#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P52789	uniprotkb:Q9NQ88	intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2	intact:EBI-3920747|ensembl:ENSP00000179259|uniprotkb:B2R840	psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym)	psi-mi:tigar_human(display_long)|uniprotkb:TIGAR(gene name)|psi-mi:TIGAR(display_short)|uniprotkb:C12orf5(gene name synonym)|uniprotkb:TP53-induced glycolysis and apoptosis regulator(gene name synonym)|uniprotkb:TP53-induced glycolysis regulatory phosphatase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cheung et al. (2012)	pubmed:23185017|doi:10.1073/pnas.1206530109|imex:IM-20736	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16025239|imex:IM-20736-1|dip:DIP-190388E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N	ensembl:ENSG00000078237(gene)|ensembl:ENST00000179259(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004083"(bisphosphoglycerate 2-phosphatase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043456"(regulation of pentose-phosphate shunt)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902153"(regulation of response to DNA damage checkpoint signaling)|go:"GO:1903301"(positive regulation of hexokinase activity)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|rcsb pdb:3DCY|reactome:R-HSA-5628897|refseq:NP_065108.1|dip:DIP-60093N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606	rogid:ffjUtBnwjatlJlNTmvrRTp1XtqU9606	rigid:orKYAYnmDmMLS479Uf27O3IPFk4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52789	uniprotkb:Q9NQ88	intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2	intact:EBI-3920747|ensembl:ENSP00000179259|uniprotkb:B2R840	psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym)	psi-mi:tigar_human(display_long)|uniprotkb:TIGAR(gene name)|psi-mi:TIGAR(display_short)|uniprotkb:C12orf5(gene name synonym)|uniprotkb:TP53-induced glycolysis and apoptosis regulator(gene name synonym)|uniprotkb:TP53-induced glycolysis regulatory phosphatase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cheung et al. (2012)	pubmed:23185017|doi:10.1073/pnas.1206530109|imex:IM-20736	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16025256|imex:IM-20736-2|dip:DIP-190388E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N	ensembl:ENSG00000078237(gene)|ensembl:ENST00000179259(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004083"(bisphosphoglycerate 2-phosphatase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043456"(regulation of pentose-phosphate shunt)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902153"(regulation of response to DNA damage checkpoint signaling)|go:"GO:1903301"(positive regulation of hexokinase activity)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|rcsb pdb:3DCY|reactome:R-HSA-5628897|refseq:NP_065108.1|dip:DIP-60093N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606	rogid:ffjUtBnwjatlJlNTmvrRTp1XtqU9606	rigid:orKYAYnmDmMLS479Uf27O3IPFk4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P52789	uniprotkb:Q9NQ88	intact:EBI-741469|uniprotkb:Q8WU87|uniprotkb:Q9UN82|ensembl:ENSP00000290573|uniprotkb:D6W5J2	intact:EBI-3920747|ensembl:ENSP00000179259|uniprotkb:B2R840	psi-mi:hxk2_human(display_long)|uniprotkb:Hexokinase type II(gene name synonym)|uniprotkb:Muscle form hexokinase(gene name synonym)|uniprotkb:HK2(gene name)|psi-mi:HK2(display_short)|uniprotkb:Hexokinase-B(gene name synonym)	psi-mi:tigar_human(display_long)|uniprotkb:TIGAR(gene name)|psi-mi:TIGAR(display_short)|uniprotkb:C12orf5(gene name synonym)|uniprotkb:TP53-induced glycolysis and apoptosis regulator(gene name synonym)|uniprotkb:TP53-induced glycolysis regulatory phosphatase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Cheung et al. (2012)	pubmed:23185017|doi:10.1073/pnas.1206530109|imex:IM-20736	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16025273|imex:IM-20736-3|dip:DIP-190388E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019158"(mannokinase activity)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022672|interpro:IPR022673|interpro:IPR043129|mint:P52789|rcsb pdb:2NZT|rcsb pdb:5HEX|rcsb pdb:5HFU|rcsb pdb:5HG1|reactome:R-HSA-70171|go:"GO:0008865"(fructokinase activity)|ensembl:ENSG00000159399(gene)|ensembl:ENST00000290573(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0002931"(response to ischemia)|go:"GO:0004340"(glucokinase activity)|go:"GO:0004396"(hexokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0007595"(lactation)|go:"GO:0008637"(apoptotic mitochondrial changes)|refseq:NP_000180.2|dip:DIP-50110N	ensembl:ENSG00000078237(gene)|ensembl:ENST00000179259(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004083"(bisphosphoglycerate 2-phosphatase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009410"(response to xenobiotic stimulus)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043456"(regulation of pentose-phosphate shunt)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0071279"(cellular response to cobalt ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902153"(regulation of response to DNA damage checkpoint signaling)|go:"GO:1903301"(positive regulation of hexokinase activity)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|rcsb pdb:3DCY|reactome:R-HSA-5628897|refseq:NP_065108.1|dip:DIP-60093N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:99w5KbKmsqMoorQz/wot6z6t2WM9606	rogid:ffjUtBnwjatlJlNTmvrRTp1XtqU9606	rigid:orKYAYnmDmMLS479Uf27O3IPFk4	false	-	flag tag:n-n|necessary binding region:258-261	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)