#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P78423	uniprotkb:P05106	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413162|imex:IM-26217-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:IB, 3A/B|antagonist:Heat denaturation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/09/11	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rigid:Yobw0hLbCCz/qEdFoQ7BHvTQZUs	false	mutation with no effect:71-71|mutation decreasing interaction strength:60-61|mutation decreasing interaction strength:60-61|mutation with no effect:83-83,78-78|mutation with no effect:78-78|sufficient binding region:25-100(IPR034127)|his tag:n-n	sufficient binding region:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P78423	uniprotkb:A0A061IJ01	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-15188267	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:a0a061ij01_crigr(display_long)|uniprotkb:H671_2g5979(orf name)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413162|imex:IM-26217-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR032695|interpro:IPR028994	-	-	-	figure legend:IB, 3A/B|antagonist:Heat denaturation|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/09/11	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:OYHo+TrFMudNqpZDEXNwcNSGDEU10029	rigid:Yobw0hLbCCz/qEdFoQ7BHvTQZUs	false	mutation with no effect:71-71|mutation decreasing interaction strength:60-61|mutation decreasing interaction strength:60-61|mutation with no effect:83-83,78-78|mutation with no effect:78-78|sufficient binding region:25-100(IPR034127)|his tag:n-n	sufficient binding region:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P78423	uniprotkb:P05106	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413265|imex:IM-26217-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:I C/D, 3C/D|agonist:Mn2+ ions|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/09/07	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rigid:Z0C+CoQ9T/UEviqXDx9rrjLl9FQ	false	mutation with no effect:71-71|mutation decreasing interaction strength:60-61|mutation decreasing interaction strength:60-61|mutation with no effect:83-83,78-78|mutation with no effect:78-78|sufficient binding region:25-100(IPR034127)|his tag:n-n	sufficient binding region:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P78423	uniprotkb:P08648	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413265|imex:IM-26217-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332	-	-	-	figure legend:I C/D, 3C/D|agonist:Mn2+ ions|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/09/07	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	rigid:Z0C+CoQ9T/UEviqXDx9rrjLl9FQ	false	mutation with no effect:71-71|mutation decreasing interaction strength:60-61|mutation decreasing interaction strength:60-61|mutation with no effect:83-83,78-78|mutation with no effect:78-78|sufficient binding region:25-100(IPR034127)|his tag:n-n	sufficient binding region:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P05106	uniprotkb:P78423	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413219|imex:IM-26217-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	-	-	-	figure legend:1E|kinetics:"KD of 1.1 × 10−8 M in 1 mM Ca2+ (Fig. 1E), KD of 6.9 × 10−9 M in 1 mM Mg2+, and KD of 3.0 × 10−10 M in 1 mM Mn2+(data not shown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-8(molar)	2017/06/26	2017/09/11	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rigid:Yobw0hLbCCz/qEdFoQ7BHvTQZUs	false	sufficient binding region:?-?	sufficient binding region:25-100(IPR034127)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05106	uniprotkb:A0A061IJ01	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-15188267	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:a0a061ij01_crigr(display_long)|uniprotkb:H671_2g5979(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413219|imex:IM-26217-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR032695|interpro:IPR028994	-	-	-	figure legend:1E|kinetics:"KD of 1.1 × 10−8 M in 1 mM Ca2+ (Fig. 1E), KD of 6.9 × 10−9 M in 1 mM Mg2+, and KD of 3.0 × 10−10 M in 1 mM Mn2+(data not shown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.1x10^-8(molar)	2017/06/26	2017/09/11	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:OYHo+TrFMudNqpZDEXNwcNSGDEU10029	rigid:Yobw0hLbCCz/qEdFoQ7BHvTQZUs	false	sufficient binding region:?-?	sufficient binding region:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78423	uniprotkb:P49238	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	intact:EBI-13626692|ensembl:ENSP00000382166|ensembl:ENSP00000439140|ensembl:ENSP00000444928|uniprotkb:A0N0N6|uniprotkb:B2R5Z4|uniprotkb:J3KP17	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:cx3c1_human(display_long)|uniprotkb:CX3CR1(gene name)|psi-mi:CX3CR1(display_short)|uniprotkb:Beta chemokine receptor-like 1(gene name synonym)|uniprotkb:CMKBRL1(gene name synonym)|uniprotkb:Fractalkine receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 13(gene name synonym)|uniprotkb:GPR13(gene name synonym)|uniprotkb:V28(gene name synonym)	psi-mi:"MI:0096"(pull down)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413301|imex:IM-26217-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	ensembl:ENSG00000168329(gene)|ensembl:ENST00000399220(transcript)|ensembl:ENST00000541347(transcript)|ensembl:ENST00000542107(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002931"(response to ischemia)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016495"(C-X3-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035176"(social behavior)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0043005"(neuron projection)|go:"GO:0045087"(innate immune response)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060074"(synapse maturation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0097447"(dendritic tree)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:0150090"(multiple spine synapse organization, single dendrite)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1904139"(regulation of microglial cell migration)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904150"(negative regulation of microglial cell mediated cytotoxicity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR005387(CX3C Fractalkine chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_001164642.1|refseq:NP_001164643.1|refseq:NP_001164645.1|refseq:NP_001328.1|dip:DIP-5879N	-	-	-	figure legend:3E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/09	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rogid:hFO4xCbwqO6rCVPNeHnj76izSUI9606	rigid:G7QRVO/Uxs9XwV6YTLXAw71QZCk	false	mutation disrupting interaction strength:71-71|mutation with no effect:60-61|sufficient binding region:25-100(IPR034127)|his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13612	uniprotkb:P78423	intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym)	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413432|imex:IM-26217-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	-	-	-	figure legend:5F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rigid:0lZhdiK0I0rTWUEVblSGSi7BYEU	false	-	his tag:n-n|sufficient binding region:25-100(IPR034127)|mutation disrupting interaction strength:60-61|mutation disrupting interaction strength:71-71	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13612	uniprotkb:P49238	intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6	intact:EBI-13626692|ensembl:ENSP00000382166|ensembl:ENSP00000439140|ensembl:ENSP00000444928|uniprotkb:A0N0N6|uniprotkb:B2R5Z4|uniprotkb:J3KP17	psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym)	psi-mi:cx3c1_human(display_long)|uniprotkb:CX3CR1(gene name)|psi-mi:CX3CR1(display_short)|uniprotkb:Beta chemokine receptor-like 1(gene name synonym)|uniprotkb:CMKBRL1(gene name synonym)|uniprotkb:Fractalkine receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 13(gene name synonym)|uniprotkb:GPR13(gene name synonym)|uniprotkb:V28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413432|imex:IM-26217-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N	ensembl:ENSG00000168329(gene)|ensembl:ENST00000399220(transcript)|ensembl:ENST00000541347(transcript)|ensembl:ENST00000542107(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002931"(response to ischemia)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016495"(C-X3-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035176"(social behavior)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0043005"(neuron projection)|go:"GO:0045087"(innate immune response)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060074"(synapse maturation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0097447"(dendritic tree)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:0150090"(multiple spine synapse organization, single dendrite)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1904139"(regulation of microglial cell migration)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904150"(negative regulation of microglial cell mediated cytotoxicity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR005387(CX3C Fractalkine chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_001164642.1|refseq:NP_001164643.1|refseq:NP_001164645.1|refseq:NP_001328.1|dip:DIP-5879N	-	-	-	figure legend:5F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606	rogid:hFO4xCbwqO6rCVPNeHnj76izSUI9606	rigid:0lZhdiK0I0rTWUEVblSGSi7BYEU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05106	uniprotkb:P78423	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413450|imex:IM-26217-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	-	-	-	figure legend:5G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rigid:ES0NpHQwRySZZ6bpjHo8ELH8Vvs	false	-	his tag:n-n|sufficient binding region:25-100(IPR034127)|mutation disrupting interaction strength:60-61|mutation disrupting interaction strength:71-71	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05106	uniprotkb:P49238	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-13626692|ensembl:ENSP00000382166|ensembl:ENSP00000439140|ensembl:ENSP00000444928|uniprotkb:A0N0N6|uniprotkb:B2R5Z4|uniprotkb:J3KP17	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:cx3c1_human(display_long)|uniprotkb:CX3CR1(gene name)|psi-mi:CX3CR1(display_short)|uniprotkb:Beta chemokine receptor-like 1(gene name synonym)|uniprotkb:CMKBRL1(gene name synonym)|uniprotkb:Fractalkine receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 13(gene name synonym)|uniprotkb:GPR13(gene name synonym)|uniprotkb:V28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413450|imex:IM-26217-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	ensembl:ENSG00000168329(gene)|ensembl:ENST00000399220(transcript)|ensembl:ENST00000541347(transcript)|ensembl:ENST00000542107(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002931"(response to ischemia)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016495"(C-X3-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035176"(social behavior)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0043005"(neuron projection)|go:"GO:0045087"(innate immune response)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060074"(synapse maturation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0097447"(dendritic tree)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:0150090"(multiple spine synapse organization, single dendrite)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1904139"(regulation of microglial cell migration)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904150"(negative regulation of microglial cell mediated cytotoxicity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR005387(CX3C Fractalkine chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_001164642.1|refseq:NP_001164643.1|refseq:NP_001164645.1|refseq:NP_001328.1|dip:DIP-5879N	-	-	-	figure legend:5G|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:hFO4xCbwqO6rCVPNeHnj76izSUI9606	rigid:ES0NpHQwRySZZ6bpjHo8ELH8Vvs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05106	uniprotkb:P78423	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413467|imex:IM-26217-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	-	-	-	figure legend:Supp fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rigid:ES0NpHQwRySZZ6bpjHo8ELH8Vvs	false	-	sufficient binding region:?-397	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P05106	uniprotkb:P49238	intact:EBI-702847|uniprotkb:A0PJW2|uniprotkb:O15495|uniprotkb:Q12806|uniprotkb:Q13413|uniprotkb:Q14648|uniprotkb:Q16499|uniprotkb:D3DXJ8|ensembl:ENSP00000452786	intact:EBI-13626692|ensembl:ENSP00000382166|ensembl:ENSP00000439140|ensembl:ENSP00000444928|uniprotkb:A0N0N6|uniprotkb:B2R5Z4|uniprotkb:J3KP17	psi-mi:itb3_human(display_long)|uniprotkb:Platelet membrane glycoprotein IIIa(gene name synonym)|uniprotkb:ITGB3(gene name)|psi-mi:ITGB3(display_short)|uniprotkb:GP3A(gene name synonym)	psi-mi:cx3c1_human(display_long)|uniprotkb:CX3CR1(gene name)|psi-mi:CX3CR1(display_short)|uniprotkb:Beta chemokine receptor-like 1(gene name synonym)|uniprotkb:CMKBRL1(gene name synonym)|uniprotkb:Fractalkine receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 13(gene name synonym)|uniprotkb:GPR13(gene name synonym)|uniprotkb:V28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413467|imex:IM-26217-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000203.2|dip:DIP-304N|ensembl:ENSG00000259207(gene)|ensembl:ENST00000559488(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0035295"(tube development)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051611"(regulation of serotonin uptake)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027068|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05106|rcsb pdb:1JV2|rcsb pdb:1KUP|rcsb pdb:1KUZ|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1M8O|rcsb pdb:1MIZ|rcsb pdb:1MK7|rcsb pdb:1MK9|rcsb pdb:1RN0|rcsb pdb:1S4X|rcsb pdb:1TYE|rcsb pdb:1U8C|rcsb pdb:2INI|rcsb pdb:2K9J|rcsb pdb:2KNC|rcsb pdb:2KV9|rcsb pdb:2L1C|rcsb pdb:2L91|rcsb pdb:2LJD|rcsb pdb:2LJE|rcsb pdb:2LJF|rcsb pdb:2MTP|rcsb pdb:2N9Y|rcsb pdb:2Q6W|rcsb pdb:2RMZ|rcsb pdb:2RN0|rcsb pdb:2VC2|rcsb pdb:2VDK|rcsb pdb:2VDL|rcsb pdb:2VDM|rcsb pdb:2VDN|rcsb pdb:2VDO|rcsb pdb:2VDP|rcsb pdb:2VDQ|rcsb pdb:2VDR|rcsb pdb:3FCS|rcsb pdb:3FCU|rcsb pdb:3IJE|rcsb pdb:3NID|rcsb pdb:3NIF|rcsb pdb:3NIG|rcsb pdb:3T3M|rcsb pdb:3T3P|rcsb pdb:3ZDX|rcsb pdb:3ZDY|rcsb pdb:3ZDZ|rcsb pdb:3ZE0|rcsb pdb:3ZE1|rcsb pdb:3ZE2|rcsb pdb:4CAK|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4O02|rcsb pdb:4Z7N|rcsb pdb:4Z7O|rcsb pdb:4Z7Q|rcsb pdb:5HDB|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6BXB|rcsb pdb:6BXF|rcsb pdb:6BXJ|rcsb pdb:6CKB|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6V4P|reactome:R-HSA-114608|reactome:R-HSA-1566948|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223	ensembl:ENSG00000168329(gene)|ensembl:ENST00000399220(transcript)|ensembl:ENST00000541347(transcript)|ensembl:ENST00000542107(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002931"(response to ischemia)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016495"(C-X3-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035176"(social behavior)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0043005"(neuron projection)|go:"GO:0045087"(innate immune response)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060074"(synapse maturation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0097447"(dendritic tree)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:0150090"(multiple spine synapse organization, single dendrite)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1904139"(regulation of microglial cell migration)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904150"(negative regulation of microglial cell mediated cytotoxicity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR005387(CX3C Fractalkine chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_001164642.1|refseq:NP_001164643.1|refseq:NP_001164645.1|refseq:NP_001328.1|dip:DIP-5879N	-	-	-	figure legend:Supp fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:EnuaoGdEG3SOqzwmTfH1OwqKuzs9606	rogid:hFO4xCbwqO6rCVPNeHnj76izSUI9606	rigid:ES0NpHQwRySZZ6bpjHo8ELH8Vvs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13612	uniprotkb:P78423	intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6	intact:EBI-15188013|ensembl:ENSP00000006053|uniprotkb:O00672	psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym)	psi-mi:x3cl1_human(display_long)|uniprotkb:C-X3-C motif chemokine 1(gene name synonym)|uniprotkb:CX3C membrane-anchored chemokine(gene name synonym)|uniprotkb:Neurotactin(gene name synonym)|uniprotkb:Small-inducible cytokine D1(gene name synonym)|uniprotkb:A-152E5.2(orf name)|uniprotkb:CX3CL1(gene name)|psi-mi:CX3CL1(display_short)|uniprotkb:FKN(gene name synonym)|uniprotkb:NTT(gene name synonym)|uniprotkb:SCYD1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413483|imex:IM-26217-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N	ensembl:ENSG00000006210(gene)|ensembl:ENST00000006053(transcript)|go:"GO:0001774"(microglial cell activation)|interpro:IPR039809|rcsb pdb:1B2T|rcsb pdb:1F2L|rcsb pdb:3ONA|rcsb pdb:4XT1|rcsb pdb:4XT3|rcsb pdb:5WB2|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016322"(neuron remodeling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031664"(regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032690"(negative regulation of interleukin-1 alpha production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0033622"(integrin activation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045237"(CXCR1 chemokine receptor binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002931"(response to ischemia)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007568"(aging)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050902"(leukocyte adhesive activation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051041"(positive regulation of calcium-independent cell-cell adhesion)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:1900450"(negative regulation of glutamate receptor signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:2001223"(negative regulation of neuron migration)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008097(Fractalkine/neurotactin)|interpro:IPR034127|interpro:IPR036048|refseq:NP_002987.1|dip:DIP-5878N	-	-	-	figure legend:Supp fig 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606	rogid:srf0W5K/ZvkeQAKq0r911cofIhc9606	rigid:0lZhdiK0I0rTWUEVblSGSi7BYEU	false	-	sufficient binding region:?-397	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P13612	uniprotkb:P49238	intact:EBI-703044|ensembl:ENSP00000380227|uniprotkb:D3DPG4|uniprotkb:Q7Z4L6	intact:EBI-13626692|ensembl:ENSP00000382166|ensembl:ENSP00000439140|ensembl:ENSP00000444928|uniprotkb:A0N0N6|uniprotkb:B2R5Z4|uniprotkb:J3KP17	psi-mi:ita4_human(display_long)|uniprotkb:Integrin alpha-IV(gene name synonym)|uniprotkb:VLA-4 subunit alpha(gene name synonym)|uniprotkb:CD49 antigen-like family member D(gene name synonym)|uniprotkb:ITGA4(gene name)|psi-mi:ITGA4(display_short)|uniprotkb:CD49D(gene name synonym)	psi-mi:cx3c1_human(display_long)|uniprotkb:CX3CR1(gene name)|psi-mi:CX3CR1(display_short)|uniprotkb:Beta chemokine receptor-like 1(gene name synonym)|uniprotkb:CMKBRL1(gene name synonym)|uniprotkb:Fractalkine receptor(gene name synonym)|uniprotkb:G-protein coupled receptor 13(gene name synonym)|uniprotkb:GPR13(gene name synonym)|uniprotkb:V28(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Fujita et al. (2012)	pubmed:23125415|imex:IM-26217	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16413483|imex:IM-26217-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0033631"(cell-cell adhesion mediated by integrin)|ensembl:ENSG00000115232(gene)|ensembl:ENST00000397033(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0003366"(cell-matrix adhesion involved in ameboidal cell migration)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030426"(growth cone)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034669"(integrin alpha4-beta7 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0046872"(metal ion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050904"(diapedesis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR032695|go:"GO:0090074"(negative regulation of protein homodimerization activity)|go:"GO:0098657"(import into cell)|go:"GO:0140039"(cell-cell adhesion in response to extracellular stimulus)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|rcsb pdb:3V4P|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990405"(protein antigen binding)|go:"GO:1990771"(clathrin-dependent extracellular exosome endocytosis)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|rcsb pdb:3V4V|rcsb pdb:4HKC|rcsb pdb:5C7Z|rcsb pdb:5FPI|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-8949275|reactome:R-HSA-9679191|refseq:NP_000876.3|refseq:NP_001303241.1|dip:DIP-34971N	ensembl:ENSG00000168329(gene)|ensembl:ENST00000399220(transcript)|ensembl:ENST00000541347(transcript)|ensembl:ENST00000542107(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002931"(response to ischemia)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016495"(C-X3-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0035176"(social behavior)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0035425"(autocrine signaling)|go:"GO:0043005"(neuron projection)|go:"GO:0045087"(innate immune response)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048874"(host-mediated regulation of intestinal microbiota composition)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060074"(synapse maturation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0097447"(dendritic tree)|go:"GO:0098883"(synapse pruning)|go:"GO:0110091"(negative regulation of hippocampal neuron apoptotic process)|go:"GO:0150090"(multiple spine synapse organization, single dendrite)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1904139"(regulation of microglial cell migration)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904150"(negative regulation of microglial cell mediated cytotoxicity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR005387(CX3C Fractalkine chemokine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_001164642.1|refseq:NP_001164643.1|refseq:NP_001164645.1|refseq:NP_001328.1|dip:DIP-5879N	-	-	-	figure legend:Supp fig 2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/06/26	2017/10/10	rogid:+eJ+J7eQCKRUc/uMuaI56AmygAQ9606	rogid:hFO4xCbwqO6rCVPNeHnj76izSUI9606	rigid:0lZhdiK0I0rTWUEVblSGSi7BYEU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)