#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9C0A0-1	uniprotkb:Q13009	intact:EBI-16035743|ensembl:ENSP00000479811	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:q9c0a0-1(display_long)|uniprotkb:CNTNAP4(gene name)|psi-mi:CNTNAP4(display_short)|uniprotkb:CASPR4(gene name synonym)|uniprotkb:KIAA1763(gene name synonym)|uniprotkb:Cell recognition molecule Caspr4(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035752|imex:IM-21001-1|dip:DIP-190597E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152910(gene)|ensembl:ENST00000611870(transcript)|intact:EBI-311406(isoform-parent)	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:P1oT4UCmiYpfcKPyTC4p4Ao9gbQ9606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:kHD3oUZvbMY3GOocFiBRW69ha/o	false	sufficient binding region:1301-1308	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18827	uniprotkb:Q13009	intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035801|imex:IM-21001-3|dip:DIP-190596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:yuYsBMx3JWcZV1RNUHqoA/yYQmA	false	sufficient binding region:303-310	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18827	uniprotkb:Q13009	intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035773|imex:IM-21001-2|dip:DIP-190596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:yuYsBMx3JWcZV1RNUHqoA/yYQmA	false	sufficient binding region:303-310|dansyl label:n-n|mutation decreasing interaction strength:306-306	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75056	uniprotkb:Q13009	intact:EBI-1642090|uniprotkb:Q5T1Z6|uniprotkb:Q5T1Z7|uniprotkb:Q96CT3|uniprotkb:Q96PR8|ensembl:ENSP00000344468	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc3_human(display_long)|uniprotkb:SDC3(gene name)|psi-mi:SDC3(display_short)|uniprotkb:KIAA0468(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035822|imex:IM-21001-4|dip:DIP-190599E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055469.3|dip:DIP-29944N|ensembl:ENSG00000162512(gene)|ensembl:ENST00000339394(transcript)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0044393"(microspike)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031194|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6wbbzXVuCZFtidcnoAjAW5x5UAU9606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:fA3B96jUa+QqrY/CGLPzL+qCX9s	false	sufficient binding region:435-442|dansyl label:n-n	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9C0A0-1	uniprotkb:Q13009	intact:EBI-16035743|ensembl:ENSP00000479811	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:q9c0a0-1(display_long)|uniprotkb:CNTNAP4(gene name)|psi-mi:CNTNAP4(display_short)|uniprotkb:CASPR4(gene name synonym)|uniprotkb:KIAA1763(gene name synonym)|uniprotkb:Cell recognition molecule Caspr4(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035845|imex:IM-21001-5|dip:DIP-190597E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000152910(gene)|ensembl:ENST00000611870(transcript)|intact:EBI-311406(isoform-parent)	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:P1oT4UCmiYpfcKPyTC4p4Ao9gbQ9606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:kHD3oUZvbMY3GOocFiBRW69ha/o	false	sufficient binding region:1301-1308	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18827	uniprotkb:Q13009	intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035866|imex:IM-21001-6|dip:DIP-190596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:yuYsBMx3JWcZV1RNUHqoA/yYQmA	false	sufficient binding region:303-310	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18827	uniprotkb:Q13009	intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035931|imex:IM-21001-9|dip:DIP-190596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:yuYsBMx3JWcZV1RNUHqoA/yYQmA	false	sufficient binding region:303-310|dansyl label:n-n	sufficient binding region:841-930|mutation decreasing interaction strength:912-912|mutation decreasing interaction strength:879-879	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P18827	uniprotkb:Q13009	intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035910|imex:IM-21001-8|dip:DIP-190596E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:yuYsBMx3JWcZV1RNUHqoA/yYQmA	false	sufficient binding region:303-310	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31431	uniprotkb:Q13009	intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035887|imex:IM-21001-7|dip:DIP-190600E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:AqN35peAWM7Edpi1+YaGhovYXgc	false	sufficient binding region:191-198|dansyl label:n-n	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P34741	uniprotkb:Q13009	intact:EBI-1172957|uniprotkb:Q9H6V1|uniprotkb:B3KQA3|ensembl:ENSP00000307046|uniprotkb:Q6PIS6	intact:EBI-1050007|uniprotkb:Q17RT7|ensembl:ENSP00000286827|uniprotkb:B7ZLR6|uniprotkb:F5GZ53	psi-mi:sdc2_human(display_long)|uniprotkb:SDC2(gene name)|psi-mi:SDC2(display_short)|uniprotkb:HSPG1(gene name synonym)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym)	psi-mi:tiam1_human(display_long)|uniprotkb:TIAM1(gene name)|psi-mi:TIAM1(display_short)|uniprotkb:T-lymphoma invasion and metastasis-inducing protein 1(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Liu et al. (2013)	pubmed:23395182|doi:10.1016/j.str.2013.01.004|imex:IM-21001	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16035960|imex:IM-21001-10|dip:DIP-190598E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002989.2|reactome:R-HSA-975634|reactome:R-HSA-8957275|ensembl:ENSG00000169439(gene)|ensembl:ENST00000302190(transcript)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031201|mint:P34741|rcsb pdb:6ITH|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-381426|reactome:R-HSA-3928662|reactome:R-HSA-4420332|dip:DIP-29943N	refseq:NP_003244.2|refseq:XP_016883936.1|refseq:XP_016883937.1|refseq:XP_016883938.1|refseq:XP_016883939.1|refseq:XP_016883940.1|refseq:XP_016883941.1|refseq:XP_016883942.1|ensembl:ENSG00000156299(gene)|ensembl:ENST00000286827(transcript)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034622"|go:"GO:0042220"(response to cocaine)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0008289"(lipid binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044304"(main axon)|go:"GO:0045202"(synapse)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:1904268"(positive regulation of Schwann cell chemotaxis)|go:"GO:1904338"(regulation of dopaminergic neuron differentiation)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000050"(regulation of non-canonical Wnt signaling pathway)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR033360|interpro:IPR035899|interpro:IPR036034|interpro:IPR040655|interpro:IPR043537|mint:Q13009|rcsb pdb:2D8I|rcsb pdb:3KZD|rcsb pdb:3KZE|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:4K2O|rcsb pdb:4K2P|rcsb pdb:4NXP|rcsb pdb:4NXQ|rcsb pdb:4NXR|reactome:R-HSA-193648|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9032845|refseq:XP_005261094.1|refseq:XP_005261095.1|refseq:XP_011528013.1|refseq:XP_011528014.1|refseq:XP_011528015.1|dip:DIP-38309N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:dUYGfiWzMHbYLZdV/ibV6RmeYUA9606	rogid:h0ruHb93yvgrex2b+d2JNrph60A9606	rigid:EAweugQwEk9SJubVkpxOXjNLQ1M	false	sufficient binding region:194-201|dansyl label:n-n	sufficient binding region:841-930	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)