#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q15116 uniprotkb:Q9NZQ7 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16427934|imex:IM-26316-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N - - - figure legend:Figure 2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/12 2017/10/18 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false 15n label:?-?|mutation:93-93|2h label:?-?|sufficient binding region:34-150|13c label:?-? sufficient binding region:1-235|his tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15116 uniprotkb:Q9BQ51 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16427959|imex:IM-26316-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 - - - figure legend:Figure 2B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/10/12 2017/10/18 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false 15n label:?-?|mutation:93-93|2h label:?-?|sufficient binding region:34-150|13c label:?-? sufficient binding region:1-220|his tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428010|imex:IM-26316-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 5 A/B, Fig 7, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:8.2x10^-6(molar) 2017/10/12 2017/10/18 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false biotin tag:?-?|sufficient binding region:1-235|his tag:?-? mutation:93-93|sufficient binding region:34-150 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428033|imex:IM-26316-21 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 5 C/D, Fig 7, table 2i|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.3x10^-6(molar) 2017/10/12 2017/10/18 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false biotin tag:?-?|sufficient binding region:1-220|his tag:?-? mutation:93-93|sufficient binding region:34-150 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:P33681 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428216|imex:IM-26316-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N - - - figure legend:Figure 5 E/F, 7, table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:18.8x10^-6(molar) 2017/10/12 2017/10/18 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 rigid:dekVHLAYv5FV/AAjOd9C0tdWZRs false biotin tag:?-?|sufficient binding region:1-235|his tag:?-? his tag:?-?|sufficient binding region:1-235 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428252|imex:IM-26316-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 6 A/B, Fig 7, table 2|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:7.5x10^-6(molar) 2017/10/12 2017/10/18 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428273|imex:IM-26316-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 6 C/D, Fig 7, table 2|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.2x10^-6(molar) 2017/10/12 2017/10/18 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:P33681 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-1031024|ensembl:ENSP00000264246|ensembl:ENSP00000418364|uniprotkb:Q5DTA9|uniprotkb:Q5DTB0 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:cd80_human(display_long)|uniprotkb:CD80(gene name)|psi-mi:CD80(display_short)|uniprotkb:CD28LG(gene name synonym)|uniprotkb:CD28LG1(gene name synonym)|uniprotkb:LAB7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym)|uniprotkb:CTLA-4 counter-receptor B7.1(gene name synonym)|uniprotkb:BB1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428302|imex:IM-26316-23 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005182.1|ensembl:ENSG00000121594(gene)|ensembl:ENST00000264246(transcript)|ensembl:ENST00000478182(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:1DR9|rcsb pdb:1I8L|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-389356|reactome:R-HSA-389357|reactome:R-HSA-389359|reactome:R-HSA-389513|reactome:R-HSA-6783783|reactome:R-HSA-6811558|dip:DIP-6044N - - - figure legend:Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:35.4x10^-6(molar) 2017/10/12 2017/10/18 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:ZKA9ziAUnKDmzBpyUysM9BfJLy09606 rigid:dekVHLAYv5FV/AAjOd9C0tdWZRs false sufficient binding region:1-235|his tag:?-? biotin tag:?-?|sufficient binding region:1-235 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02242 uniprotkb:Q9EP73 intact:EBI-5258903|ensembl:ENSMUSP00000027507 intact:EBI-5258879|ensembl:ENSMUSP00000016640 psi-mi:pdcd1_mouse(display_long)|uniprotkb:Pdcd1(gene name)|psi-mi:Pdcd1(display_short)|uniprotkb:Pd1(gene name synonym) psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428321|imex:IM-26316-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032824.1|dip:DIP-29730N|ensembl:ENSMUSG00000026285(gene)|ensembl:ENSMUST00000027507(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002644"(negative regulation of tolerance induction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|rcsb pdb:1NPU|rcsb pdb:3BIK|rcsb pdb:3BP5|rcsb pdb:3BP6|rcsb pdb:3RNK|rcsb pdb:3RNQ|rcsb pdb:3SBW|reactome:R-MMU-389948 refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) - - - figure legend:Table 2, fig 8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:29.8x10^-6(molar) 2017/10/12 2017/10/18 rogid:uMdviLCRVTa0x+xPdJW0k0MkdVQ10090 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rigid:HEvitUQF5EurjTq1e3nVzphMtJw false sufficient binding region:1-167|his tag:?-?|fc-igg tag:?-? biotin tag:?-?|sufficient binding region:1-234 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q02242 uniprotkb:P46718 intact:EBI-5258903|ensembl:ENSMUSP00000027507 intact:EBI-16428414|uniprotkb:Q8BR06 psi-mi:pdcd1_mouse(display_long)|uniprotkb:Pdcd1(gene name)|psi-mi:Pdcd1(display_short)|uniprotkb:Pd1(gene name synonym) psi-mi:pdcd2_mouse(display_long)|uniprotkb:Zinc finger protein Rp-8(gene name synonym)|uniprotkb:Pdcd2(gene name)|psi-mi:Pdcd2(display_short)|uniprotkb:Rp8(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428390|imex:IM-26316-15 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032824.1|dip:DIP-29730N|ensembl:ENSMUSG00000026285(gene)|ensembl:ENSMUST00000027507(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002644"(negative regulation of tolerance induction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|rcsb pdb:1NPU|rcsb pdb:3BIK|rcsb pdb:3BP5|rcsb pdb:3BP6|rcsb pdb:3RNK|rcsb pdb:3RNQ|rcsb pdb:3SBW|reactome:R-MMU-389948 go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|refseq:NP_032825.2|interpro:IPR007320(Programmed cell death protein 2, C-terminal)|interpro:IPR002893(Zinc finger, MYND-type) - - - figure legend:Table 2, fig 8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:38.4x10^-6(molar) 2017/10/12 2017/10/18 rogid:uMdviLCRVTa0x+xPdJW0k0MkdVQ10090 rogid:onFplaRLJCwdTRR9dADk6zWmXRU10090 rigid:pfP1na7rkZAmenlf/dGrKZsyMD8 false sufficient binding region:1-167|his tag:?-?|fc-igg tag:?-? biotin tag:?-?|sufficient binding region:1-217..220 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q00609 uniprotkb:Q9EP73 intact:EBI-5258929|uniprotkb:Q61332|ensembl:ENSMUSP00000097404|ensembl:ENSMUSP00000156031 intact:EBI-5258879|ensembl:ENSMUSP00000016640 psi-mi:cd80_mouse(display_long)|uniprotkb:Cd80(gene name)|psi-mi:Cd80(display_short)|uniprotkb:B7(gene name synonym)|uniprotkb:Activation B7-1 antigen(gene name synonym) psi-mi:pd1l1_mouse(display_long)|uniprotkb:Cd274(gene name)|psi-mi:Cd274(display_short)|uniprotkb:B7h1(gene name synonym)|uniprotkb:Pdcd1l1(gene name synonym)|uniprotkb:Pdcd1lg1(gene name synonym)|uniprotkb:Pdl1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428438|imex:IM-26316-17 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033985.3|ensembl:ENSMUSG00000075122(gene)|ensembl:ENSMUST00000099816(transcript)|ensembl:ENSMUST00000231716(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098636"(protein complex involved in cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037676|interpro:IPR042711|rcsb pdb:4RWH|reactome:R-MMU-1257604|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-6811558|go:"GO:0042102"(positive regulation of T cell proliferation) refseq:NP_068693.1|dip:DIP-46167N|ensembl:ENSMUST00000016640(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6SRU|reactome:R-MMU-389948|ensembl:ENSMUSG00000016496(gene) - - - figure legend:Table 2, fig 8|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:79.3x10^-6(molar) 2017/10/12 2017/10/18 rogid:3cw76UQyfJUUhyvErKHL4Ura1D010090 rogid:/X8ANofcN0EY3FB9vpoo+LeLJSI10090 rigid:DqLWup3ULbHq5WNZXysLpJkx1T4 false sufficient binding region:1-240|his tag:?-? biotin tag:?-?|sufficient binding region:1-234 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-16428801|imex:IM-26316-44 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-1|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.6x10^-6(molar) 2017/10/12 2017/10/19 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562870|imex:IM-26316-46 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-2|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:2.2x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562886|imex:IM-26316-26 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-3|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.04x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562902|imex:IM-26316-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-4|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3.38x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562918|imex:IM-26316-30 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-5|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.74x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562934|imex:IM-26316-48 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-6|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.96x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562950|imex:IM-26316-50 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-7|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.85x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562966|imex:IM-26316-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-8|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.63x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NZQ7 uniprotkb:Q15116 intact:EBI-4314282|uniprotkb:B4DU27|uniprotkb:Q6WEX4|uniprotkb:B2RBA2|uniprotkb:Q66RK1|uniprotkb:Q9NUZ5|uniprotkb:Q14CJ2|uniprotkb:Q2V8D5|ensembl:ENSP00000370989 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l1_human(display_long)|uniprotkb:CD274(gene name)|psi-mi:CD274(display_short)|uniprotkb:B7H1(gene name synonym)|uniprotkb:PDCD1L1(gene name synonym)|uniprotkb:PDCD1LG1(gene name synonym)|uniprotkb:PDL1(gene name synonym)|uniprotkb:B7 homolog 1(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562982|imex:IM-26316-34 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_054862.1|refseq:NP_001254635.1|ensembl:ENSG00000120217(gene)|ensembl:ENST00000381577(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002845"(positive regulation of tolerance induction to tumor cell)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034097"(response to cytokine)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901998"(toxin transport)|go:"GO:1903556"(negative regulation of tumor necrosis factor superfamily cytokine production)|go:"GO:1905404"(positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2001186"(negative regulation of CD8-positive, alpha-beta T cell activation)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3BIK|rcsb pdb:3BIS|rcsb pdb:3FN3|rcsb pdb:3SBW|rcsb pdb:4Z18|rcsb pdb:4ZQK|rcsb pdb:5C3T|rcsb pdb:5GGT|rcsb pdb:5GRJ|rcsb pdb:5IUS|rcsb pdb:5J89|rcsb pdb:5J8O|rcsb pdb:5JDR|rcsb pdb:5JDS|rcsb pdb:5N2D|rcsb pdb:5N2F|rcsb pdb:5NIU|rcsb pdb:5O45|rcsb pdb:5O4Y|rcsb pdb:5X8L|rcsb pdb:5X8M|rcsb pdb:5XJ4|rcsb pdb:5XXY|rcsb pdb:6L8R|rcsb pdb:6NM7|rcsb pdb:6NM8|rcsb pdb:6NNV|rcsb pdb:6NOJ|rcsb pdb:6NOS|rcsb pdb:6NP9|rcsb pdb:6PV9|rcsb pdb:6R3K|rcsb pdb:6RPG|rcsb pdb:6VQN|rcsb pdb:6YCR|rcsb pdb:7BEA|rcsb pdb:7C88|reactome:R-HSA-389948|interpro:IPR036179|dip:DIP-29731N refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 B, table 3i-9|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|kinetics:Kd values ranged from 1.6 uM at pH 6.0 to 3.04 uM at pH 8.0. A rise in temperature lowered the Kd from 3.38 uM at 10degC to ~1.8 uM at 15-25 degC.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.94x10^-6(molar) 2017/10/12 2018/05/21 rogid:xgS8qLw0RrD1mMV3JswLYfX8NBQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:UCghd0MiNpAZwi8Qa4DDpPh4u+o false sufficient binding region:1-235|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562836|imex:IM-26316-24 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-1|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.5x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20562999|imex:IM-26316-36 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-2|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.45x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20563014|imex:IM-26316-52 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-3|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.56x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20563029|imex:IM-26316-54 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-4|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.42x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20563044|imex:IM-26316-38 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-5|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.27x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20563059|imex:IM-26316-56 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-6|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.34x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20563074|imex:IM-26316-40 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-7|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.38x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20563089|imex:IM-26316-58 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-8|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.48x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BQ51 uniprotkb:Q15116 intact:EBI-16427978|ensembl:ENSP00000380855|uniprotkb:Q14CN8|uniprotkb:Q5T7Z6|uniprotkb:Q6JXL8|uniprotkb:Q6JXL9 intact:EBI-4314328|uniprotkb:O00517|uniprotkb:Q8IX89|intact:EBI-28971758|ensembl:ENSP00000335062|ensembl:ENSP00000480684 psi-mi:pd1l2_human(display_long)|uniprotkb:Butyrophilin B7-DC(gene name synonym)|uniprotkb:PDCD1LG2(gene name)|psi-mi:PDCD1LG2(display_short)|uniprotkb:B7DC(gene name synonym)|uniprotkb:CD273(gene name synonym)|uniprotkb:PDCD1L2(gene name synonym)|uniprotkb:PDL2(gene name synonym) psi-mi:pdcd1_human(display_long)|uniprotkb:PDCD1(gene name)|psi-mi:PDCD1(display_short)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Cheng et al. (2013) imex:IM-26316|pubmed:23417675 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-20563104|imex:IM-26316-42 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000197646(gene)|ensembl:ENST00000397747(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:6UMT|reactome:R-HSA-389948|refseq:NP_079515.2 refseq:NP_005009.2|ensembl:ENSP00000335062|ensembl:ENSP00000480684|ensembl:ENSG00000188389(gene)|ensembl:ENSG00000276977(gene)|ensembl:ENST00000334409(transcript)|ensembl:ENST00000618185(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0007275"(multicellular organism development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042379|mint:Q15116|rcsb pdb:2M2D|rcsb pdb:3RRQ|rcsb pdb:4ZQK|rcsb pdb:5B8C|rcsb pdb:5GGR|rcsb pdb:5GGS|rcsb pdb:5IUS|rcsb pdb:5JXE|rcsb pdb:5WT9|rcsb pdb:6HIG|rcsb pdb:6J14|rcsb pdb:6J15|rcsb pdb:6JBT|rcsb pdb:6JJP|rcsb pdb:6K0Y|rcsb pdb:6R5G|rcsb pdb:6ROY|rcsb pdb:6ROZ|rcsb pdb:6UMT|rcsb pdb:6UMU|rcsb pdb:6UMV|rcsb pdb:6XKR|rcsb pdb:7BXA|rcsb pdb:7CGW|rcsb pdb:7CU5|reactome:R-HSA-389948|reactome:R-HSA-9679191|dip:DIP-44126N - - - figure legend:Figure 9 A/B, table 3-9|comment:It is not stated which hPD-1 Fc construct was used nor which expression system.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:0.46x10^-6(molar) 2017/10/12 2018/05/21 rogid:8VYU/YGsl0tu2fwuMftHWRKZutQ9606 rogid:/2q/ETcmMQyfvNb1CvRfrVc9f4s9606 rigid:wbe4rMplCkX7GCZdNRNNN5JGaE8 false sufficient binding region:1-220|his tag:?-? sufficient binding region:1-144..167|fc-igg tag:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)