016873235.1|refseq:XP_016873236.1|refseq:XP_016873237.1|dip:DIP-46008N|ensembl:ENSG00000133794(gene)|ensembl:ENST00000403290(transcript)|ensembl:ENST00000403510(transcript)|ensembl:ENST00000529388(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4H10|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:UJwUJQAcLUT6aEBNSUZOF6YyvMA9606 rigid:90qthHxNzpKn7+oWqM5a9XRJJ9Q false flag tag:n-n|mutation:339-339 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:P63208-1 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041208|imex:IM-21071-10|dip:DIP-190918E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:90qthHxNzpKn7+oWqM5a9XRJJ9Q false flag tag:n-n|mutation:339-339 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:Q9UKT7 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041208|imex:IM-21071-10|dip:DIP-190918E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rigid:90qthHxNzpKn7+oWqM5a9XRJJ9Q false flag tag:n-n|mutation:339-339 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:O00327 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-1794206|uniprotkb:O00313|uniprotkb:O00314|uniprotkb:O00315|uniprotkb:O00316|uniprotkb:O00317|uniprotkb:Q99631|uniprotkb:Q99649|uniprotkb:Q8IUT4|uniprotkb:D3DQW6|uniprotkb:A8K645|uniprotkb:B7WPG7|uniprotkb:B5ME11|uniprotkb:Q4G136|uniprotkb:A2I2N6|intact:EBI-28970920|ensembl:ENSP00000384517|ensembl:ENSP00000385581|ensembl:ENSP00000433571 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:bmal1_human(display_long)|uniprotkb:ARNTL(gene name)|psi-mi:ARNTL(display_short)|uniprotkb:BMAL1(gene name synonym)|uniprotkb:MOP3(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)|uniprotkb:Member of PAS protein 3(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP3(gene name synonym)|uniprotkb:bHLH-PAS protein JAP3(gene name synonym)|uniprotkb:BHLHE5(gene name synonym)|uniprotkb:PASD3(gene name synonym)|uniprotkb:PAS domain-containing protein 3(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041314|imex:IM-21071-15|dip:DIP-190920E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENST00000389707|ensembl:ENSP00000374357|ensembl:ENST00000401424|ensembl:ENSP00000385915|ensembl:ENSP00000384517|ensembl:ENST00000403482|ensembl:ENSP00000385897|ensembl:ENSP00000385581|ensembl:ENSP00000433571|refseq:XP_011518414.1|refseq:XP_011518415.1|refseq:NP_001025443.1|refseq:NP_001025444.1|refseq:NP_001169.3|refseq:XP_016873232.1|refseq:NP_001284648.1|refseq:NP_001284651.1|refseq:NP_001284653.1|refseq:XP_016873231.1|refseq:XP_016873235.1|refseq:XP_016873236.1|refseq:XP_016873237.1|dip:DIP-46008N|ensembl:ENSG00000133794(gene)|ensembl:ENST00000403290(transcript)|ensembl:ENST00000403510(transcript)|ensembl:ENST00000529388(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016605"(PML body)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033391"(chromatoid body)|go:"GO:0034751"(aryl hydrocarbon receptor complex)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051775"(response to redox state)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000074"(regulation of type B pancreatic cell development)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR035965|interpro:IPR036638|rcsb pdb:4H10|reactome:R-HSA-1368108|reactome:R-HSA-1989781|reactome:R-HSA-400253|reactome:R-HSA-9707616 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:UJwUJQAcLUT6aEBNSUZOF6YyvMA9606 rigid:Wi7tOWvCJfnZqbolF1V9z9KmJxk false flag tag:n-n|mutation:428-428|mutation:499-499 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9R194 uniprotkb:O15534 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 intact:EBI-2557276|uniprotkb:B4DI49|uniprotkb:B2RPA8|uniprotkb:D3DTR3|ensembl:ENSP00000314420 psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:per1_human(display_long)|uniprotkb:KIAA0482(gene name synonym)|uniprotkb:PER(gene name synonym)|uniprotkb:RIGUI(gene name synonym)|uniprotkb:Circadian clock protein PERIOD 1(gene name synonym)|uniprotkb:Circadian pacemaker protein Rigui(gene name synonym)|uniprotkb:PER1(gene name)|psi-mi:PER1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041314|imex:IM-21071-15|dip:DIP-190920E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 ensembl:ENSG00000179094(gene)|ensembl:ENST00000317276(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019900"(kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051591"(response to cAMP)|go:"GO:0070888"(E-box binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR013655(PAS fold-3)|interpro:IPR022728|interpro:IPR035965|rcsb pdb:1UL6|reactome:R-HSA-400253|refseq:NP_002607.2|refseq:XP_005256746.1|ensembl:ENSP00000314420|ensembl:ENST00000354903|ensembl:ENSP00000346979|dip:DIP-56603N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rogid:pLY3Sbn659CD2bY07SU8ysJxSSg9606 rigid:Wi7tOWvCJfnZqbolF1V9z9KmJxk false flag tag:n-n|mutation:428-428|mutation:499-499 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKT7 uniprotkb:Q9WTX5 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 intact:EBI-1202363|uniprotkb:Q8C5H6|ensembl:ENSMUSP00000038744|ensembl:ENSMUSP00000104700 psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:skp1_mouse(display_long)|uniprotkb:Skp1(gene name)|psi-mi:Skp1(display_short)|uniprotkb:Skp1a(gene name synonym)|uniprotkb:S-phase kinase-associated protein 1A(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:p19A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041340|imex:IM-21071-16|dip:DIP-190915E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N refseq:NP_035673.3|refseq:XP_006532849.1|go:"GO:0019904"(protein domain specific binding)|ensembl:ENSMUSG00000036309(gene)|ensembl:ENSMUST00000037324(transcript)|ensembl:ENSMUST00000109072(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:Q9WTX5|reactome:R-MMU-1169091|reactome:R-MMU-1170546|reactome:R-MMU-187577|reactome:R-MMU-195253|reactome:R-MMU-202424|reactome:R-MMU-2565942|reactome:R-MMU-2871837|reactome:R-MMU-5607761|reactome:R-MMU-5607764|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5676590|reactome:R-MMU-5684264|reactome:R-MMU-68949|reactome:R-MMU-69231|reactome:R-MMU-8854050|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-917937|reactome:R-MMU-9708530|reactome:R-MMU-983168|dip:DIP-38596N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rogid:qGk720KMKAbBPguy2tmUOZsLxRQ10090 rigid:gs+o6g0L28YnGX7K0RDIeTkgRls false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9UKT7 uniprotkb:Q9R194 intact:EBI-2557269|uniprotkb:Q9P122|uniprotkb:B2RB04|ensembl:ENSP00000347834 intact:EBI-1266619|uniprotkb:O08706|uniprotkb:Q6A024|ensembl:ENSMUSP00000088047|ensembl:ENSMUSP00000106909 psi-mi:fbxl3_human(display_long)|uniprotkb:FBL3A(gene name synonym)|uniprotkb:FBXL3A(gene name synonym)|uniprotkb:F-box and leucine-rich repeat protein 3A(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 3A(gene name synonym)|uniprotkb:FBXL3(gene name)|psi-mi:FBXL3(display_short) psi-mi:cry2_mouse(display_long)|uniprotkb:Cry2(gene name)|psi-mi:Cry2(display_short)|uniprotkb:Kiaa0658(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Xing et al. (2013) pubmed:23503662|doi:"https://doi.org/10.1038/nature11964"|imex:IM-21071 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16041340|imex:IM-21071-16|dip:DIP-190915E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000005812(gene)|ensembl:ENST00000355619(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR032675|interpro:IPR036047|reactome:R-HSA-390471|reactome:R-HSA-400253|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4I6J|refseq:NP_036290.1|refseq:XP_005266393.1|dip:DIP-40770N refseq:NP_034093.1|refseq:XP_017170770.1|dip:DIP-38517N|ensembl:ENSMUSG00000068742(gene)|ensembl:ENSMUST00000090559(transcript)|ensembl:ENSMUST00000111278(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009416"(response to light stimulus)|go:"GO:0009881"(photoreceptor activity)|go:"GO:0014823"(response to activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0018298"(protein-chromophore linkage)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019915"(lipid storage)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071949"(FAD binding)|go:"GO:2000118"(regulation of sodium-dependent phosphate transport)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|go:"GO:2000850"(negative regulation of glucocorticoid secretion)|interpro:IPR005101(DNA photolyase, FAD-binding/Cryptochrome, C-terminal)|interpro:IPR006050(DNA photolyase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR036134|interpro:IPR036155|mint:Q9R194|rcsb pdb:4I6E|rcsb pdb:4I6G|rcsb pdb:4I6J|rcsb pdb:4MLP|rcsb pdb:4U8H|rcsb pdb:6KX8|rcsb pdb:7D0N|rcsb pdb:7EJ9 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/07 2017/08/10 rogid:mD6wOlgnRmPCJbcVdLQnmcn+gkM9606 rogid:00SKIwCL33BKjjyPSsxZUR5Sjbs10090 rigid:gs+o6g0L28YnGX7K0RDIeTkgRls false flag tag:n-n - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)