#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O14746 uniprotkb:Q96AP0 intact:EBI-1772203|uniprotkb:O14783|uniprotkb:Q2XS35|uniprotkb:Q8N6C3|uniprotkb:Q8NG46|uniprotkb:Q8NG38|ensembl:ENSP00000309572 intact:EBI-717666|uniprotkb:Q562H5|uniprotkb:Q9H8F9|uniprotkb:A0A0C4DGT6|ensembl:ENSP00000478084 psi-mi:tert_human(display_long)|uniprotkb:TERT(gene name)|psi-mi:TERT(display_short)|uniprotkb:EST2(gene name synonym)|uniprotkb:TCS1(gene name synonym)|uniprotkb:TRT(gene name synonym)|uniprotkb:Telomerase catalytic subunit(gene name synonym)|uniprotkb:HEST2(gene name synonym)|uniprotkb:Telomerase-associated protein 2(gene name synonym) psi-mi:acd_human(display_long)|uniprotkb:POT1 and TIN2-interacting protein(gene name synonym)|uniprotkb:ACD(gene name)|psi-mi:ACD(display_short)|uniprotkb:PIP1(gene name synonym)|uniprotkb:PTOP(gene name synonym)|uniprotkb:TINT1(gene name synonym)|uniprotkb:TPP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Nandakumar et al. (2012) pubmed:23103865|doi:10.1038/nature11648|imex:IM-20813 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16019505|imex:IM-20813-1|dip:DIP-190575E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180305.1|refseq:NP_937983.2|dip:DIP-40646N|ensembl:ENSG00000164362(gene)|ensembl:ENST00000310581(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000333"(telomerase catalytic core complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001172"(transcription, RNA-templated)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003720"(telomerase activity)|go:"GO:0003721"(telomerase RNA reverse transcriptase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003964"(RNA-directed DNA polymerase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0022616"(DNA strand elongation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031379"(RNA-directed RNA polymerase complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042635"(positive regulation of hair cycle)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0062103"(double-stranded RNA biosynthetic process)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0070200"(establishment of protein localization to telomere)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0090399"(replicative senescence)|go:"GO:0098680"(template-free RNA nucleotidyltransferase)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903620"(positive regulation of transdifferentiation)|go:"GO:1903704"(negative regulation of production of siRNA involved in RNA interference)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990572"(TERT-RMRP complex)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000477("RNA-directed DNA polymerase (reverse transcriptase)")|interpro:IPR003545(Telomere reverse transcriptase)|interpro:IPR021891|interpro:IPR043502|mint:O14746|rcsb pdb:2BCK|rcsb pdb:4B18|rcsb pdb:4MNQ|rcsb pdb:5MEN|rcsb pdb:5MEO|rcsb pdb:5MEP|rcsb pdb:5MER|rcsb pdb:5UGW|rcsb pdb:7BG9|reactome:R-HSA-171319|reactome:R-HSA-201722|rcsb pdb:5MEQ refseq:NP_001075955.1|refseq:NP_001075956.1|refseq:NP_075065.2|go:"GO:0035282"(segmentation)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060381"(positive regulation of single-stranded telomeric DNA binding)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070200"(establishment of protein localization to telomere)|interpro:IPR019437|interpro:IPR028631|rcsb pdb:2I46|rcsb pdb:5H65|rcsb pdb:5I2X|rcsb pdb:5I2Y|rcsb pdb:5UN7|rcsb pdb:5XYF|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|ensembl:ENSG00000102977(gene)|ensembl:ENST00000620761(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0001655"(urogenital system development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032202"(telomere assembly)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|dip:DIP-29611N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/09/20 rogid:jHm8Li7IWhFinYJ5gmXQJypHdUc9606 rogid:Z073GMd5V0shLNtElKVeCwr5fCA9606 rigid:O6LfJdeXx4TpUs73M/rqLaOpjB8 false - flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)