#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08575	uniprotkb:Q9BZW8	intact:EBI-1341|uniprotkb:A8K7W6|uniprotkb:Q16614|uniprotkb:Q9H0Y6|uniprotkb:A0A0A0MT22|uniprotkb:X6R433|ensembl:ENSP00000411355|ensembl:ENSP00000458322|ensembl:ENSP00000461074	intact:EBI-1580565|uniprotkb:Q96T47|uniprotkb:Q9NQD2|uniprotkb:Q9NQD3|uniprotkb:Q9Y288|uniprotkb:Q5VYI2|uniprotkb:Q5VYI6|uniprotkb:Q5VYI7|ensembl:ENSP00000357012	psi-mi:ptprc_human(display_long)|uniprotkb:PTPRC(gene name)|psi-mi:PTPRC(display_short)|uniprotkb:CD45(gene name synonym)|uniprotkb:T200(gene name synonym)|uniprotkb:Leukocyte common antigen(gene name synonym)	psi-mi:cd244_human(display_long)|uniprotkb:NK cell type I receptor protein 2B4(gene name synonym)|uniprotkb:NK cell activation-inducing ligand(gene name synonym)|uniprotkb:CD244(gene name)|psi-mi:CD244(display_short)|uniprotkb:2B4(gene name synonym)|uniprotkb:SLAM family member 4(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15100797|imex:IM-25790-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002829.3|refseq:NP_563578.2|dip:DIP-224N|refseq:XP_006711535.1|refseq:XP_006711536.1|refseq:XP_006711537.1|ensembl:ENSG00000081237(gene)|ensembl:ENSG00000262418(gene)|ensembl:ENST00000442510(transcript)|ensembl:ENST00000573477(transcript)|ensembl:ENST00000573679(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005001"(transmembrane receptor protein tyrosine phosphatase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032059"(bleb)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0044855"(plasma membrane raft distribution)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045588"(positive regulation of gamma-delta T cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048539"(bone marrow development)|go:"GO:0048864"(stem cell development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050857"(positive regulation of antigen receptor-mediated signaling pathway)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0098857"(membrane microdomain)|go:"GO:1903615"(positive regulation of protein tyrosine phosphatase activity)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904155"(DN2 thymocyte differentiation)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000473"(positive regulation of hematopoietic stem cell migration)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016335(Leukocyte common antigen)|interpro:IPR024739|interpro:IPR029021|interpro:IPR036116|mint:P08575|rcsb pdb:1YGR|rcsb pdb:1YGU|rcsb pdb:5FMV|rcsb pdb:5FN6|rcsb pdb:5FN7|reactome:R-HSA-202427|reactome:R-HSA-416700|reactome:R-HSA-6798695	refseq:XP_011507924.1|refseq:NP_001160135.1|refseq:NP_001160136.1|refseq:NP_057466.1|dip:DIP-40331N|ensembl:ENSG00000122223(gene)|ensembl:ENST00000368033(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071663"(positive regulation of granzyme B production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR024303|interpro:IPR024304|interpro:IPR036179|reactome:R-HSA-202733	go:"GO:0045121"(membrane raft)	-	-	figure legend:3A|comment:both CD45 and FynT are only markers for raft and soluble fractions respectively.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2018/04/06	rogid:rrMiH60EcAzRWaaapYTjNU5+1IY9606	rogid:QORMx+ZJyNjvraEeZH1rBgcD2bU9606	rigid:No2CHiiNYMRRK5oHZpWrifFJjW0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06241-2	uniprotkb:Q9BZW8	intact:EBI-8050137|intact:MINT-4990957|ensembl:ENSP00000357667|ensembl:ENSP00000357671|ensembl:ENSP00000440646	intact:EBI-1580565|uniprotkb:Q96T47|uniprotkb:Q9NQD2|uniprotkb:Q9NQD3|uniprotkb:Q9Y288|uniprotkb:Q5VYI2|uniprotkb:Q5VYI6|uniprotkb:Q5VYI7|ensembl:ENSP00000357012	psi-mi:p06241-2(display_long)|uniprotkb:FYN(gene name)|psi-mi:FYN(display_short)|uniprotkb:Proto-oncogene Syn(gene name synonym)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)|uniprotkb:Src-like kinase(gene name synonym)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:T(isoform synonym)	psi-mi:cd244_human(display_long)|uniprotkb:NK cell type I receptor protein 2B4(gene name synonym)|uniprotkb:NK cell activation-inducing ligand(gene name synonym)|uniprotkb:CD244(gene name)|psi-mi:CD244(display_short)|uniprotkb:2B4(gene name synonym)|uniprotkb:SLAM family member 4(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15100883|imex:IM-25790-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-515315(isoform-parent)|uniprotkb:P06241-2(isoform-parent)|ensembl:ENSG00000010810(gene)|ensembl:ENST00000368678(transcript)|ensembl:ENST00000368682(transcript)|ensembl:ENST00000538466(transcript)	refseq:XP_011507924.1|refseq:NP_001160135.1|refseq:NP_001160136.1|refseq:NP_057466.1|dip:DIP-40331N|ensembl:ENSG00000122223(gene)|ensembl:ENST00000368033(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071663"(positive regulation of granzyme B production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR024303|interpro:IPR024304|interpro:IPR036179|reactome:R-HSA-202733	-	comment:mint	-	figure legend:3Ai|comment:both CD45 and FynT are only markers for raft and soluble fractions respectively.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2017/06/12	rogid:h8VaUfUV70ooukii6EUr1yzeIcg9606	rogid:QORMx+ZJyNjvraEeZH1rBgcD2bU9606	rigid:i3Ucdc9affro526zeyMs8vLfHbI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BZW8	uniprotkb:O60880	intact:EBI-1580565|uniprotkb:Q96T47|uniprotkb:Q9NQD2|uniprotkb:Q9NQD3|uniprotkb:Q9Y288|uniprotkb:Q5VYI2|uniprotkb:Q5VYI6|uniprotkb:Q5VYI7|ensembl:ENSP00000357012	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	psi-mi:cd244_human(display_long)|uniprotkb:NK cell type I receptor protein 2B4(gene name synonym)|uniprotkb:NK cell activation-inducing ligand(gene name synonym)|uniprotkb:CD244(gene name)|psi-mi:CD244(display_short)|uniprotkb:2B4(gene name synonym)|uniprotkb:SLAM family member 4(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 4(gene name synonym)	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15100890|imex:IM-25790-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507924.1|refseq:NP_001160135.1|refseq:NP_001160136.1|refseq:NP_057466.1|dip:DIP-40331N|ensembl:ENSG00000122223(gene)|ensembl:ENST00000368033(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071663"(positive regulation of granzyme B production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR024303|interpro:IPR024304|interpro:IPR036179|reactome:R-HSA-202733	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	-	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	figure legend:3C|comment:EAT2 was not precipitated in  SAP knockdown cells.|agonist:CD4 knockdown|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2017/06/12	rogid:QORMx+ZJyNjvraEeZH1rBgcD2bU9606	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rigid:5I3lFWJACle4jPGZppAeRU3zgSc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BZW8	uniprotkb:O14796	intact:EBI-1580565|uniprotkb:Q96T47|uniprotkb:Q9NQD2|uniprotkb:Q9NQD3|uniprotkb:Q9Y288|uniprotkb:Q5VYI2|uniprotkb:Q5VYI6|uniprotkb:Q5VYI7|ensembl:ENSP00000357012	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:cd244_human(display_long)|uniprotkb:NK cell type I receptor protein 2B4(gene name synonym)|uniprotkb:NK cell activation-inducing ligand(gene name synonym)|uniprotkb:CD244(gene name)|psi-mi:CD244(display_short)|uniprotkb:2B4(gene name synonym)|uniprotkb:SLAM family member 4(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 4(gene name synonym)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15100890|imex:IM-25790-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507924.1|refseq:NP_001160135.1|refseq:NP_001160136.1|refseq:NP_057466.1|dip:DIP-40331N|ensembl:ENSG00000122223(gene)|ensembl:ENST00000368033(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071663"(positive regulation of granzyme B production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR024303|interpro:IPR024304|interpro:IPR036179|reactome:R-HSA-202733	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	-	-	figure legend:3C|comment:EAT2 was not precipitated in  SAP knockdown cells.|agonist:CD4 knockdown|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2017/06/12	rogid:QORMx+ZJyNjvraEeZH1rBgcD2bU9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:5I3lFWJACle4jPGZppAeRU3zgSc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DU3	uniprotkb:O60880	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15100934|imex:IM-25790-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	-	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	figure legend:3E|comment:EAT2 was not precipitated in  SAP knockdown cells.|agonist:CD4 knockdown|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2017/06/12	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96DU3	uniprotkb:O14796	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15100934|imex:IM-25790-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	-	-	figure legend:3E|comment:EAT2 was not precipitated in  SAP knockdown cells.|agonist:CD4 knockdown|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2017/06/12	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:LARmFGm9FHhm6FEQgzDIMA9CErM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BZW8	uniprotkb:O14796	intact:EBI-1580565|uniprotkb:Q96T47|uniprotkb:Q9NQD2|uniprotkb:Q9NQD3|uniprotkb:Q9Y288|uniprotkb:Q5VYI2|uniprotkb:Q5VYI6|uniprotkb:Q5VYI7|ensembl:ENSP00000357012	intact:EBI-3923013|uniprotkb:Q8NI18|uniprotkb:B2RBN6|uniprotkb:Q969K9|uniprotkb:Q5T0L1|ensembl:ENSP00000356906	psi-mi:cd244_human(display_long)|uniprotkb:NK cell type I receptor protein 2B4(gene name synonym)|uniprotkb:NK cell activation-inducing ligand(gene name synonym)|uniprotkb:CD244(gene name)|psi-mi:CD244(display_short)|uniprotkb:2B4(gene name synonym)|uniprotkb:SLAM family member 4(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 4(gene name synonym)	psi-mi:sh21b_human(display_long)|uniprotkb:SH2D1B(gene name)|psi-mi:SH2D1B(display_short)|uniprotkb:EAT2(gene name synonym)|uniprotkb:EWS/FLI1-activated transcript 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15102199|imex:IM-25790-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011507924.1|refseq:NP_001160135.1|refseq:NP_001160136.1|refseq:NP_057466.1|dip:DIP-40331N|ensembl:ENSG00000122223(gene)|ensembl:ENST00000368033(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071663"(positive regulation of granzyme B production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR024303|interpro:IPR024304|interpro:IPR036179|reactome:R-HSA-202733	refseq:NP_444512.2|ensembl:ENSG00000198574(gene)|ensembl:ENST00000367929(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002366"(leukocyte activation involved in immune response)|go:"GO:0002717"(positive regulation of natural killer cell mediated immunity)|go:"GO:0005829"(cytosol)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|interpro:IPR000980(SH2 motif)|interpro:IPR035049|interpro:IPR036860|rcsb pdb:5KAZ|reactome:R-HSA-198933	-	-	-	figure legend:"3C (lanes 3-4)"|comment:"EAT2  was only (weakly) precipitated in  CD4 knockdown cells."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2017/06/15	rogid:QORMx+ZJyNjvraEeZH1rBgcD2bU9606	rogid:sbsE/jcSEsUrt8tK/EDz33pQqNQ9606	rigid:wmC+aIBzp/hWQW+hXHPUnHdTpEU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:Q96DU3	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-14058448|uniprotkb:A6NMW2|uniprotkb:B2R8X8|uniprotkb:Q14CF0|uniprotkb:Q5TAS4|uniprotkb:Q5TAS6|uniprotkb:Q5TAT3|uniprotkb:Q96DV0|ensembl:ENSP00000357036	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:slaf6_human(display_long)|uniprotkb:KALI(gene name synonym)|uniprotkb:SLAMF6(gene name)|psi-mi:SLAMF6(display_short)|uniprotkb:Activating NK receptor(gene name synonym)|uniprotkb:NK-T-B-antigen(gene name synonym)|uniprotkb:UNQ6123/PRO20080(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15102214|imex:IM-25790-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:NP_001171643.1|refseq:NP_001171644.1|refseq:NP_001171645.1|refseq:NP_443163.1|ensembl:ENSG00000162739(gene)|ensembl:ENST00000368057(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2IF7|reactome:R-HSA-198933	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:3E-1|comment:EAT2 was not precipitated in  SAP knockdown cells.|comment:"At time  point \"0\" for shSAP transfection  (lane 5),   EAT2 was only very weakly  precipitated."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-nk92)|taxid:9606(human NK cell line NK92)	-	2017/05/08	2017/06/26	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:rUujUH968ooEkRgUiIeCBZbsjCs9606	rigid:M9myN80LRe6lQBLe1EABCeU9gI8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O60880	uniprotkb:Q9BZW8	intact:EBI-6983382|ensembl:ENSP00000360181|uniprotkb:O95386|uniprotkb:Q6FGS6|uniprotkb:O95385|intact:MINT-113697|uniprotkb:A8MSW0|uniprotkb:O95384|uniprotkb:O95383|uniprotkb:Q9UNR0	intact:EBI-1580565|uniprotkb:Q96T47|uniprotkb:Q9NQD2|uniprotkb:Q9NQD3|uniprotkb:Q9Y288|uniprotkb:Q5VYI2|uniprotkb:Q5VYI6|uniprotkb:Q5VYI7|ensembl:ENSP00000357012	psi-mi:sh21a_human(display_long)|uniprotkb:SH2D1A(gene name)|psi-mi:SH2D1A(display_short)|uniprotkb:DSHP(gene name synonym)|uniprotkb:SAP(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule-associated protein(gene name synonym)|uniprotkb:T-cell signal transduction molecule SAP(gene name synonym)|uniprotkb:Duncan disease SH2-protein(gene name synonym)	psi-mi:cd244_human(display_long)|uniprotkb:NK cell type I receptor protein 2B4(gene name synonym)|uniprotkb:NK cell activation-inducing ligand(gene name synonym)|uniprotkb:CD244(gene name)|psi-mi:CD244(display_short)|uniprotkb:2B4(gene name synonym)|uniprotkb:SLAM family member 4(gene name synonym)|uniprotkb:Signaling lymphocytic activation molecule 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Meinke et al. (2012)	pubmed:23346089|imex:IM-25790	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15100927|imex:IM-25790-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1D4W|rcsb pdb:1KA6|rcsb pdb:1KA7|rcsb pdb:1M27|reactome:R-HSA-198933|ensembl:ENSG00000183918(gene)|ensembl:ENST00000371139(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006959"(humoral immune response)|go:"GO:0006968"(cellular defense response)|rcsb pdb:1D4T|go:"GO:0007267"(cell-cell signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|interpro:IPR000980(SH2 motif)|interpro:IPR017289(SH2 protein 1A)|interpro:IPR035876|interpro:IPR036860|rcsb pdb:1D1Z|refseq:NP_001108409.1|refseq:NP_002342.1|dip:DIP-40768N	refseq:XP_011507924.1|refseq:NP_001160135.1|refseq:NP_001160136.1|refseq:NP_057466.1|dip:DIP-40331N|ensembl:ENSG00000122223(gene)|ensembl:ENST00000368033(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0060732"(positive regulation of inositol phosphate biosynthetic process)|go:"GO:0071663"(positive regulation of granzyme B production)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR024303|interpro:IPR024304|interpro:IPR036179|reactome:R-HSA-202733	-	comment:mint|function:Inhibitor of the SLAM self-association. Acts by blocking recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to a docking site in the slam cytoplasmic region|function:"Defects in SH2D1A are a cause of lymphoproliferative syndrome X-linked type 1 (XLP1) [MIM:308240]; also known as X-linked lymphoproliferative disease (XLPD) or Duncan disease. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma"	-	figure legend:3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-yt-s)|taxid:9606(human YT-S NK cell line)	-	2017/05/08	2017/06/12	rogid:tJL+FA6RUPeEknwUp85WT2p0+/c9606	rogid:QORMx+ZJyNjvraEeZH1rBgcD2bU9606	rigid:SXrNxSAQPhao9TUEliGAz+sXCJs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)