#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99523	uniprotkb:P28799	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Prudencio et al. (2012)	pubmed:23236149|doi:"https://doi.org/10.1073/pnas.1211577110"|imex:IM-20817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027781|imex:IM-20817-1|dip:DIP-190585E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:hTj7SSQMuvHSsU4Aym9gwgORloU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99523	uniprotkb:P28799	intact:EBI-1057058|uniprotkb:Q8IZ49|uniprotkb:C0JYZ0|uniprotkb:B4DWI3|ensembl:ENSP00000256637	intact:EBI-747754|uniprotkb:P23781|uniprotkb:P23782|uniprotkb:P23783|uniprotkb:P23784|uniprotkb:Q9BWE7|uniprotkb:Q9UCH0|ensembl:ENSP00000053867|uniprotkb:Q53Y88|uniprotkb:Q540U8|uniprotkb:D3DX55|uniprotkb:Q53HQ8|uniprotkb:Q9H8S1	psi-mi:sort_human(display_long)|uniprotkb:SORT1(gene name)|psi-mi:SORT1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 95(gene name synonym)|uniprotkb:100 kDa NT receptor(gene name synonym)	psi-mi:grn_human(display_long)|uniprotkb:Proepithelin(gene name synonym)|uniprotkb:GRN(gene name)|psi-mi:GRN(display_short)|uniprotkb:Acrogranin(gene name synonym)|uniprotkb:Epithelin precursor(gene name synonym)|uniprotkb:Glycoprotein of 88 Kda(gene name synonym)|uniprotkb:Granulin precursor(gene name synonym)|uniprotkb:PC cell-derived growth factor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Prudencio et al. (2012)	pubmed:23236149|doi:"https://doi.org/10.1073/pnas.1211577110"|imex:IM-20817	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027798|imex:IM-20817-2|dip:DIP-190585E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192157.1|refseq:NP_002950.3|ensembl:ENSG00000134243(gene)|ensembl:ENST00000256637(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q99523|rcsb pdb:3F6K|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:4MSL|rcsb pdb:4N7E|rcsb pdb:4PO7|rcsb pdb:5MRH|rcsb pdb:5MRI|rcsb pdb:6EHO|rcsb pdb:6X3L|rcsb pdb:6X48|rcsb pdb:6X4H|reactome:R-HSA-432722|go:"GO:0032868"(response to insulin)|dip:DIP-41798N	refseq:NP_002078.1|ensembl:ENSG00000030582(gene)|ensembl:ENST00000053867(transcript)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0007040"(lysosome organization)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007165"(signal transduction)|go:"GO:0008083"(growth factor activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|refseq:XP_005257310.1|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0060266"(negative regulation of respiratory burst involved in inflammatory response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106016"(positive regulation of inflammatory response to wounding)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1902564"(negative regulation of neutrophil activation)|go:"GO:1903334"(positive regulation of protein folding)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905247"(positive regulation of aspartic-type peptidase activity)|go:"GO:1905673"(positive regulation of lysosome organization)|interpro:IPR000118(Granulin)|interpro:IPR037277|interpro:IPR039036|mint:P28799|rcsb pdb:1G26|rcsb pdb:2JYE|rcsb pdb:2JYT|rcsb pdb:2JYU|rcsb pdb:2JYV|rcsb pdb:6NUG|reactome:R-HSA-6798695|dip:DIP-41742N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:h/+2jen/dw+5leVis906F7iBs/A9606	rogid:SaujQCj7wHfPYunGzgTgG+jQgA89606	rigid:hTj7SSQMuvHSsU4Aym9gwgORloU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)