#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P11464-1	reactome:R-HSA-114514	intact:EBI-16007657|ensembl:ENSP00000413041	intact:EBI-2554508|matrixdb:MULT_24_human|wwpdb:3fcs|emdb:2281|wwpdb:2vc2|wwpdb:3nif|wwpdb:3nig|wwpdb:2vdk|wwpdb:2vdn|wwpdb:3nid|wwpdb:3fcu|wwpdb:2vdm|wwpdb:2vdl|wwpdb:1TYE|chembl target:CHEMBL2093869|reactome:R-HSA-114513|reactome:R-HSA-432107|reactome:R-HSA-432105|wwpdb:4cak|signor:SIGNOR-C173	psi-mi:p11464-1(display_long)|uniprotkb:CD66 antigen-like family member F(gene name synonym)|uniprotkb:Fetal liver non-specific cross-reactive antigen 1/2(gene name synonym)|uniprotkb:PSG95(gene name synonym)|uniprotkb:Pregnancy-specific beta-1 glycoprotein C/D(gene name synonym)|uniprotkb:PSG-1a(isoform synonym)|uniprotkb:PSG1(gene name)|psi-mi:PSG1(display_short)|uniprotkb:B1G1(gene name synonym)|uniprotkb:PSBG1(gene name synonym)|uniprotkb:PSGGA(gene name synonym)	psi-mi:intg_a2b_b3_human(display_short)|psi-mi:R-HSA-114514(display_long)|intact:alpha2b-beta3 integrin complex(complex synonym)|intact:alpha-2b/beta-3 integrin complex(complex synonym)|intact:alpha-IIb/beta-3 integrin complex(complex synonym)|intact:integrin alpha2b-beta3 complex(complex synonym)|intact:"ITGA2B:ITGB3"(complex systematic name)|intact:Integrin alphaIIb-beta3 complex(complex recommended name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shanley et al. (2012)	pubmed:23469002|imex:IM-26132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16008939|imex:IM-26132-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000231924(gene)|ensembl:ENST00000436291(transcript)|intact:EBI-716740(isoform-parent)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0070442"(integrin alphaIIb-beta3 complex)|efo:"Orphanet:849"(see-also)|intact:EBI-1040341(exp-evidence)|complex portal:CPX-1799(complex-primary)|evidence ontology:"ECO:0000353"	-	-	disease:Glanzmann thrombasthenia -  a disease of platelet aggregation characterized by mucocutaneous bleeding of mild-to-moderate severity.|curated-complex:"Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Integrin alphaIIb-beta3 is the most abundant surface-expressed integrin (40,000-80,000 copies per platelet) with another pool located in internal membranes and which can be exposed after platelet activation. Receptor for von Willebrand factor, fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands or H-H-L-G-G-G-A-K-Q-A-G-D-V in the case of fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface."|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	figure legend:2Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/05	2017/08/07	rogid:+2rx+KbkQ6/e9xUhYsQZfUlh/GU9606	-	-	false	his tag:c-c|v5 tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11464-1	reactome:R-HSA-114514	intact:EBI-16007657|ensembl:ENSP00000413041	intact:EBI-2554508|matrixdb:MULT_24_human|wwpdb:3fcs|emdb:2281|wwpdb:2vc2|wwpdb:3nif|wwpdb:3nig|wwpdb:2vdk|wwpdb:2vdn|wwpdb:3nid|wwpdb:3fcu|wwpdb:2vdm|wwpdb:2vdl|wwpdb:1TYE|chembl target:CHEMBL2093869|reactome:R-HSA-114513|reactome:R-HSA-432107|reactome:R-HSA-432105|wwpdb:4cak|signor:SIGNOR-C173	psi-mi:p11464-1(display_long)|uniprotkb:CD66 antigen-like family member F(gene name synonym)|uniprotkb:Fetal liver non-specific cross-reactive antigen 1/2(gene name synonym)|uniprotkb:PSG95(gene name synonym)|uniprotkb:Pregnancy-specific beta-1 glycoprotein C/D(gene name synonym)|uniprotkb:PSG-1a(isoform synonym)|uniprotkb:PSG1(gene name)|psi-mi:PSG1(display_short)|uniprotkb:B1G1(gene name synonym)|uniprotkb:PSBG1(gene name synonym)|uniprotkb:PSGGA(gene name synonym)	psi-mi:intg_a2b_b3_human(display_short)|psi-mi:R-HSA-114514(display_long)|intact:alpha2b-beta3 integrin complex(complex synonym)|intact:alpha-2b/beta-3 integrin complex(complex synonym)|intact:alpha-IIb/beta-3 integrin complex(complex synonym)|intact:integrin alpha2b-beta3 complex(complex synonym)|intact:"ITGA2B:ITGB3"(complex systematic name)|intact:Integrin alphaIIb-beta3 complex(complex recommended name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shanley et al. (2012)	pubmed:23469002|imex:IM-26132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16013366|imex:IM-26132-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000231924(gene)|ensembl:ENST00000436291(transcript)|intact:EBI-716740(isoform-parent)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0070442"(integrin alphaIIb-beta3 complex)|efo:"Orphanet:849"(see-also)|intact:EBI-1040341(exp-evidence)|complex portal:CPX-1799(complex-primary)|evidence ontology:"ECO:0000353"	-	-	disease:Glanzmann thrombasthenia -  a disease of platelet aggregation characterized by mucocutaneous bleeding of mild-to-moderate severity.|curated-complex:"Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Integrin alphaIIb-beta3 is the most abundant surface-expressed integrin (40,000-80,000 copies per platelet) with another pool located in internal membranes and which can be exposed after platelet activation. Receptor for von Willebrand factor, fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands or H-H-L-G-G-G-A-K-Q-A-G-D-V in the case of fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface."|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	figure legend:2 A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/05	2017/08/07	rogid:+2rx+KbkQ6/e9xUhYsQZfUlh/GU9606	-	-	false	his tag:c-c|v5 tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11464-1	reactome:R-HSA-114514	intact:EBI-16007657|ensembl:ENSP00000413041	intact:EBI-2554508|matrixdb:MULT_24_human|wwpdb:3fcs|emdb:2281|wwpdb:2vc2|wwpdb:3nif|wwpdb:3nig|wwpdb:2vdk|wwpdb:2vdn|wwpdb:3nid|wwpdb:3fcu|wwpdb:2vdm|wwpdb:2vdl|wwpdb:1TYE|chembl target:CHEMBL2093869|reactome:R-HSA-114513|reactome:R-HSA-432107|reactome:R-HSA-432105|wwpdb:4cak|signor:SIGNOR-C173	psi-mi:p11464-1(display_long)|uniprotkb:CD66 antigen-like family member F(gene name synonym)|uniprotkb:Fetal liver non-specific cross-reactive antigen 1/2(gene name synonym)|uniprotkb:PSG95(gene name synonym)|uniprotkb:Pregnancy-specific beta-1 glycoprotein C/D(gene name synonym)|uniprotkb:PSG-1a(isoform synonym)|uniprotkb:PSG1(gene name)|psi-mi:PSG1(display_short)|uniprotkb:B1G1(gene name synonym)|uniprotkb:PSBG1(gene name synonym)|uniprotkb:PSGGA(gene name synonym)	psi-mi:intg_a2b_b3_human(display_short)|psi-mi:R-HSA-114514(display_long)|intact:alpha2b-beta3 integrin complex(complex synonym)|intact:alpha-2b/beta-3 integrin complex(complex synonym)|intact:alpha-IIb/beta-3 integrin complex(complex synonym)|intact:integrin alpha2b-beta3 complex(complex synonym)|intact:"ITGA2B:ITGB3"(complex systematic name)|intact:Integrin alphaIIb-beta3 complex(complex recommended name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shanley et al. (2012)	pubmed:23469002|imex:IM-26132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16024177|imex:IM-26132-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000231924(gene)|ensembl:ENST00000436291(transcript)|intact:EBI-716740(isoform-parent)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0070442"(integrin alphaIIb-beta3 complex)|efo:"Orphanet:849"(see-also)|intact:EBI-1040341(exp-evidence)|complex portal:CPX-1799(complex-primary)|evidence ontology:"ECO:0000353"	-	-	disease:Glanzmann thrombasthenia -  a disease of platelet aggregation characterized by mucocutaneous bleeding of mild-to-moderate severity.|curated-complex:"Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Integrin alphaIIb-beta3 is the most abundant surface-expressed integrin (40,000-80,000 copies per platelet) with another pool located in internal membranes and which can be exposed after platelet activation. Receptor for von Willebrand factor, fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands or H-H-L-G-G-G-A-K-Q-A-G-D-V in the case of fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface."|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	figure legend:Supp 5|comment:N_terminal_region only showed weak interaction.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/05	2017/08/07	rogid:+2rx+KbkQ6/e9xUhYsQZfUlh/GU9606	-	-	false	his tag:c-c|v5 tag:c-c|sufficient binding region:1-144(IPR013783)|mutation with no effect:126-128	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11464-1	reactome:R-HSA-114514	intact:EBI-16007657|ensembl:ENSP00000413041	intact:EBI-2554508|matrixdb:MULT_24_human|wwpdb:3fcs|emdb:2281|wwpdb:2vc2|wwpdb:3nif|wwpdb:3nig|wwpdb:2vdk|wwpdb:2vdn|wwpdb:3nid|wwpdb:3fcu|wwpdb:2vdm|wwpdb:2vdl|wwpdb:1TYE|chembl target:CHEMBL2093869|reactome:R-HSA-114513|reactome:R-HSA-432107|reactome:R-HSA-432105|wwpdb:4cak|signor:SIGNOR-C173	psi-mi:p11464-1(display_long)|uniprotkb:CD66 antigen-like family member F(gene name synonym)|uniprotkb:Fetal liver non-specific cross-reactive antigen 1/2(gene name synonym)|uniprotkb:PSG95(gene name synonym)|uniprotkb:Pregnancy-specific beta-1 glycoprotein C/D(gene name synonym)|uniprotkb:PSG-1a(isoform synonym)|uniprotkb:PSG1(gene name)|psi-mi:PSG1(display_short)|uniprotkb:B1G1(gene name synonym)|uniprotkb:PSBG1(gene name synonym)|uniprotkb:PSGGA(gene name synonym)	psi-mi:intg_a2b_b3_human(display_short)|psi-mi:R-HSA-114514(display_long)|intact:alpha2b-beta3 integrin complex(complex synonym)|intact:alpha-2b/beta-3 integrin complex(complex synonym)|intact:alpha-IIb/beta-3 integrin complex(complex synonym)|intact:integrin alpha2b-beta3 complex(complex synonym)|intact:"ITGA2B:ITGB3"(complex systematic name)|intact:Integrin alphaIIb-beta3 complex(complex recommended name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shanley et al. (2012)	pubmed:23469002|imex:IM-26132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16003653|imex:IM-26132-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	ensembl:ENSG00000231924(gene)|ensembl:ENST00000436291(transcript)|intact:EBI-716740(isoform-parent)	pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0070442"(integrin alphaIIb-beta3 complex)|efo:"Orphanet:849"(see-also)|intact:EBI-1040341(exp-evidence)|complex portal:CPX-1799(complex-primary)|evidence ontology:"ECO:0000353"	-	-	disease:Glanzmann thrombasthenia -  a disease of platelet aggregation characterized by mucocutaneous bleeding of mild-to-moderate severity.|curated-complex:"Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Integrin alphaIIb-beta3 is the most abundant surface-expressed integrin (40,000-80,000 copies per platelet) with another pool located in internal membranes and which can be exposed after platelet activation. Receptor for von Willebrand factor, fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands or H-H-L-G-G-G-A-K-Q-A-G-D-V in the case of fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface."|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/05	2017/08/07	rogid:+2rx+KbkQ6/e9xUhYsQZfUlh/GU9606	-	-	false	his tag:c-c|v5 tag:c-c|sufficient binding region:1-34,145-419	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)