#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q08214 uniprotkb:P38920 intact:EBI-12303|ensemblfungi:YOL043C|uniprotkb:D6W223 intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:nth2_yeast(display_long)|uniprotkb:NTG2(gene name)|psi-mi:NTG2(display_short)|uniprotkb:Endonuclease III-like glycosylase 2(gene name synonym)|uniprotkb:Redoxyendonuclease 2(gene name synonym)|uniprotkb:SCR2(gene name synonym)|uniprotkb:YOL043C(locus name)|uniprotkb:"Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2"(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038465|imex:IM-21116-1|dip:DIP-17907E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YOL043C(gene)|go:"GO:0000703"(oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004036(Endonuclease III, conserved site-2)|ensemblfungi:YOL043C_mRNA(transcript)|interpro:IPR011257(DNA glycosylase)|interpro:IPR023170|interpro:IPR030841|rcsb pdb:4FMN|refseq:NP_014599.1|sgd:S000005403|reactome:R-SCE-110329|dip:DIP-2956N rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:517F81C3BA3DDCF7 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:kDksGJ88iObL/xZaZcT5h7ZnQLk559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:BJtTRDML8LbNeqswPSMM8C9wkIo false - sufficient binding region:485-769|mutation disrupting interaction strength:511-511 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P39875 uniprotkb:P38920 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038555|imex:IM-21116-5|dip:DIP-17908E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:78E22F6B265DB3AA crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:EKsjtBJ/Jiq5RlKvr49wK0LaDTs false sufficient binding region:400-702 sufficient binding region:485-769|mutation disrupting interaction strength:511-511 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P39875 uniprotkb:P38920 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038531|imex:IM-21116-4|dip:DIP-190989E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:78E22F6B265DB3AA crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:QR5d80qZGUtVCnosxLEwhbSVgPo false sufficient binding region:443-450 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P39875 uniprotkb:P14242 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C intact:EBI-13561|uniprotkb:Q2I044|uniprotkb:Q2I045|uniprotkb:Q45TY4|uniprotkb:Q8TG48|uniprotkb:Q8TG50|uniprotkb:Q8TG54|uniprotkb:Q8TG57|uniprotkb:D6W197|ensemblfungi:YNL082W psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:pms1_yeast(display_long)|uniprotkb:PMS1(gene name)|psi-mi:PMS1(display_short)|uniprotkb:YNL082W(locus name)|uniprotkb:N2317(orf name)|uniprotkb:Postmeiotic segregation protein 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038531|imex:IM-21116-4|dip:DIP-190989E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO sgd:S000005026|refseq:NP_014317.4|ensemblfungi:YNL082W(gene)|ensemblfungi:YNL082W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042121|rcsb pdb:3H4L|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|reactome:R-SCE-5358565|mint:P14242|dip:DIP-2416N psi-mi:"MI:0465"(dip) crc64:78E22F6B265DB3AA crc64:2E0FFBC59B718854 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 rogid:JMHy1ud9pY728nqxAv82qHJ6eZk559292 rigid:QR5d80qZGUtVCnosxLEwhbSVgPo false sufficient binding region:443-450 sufficient binding region:635-873 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35187 uniprotkb:P38920 intact:EBI-17059|uniprotkb:D6W014|ensemblfungi:YMR190C intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:sgs1_yeast(display_long)|uniprotkb:SGS1(gene name)|psi-mi:SGS1(display_short)|uniprotkb:TPS1(gene name synonym)|uniprotkb:YMR190C(locus name)|uniprotkb:YM9646.02C(orf name)|uniprotkb:Helicase TPS1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16038509|imex:IM-21116-3|dip:DIP-190990E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006265"(DNA topological change)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010520"(regulation of reciprocal meiotic recombination)|go:"GO:0010947"(negative regulation of meiotic joint molecule formation)|go:"GO:0031422"(RecQ family helicase-topoisomerase III complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051276"(chromosome organization)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0005634"(nucleus)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR022758|interpro:IPR027417|interpro:IPR032284|interpro:IPR036388|rcsb pdb:1D8B|interpro:IPR001650(DNA/RNA helicase, C-terminal)|refseq:NP_013915.1|sgd:S000004802|ensemblfungi:YMR190C(gene)|ensemblfungi:YMR190C_mRNA(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|dip:DIP-2911N|mint:P35187 rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:0DC320B41756A3C3 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:kSX/9U/Qjnhm6doWBmFCKOC8dJo559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:NQMoBovRJD1gcHAq9HqOagw0m4k false sufficient binding region:1381-1388 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14242 uniprotkb:P38920 intact:EBI-13561|uniprotkb:Q2I044|uniprotkb:Q2I045|uniprotkb:Q45TY4|uniprotkb:Q8TG48|uniprotkb:Q8TG50|uniprotkb:Q8TG54|uniprotkb:Q8TG57|uniprotkb:D6W197|ensemblfungi:YNL082W intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:pms1_yeast(display_long)|uniprotkb:PMS1(gene name)|psi-mi:PMS1(display_short)|uniprotkb:YNL082W(locus name)|uniprotkb:N2317(orf name)|uniprotkb:Postmeiotic segregation protein 1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16038488|imex:IM-21116-2|dip:DIP-2913E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005026|refseq:NP_014317.4|ensemblfungi:YNL082W(gene)|ensemblfungi:YNL082W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042121|rcsb pdb:3H4L|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|reactome:R-SCE-5358565|mint:P14242|dip:DIP-2416N rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:2E0FFBC59B718854 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:JMHy1ud9pY728nqxAv82qHJ6eZk559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:xB+nuhExIJTnwHXwIAQ2ix0fvKw false sufficient binding region:635-873 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14242 uniprotkb:P38920 intact:EBI-13561|uniprotkb:Q2I044|uniprotkb:Q2I045|uniprotkb:Q45TY4|uniprotkb:Q8TG48|uniprotkb:Q8TG50|uniprotkb:Q8TG54|uniprotkb:Q8TG57|uniprotkb:D6W197|ensemblfungi:YNL082W intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:pms1_yeast(display_long)|uniprotkb:PMS1(gene name)|psi-mi:PMS1(display_short)|uniprotkb:YNL082W(locus name)|uniprotkb:N2317(orf name)|uniprotkb:Postmeiotic segregation protein 1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038579|imex:IM-21116-6|dip:DIP-2913E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005026|refseq:NP_014317.4|ensemblfungi:YNL082W(gene)|ensemblfungi:YNL082W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042121|rcsb pdb:3H4L|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|reactome:R-SCE-5358565|mint:P14242|dip:DIP-2416N rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:2E0FFBC59B718854 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:JMHy1ud9pY728nqxAv82qHJ6eZk559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:xB+nuhExIJTnwHXwIAQ2ix0fvKw false sufficient binding region:635-873|maltose binding protein tag:n-n sufficient binding region:485-769|glutathione s tranferase tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q08214 uniprotkb:P38920 intact:EBI-12303|ensemblfungi:YOL043C|uniprotkb:D6W223 intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:nth2_yeast(display_long)|uniprotkb:NTG2(gene name)|psi-mi:NTG2(display_short)|uniprotkb:Endonuclease III-like glycosylase 2(gene name synonym)|uniprotkb:Redoxyendonuclease 2(gene name synonym)|uniprotkb:SCR2(gene name synonym)|uniprotkb:YOL043C(locus name)|uniprotkb:"Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2"(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16038604|imex:IM-21116-7|dip:DIP-17907E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:YOL043C(gene)|go:"GO:0000703"(oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004036(Endonuclease III, conserved site-2)|ensemblfungi:YOL043C_mRNA(transcript)|interpro:IPR011257(DNA glycosylase)|interpro:IPR023170|interpro:IPR030841|rcsb pdb:4FMN|refseq:NP_014599.1|sgd:S000005403|reactome:R-SCE-110329|dip:DIP-2956N rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:517F81C3BA3DDCF7 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:kDksGJ88iObL/xZaZcT5h7ZnQLk559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:BJtTRDML8LbNeqswPSMM8C9wkIo false sufficient binding region:22-29|mutation decreasing interaction strength:26-26|mutation disrupting interaction strength:27-27|mutation disrupting interaction strength:27-27 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P39875 uniprotkb:P38920 intact:EBI-6738|uniprotkb:D6W299|ensemblfungi:YOR033C intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:exo1_yeast(display_long)|uniprotkb:EXO1(gene name)|psi-mi:EXO1(display_short)|uniprotkb:DHS1(gene name synonym)|uniprotkb:YOR033C(locus name)|uniprotkb:OR26.23(orf name)|uniprotkb:Exodeoxyribonuclease I(gene name synonym)|uniprotkb:Protein DHS1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16038726|imex:IM-21116-12|dip:DIP-17908E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_014676.1|sgd:S000005559|reactome:R-SCE-5358565|dip:DIP-2421N|ensemblfungi:YOR033C(gene)|ensemblfungi:YOR033C_mRNA(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0035312"(5'-3' exodeoxyribonuclease activity)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0046872"(metal ion binding)|interpro:IPR006084("DNA repair protein (XPGC)/yeast Rad")|interpro:IPR006085(XPG N-terminal)|interpro:IPR006086(XPG I)|interpro:IPR008918(Helix-hairpin-helix motif, class 2)|interpro:IPR019974|interpro:IPR029060|interpro:IPR032641|interpro:IPR036279|interpro:IPR037315|interpro:IPR044752|rcsb pdb:4FMO rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:78E22F6B265DB3AA crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:sqo9MuVPozgKw5hQO4pcxFgLroM559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:EKsjtBJ/Jiq5RlKvr49wK0LaDTs false sufficient binding region:443-450 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14242 uniprotkb:P38920 intact:EBI-13561|uniprotkb:Q2I044|uniprotkb:Q2I045|uniprotkb:Q45TY4|uniprotkb:Q8TG48|uniprotkb:Q8TG50|uniprotkb:Q8TG54|uniprotkb:Q8TG57|uniprotkb:D6W197|ensemblfungi:YNL082W intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:pms1_yeast(display_long)|uniprotkb:PMS1(gene name)|psi-mi:PMS1(display_short)|uniprotkb:YNL082W(locus name)|uniprotkb:N2317(orf name)|uniprotkb:Postmeiotic segregation protein 1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038702|imex:IM-21116-11|dip:DIP-2913E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005026|refseq:NP_014317.4|ensemblfungi:YNL082W(gene)|ensemblfungi:YNL082W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042121|rcsb pdb:3H4L|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|reactome:R-SCE-5358565|mint:P14242|dip:DIP-2416N rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:2E0FFBC59B718854 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:JMHy1ud9pY728nqxAv82qHJ6eZk559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:xB+nuhExIJTnwHXwIAQ2ix0fvKw false sufficient binding region:611-873 sufficient binding region:485-769|mutation disrupting interaction strength:547-547 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14242 uniprotkb:P38920 intact:EBI-13561|uniprotkb:Q2I044|uniprotkb:Q2I045|uniprotkb:Q45TY4|uniprotkb:Q8TG48|uniprotkb:Q8TG50|uniprotkb:Q8TG54|uniprotkb:Q8TG57|uniprotkb:D6W197|ensemblfungi:YNL082W intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:pms1_yeast(display_long)|uniprotkb:PMS1(gene name)|psi-mi:PMS1(display_short)|uniprotkb:YNL082W(locus name)|uniprotkb:N2317(orf name)|uniprotkb:Postmeiotic segregation protein 1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038676|imex:IM-21116-10|dip:DIP-2913E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005026|refseq:NP_014317.4|ensemblfungi:YNL082W(gene)|ensemblfungi:YNL082W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042121|rcsb pdb:3H4L|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|reactome:R-SCE-5358565|mint:P14242|dip:DIP-2416N rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:2E0FFBC59B718854 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:JMHy1ud9pY728nqxAv82qHJ6eZk559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:xB+nuhExIJTnwHXwIAQ2ix0fvKw false sufficient binding region:611-873|mutation disrupting interaction strength:870-870|necessary binding region:864-873 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P14242 uniprotkb:P38920 intact:EBI-13561|uniprotkb:Q2I044|uniprotkb:Q2I045|uniprotkb:Q45TY4|uniprotkb:Q8TG48|uniprotkb:Q8TG50|uniprotkb:Q8TG54|uniprotkb:Q8TG57|uniprotkb:D6W197|ensemblfungi:YNL082W intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:pms1_yeast(display_long)|uniprotkb:PMS1(gene name)|psi-mi:PMS1(display_short)|uniprotkb:YNL082W(locus name)|uniprotkb:N2317(orf name)|uniprotkb:Postmeiotic segregation protein 1(gene name synonym) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16038655|imex:IM-21116-9|dip:DIP-2913E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) sgd:S000005026|refseq:NP_014317.4|ensemblfungi:YNL082W(gene)|ensemblfungi:YNL082W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042121|rcsb pdb:3H4L|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|reactome:R-SCE-5358565|mint:P14242|dip:DIP-2416N rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:2E0FFBC59B718854 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:JMHy1ud9pY728nqxAv82qHJ6eZk559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:xB+nuhExIJTnwHXwIAQ2ix0fvKw false sufficient binding region:635-873 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12083 uniprotkb:P38920 intact:EBI-31634|uniprotkb:D6W3K4|ensemblfungi:YPL164C intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 psi-mi:mlh3_yeast(display_long)|uniprotkb:MLH3(gene name)|psi-mi:MLH3(display_short)|uniprotkb:MutL protein homolog 3(gene name synonym)|uniprotkb:P2550(orf name)|uniprotkb:YPL164C(locus name) psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038634|imex:IM-21116-8|dip:DIP-2911E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_015161.1|sgd:S000006085|dip:DIP-2414N|ensemblfungi:YPL164C(gene)|ensemblfungi:YPL164C_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR028830|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042120|rcsb pdb:6RMN|rcsb pdb:6SHX|rcsb pdb:6SNS|rcsb pdb:6SNV rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N psi-mi:"MI:0465"(dip) crc64:970FD7F57EB6E3B1 crc64:B2DBB31DE3943171 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2017/08/10 rogid:g47/5yM9oWZ13CIZOZ7QT6A+LW0559292 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rigid:gfcfSC0/08jR2Lw5wyA36U18pDo false sufficient binding region:460-715 sufficient binding region:485-769 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P38920 uniprotkb:Q08214 intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 intact:EBI-12303|ensemblfungi:YOL043C|uniprotkb:D6W223 psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:nth2_yeast(display_long)|uniprotkb:NTG2(gene name)|psi-mi:NTG2(display_short)|uniprotkb:Endonuclease III-like glycosylase 2(gene name synonym)|uniprotkb:Redoxyendonuclease 2(gene name synonym)|uniprotkb:SCR2(gene name synonym)|uniprotkb:YOL043C(locus name)|uniprotkb:"Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2"(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038748|imex:IM-21116-13|dip:DIP-190988E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N ensemblfungi:YOL043C(gene)|go:"GO:0000703"(oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006285"(base-excision repair, AP site formation)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0140078"("class I DNA-(apurinic or apyrimidinic site) endonuclease activity")|interpro:IPR003265(HhH-GPD)|interpro:IPR003651(Iron-sulphur cluster loop)|interpro:IPR004036(Endonuclease III, conserved site-2)|ensemblfungi:YOL043C_mRNA(transcript)|interpro:IPR011257(DNA glycosylase)|interpro:IPR023170|interpro:IPR030841|rcsb pdb:4FMN|refseq:NP_014599.1|sgd:S000005403|reactome:R-SCE-110329|dip:DIP-2956N psi-mi:"MI:0465"(dip) crc64:B2DBB31DE3943171 crc64:517F81C3BA3DDCF7 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rogid:kDksGJ88iObL/xZaZcT5h7ZnQLk559292 rigid:h4n9Rl/0MWtu7r0pURRwUFtD+xw false sufficient binding region:485-769 sufficient binding region:22-29 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P38920 uniprotkb:P14242 intact:EBI-11003|uniprotkb:Q2I028|uniprotkb:Q2I029|uniprotkb:Q2I031|uniprotkb:Q2I032|uniprotkb:Q2I033|uniprotkb:Q2I034|uniprotkb:Q2I035|uniprotkb:Q2I036|uniprotkb:Q2I038|uniprotkb:Q2I039|uniprotkb:Q2I041|ensemblfungi:YMR167W|uniprotkb:D6VZY9 intact:EBI-13561|uniprotkb:Q2I044|uniprotkb:Q2I045|uniprotkb:Q45TY4|uniprotkb:Q8TG48|uniprotkb:Q8TG50|uniprotkb:Q8TG54|uniprotkb:Q8TG57|uniprotkb:D6W197|ensemblfungi:YNL082W psi-mi:mlh1_yeast(display_long)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:YMR167W(locus name)|uniprotkb:YM8520.16(orf name)|uniprotkb:PMS2(gene name synonym)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:Post meiotic segregation protein 2(gene name synonym) psi-mi:pms1_yeast(display_long)|uniprotkb:PMS1(gene name)|psi-mi:PMS1(display_short)|uniprotkb:YNL082W(locus name)|uniprotkb:N2317(orf name)|uniprotkb:Postmeiotic segregation protein 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Gueneau et al. (2013) pubmed:23435383|doi:10.1038/nsmb.2511|imex:IM-21116 taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16038748|imex:IM-21116-13|dip:DIP-190988E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:6SNS|rcsb pdb:6SNV|reactome:R-SCE-5358565|ensemblfungi:YMR167W(gene)|ensemblfungi:YMR167W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000713"(meiotic heteroduplex formation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006298"(mismatch repair)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0032390"(MutLbeta complex)|go:"GO:0097587"(MutLgamma complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|rcsb pdb:6RMN|rcsb pdb:6SHX|refseq:NP_013890.1|sgd:S000004777|mint:P38920|dip:DIP-2412N sgd:S000005026|refseq:NP_014317.4|ensemblfungi:YNL082W(gene)|ensemblfungi:YNL082W_mRNA(transcript)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006298"(mismatch repair)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR014790(MutL, C-terminal, dimerisation)|interpro:IPR020568|interpro:IPR036890|interpro:IPR037198|interpro:IPR038973|interpro:IPR042121|rcsb pdb:3H4L|rcsb pdb:4E4W|rcsb pdb:4FMN|rcsb pdb:4FMO|reactome:R-SCE-5358565|mint:P14242|dip:DIP-2416N psi-mi:"MI:0465"(dip) crc64:B2DBB31DE3943171 crc64:2E0FFBC59B718854 full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rZq8/zWV2xAiYIDDuGGsp+YjSnY559292 rogid:JMHy1ud9pY728nqxAv82qHJ6eZk559292 rigid:h4n9Rl/0MWtu7r0pURRwUFtD+xw false sufficient binding region:485-769 sufficient binding region:635-873 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)