#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0AAM1	uniprotkb:P0ACD8	intact:EBI-1134138|uniprotkb:P19929|ensemblbacteria:AAC74059|ensemblbacteria:BAA35739	intact:EBI-851493|uniprotkb:P19927|uniprotkb:P78056|ensemblbacteria:AAC74058|ensemblbacteria:BAA35738	psi-mi:cybh_ecoli(display_long)|uniprotkb:hyaC(gene name)|psi-mi:hyaC(display_short)|uniprotkb:b0974(locus name)|uniprotkb:JW0956(locus name)	psi-mi:mbhl_ecoli(display_long)|uniprotkb:Membrane-bound hydrogenase 1 large subunit(gene name synonym)|uniprotkb:NiFe hydrogenase(gene name synonym)|uniprotkb:hyaB(gene name)|psi-mi:hyaB(display_short)|uniprotkb:b0973(locus name)|uniprotkb:JW0955(locus name)	psi-mi:"MI:0071"(molecular sieving)	Volbeda et al. (2013)	pubmed:23260654|doi:"https://doi.org/10.1016/j.str.2012.11.010"|imex:IM-20744	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16028637|imex:IM-20744-1|dip:DIP-190400E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001186424.1|refseq:NP_415493.1|ensemblbacteria:BAA35739(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0020037"(heme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|interpro:IPR000516(Nickel-dependent hydrogenase b-type cytochrome subunit)|interpro:IPR011577(Cytochrome B561, bacterial)|interpro:IPR016174(Transmembrane di-haem cytochrome)|rcsb pdb:4GD3|ensemblbacteria:AAC74059(transcript)|ensemblbacteria:b0974(gene)|ensemblbacteria:BAA35739(gene)|dip:DIP-35859N	refseq:NP_415492.1|refseq:WP_000107384.1|dip:DIP-36180N|ensemblbacteria:AAC74058(transcript)|ensemblbacteria:b0973(gene)|ensemblbacteria:BAA35738(gene)|ensemblbacteria:BAA35738(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0008901"(ferredoxin hydrogenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016151"(nickel cation binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|interpro:IPR001501(Nickel-dependent hydrogenase, large subunit)|interpro:IPR018194|interpro:IPR029014|rcsb pdb:3UQY|rcsb pdb:3USC|rcsb pdb:3USE|rcsb pdb:4GD3|rcsb pdb:4UE3|rcsb pdb:5A4F|rcsb pdb:5A4I|rcsb pdb:5A4M|rcsb pdb:5ADU|rcsb pdb:5JRD|rcsb pdb:5LMM|rcsb pdb:5LRY|rcsb pdb:6FPI|rcsb pdb:6FPO|rcsb pdb:6FPW|rcsb pdb:6G7R|rcsb pdb:6G94|rcsb pdb:6GAL|rcsb pdb:6RP2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:poiKC0MEbVd/jvwtRH4NQIfKYao83333	rogid:firEXZy87IzwBqxxSdMr2x7QvJs83333	rigid:oau5wvOQzlxUIX3Qml1bZTR2CBw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AAM1	uniprotkb:P69739	intact:EBI-1134138|uniprotkb:P19929|ensemblbacteria:AAC74059|ensemblbacteria:BAA35739	intact:EBI-9124108|uniprotkb:P19928|ensemblbacteria:AAC74057|ensemblbacteria:BAA35737	psi-mi:cybh_ecoli(display_long)|uniprotkb:hyaC(gene name)|psi-mi:hyaC(display_short)|uniprotkb:b0974(locus name)|uniprotkb:JW0956(locus name)	psi-mi:mbhs_ecoli(display_long)|uniprotkb:Membrane-bound hydrogenase 1 small subunit(gene name synonym)|uniprotkb:NiFe hydrogenase(gene name synonym)|uniprotkb:JW0954(locus name)|uniprotkb:b0972(locus name)|uniprotkb:hyaA(gene name)|psi-mi:hyaA(display_short)	psi-mi:"MI:0071"(molecular sieving)	Volbeda et al. (2013)	pubmed:23260654|doi:"https://doi.org/10.1016/j.str.2012.11.010"|imex:IM-20744	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16028637|imex:IM-20744-1|dip:DIP-190400E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001186424.1|refseq:NP_415493.1|ensemblbacteria:BAA35739(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0020037"(heme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|interpro:IPR000516(Nickel-dependent hydrogenase b-type cytochrome subunit)|interpro:IPR011577(Cytochrome B561, bacterial)|interpro:IPR016174(Transmembrane di-haem cytochrome)|rcsb pdb:4GD3|ensemblbacteria:AAC74059(transcript)|ensemblbacteria:b0974(gene)|ensemblbacteria:BAA35739(gene)|dip:DIP-35859N	refseq:NP_415491.1|refseq:WP_001058323.1|dip:DIP-47848N|ensemblbacteria:AAC74057(transcript)|ensemblbacteria:b0972(gene)|ensemblbacteria:BAA35737(gene)|ensemblbacteria:BAA35737(transcript)|go:"GO:0006113"(fermentation)|go:"GO:0008901"(ferredoxin hydrogenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0009375"(ferredoxin hydrogenase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|rcsb pdb:5A4I|rcsb pdb:5A4M|rcsb pdb:5ADU|rcsb pdb:5JRD|rcsb pdb:6FPI|rcsb pdb:6FPW|rcsb pdb:6G7R|rcsb pdb:6GAL|rcsb pdb:6RP2|go:"GO:0031237"(intrinsic component of periplasmic side of plasma membrane)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001821([Ni-Fe]-hydrogenase, small subunit)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006311(Twin-arginine translocation pathway signal)|interpro:IPR019546|interpro:IPR027394|interpro:IPR037024|interpro:IPR037148|rcsb pdb:3UQY|rcsb pdb:3USC|rcsb pdb:3USE|rcsb pdb:4GD3|rcsb pdb:4UE3|rcsb pdb:5A4F	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:poiKC0MEbVd/jvwtRH4NQIfKYao83333	rogid:E43AQkd5RVOzn1UE4JbHrcVKERM83333	rigid:oau5wvOQzlxUIX3Qml1bZTR2CBw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AAM1	uniprotkb:P0ACD8	intact:EBI-1134138|uniprotkb:P19929|ensemblbacteria:AAC74059|ensemblbacteria:BAA35739	intact:EBI-851493|uniprotkb:P19927|uniprotkb:P78056|ensemblbacteria:AAC74058|ensemblbacteria:BAA35738	psi-mi:cybh_ecoli(display_long)|uniprotkb:hyaC(gene name)|psi-mi:hyaC(display_short)|uniprotkb:b0974(locus name)|uniprotkb:JW0956(locus name)	psi-mi:mbhl_ecoli(display_long)|uniprotkb:Membrane-bound hydrogenase 1 large subunit(gene name synonym)|uniprotkb:NiFe hydrogenase(gene name synonym)|uniprotkb:hyaB(gene name)|psi-mi:hyaB(display_short)|uniprotkb:b0973(locus name)|uniprotkb:JW0955(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Volbeda et al. (2013)	pubmed:23260654|doi:"https://doi.org/10.1016/j.str.2012.11.010"|imex:IM-20744	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16028656|imex:IM-20744-2|dip:DIP-190400E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001186424.1|refseq:NP_415493.1|ensemblbacteria:BAA35739(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0020037"(heme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|interpro:IPR000516(Nickel-dependent hydrogenase b-type cytochrome subunit)|interpro:IPR011577(Cytochrome B561, bacterial)|interpro:IPR016174(Transmembrane di-haem cytochrome)|rcsb pdb:4GD3|ensemblbacteria:AAC74059(transcript)|ensemblbacteria:b0974(gene)|ensemblbacteria:BAA35739(gene)|dip:DIP-35859N	refseq:NP_415492.1|refseq:WP_000107384.1|dip:DIP-36180N|ensemblbacteria:AAC74058(transcript)|ensemblbacteria:b0973(gene)|ensemblbacteria:BAA35738(gene)|ensemblbacteria:BAA35738(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0008901"(ferredoxin hydrogenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0016020"(membrane)|go:"GO:0016151"(nickel cation binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|interpro:IPR001501(Nickel-dependent hydrogenase, large subunit)|interpro:IPR018194|interpro:IPR029014|rcsb pdb:3UQY|rcsb pdb:3USC|rcsb pdb:3USE|rcsb pdb:4GD3|rcsb pdb:4UE3|rcsb pdb:5A4F|rcsb pdb:5A4I|rcsb pdb:5A4M|rcsb pdb:5ADU|rcsb pdb:5JRD|rcsb pdb:5LMM|rcsb pdb:5LRY|rcsb pdb:6FPI|rcsb pdb:6FPO|rcsb pdb:6FPW|rcsb pdb:6G7R|rcsb pdb:6G94|rcsb pdb:6GAL|rcsb pdb:6RP2	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:poiKC0MEbVd/jvwtRH4NQIfKYao83333	rogid:firEXZy87IzwBqxxSdMr2x7QvJs83333	rigid:oau5wvOQzlxUIX3Qml1bZTR2CBw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AAM1	uniprotkb:P69739	intact:EBI-1134138|uniprotkb:P19929|ensemblbacteria:AAC74059|ensemblbacteria:BAA35739	intact:EBI-9124108|uniprotkb:P19928|ensemblbacteria:AAC74057|ensemblbacteria:BAA35737	psi-mi:cybh_ecoli(display_long)|uniprotkb:hyaC(gene name)|psi-mi:hyaC(display_short)|uniprotkb:b0974(locus name)|uniprotkb:JW0956(locus name)	psi-mi:mbhs_ecoli(display_long)|uniprotkb:Membrane-bound hydrogenase 1 small subunit(gene name synonym)|uniprotkb:NiFe hydrogenase(gene name synonym)|uniprotkb:JW0954(locus name)|uniprotkb:b0972(locus name)|uniprotkb:hyaA(gene name)|psi-mi:hyaA(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Volbeda et al. (2013)	pubmed:23260654|doi:"https://doi.org/10.1016/j.str.2012.11.010"|imex:IM-20744	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16028656|imex:IM-20744-2|dip:DIP-190400E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:WP_001186424.1|refseq:NP_415493.1|ensemblbacteria:BAA35739(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006113"(fermentation)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0020037"(heme binding)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|interpro:IPR000516(Nickel-dependent hydrogenase b-type cytochrome subunit)|interpro:IPR011577(Cytochrome B561, bacterial)|interpro:IPR016174(Transmembrane di-haem cytochrome)|rcsb pdb:4GD3|ensemblbacteria:AAC74059(transcript)|ensemblbacteria:b0974(gene)|ensemblbacteria:BAA35739(gene)|dip:DIP-35859N	refseq:NP_415491.1|refseq:WP_001058323.1|dip:DIP-47848N|ensemblbacteria:AAC74057(transcript)|ensemblbacteria:b0972(gene)|ensemblbacteria:BAA35737(gene)|ensemblbacteria:BAA35737(transcript)|go:"GO:0006113"(fermentation)|go:"GO:0008901"(ferredoxin hydrogenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009061"(anaerobic respiration)|go:"GO:0009375"(ferredoxin hydrogenase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|rcsb pdb:5A4I|rcsb pdb:5A4M|rcsb pdb:5ADU|rcsb pdb:5JRD|rcsb pdb:6FPI|rcsb pdb:6FPW|rcsb pdb:6G7R|rcsb pdb:6GAL|rcsb pdb:6RP2|go:"GO:0031237"(intrinsic component of periplasmic side of plasma membrane)|go:"GO:0033748"("hydrogenase (acceptor) activity")|go:"GO:0044569"([Ni-Fe] hydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001821([Ni-Fe]-hydrogenase, small subunit)|interpro:IPR006137(NADH ubiquinone oxidoreductase, 20 kDa subunit)|interpro:IPR006311(Twin-arginine translocation pathway signal)|interpro:IPR019546|interpro:IPR027394|interpro:IPR037024|interpro:IPR037148|rcsb pdb:3UQY|rcsb pdb:3USC|rcsb pdb:3USE|rcsb pdb:4GD3|rcsb pdb:4UE3|rcsb pdb:5A4F	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:poiKC0MEbVd/jvwtRH4NQIfKYao83333	rogid:E43AQkd5RVOzn1UE4JbHrcVKERM83333	rigid:oau5wvOQzlxUIX3Qml1bZTR2CBw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)