#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:C4LYV4	uniprotkb:C4M483	intact:EBI-16029107|ensemblprotists:GAT94020|ensemblprotists:rna_EHI_010670-1|uniprotkb:A0A175JJX7	intact:EBI-16029089|ensemblprotists:GAT96163|ensemblprotists:rna_EHI_140350-1|uniprotkb:A0A175JS08	psi-mi:c4lyv4_enthi(display_long)|uniprotkb:EHI_010670(orf name)	psi-mi:c4m483_enthi(display_long)|uniprotkb:EHI_140350(orf name)	psi-mi:"MI:0096"(pull down)	Bosch et al. (2013)	pubmed:23260656|doi:10.1016/j.str.2012.11.012|imex:IM-20746	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16029122|imex:IM-20746-1|dip:DIP-190408E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblprotists:CL6EHI_010670(gene)|ensemblprotists:EHI_010670(gene)|ensemblprotists:GAT94020(transcript)|ensemblprotists:rna_EHI_010670-1(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR035899|interpro:IPR036305|rcsb pdb:4GOU|dip:DIP-60101N|refseq:XP_653063.1	rcsb pdb:4FID|ensemblprotists:CL6EHI_140350(gene)|ensemblprotists:EHI_140350(gene)|ensemblprotists:GAT96163(transcript)|ensemblprotists:rna_EHI_140350-1(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|dip:DIP-60100N|refseq:XP_651737.2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KkICO5SvceCJxl5Cel8gsXWxIfo5759	rogid:0HoMtE5hfsjH6Mwoy7p57ZzMjKc5759	rigid:o3B+LJm1Yssh4/xXpd8+oyN1HYI	false	sufficient binding region:1-152|ha tag:n-n	his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:C4LYV4	uniprotkb:C4M483	intact:EBI-16029107|ensemblprotists:GAT94020|ensemblprotists:rna_EHI_010670-1|uniprotkb:A0A175JJX7	intact:EBI-16029089|ensemblprotists:GAT96163|ensemblprotists:rna_EHI_140350-1|uniprotkb:A0A175JS08	psi-mi:c4lyv4_enthi(display_long)|uniprotkb:EHI_010670(orf name)	psi-mi:c4m483_enthi(display_long)|uniprotkb:EHI_140350(orf name)	psi-mi:"MI:0419"(gtpase assay)	Bosch et al. (2013)	pubmed:23260656|doi:10.1016/j.str.2012.11.012|imex:IM-20746	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16029165|imex:IM-20746-3|dip:DIP-190408E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblprotists:CL6EHI_010670(gene)|ensemblprotists:EHI_010670(gene)|ensemblprotists:GAT94020(transcript)|ensemblprotists:rna_EHI_010670-1(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR035899|interpro:IPR036305|rcsb pdb:4GOU|dip:DIP-60101N|refseq:XP_653063.1	rcsb pdb:4FID|ensemblprotists:CL6EHI_140350(gene)|ensemblprotists:EHI_140350(gene)|ensemblprotists:GAT96163(transcript)|ensemblprotists:rna_EHI_140350-1(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|dip:DIP-60100N|refseq:XP_651737.2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KkICO5SvceCJxl5Cel8gsXWxIfo5759	rogid:0HoMtE5hfsjH6Mwoy7p57ZzMjKc5759	rigid:o3B+LJm1Yssh4/xXpd8+oyN1HYI	false	mutation disrupting interaction strength:39-39|mutation disrupting interaction strength:83-83	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:C4LYV4	uniprotkb:C4M483	intact:EBI-16029107|ensemblprotists:GAT94020|ensemblprotists:rna_EHI_010670-1|uniprotkb:A0A175JJX7	intact:EBI-16029089|ensemblprotists:GAT96163|ensemblprotists:rna_EHI_140350-1|uniprotkb:A0A175JS08	psi-mi:c4lyv4_enthi(display_long)|uniprotkb:EHI_010670(orf name)	psi-mi:c4m483_enthi(display_long)|uniprotkb:EHI_140350(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Bosch et al. (2013)	pubmed:23260656|doi:10.1016/j.str.2012.11.012|imex:IM-20746	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16029188|imex:IM-20746-4|dip:DIP-190408E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblprotists:CL6EHI_010670(gene)|ensemblprotists:EHI_010670(gene)|ensemblprotists:GAT94020(transcript)|ensemblprotists:rna_EHI_010670-1(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR035899|interpro:IPR036305|rcsb pdb:4GOU|dip:DIP-60101N|refseq:XP_653063.1	rcsb pdb:4FID|ensemblprotists:CL6EHI_140350(gene)|ensemblprotists:EHI_140350(gene)|ensemblprotists:GAT96163(transcript)|ensemblprotists:rna_EHI_140350-1(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|dip:DIP-60100N|refseq:XP_651737.2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KkICO5SvceCJxl5Cel8gsXWxIfo5759	rogid:0HoMtE5hfsjH6Mwoy7p57ZzMjKc5759	rigid:o3B+LJm1Yssh4/xXpd8+oyN1HYI	false	-	mutation decreasing interaction strength:189-189|mutation disrupting interaction strength:168-168	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q24816	uniprotkb:C4LYV4	intact:EBI-16029211	intact:EBI-16029107|ensemblprotists:GAT94020|ensemblprotists:rna_EHI_010670-1|uniprotkb:A0A175JJX7	psi-mi:racc_enthi(display_long)|uniprotkb:RACC(gene name)|psi-mi:RACC(display_short)	psi-mi:c4lyv4_enthi(display_long)|uniprotkb:EHI_010670(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Bosch et al. (2013)	pubmed:23260656|doi:10.1016/j.str.2012.11.012|imex:IM-20746	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16029227|imex:IM-20746-5|dip:DIP-190409E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|rcsb pdb:4MIT|dip:DIP-60102N	ensemblprotists:CL6EHI_010670(gene)|ensemblprotists:EHI_010670(gene)|ensemblprotists:GAT94020(transcript)|ensemblprotists:rna_EHI_010670-1(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR035899|interpro:IPR036305|rcsb pdb:4GOU|dip:DIP-60101N|refseq:XP_653063.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:pvowqjOvguwb/m/E/3Z+niu34Hk5759	rogid:KkICO5SvceCJxl5Cel8gsXWxIfo5759	rigid:LX+oQbNIb1JcX93VFOzSIJgUexA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:C4LYV4	uniprotkb:C4M483	intact:EBI-16029107|ensemblprotists:GAT94020|ensemblprotists:rna_EHI_010670-1|uniprotkb:A0A175JJX7	intact:EBI-16029089|ensemblprotists:GAT96163|ensemblprotists:rna_EHI_140350-1|uniprotkb:A0A175JS08	psi-mi:c4lyv4_enthi(display_long)|uniprotkb:EHI_010670(orf name)	psi-mi:c4m483_enthi(display_long)|uniprotkb:EHI_140350(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Bosch et al. (2013)	pubmed:23260656|doi:10.1016/j.str.2012.11.012|imex:IM-20746	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16029145|imex:IM-20746-2|dip:DIP-190408E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblprotists:CL6EHI_010670(gene)|ensemblprotists:EHI_010670(gene)|ensemblprotists:GAT94020(transcript)|ensemblprotists:rna_EHI_010670-1(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR035899|interpro:IPR036305|rcsb pdb:4GOU|dip:DIP-60101N|refseq:XP_653063.1	rcsb pdb:4FID|ensemblprotists:CL6EHI_140350(gene)|ensemblprotists:EHI_140350(gene)|ensemblprotists:GAT96163(transcript)|ensemblprotists:rna_EHI_140350-1(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|dip:DIP-60100N|refseq:XP_651737.2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KkICO5SvceCJxl5Cel8gsXWxIfo5759	rogid:0HoMtE5hfsjH6Mwoy7p57ZzMjKc5759	rigid:o3B+LJm1Yssh4/xXpd8+oyN1HYI	false	mutation disrupting interaction strength:83-83	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:C4LYV4	uniprotkb:C4M483	intact:EBI-16029107|ensemblprotists:GAT94020|ensemblprotists:rna_EHI_010670-1|uniprotkb:A0A175JJX7	intact:EBI-16029089|ensemblprotists:GAT96163|ensemblprotists:rna_EHI_140350-1|uniprotkb:A0A175JS08	psi-mi:c4lyv4_enthi(display_long)|uniprotkb:EHI_010670(orf name)	psi-mi:c4m483_enthi(display_long)|uniprotkb:EHI_140350(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Bosch et al. (2013)	pubmed:23260656|doi:10.1016/j.str.2012.11.012|imex:IM-20746	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	taxid:5759(enthi)|taxid:5759(Entamoeba histolytica)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16029244|imex:IM-20746-6|dip:DIP-190408E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblprotists:CL6EHI_010670(gene)|ensemblprotists:EHI_010670(gene)|ensemblprotists:GAT94020(transcript)|ensemblprotists:rna_EHI_010670-1(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0016020"(membrane)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR035899|interpro:IPR036305|rcsb pdb:4GOU|dip:DIP-60101N|refseq:XP_653063.1	rcsb pdb:4FID|ensemblprotists:CL6EHI_140350(gene)|ensemblprotists:EHI_140350(gene)|ensemblprotists:GAT96163(transcript)|ensemblprotists:rna_EHI_140350-1(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|dip:DIP-60100N|refseq:XP_651737.2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:KkICO5SvceCJxl5Cel8gsXWxIfo5759	rogid:0HoMtE5hfsjH6Mwoy7p57ZzMjKc5759	rigid:o3B+LJm1Yssh4/xXpd8+oyN1HYI	false	mutation disrupting interaction strength:39-39	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)