#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027141|imex:IM-20759-1|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226	sufficient binding region:21-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P06340	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-10194851|uniprotkb:Q9TQC7|uniprotkb:Q9TQD0|uniprotkb:Q9TQD1|uniprotkb:Q58HU1|uniprotkb:Q9TQC8|uniprotkb:Q9TQD3|uniprotkb:Q9TQC9|uniprotkb:Q9TQC6|uniprotkb:Q5STC7|uniprotkb:Q58HU0|uniprotkb:Q9TQD2|ensembl:ENSP00000229829|ensembl:ENSP00000372713|ensembl:ENSP00000395737|ensembl:ENSP00000397945|ensembl:ENSP00000398819|ensembl:ENSP00000401504|ensembl:ENSP00000416448	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:doa_human(display_long)|uniprotkb:HLA-DOA(gene name)|psi-mi:HLA-DOA(display_short)|uniprotkb:HLA-DNA(gene name synonym)|uniprotkb:HLA-DZA(gene name synonym)|uniprotkb:MHC DN-alpha(gene name synonym)|uniprotkb:MHC DZ alpha(gene name synonym)|uniprotkb:MHC class II antigen DOA(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027141|imex:IM-20759-1|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002110.1|ensembl:ENST00000426070(transcript)|ensembl:ENST00000426685(transcript)|ensembl:ENST00000434335(transcript)|ensembl:ENST00000438987(transcript)|ensembl:ENST00000452598(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0045580"(regulation of T cell differentiation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000204252(gene)|ensembl:ENSG00000206292(gene)|ensembl:ENSG00000230141(gene)|ensembl:ENSG00000231558(gene)|ensembl:ENSG00000232957(gene)|ensembl:ENSG00000232962(gene)|ensembl:ENSG00000235744(gene)|ensembl:ENST00000229829(transcript)|ensembl:ENST00000383226(transcript)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60116N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:tzD2VzM1xtzwavKb+PN5JE+Uahk9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226	sufficient binding region:27-207	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P13765	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-16027091|ensembl:ENSP00000390020|ensembl:ENSP00000394783|ensembl:ENSP00000395780|ensembl:ENSP00000397268|ensembl:ENSP00000405108|ensembl:ENSP00000410390|ensembl:ENSP00000496848|uniprotkb:B0V0Y0|uniprotkb:Q29746|uniprotkb:Q29825|uniprotkb:Q6FHC2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dob_human(display_long)|uniprotkb:HLA-DOB(gene name)|psi-mi:HLA-DOB(display_short)|uniprotkb:MHC class II antigen DOB(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027141|imex:IM-20759-1|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000239457(gene)|ensembl:ENSG00000241106(gene)|ensembl:ENSG00000241386(gene)|ensembl:ENSG00000241910(gene)|ensembl:ENSG00000243496(gene)|ensembl:ENSG00000243612(gene)|ensembl:ENST00000426644(transcript)|ensembl:ENST00000438763(transcript)|ensembl:ENST00000447178(transcript)|ensembl:ENST00000454286(transcript)|ensembl:ENST00000454969(transcript)|ensembl:ENST00000456406(transcript)|ensembl:ENST00000648009(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60117N|refseq:NP_002111.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jwlKsawyiSbTSwv4lQvm1QJL4sQ9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226	sufficient binding region:30-218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13765	uniprotkb:P06340	intact:EBI-16027091|ensembl:ENSP00000390020|ensembl:ENSP00000394783|ensembl:ENSP00000395780|ensembl:ENSP00000397268|ensembl:ENSP00000405108|ensembl:ENSP00000410390|ensembl:ENSP00000496848|uniprotkb:B0V0Y0|uniprotkb:Q29746|uniprotkb:Q29825|uniprotkb:Q6FHC2	intact:EBI-10194851|uniprotkb:Q9TQC7|uniprotkb:Q9TQD0|uniprotkb:Q9TQD1|uniprotkb:Q58HU1|uniprotkb:Q9TQC8|uniprotkb:Q9TQD3|uniprotkb:Q9TQC9|uniprotkb:Q9TQC6|uniprotkb:Q5STC7|uniprotkb:Q58HU0|uniprotkb:Q9TQD2|ensembl:ENSP00000229829|ensembl:ENSP00000372713|ensembl:ENSP00000395737|ensembl:ENSP00000397945|ensembl:ENSP00000398819|ensembl:ENSP00000401504|ensembl:ENSP00000416448	psi-mi:dob_human(display_long)|uniprotkb:HLA-DOB(gene name)|psi-mi:HLA-DOB(display_short)|uniprotkb:MHC class II antigen DOB(gene name synonym)	psi-mi:doa_human(display_long)|uniprotkb:HLA-DOA(gene name)|psi-mi:HLA-DOA(display_short)|uniprotkb:HLA-DNA(gene name synonym)|uniprotkb:HLA-DZA(gene name synonym)|uniprotkb:MHC DN-alpha(gene name synonym)|uniprotkb:MHC DZ alpha(gene name synonym)|uniprotkb:MHC class II antigen DOA(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027168|imex:IM-20759-2|dip:DIP-190440E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000239457(gene)|ensembl:ENSG00000241106(gene)|ensembl:ENSG00000241386(gene)|ensembl:ENSG00000241910(gene)|ensembl:ENSG00000243496(gene)|ensembl:ENSG00000243612(gene)|ensembl:ENST00000426644(transcript)|ensembl:ENST00000438763(transcript)|ensembl:ENST00000447178(transcript)|ensembl:ENST00000454286(transcript)|ensembl:ENST00000454969(transcript)|ensembl:ENST00000456406(transcript)|ensembl:ENST00000648009(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60117N|refseq:NP_002111.1	refseq:NP_002110.1|ensembl:ENST00000426070(transcript)|ensembl:ENST00000426685(transcript)|ensembl:ENST00000434335(transcript)|ensembl:ENST00000438987(transcript)|ensembl:ENST00000452598(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0045580"(regulation of T cell differentiation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000204252(gene)|ensembl:ENSG00000206292(gene)|ensembl:ENSG00000230141(gene)|ensembl:ENSG00000231558(gene)|ensembl:ENSG00000232957(gene)|ensembl:ENSG00000232962(gene)|ensembl:ENSG00000235744(gene)|ensembl:ENST00000229829(transcript)|ensembl:ENST00000383226(transcript)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60116N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:jwlKsawyiSbTSwv4lQvm1QJL4sQ9606	rogid:tzD2VzM1xtzwavKb+PN5JE+Uahk9606	rigid:Dr7Sj2hWIAh9gIG2hZVoL2neQjA	false	sufficient binding region:30-218	sufficient binding region:27-207	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027189|imex:IM-20759-3|dip:DIP-190441E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	rigid:S+47sW9LWBU9MPWeiiGnEGXhlNg	false	sufficient binding region:39-226	sufficient binding region:21-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027211|imex:IM-20759-4|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226	sufficient binding region:21-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P06340	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-10194851|uniprotkb:Q9TQC7|uniprotkb:Q9TQD0|uniprotkb:Q9TQD1|uniprotkb:Q58HU1|uniprotkb:Q9TQC8|uniprotkb:Q9TQD3|uniprotkb:Q9TQC9|uniprotkb:Q9TQC6|uniprotkb:Q5STC7|uniprotkb:Q58HU0|uniprotkb:Q9TQD2|ensembl:ENSP00000229829|ensembl:ENSP00000372713|ensembl:ENSP00000395737|ensembl:ENSP00000397945|ensembl:ENSP00000398819|ensembl:ENSP00000401504|ensembl:ENSP00000416448	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:doa_human(display_long)|uniprotkb:HLA-DOA(gene name)|psi-mi:HLA-DOA(display_short)|uniprotkb:HLA-DNA(gene name synonym)|uniprotkb:HLA-DZA(gene name synonym)|uniprotkb:MHC DN-alpha(gene name synonym)|uniprotkb:MHC DZ alpha(gene name synonym)|uniprotkb:MHC class II antigen DOA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027211|imex:IM-20759-4|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002110.1|ensembl:ENST00000426070(transcript)|ensembl:ENST00000426685(transcript)|ensembl:ENST00000434335(transcript)|ensembl:ENST00000438987(transcript)|ensembl:ENST00000452598(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0045580"(regulation of T cell differentiation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000204252(gene)|ensembl:ENSG00000206292(gene)|ensembl:ENSG00000230141(gene)|ensembl:ENSG00000231558(gene)|ensembl:ENSG00000232957(gene)|ensembl:ENSG00000232962(gene)|ensembl:ENSG00000235744(gene)|ensembl:ENST00000229829(transcript)|ensembl:ENST00000383226(transcript)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60116N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:tzD2VzM1xtzwavKb+PN5JE+Uahk9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226	sufficient binding region:27-207	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P13765	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-16027091|ensembl:ENSP00000390020|ensembl:ENSP00000394783|ensembl:ENSP00000395780|ensembl:ENSP00000397268|ensembl:ENSP00000405108|ensembl:ENSP00000410390|ensembl:ENSP00000496848|uniprotkb:B0V0Y0|uniprotkb:Q29746|uniprotkb:Q29825|uniprotkb:Q6FHC2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dob_human(display_long)|uniprotkb:HLA-DOB(gene name)|psi-mi:HLA-DOB(display_short)|uniprotkb:MHC class II antigen DOB(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027211|imex:IM-20759-4|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000239457(gene)|ensembl:ENSG00000241106(gene)|ensembl:ENSG00000241386(gene)|ensembl:ENSG00000241910(gene)|ensembl:ENSG00000243496(gene)|ensembl:ENSG00000243612(gene)|ensembl:ENST00000426644(transcript)|ensembl:ENST00000438763(transcript)|ensembl:ENST00000447178(transcript)|ensembl:ENST00000454286(transcript)|ensembl:ENST00000454969(transcript)|ensembl:ENST00000456406(transcript)|ensembl:ENST00000648009(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60117N|refseq:NP_002111.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jwlKsawyiSbTSwv4lQvm1QJL4sQ9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226	sufficient binding region:30-218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P13765	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-16027091|ensembl:ENSP00000390020|ensembl:ENSP00000394783|ensembl:ENSP00000395780|ensembl:ENSP00000397268|ensembl:ENSP00000405108|ensembl:ENSP00000410390|ensembl:ENSP00000496848|uniprotkb:B0V0Y0|uniprotkb:Q29746|uniprotkb:Q29825|uniprotkb:Q6FHC2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dob_human(display_long)|uniprotkb:HLA-DOB(gene name)|psi-mi:HLA-DOB(display_short)|uniprotkb:MHC class II antigen DOB(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027238|imex:IM-20759-5|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000239457(gene)|ensembl:ENSG00000241106(gene)|ensembl:ENSG00000241386(gene)|ensembl:ENSG00000241910(gene)|ensembl:ENSG00000243496(gene)|ensembl:ENSG00000243612(gene)|ensembl:ENST00000426644(transcript)|ensembl:ENST00000438763(transcript)|ensembl:ENST00000447178(transcript)|ensembl:ENST00000454286(transcript)|ensembl:ENST00000454969(transcript)|ensembl:ENST00000456406(transcript)|ensembl:ENST00000648009(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002504"(antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60117N|refseq:NP_002111.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:jwlKsawyiSbTSwv4lQvm1QJL4sQ9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226|flag tag:c-c	sufficient binding region:30-218	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P06340	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-10194851|uniprotkb:Q9TQC7|uniprotkb:Q9TQD0|uniprotkb:Q9TQD1|uniprotkb:Q58HU1|uniprotkb:Q9TQC8|uniprotkb:Q9TQD3|uniprotkb:Q9TQC9|uniprotkb:Q9TQC6|uniprotkb:Q5STC7|uniprotkb:Q58HU0|uniprotkb:Q9TQD2|ensembl:ENSP00000229829|ensembl:ENSP00000372713|ensembl:ENSP00000395737|ensembl:ENSP00000397945|ensembl:ENSP00000398819|ensembl:ENSP00000401504|ensembl:ENSP00000416448	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:doa_human(display_long)|uniprotkb:HLA-DOA(gene name)|psi-mi:HLA-DOA(display_short)|uniprotkb:HLA-DNA(gene name synonym)|uniprotkb:HLA-DZA(gene name synonym)|uniprotkb:MHC DN-alpha(gene name synonym)|uniprotkb:MHC DZ alpha(gene name synonym)|uniprotkb:MHC class II antigen DOA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027238|imex:IM-20759-5|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	refseq:NP_002110.1|ensembl:ENST00000426070(transcript)|ensembl:ENST00000426685(transcript)|ensembl:ENST00000434335(transcript)|ensembl:ENST00000438987(transcript)|ensembl:ENST00000452598(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002587"(negative regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0032395"(MHC class II receptor activity)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0045580"(regulation of T cell differentiation)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|ensembl:ENSG00000204252(gene)|ensembl:ENSG00000206292(gene)|ensembl:ENSG00000230141(gene)|ensembl:ENSG00000231558(gene)|ensembl:ENSG00000232957(gene)|ensembl:ENSG00000232962(gene)|ensembl:ENSG00000235744(gene)|ensembl:ENST00000229829(transcript)|ensembl:ENST00000383226(transcript)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:4I0P|reactome:R-HSA-2132295|dip:DIP-60116N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:tzD2VzM1xtzwavKb+PN5JE+Uahk9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226|flag tag:c-c	sufficient binding region:27-207	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027238|imex:IM-20759-5|dip:DIP-190442E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	rigid:BE8wFn7AZUrbIY0k/EdZn6lqScI	false	sufficient binding region:39-226|flag tag:c-c	sufficient binding region:21-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28067	uniprotkb:P28068	intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591	intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2	psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym)	psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Guce et al. (2013)	pubmed:23222639|doi:10.1038/nsmb.2460|imex:IM-20759	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16027267|imex:IM-20759-6|dip:DIP-190441E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N	ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2018/12/05	rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606	rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606	rigid:S+47sW9LWBU9MPWeiiGnEGXhlNg	false	sufficient binding region:39-226|flag tag:c-c	sufficient binding region:21-211	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)