#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29475	intact:EBI-4399559	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	dip:DIP-24261N	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23222885|doi:10.1038/nchembio.1140|imex:IM-24827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027379|imex:IM-24827-1|dip:DIP-199819E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:vsl4Y07OPnkvr6uumWdIHftut4M	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P29475	intact:EBI-4399559	intact:EBI-7164065|intact:EBI-28983773|ensembl:ENSP00000320758|uniprotkb:O75713|uniprotkb:E9PH30|intact:MINT-122019	dip:DIP-24261N	psi-mi:nos1_human(display_long)|uniprotkb:NOS1(gene name)|psi-mi:NOS1(display_short)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2013)	pubmed:23222885|doi:10.1038/nchembio.1140|imex:IM-24827	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027396|imex:IM-24827-2|dip:DIP-199819E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536700.1|ensembl:ENSP00000320758|ensembl:ENST00000338101|ensembl:ENSP00000337459|ensembl:ENST00000618760|ensembl:ENSP00000477999|ensembl:ENSG00000089250(gene)|ensembl:ENST00000317775(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007520"(myoblast fusion)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0020037"(heme binding)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042738"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|rcsb pdb:5UO1|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR039261|mint:P29475|rcsb pdb:4D1N|rcsb pdb:4UCH|rcsb pdb:4UH5|rcsb pdb:4UH6|rcsb pdb:4V3U|rcsb pdb:5ADF|rcsb pdb:5ADG|rcsb pdb:5ADI|rcsb pdb:5FVU|rcsb pdb:5FVV|rcsb pdb:5FVW|rcsb pdb:5FVX|rcsb pdb:5UO3|rcsb pdb:5UO4|rcsb pdb:5UO5|rcsb pdb:5UO6|rcsb pdb:5UO7|rcsb pdb:5VUV|rcsb pdb:5VUW|rcsb pdb:5VUX|rcsb pdb:5VUY|rcsb pdb:5VUZ|rcsb pdb:5VV0|rcsb pdb:5VV1|rcsb pdb:5VV2|rcsb pdb:5VV3|rcsb pdb:5VV4|rcsb pdb:5VV5|rcsb pdb:6AUY|rcsb pdb:6AUZ|rcsb pdb:6AV0|rcsb pdb:6AV1|rcsb pdb:6AV2|rcsb pdb:6AV3|rcsb pdb:6AV4|rcsb pdb:6AV5|rcsb pdb:6CIC|rcsb pdb:6CID|rcsb pdb:6NG1|rcsb pdb:6NG2|rcsb pdb:6NG4|rcsb pdb:6NG5|rcsb pdb:6NG6|rcsb pdb:6NG7|rcsb pdb:6NG8|rcsb pdb:6NGA|rcsb pdb:6NGB|rcsb pdb:6NGC|rcsb pdb:6NGD|rcsb pdb:6NGE|rcsb pdb:6NGF|rcsb pdb:5UO2|rcsb pdb:6NGH|rcsb pdb:6NGI|rcsb pdb:6NHB|rcsb pdb:6NHC|rcsb pdb:6PNA|rcsb pdb:6PNB|rcsb pdb:6PNC|rcsb pdb:6PND|rcsb pdb:6PNE|rcsb pdb:6PNF|rcsb pdb:6PNG|rcsb pdb:6PNH|rcsb pdb:6PO5|rcsb pdb:6PO7|rcsb pdb:6PO8|rcsb pdb:6PO9|rcsb pdb:6POA|rcsb pdb:6POB|rcsb pdb:6POC|rcsb pdb:6POT|reactome:R-HSA-1222556|reactome:R-HSA-392154|reactome:R-HSA-5578775|refseq:NP_001191143.1|refseq:NP_000611.1|refseq:NP_001191147.1|refseq:NP_001191142.1|refseq:XP_016874834.1|refseq:XP_016874835.1|refseq:XP_016874836.1|dip:DIP-40999N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	comment:mint|function:"Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter"|function:"Genetic variations in NOS1 gene are associated with susceptibility to infantile hypertrophic pyloric stenosis type 1 (IHPS1) [MIM:179010]. IHPS has an incidence of 1-5 per 1'000 live births in whites and a marked preponderance of males to females (4:1). IHPS is the most frequent disorder requiring surgery in the first year of life. The disorder is characterized by hypertrophy and hyperplasia of the circular muscle layer of the pylorus, leading to persistent vomiting 2-12 weeks after birth. Defective pyloric relaxation and increased pyloric smooth muscle mass have been suggested to be responsible for gastric-outlet obstruction"	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:El1bLhrX0trPS1atMOWTFpDa3XU9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:vsl4Y07OPnkvr6uumWdIHftut4M	false	-	ha tag:0-0	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)