#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15475	uniprotkb:O00167-1	intact:EBI-743675|uniprotkb:Q96H64|uniprotkb:Q53Y16|ensembl:ENSP00000494686	intact:EBI-16038245|ensembl:ENSP00000333640	psi-mi:six1_human(display_long)|uniprotkb:Sine oculis homeobox homolog 1(gene name synonym)|uniprotkb:SIX1(gene name)|psi-mi:SIX1(display_short)	psi-mi:o00167-1(display_long)|uniprotkb:EYA2(gene name)|psi-mi:EYA2(display_short)|uniprotkb:EAB1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Patrick et al. (2013)	pubmed:23435380|doi:10.1038/nsmb.2505|imex:IM-21114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16038251|imex:IM-21114-1|dip:DIP-68995E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005973.1|ensembl:ENSG00000126778(gene)|ensembl:ENST00000645694(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001822"(kidney development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014857"(regulation of skeletal muscle cell proliferation)|go:"GO:0021610"(facial nerve morphogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048538"(thymus development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048839"(inner ear development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0072075"(metanephric mesenchyme development)|interpro:IPR031278|interpro:IPR031701|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|mint:Q15475|rcsb pdb:4EGC|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072172"(mesonephric tubule formation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|dip:DIP-34448N	ensembl:ENSG00000064655(gene)|ensembl:ENST00000327619(transcript)|intact:EBI-750211(isoform-parent)|uniprotkb:O00167-1(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CDsvqBP4KDSbYoxt3Qi/sdP9ivo9606	rogid:GzEF57gMLHQVYIXIpdcf3XffCS49606	rigid:Lf5CTq5OtZmBoIhmmfzcmNXbpLw	false	sufficient binding region:1-189|maltose binding protein tag:n-n	sufficient binding region:253-538	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15475	uniprotkb:O00167-1	intact:EBI-743675|uniprotkb:Q96H64|uniprotkb:Q53Y16|ensembl:ENSP00000494686	intact:EBI-16038245|ensembl:ENSP00000333640	psi-mi:six1_human(display_long)|uniprotkb:Sine oculis homeobox homolog 1(gene name synonym)|uniprotkb:SIX1(gene name)|psi-mi:SIX1(display_short)	psi-mi:o00167-1(display_long)|uniprotkb:EYA2(gene name)|psi-mi:EYA2(display_short)|uniprotkb:EAB1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Patrick et al. (2013)	pubmed:23435380|doi:10.1038/nsmb.2505|imex:IM-21114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16038274|imex:IM-21114-2|dip:DIP-68995E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005973.1|ensembl:ENSG00000126778(gene)|ensembl:ENST00000645694(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001822"(kidney development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014857"(regulation of skeletal muscle cell proliferation)|go:"GO:0021610"(facial nerve morphogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048538"(thymus development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048839"(inner ear development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0072075"(metanephric mesenchyme development)|interpro:IPR031278|interpro:IPR031701|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|mint:Q15475|rcsb pdb:4EGC|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072172"(mesonephric tubule formation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|dip:DIP-34448N	ensembl:ENSG00000064655(gene)|ensembl:ENST00000327619(transcript)|intact:EBI-750211(isoform-parent)|uniprotkb:O00167-1(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CDsvqBP4KDSbYoxt3Qi/sdP9ivo9606	rogid:GzEF57gMLHQVYIXIpdcf3XffCS49606	rigid:Lf5CTq5OtZmBoIhmmfzcmNXbpLw	false	sufficient binding region:1-189|maltose binding protein tag:n-n|mutation disrupting interaction strength:16-16	sufficient binding region:253-538	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15475	uniprotkb:O00167-1	intact:EBI-743675|uniprotkb:Q96H64|uniprotkb:Q53Y16|ensembl:ENSP00000494686	intact:EBI-16038245|ensembl:ENSP00000333640	psi-mi:six1_human(display_long)|uniprotkb:Sine oculis homeobox homolog 1(gene name synonym)|uniprotkb:SIX1(gene name)|psi-mi:SIX1(display_short)	psi-mi:o00167-1(display_long)|uniprotkb:EYA2(gene name)|psi-mi:EYA2(display_short)|uniprotkb:EAB1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Patrick et al. (2013)	pubmed:23435380|doi:10.1038/nsmb.2505|imex:IM-21114	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16038300|imex:IM-21114-3|dip:DIP-68995E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005973.1|ensembl:ENSG00000126778(gene)|ensembl:ENST00000645694(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001822"(kidney development)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014857"(regulation of skeletal muscle cell proliferation)|go:"GO:0021610"(facial nerve morphogenesis)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030910"(olfactory placode formation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048538"(thymus development)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048699"(generation of neurons)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048839"(inner ear development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051451"(myoblast migration)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0061055"(myotome development)|go:"GO:0061197"(fungiform papilla morphogenesis)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071599"(otic vesicle development)|go:"GO:0072075"(metanephric mesenchyme development)|interpro:IPR031278|interpro:IPR031701|go:"GO:0072095"(regulation of branch elongation involved in ureteric bud branching)|mint:Q15475|rcsb pdb:4EGC|go:"GO:0072107"(positive regulation of ureteric bud formation)|go:"GO:0072172"(mesonephric tubule formation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:1905243"(cellular response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000729"(positive regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|dip:DIP-34448N	ensembl:ENSG00000064655(gene)|ensembl:ENST00000327619(transcript)|intact:EBI-750211(isoform-parent)|uniprotkb:O00167-1(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:CDsvqBP4KDSbYoxt3Qi/sdP9ivo9606	rogid:GzEF57gMLHQVYIXIpdcf3XffCS49606	rigid:Lf5CTq5OtZmBoIhmmfzcmNXbpLw	false	sufficient binding region:1-189|maltose binding protein tag:n-n	sufficient binding region:253-538|mutation disrupting interaction strength:532-532|mutation decreasing interaction strength:516-516	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)