#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97333	uniprotkb:P70207	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	intact:EBI-771272|uniprotkb:Q6NVE6|uniprotkb:Q6PHN4|uniprotkb:Q80TZ7|uniprotkb:Q8R1I4|ensembl:ENSMUSP00000027952	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:plxa2_mouse(display_long)|uniprotkb:Plxna2(gene name)|psi-mi:Plxna2(display_short)|uniprotkb:Kiaa0463(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Janssen et al. (2012)	pubmed:23104057|doi:10.1038/nsmb.2416|imex:IM-20609	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16019551|imex:IM-20609-1|dip:DIP-190168E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	refseq:NP_032908.2|dip:DIP-32252N|ensembl:ENSMUSG00000026640(gene)|ensembl:ENSMUST00000027952(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0021915"(neural tube development)|go:"GO:0021935"(cerebellar granule cell precursor tangential migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060174"(limb bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042826|rcsb pdb:3AL8|rcsb pdb:3AL9|rcsb pdb:3OKT|rcsb pdb:3OKY|rcsb pdb:4GZA|rcsb pdb:5L5G|rcsb pdb:5L74|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rogid:nzfx1kD2CVYGymwROVFeLEby09E10090	rigid:b1mEp6mCKXjdRfNiM4j9XM61P1g	false	sufficient binding region:22-586	sufficient binding region:35-703	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97333	uniprotkb:O08665	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	intact:EBI-8586029|uniprotkb:Q62215|intact:UNK-5361021|uniprotkb:Q62180|uniprotkb:E9QK85|uniprotkb:Q5BL08	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:sem3a_mouse(display_long)|uniprotkb:Sema3a(gene name)|psi-mi:Sema3a(display_short)|uniprotkb:Semad(gene name synonym)|uniprotkb:SemD(gene name synonym)|uniprotkb:Semaphorin III(gene name synonym)|uniprotkb:Semaphorin-D(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Janssen et al. (2012)	pubmed:23104057|doi:10.1038/nsmb.2416|imex:IM-20609	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16019551|imex:IM-20609-1|dip:DIP-190168E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	go:"GO:0001755"(neural crest cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038191"(neuropilin binding)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1903045"(neural crest cell migration involved in sympathetic nervous system development)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042820|rcsb pdb:1Q47|rcsb pdb:4GZ8|rcsb pdb:4GZA|rcsb pdb:7M0R|refseq:XP_011238967.1|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|refseq:NP_033178.2|refseq:NP_001230001.1|refseq:NP_001230002.1|refseq:XP_006503620.1|refseq:XP_006503621.1|refseq:XP_006503622.1|dip:DIP-59997N	psi-mi:"MI:0465"(dip)	-	comment:mint|function:Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rogid:85xdMklgHWUwf4yQ/vviijWVByA10090	rigid:b1mEp6mCKXjdRfNiM4j9XM61P1g	false	sufficient binding region:22-586	sufficient binding region:21-555	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97333	uniprotkb:P70207	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	intact:EBI-771272|uniprotkb:Q6NVE6|uniprotkb:Q6PHN4|uniprotkb:Q80TZ7|uniprotkb:Q8R1I4|ensembl:ENSMUSP00000027952	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:plxa2_mouse(display_long)|uniprotkb:Plxna2(gene name)|psi-mi:Plxna2(display_short)|uniprotkb:Kiaa0463(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Janssen et al. (2012)	pubmed:23104057|doi:10.1038/nsmb.2416|imex:IM-20609	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16019599|imex:IM-20609-3|dip:DIP-190170E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	refseq:NP_032908.2|dip:DIP-32252N|ensembl:ENSMUSG00000026640(gene)|ensembl:ENSMUST00000027952(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0021915"(neural tube development)|go:"GO:0021935"(cerebellar granule cell precursor tangential migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060174"(limb bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042826|rcsb pdb:3AL8|rcsb pdb:3AL9|rcsb pdb:3OKT|rcsb pdb:3OKY|rcsb pdb:4GZA|rcsb pdb:5L5G|rcsb pdb:5L74|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rogid:nzfx1kD2CVYGymwROVFeLEby09E10090	rigid:ASrMgpZ/wRvaVbdxakU/IHCNsCA	false	sufficient binding region:22-586|mutation disrupting interaction strength:74-74,73-73	sufficient binding region:35-703	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08665	uniprotkb:P97333	intact:EBI-8586029|uniprotkb:Q62215|intact:UNK-5361021|uniprotkb:Q62180|uniprotkb:E9QK85|uniprotkb:Q5BL08	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	psi-mi:sem3a_mouse(display_long)|uniprotkb:Sema3a(gene name)|psi-mi:Sema3a(display_short)|uniprotkb:Semad(gene name synonym)|uniprotkb:SemD(gene name synonym)|uniprotkb:Semaphorin III(gene name synonym)|uniprotkb:Semaphorin-D(gene name synonym)	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Janssen et al. (2012)	pubmed:23104057|doi:10.1038/nsmb.2416|imex:IM-20609	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16019624|imex:IM-20609-4|dip:DIP-190169E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001755"(neural crest cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038191"(neuropilin binding)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1903045"(neural crest cell migration involved in sympathetic nervous system development)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042820|rcsb pdb:1Q47|rcsb pdb:4GZ8|rcsb pdb:4GZA|rcsb pdb:7M0R|refseq:XP_011238967.1|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|refseq:NP_033178.2|refseq:NP_001230001.1|refseq:NP_001230002.1|refseq:XP_006503620.1|refseq:XP_006503621.1|refseq:XP_006503622.1|dip:DIP-59997N	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	psi-mi:"MI:0465"(dip)	comment:mint|function:Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:85xdMklgHWUwf4yQ/vviijWVByA10090	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rigid:PgwIQY/ajjcBrj1MWEuxXqefu2Q	false	sufficient binding region:21-568	sufficient binding region:22-586|mutation disrupting interaction strength:74-74,73-73	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08665	uniprotkb:O08665	intact:EBI-8586029|uniprotkb:Q62215|intact:UNK-5361021|uniprotkb:Q62180|uniprotkb:E9QK85|uniprotkb:Q5BL08	intact:EBI-8586029|uniprotkb:Q62215|intact:UNK-5361021|uniprotkb:Q62180|uniprotkb:E9QK85|uniprotkb:Q5BL08	psi-mi:sem3a_mouse(display_long)|uniprotkb:Sema3a(gene name)|psi-mi:Sema3a(display_short)|uniprotkb:Semad(gene name synonym)|uniprotkb:SemD(gene name synonym)|uniprotkb:Semaphorin III(gene name synonym)|uniprotkb:Semaphorin-D(gene name synonym)	psi-mi:sem3a_mouse(display_long)|uniprotkb:Sema3a(gene name)|psi-mi:Sema3a(display_short)|uniprotkb:Semad(gene name synonym)|uniprotkb:SemD(gene name synonym)|uniprotkb:Semaphorin III(gene name synonym)|uniprotkb:Semaphorin-D(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Janssen et al. (2012)	pubmed:23104057|doi:10.1038/nsmb.2416|imex:IM-20609	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16019650|imex:IM-20609-5|dip:DIP-190171E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001755"(neural crest cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038191"(neuropilin binding)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1903045"(neural crest cell migration involved in sympathetic nervous system development)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042820|rcsb pdb:1Q47|rcsb pdb:4GZ8|rcsb pdb:4GZA|rcsb pdb:7M0R|refseq:XP_011238967.1|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|refseq:NP_033178.2|refseq:NP_001230001.1|refseq:NP_001230002.1|refseq:XP_006503620.1|refseq:XP_006503621.1|refseq:XP_006503622.1|dip:DIP-59997N	go:"GO:0001755"(neural crest cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038191"(neuropilin binding)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1903045"(neural crest cell migration involved in sympathetic nervous system development)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042820|rcsb pdb:1Q47|rcsb pdb:4GZ8|rcsb pdb:4GZA|rcsb pdb:7M0R|refseq:XP_011238967.1|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|refseq:NP_033178.2|refseq:NP_001230001.1|refseq:NP_001230002.1|refseq:XP_006503620.1|refseq:XP_006503621.1|refseq:XP_006503622.1|dip:DIP-59997N	psi-mi:"MI:0465"(dip)	comment:mint|function:Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally	comment:mint|function:Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:85xdMklgHWUwf4yQ/vviijWVByA10090	rogid:85xdMklgHWUwf4yQ/vviijWVByA10090	rigid:bmFOxJTmeLKpGeIdsk2LrGiw/rY	false	sufficient binding region:21-675|mutation:555-555,551-551	sufficient binding region:21-675|mutation:555-555,551-551	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P97333	uniprotkb:P70207	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	intact:EBI-771272|uniprotkb:Q6NVE6|uniprotkb:Q6PHN4|uniprotkb:Q80TZ7|uniprotkb:Q8R1I4|ensembl:ENSMUSP00000027952	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:plxa2_mouse(display_long)|uniprotkb:Plxna2(gene name)|psi-mi:Plxna2(display_short)|uniprotkb:Kiaa0463(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Janssen et al. (2012)	pubmed:23104057|doi:10.1038/nsmb.2416|imex:IM-20609	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16019575|imex:IM-20609-2|dip:DIP-190170E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	refseq:NP_032908.2|dip:DIP-32252N|ensembl:ENSMUSG00000026640(gene)|ensembl:ENSMUST00000027952(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0021915"(neural tube development)|go:"GO:0021935"(cerebellar granule cell precursor tangential migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051642"(centrosome localization)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060174"(limb bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042826|rcsb pdb:3AL8|rcsb pdb:3AL9|rcsb pdb:3OKT|rcsb pdb:3OKY|rcsb pdb:4GZA|rcsb pdb:5L5G|rcsb pdb:5L74|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rogid:nzfx1kD2CVYGymwROVFeLEby09E10090	rigid:ASrMgpZ/wRvaVbdxakU/IHCNsCA	false	sufficient binding region:22-586	sufficient binding region:35-703|mutation decreasing interaction strength:275-275	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08665	uniprotkb:P97333	intact:EBI-8586029|uniprotkb:Q62215|intact:UNK-5361021|uniprotkb:Q62180|uniprotkb:E9QK85|uniprotkb:Q5BL08	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	psi-mi:sem3a_mouse(display_long)|uniprotkb:Sema3a(gene name)|psi-mi:Sema3a(display_short)|uniprotkb:Semad(gene name synonym)|uniprotkb:SemD(gene name synonym)|uniprotkb:Semaphorin III(gene name synonym)|uniprotkb:Semaphorin-D(gene name synonym)	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Janssen et al. (2012)	pubmed:23104057|doi:10.1038/nsmb.2416|imex:IM-20609	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16019672|imex:IM-20609-6|dip:DIP-190169E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001755"(neural crest cell migration)|go:"GO:0001764"(neuron migration)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030215"(semaphorin receptor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038191"(neuropilin binding)|go:"GO:0045499"(chemorepellent activity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1903045"(neural crest cell migration involved in sympathetic nervous system development)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:2000020"(positive regulation of male gonad development)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027231|interpro:IPR036179|interpro:IPR036352|interpro:IPR042820|rcsb pdb:1Q47|rcsb pdb:4GZ8|rcsb pdb:4GZA|rcsb pdb:7M0R|refseq:XP_011238967.1|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|refseq:NP_033178.2|refseq:NP_001230001.1|refseq:NP_001230002.1|refseq:XP_006503620.1|refseq:XP_006503621.1|refseq:XP_006503622.1|dip:DIP-59997N	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	psi-mi:"MI:0465"(dip)	comment:mint|function:Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:85xdMklgHWUwf4yQ/vviijWVByA10090	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rigid:PgwIQY/ajjcBrj1MWEuxXqefu2Q	false	sufficient binding region:21-568|mutation decreasing interaction strength:355-355,353-353	sufficient binding region:22-586	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)