#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8IV48 uniprotkb:Q14493 intact:EBI-5459222|uniprotkb:A8K4U7|uniprotkb:Q9NSX3|ensembl:ENSP00000250263|ensembl:ENSP00000430190 intact:EBI-2696402|uniprotkb:B3KRJ5|ensembl:ENSP00000417686 psi-mi:eri1_human(display_long)|uniprotkb:ERI1(gene name)|psi-mi:ERI1(display_short)|uniprotkb:3'EXO(gene name synonym)|uniprotkb:THEX1(gene name synonym)|uniprotkb:3'-5' exonuclease ERI1(gene name synonym)|uniprotkb:Eri-1 homolog(gene name synonym)|uniprotkb:Histone mRNA 3'-end-specific exoribonuclease(gene name synonym)|uniprotkb:Histone mRNA 3'-exonuclease 1(gene name synonym)|uniprotkb:Protein 3'hExo(gene name synonym) psi-mi:slbp_human(display_long)|uniprotkb:SLBP(gene name)|psi-mi:SLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Histone stem-loop-binding protein(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Tan et al. (2013) pubmed:23329046|doi:"https://doi.org/10.1126/science.1228705"|imex:IM-24234 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16032530|imex:IM-24234-1|dip:DIP-198780E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699163.2|dip:DIP-61409N|ensembl:ENSG00000104626(gene)|ensembl:ENST00000250263(transcript)|ensembl:ENST00000519292(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0019843"(rRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031125"(rRNA 3'-end processing)|go:"GO:0043022"(ribosome binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036361|interpro:IPR036397|rcsb pdb:1W0H|rcsb pdb:1ZBH|rcsb pdb:1ZBU|rcsb pdb:4L8R|rcsb pdb:4QOZ|reactome:R-HSA-6791226 refseq:NP_001293003.1|refseq:NP_001293004.1|refseq:NP_006518.1|ensembl:ENSG00000163950(gene)|ensembl:ENST00000489418(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR026502|interpro:IPR029344|interpro:IPR038294|mint:Q14493|rcsb pdb:2KJM|rcsb pdb:4L8R|rcsb pdb:4QOZ|reactome:R-HSA-159230|reactome:R-HSA-73856|reactome:R-HSA-77588|dip:DIP-57045N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:wtuZZZVatZWPvuO1g3sT/FJsBPE9606 rogid:Rt3HJRsfQ5SAgjMsloMR6H7Emho9606 rigid:2BqmBCD3Frbtrk28bGX4CxFuPz8 false sufficient binding region:55-349 sufficient binding region:125-223 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IV48 uniprotkb:Q14493 intact:EBI-5459222|uniprotkb:A8K4U7|uniprotkb:Q9NSX3|ensembl:ENSP00000250263|ensembl:ENSP00000430190 intact:EBI-2696402|uniprotkb:B3KRJ5|ensembl:ENSP00000417686 psi-mi:eri1_human(display_long)|uniprotkb:ERI1(gene name)|psi-mi:ERI1(display_short)|uniprotkb:3'EXO(gene name synonym)|uniprotkb:THEX1(gene name synonym)|uniprotkb:3'-5' exonuclease ERI1(gene name synonym)|uniprotkb:Eri-1 homolog(gene name synonym)|uniprotkb:Histone mRNA 3'-end-specific exoribonuclease(gene name synonym)|uniprotkb:Histone mRNA 3'-exonuclease 1(gene name synonym)|uniprotkb:Protein 3'hExo(gene name synonym) psi-mi:slbp_human(display_long)|uniprotkb:SLBP(gene name)|psi-mi:SLBP(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Histone stem-loop-binding protein(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Tan et al. (2013) pubmed:23329046|doi:"https://doi.org/10.1126/science.1228705"|imex:IM-24234 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16032552|imex:IM-24234-2|dip:DIP-198780E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_699163.2|dip:DIP-61409N|ensembl:ENSG00000104626(gene)|ensembl:ENST00000250263(transcript)|ensembl:ENST00000519292(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000467"("exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0019843"(rRNA binding)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031125"(rRNA 3'-end processing)|go:"GO:0043022"(ribosome binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR036361|interpro:IPR036397|rcsb pdb:1W0H|rcsb pdb:1ZBH|rcsb pdb:1ZBU|rcsb pdb:4L8R|rcsb pdb:4QOZ|reactome:R-HSA-6791226 refseq:NP_001293003.1|refseq:NP_001293004.1|refseq:NP_006518.1|ensembl:ENSG00000163950(gene)|ensembl:ENST00000489418(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006398"(mRNA 3'-end processing by stem-loop binding and cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0071204"(histone pre-mRNA 3'end processing complex)|go:"GO:0071207"(histone pre-mRNA stem-loop binding)|go:"GO:0071208"(histone pre-mRNA DCP binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR026502|interpro:IPR029344|interpro:IPR038294|mint:Q14493|rcsb pdb:2KJM|rcsb pdb:4L8R|rcsb pdb:4QOZ|reactome:R-HSA-159230|reactome:R-HSA-73856|reactome:R-HSA-77588|dip:DIP-57045N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:wtuZZZVatZWPvuO1g3sT/FJsBPE9606 rogid:Rt3HJRsfQ5SAgjMsloMR6H7Emho9606 rigid:2BqmBCD3Frbtrk28bGX4CxFuPz8 false sufficient binding region:55-349 sufficient binding region:125-223 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)