#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27487	uniprotkb:K0BRG7	intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731	intact:EBI-16040613	psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym)	psi-mi:k0brg7_mers(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0096"(pull down)	Raj et al. (2013)	pubmed:23486063|doi:10.1038/nature12005|imex:IM-21086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16040632|imex:IM-21086-1|dip:DIP-190936E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR044337|interpro:IPR044376|interpro:IPR044873|interpro:IPR044874|rcsb pdb:4KQZ|rcsb pdb:4KR0|rcsb pdb:5DO2|rcsb pdb:6Q04|rcsb pdb:6Q05|rcsb pdb:6Q06|rcsb pdb:6Q07|dip:DIP-60213N	psi-mi:"MI:0465"(dip)	-	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2020/04/28	rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606	rogid:EGMgj5eReaW6Z/cduHj4yr/Zh7k1235996	rigid:dFQExS5mnRifbPt6wraMqjKZl3g	false	-	sufficient binding region:1-747|fc-igg tag:c-c	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P59594	uniprotkb:P59594	intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6	intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6	psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0808"(comigration in sds page)	Raj et al. (2013)	pubmed:23486063|doi:10.1038/nature12005|imex:IM-21086	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0465"(DIP)	intact:EBI-16040676|imex:IM-21086-3|dip:DIP-57119E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110	go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110	psi-mi:"MI:0465"(dip)	-	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2020/04/09	rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009	rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009	rigid:229l+RXp8RYZFbEn5VMlsZ51FNE	false	sufficient binding region:1-676|fc-igg tag:c-c	sufficient binding region:1-676|fc-igg tag:c-c	-	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P27487	uniprotkb:K0BRG7	intact:EBI-2871277|uniprotkb:Q53TN1|ensembl:ENSP00000353731	intact:EBI-16040613	psi-mi:dpp4_human(display_long)|uniprotkb:DPP4(gene name)|psi-mi:DPP4(display_short)|uniprotkb:ADCP2(gene name synonym)|uniprotkb:CD26(gene name synonym)|uniprotkb:ADABP(gene name synonym)|uniprotkb:Adenosine deaminase complexing protein 2(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV(gene name synonym)|uniprotkb:T-cell activation antigen CD26(gene name synonym)|uniprotkb:TP103(gene name synonym)	psi-mi:k0brg7_mers(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0096"(pull down)	Raj et al. (2013)	pubmed:23486063|doi:10.1038/nature12005|imex:IM-21086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16040696|imex:IM-21086-4|dip:DIP-190936E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001926.2|dip:DIP-351N|ensembl:ENSG00000197635(gene)|ensembl:ENST00000360534(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007155"(cell adhesion)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0033632"(regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0036343"(psychomotor behavior)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR002471(Peptidase S9, serine active site)|interpro:IPR029058|mint:P27487|rcsb pdb:1J2E|rcsb pdb:1N1M|rcsb pdb:1NU6|rcsb pdb:1NU8|rcsb pdb:1PFQ|rcsb pdb:1R9M|rcsb pdb:1R9N|rcsb pdb:1RWQ|rcsb pdb:1TK3|rcsb pdb:1TKR|rcsb pdb:1U8E|rcsb pdb:1W1I|rcsb pdb:1WCY|rcsb pdb:1X70|rcsb pdb:2AJL|rcsb pdb:2BGN|rcsb pdb:2BGR|rcsb pdb:2BUB|rcsb pdb:2FJP|rcsb pdb:2G5P|rcsb pdb:2G5T|rcsb pdb:2G63|rcsb pdb:2HHA|rcsb pdb:2I03|rcsb pdb:2I78|rcsb pdb:2IIV|rcsb pdb:2JID|rcsb pdb:2OAG|rcsb pdb:2OGZ|rcsb pdb:2OLE|rcsb pdb:2ONC|rcsb pdb:2OPH|rcsb pdb:2OQI|rcsb pdb:2OQV|rcsb pdb:2P8S|rcsb pdb:2QJR|rcsb pdb:2QKY|rcsb pdb:2QOE|rcsb pdb:2QT9|rcsb pdb:2IIT|rcsb pdb:2QTB|rcsb pdb:2RGU|rcsb pdb:2RIP|rcsb pdb:3BJM|rcsb pdb:3C43|rcsb pdb:3C45|rcsb pdb:3CCB|rcsb pdb:3CCC|rcsb pdb:3D4L|rcsb pdb:3EIO|rcsb pdb:3F8S|rcsb pdb:3G0B|rcsb pdb:3G0C|rcsb pdb:3G0D|rcsb pdb:3G0G|rcsb pdb:3H0C|rcsb pdb:3HAB|rcsb pdb:3HAC|rcsb pdb:3KWF|rcsb pdb:3KWJ|rcsb pdb:3NOX|rcsb pdb:3O95|rcsb pdb:3O9V|rcsb pdb:3OC0|rcsb pdb:3OPM|rcsb pdb:3Q0T|rcsb pdb:3Q8W|rcsb pdb:3SWW|rcsb pdb:3SX4|rcsb pdb:3VJK|rcsb pdb:3VJL|rcsb pdb:3VJM|rcsb pdb:3W2T|rcsb pdb:3WQH|rcsb pdb:4A5S|rcsb pdb:4DSA|rcsb pdb:4DSZ|rcsb pdb:4DTC|rcsb pdb:4G1F|rcsb pdb:4J3J|rcsb pdb:4JH0|rcsb pdb:4KR0|rcsb pdb:4L72|rcsb pdb:4LKO|rcsb pdb:4N8D|rcsb pdb:4N8E|rcsb pdb:4PNZ|rcsb pdb:4PV7|rcsb pdb:4QZV|rcsb pdb:5I7U|rcsb pdb:5ISM|rcsb pdb:5J3J|rcsb pdb:5KBY|rcsb pdb:5T4B|rcsb pdb:5T4E|rcsb pdb:5T4F|rcsb pdb:5T4H|rcsb pdb:5Y7H|rcsb pdb:5Y7J|rcsb pdb:5Y7K|rcsb pdb:5ZID|rcsb pdb:6B1E|rcsb pdb:6B1O|reactome:R-HSA-381771|reactome:R-HSA-400511|rcsb pdb:3QBJ	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR044337|interpro:IPR044376|interpro:IPR044873|interpro:IPR044874|rcsb pdb:4KQZ|rcsb pdb:4KR0|rcsb pdb:5DO2|rcsb pdb:6Q04|rcsb pdb:6Q05|rcsb pdb:6Q06|rcsb pdb:6Q07|dip:DIP-60213N	psi-mi:"MI:0465"(dip)	-	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2020/04/28	rogid:D8cgqdBbAfEQk+G2GhDuJvrkBcE9606	rogid:EGMgj5eReaW6Z/cduHj4yr/Zh7k1235996	rigid:dFQExS5mnRifbPt6wraMqjKZl3g	false	sufficient binding region:39-766	sufficient binding region:1-747|fc-igg tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:Q9BYF1	uniprotkb:P59594	intact:EBI-7730807|ensembl:ENSP00000252519|ensembl:ENSP00000389326|ensembl:ENSP00000504103|ensembl:ENSP00000505992|intact:EBI-25767352|uniprotkb:Q9UFZ6|uniprotkb:Q9NRA7|intact:MINT-4538816|uniprotkb:C7ECU1|uniprotkb:Q6UWP0|uniprotkb:Q86WT0|uniprotkb:A0A7D6JAD5|intact:EBI-15814450	intact:EBI-15582614|intact:EBI-16063777|uniprotkb:Q6QU82|uniprotkb:Q7T696|uniprotkb:Q7TA19|uniprotkb:Q7TFA2|uniprotkb:Q7TFB1|uniprotkb:Q80BV6	psi-mi:ace2_human(display_long)|uniprotkb:ACE2(gene name)|psi-mi:ACE2(display_short)|uniprotkb:UNQ868/PRO1885(orf name)|uniprotkb:Angiotensin-converting enzyme homolog(gene name synonym)|uniprotkb:Metalloprotease MPROT15(gene name synonym)|uniprotkb:Angiotensin-converting enzyme-related carboxypeptidase(gene name synonym)	psi-mi:spike_sars(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:2(orf name)	psi-mi:"MI:0096"(pull down)	Raj et al. (2013)	pubmed:23486063|doi:10.1038/nature12005|imex:IM-21086	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:694009(sars-cov)|taxid:694009(Human SARS coronavirus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16040653|imex:IM-21086-2|dip:DIP-190937E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000252519(transcript)|ensembl:ENST00000427411(transcript)|ensembl:ENST00000678073(transcript)|ensembl:ENST00000680121(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006508"(proteolysis)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0015827"(tryptophan transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|ensembl:ENSG00000130234(gene)|go:"GO:0051957"(positive regulation of amino acid transport)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905737"(positive regulation of L-proline import across plasma membrane)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|interpro:IPR031588|mint:Q9BYF1|rcsb pdb:1R42|rcsb pdb:1R4L|rcsb pdb:1XJP|rcsb pdb:2AJF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3KBH|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:6ACG|rcsb pdb:6ACJ|rcsb pdb:6ACK|rcsb pdb:6CS2|rcsb pdb:6LZG|rcsb pdb:6M0J|rcsb pdb:6M17|rcsb pdb:6M18|go:"GO:0050727"(regulation of inflammatory response)|rcsb pdb:6M1D|rcsb pdb:6VW1|rcsb pdb:7A91|rcsb pdb:7A92|rcsb pdb:7A94|rcsb pdb:7A95|rcsb pdb:7A96|rcsb pdb:7A97|rcsb pdb:7A98|rcsb pdb:7BH9|rcsb pdb:7CT5|rcsb pdb:7DDO|rcsb pdb:7DDP|rcsb pdb:7DF4|rcsb pdb:7DMU|rcsb pdb:7DWX|rcsb pdb:7DX4|rcsb pdb:7DX5|rcsb pdb:7DX6|rcsb pdb:7DX7|rcsb pdb:7DX8|rcsb pdb:7DX9|rcsb pdb:7JVO|rcsb pdb:7KJ2|rcsb pdb:7KJ3|rcsb pdb:7KJ4|rcsb pdb:7KMB|rcsb pdb:7KMS|rcsb pdb:7KMZ|rcsb pdb:7KNB|rcsb pdb:7KNE|rcsb pdb:7KNH|rcsb pdb:7L0N|rcsb pdb:7L7F|rcsb pdb:7LO4|rcsb pdb:7MJM|rcsb pdb:7MJN|rcsb pdb:7NXC|reactome:R-HSA-2022377|reactome:R-HSA-9678110|reactome:R-HSA-9679191|reactome:R-HSA-9694614|rcsb pdb:7KNI|dip:DIP-44689N|refseq:NP_068576.1	go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039587"(suppression by virus of host tetherin activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046789"(host cell surface receptor binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR044341|interpro:IPR044370|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1Q4Z|rcsb pdb:1T7G|rcsb pdb:1U4K|rcsb pdb:1WNC|rcsb pdb:1WYY|rcsb pdb:1XJP|rcsb pdb:1ZV7|rcsb pdb:1ZV8|rcsb pdb:1ZVB|rcsb pdb:2AJF|rcsb pdb:2BEQ|rcsb pdb:2BEZ|rcsb pdb:2DD8|rcsb pdb:2FXP|rcsb pdb:2GHV|rcsb pdb:2GHW|rcsb pdb:2RUM|rcsb pdb:2RUN|rcsb pdb:2RUO|rcsb pdb:3BGF|rcsb pdb:3D0G|rcsb pdb:3D0H|rcsb pdb:3D0I|rcsb pdb:3SCI|rcsb pdb:3SCJ|rcsb pdb:3SCK|rcsb pdb:3SCL|rcsb pdb:5WRG|rcsb pdb:5X4S|rcsb pdb:5X58|rcsb pdb:5X5B|rcsb pdb:5XJK|rcsb pdb:5XLR|rcsb pdb:5ZVM|rcsb pdb:6ACC|rcsb pdb:6ACD|rcsb pdb:6ACG|rcsb pdb:6ACK|rcsb pdb:6CRV|rcsb pdb:6CRW|rcsb pdb:6CRX|rcsb pdb:6CRZ|rcsb pdb:6CS0|rcsb pdb:6CS1|rcsb pdb:6CS2|rcsb pdb:6M3W|rcsb pdb:6NB6|rcsb pdb:6NB7|rcsb pdb:6VW1|rcsb pdb:6WAQ|rcsb pdb:7JN5|rcsb pdb:6ACJ|dip:DIP-29105N|reactome:R-HSA-9679509|reactome:R-HSA-9683686|reactome:R-HSA-9683701|refseq:NP_828851.1|reactome:R-HSA-9678110	psi-mi:"MI:0465"(dip)	comment:mint|function:Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2020/10/22	rogid:ZxuR6gzxz4Ns+hYH5uksGdn8S7o9606	rogid:H4uZUhfNNQNcF4O+7CmC50IoAi8694009	rigid:RfmpiMBj3JxEzdNSOZb1l0E86N0	false	sufficient binding region:1-614	sufficient binding region:1-676|fc-igg tag:c-c	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:K0BRG7	uniprotkb:K0BRG7	intact:EBI-16040613	intact:EBI-16040613	psi-mi:k0brg7_mers(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:k0brg7_mers(display_long)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:S(gene name)|psi-mi:S(display_short)	psi-mi:"MI:0808"(comigration in sds page)	Raj et al. (2013)	pubmed:23486063|doi:10.1038/nature12005|imex:IM-21086	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	taxid:1235996(cv2ce)|taxid:1235996(Human betacoronavirus 2c EMC/2012)	psi-mi:"MI:0195"(covalent binding)	psi-mi:"MI:0465"(DIP)	intact:EBI-16040719|imex:IM-21086-5|dip:DIP-190938E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR044337|interpro:IPR044376|interpro:IPR044873|interpro:IPR044874|rcsb pdb:4KQZ|rcsb pdb:4KR0|rcsb pdb:5DO2|rcsb pdb:6Q04|rcsb pdb:6Q05|rcsb pdb:6Q06|rcsb pdb:6Q07|dip:DIP-60213N	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR036326|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR044337|interpro:IPR044376|interpro:IPR044873|interpro:IPR044874|rcsb pdb:4KQZ|rcsb pdb:4KR0|rcsb pdb:5DO2|rcsb pdb:6Q04|rcsb pdb:6Q05|rcsb pdb:6Q06|rcsb pdb:6Q07|dip:DIP-60213N	psi-mi:"MI:0465"(dip)	-	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2020/04/28	rogid:EGMgj5eReaW6Z/cduHj4yr/Zh7k1235996	rogid:EGMgj5eReaW6Z/cduHj4yr/Zh7k1235996	rigid:scLcHPcSaOgEwpobSTi11lA/cQ8	false	sufficient binding region:1-747|fc-igg tag:c-c	sufficient binding region:1-747|fc-igg tag:c-c	-	0	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)