#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9NPI6 uniprotkb:Q9NPJ4-1 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-16018718|ensembl:ENSP00000334840|ensembl:ENSP00000363592|ensembl:ENSP00000497590 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:q9npj4-1(display_long)|uniprotkb:PNRC2(gene name)|psi-mi:PNRC2(display_short)|uniprotkb:HSPC208(orf name) psi-mi:"MI:0018"(two hybrid) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16018724|imex:IM-20600-1|dip:DIP-190152E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N ensembl:ENSG00000189266(gene)|ensembl:ENST00000334351(transcript)|ensembl:ENST00000374468(transcript)|ensembl:ENST00000647887(transcript)|intact:EBI-726549(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:95yy4wkOEjSuRUGby7OanMTNtCk9606 rigid:9VS3Uw25VhecwLwPB0JND+kdBec false mutation disrupting interaction strength:96-96|mutation decreasing interaction strength:36-36|mutation decreasing interaction strength:45-45|mutation decreasing interaction strength:94-94|mutation decreasing interaction strength:98-98 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NPI6 uniprotkb:Q9NPJ4-1 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-16018718|ensembl:ENSP00000334840|ensembl:ENSP00000363592|ensembl:ENSP00000497590 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:q9npj4-1(display_long)|uniprotkb:PNRC2(gene name)|psi-mi:PNRC2(display_short)|uniprotkb:HSPC208(orf name) psi-mi:"MI:0114"(x-ray crystallography) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16018757|imex:IM-20600-2|dip:DIP-190152E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N ensembl:ENSG00000189266(gene)|ensembl:ENST00000334351(transcript)|ensembl:ENST00000374468(transcript)|ensembl:ENST00000647887(transcript)|intact:EBI-726549(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:95yy4wkOEjSuRUGby7OanMTNtCk9606 rigid:9VS3Uw25VhecwLwPB0JND+kdBec false sufficient binding region:1-130 sufficient binding region:1-121 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NPI6 uniprotkb:Q9NPJ4-1 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-16018718|ensembl:ENSP00000334840|ensembl:ENSP00000363592|ensembl:ENSP00000497590 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:q9npj4-1(display_long)|uniprotkb:PNRC2(gene name)|psi-mi:PNRC2(display_short)|uniprotkb:HSPC208(orf name) psi-mi:"MI:0071"(molecular sieving) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16018778|imex:IM-20600-3|dip:DIP-190152E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N ensembl:ENSG00000189266(gene)|ensembl:ENST00000334351(transcript)|ensembl:ENST00000374468(transcript)|ensembl:ENST00000647887(transcript)|intact:EBI-726549(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:95yy4wkOEjSuRUGby7OanMTNtCk9606 rigid:9VS3Uw25VhecwLwPB0JND+kdBec false sufficient binding region:1-130 sufficient binding region:1-121 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IU60 uniprotkb:Q9NPI6 intact:EBI-521577|uniprotkb:Q6P2D4|uniprotkb:Q7Z5W5|uniprotkb:Q8NBG5|uniprotkb:C9J778|ensembl:ENSP00000373715 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:dcp2_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 20(gene name synonym)|uniprotkb:DCP2(gene name)|psi-mi:DCP2(display_short)|uniprotkb:NUDT20(gene name synonym)|uniprotkb:mRNA-decapping enzyme 2(gene name synonym) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16018799|imex:IM-20600-4|dip:DIP-60791E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001229306.1|refseq:NP_689837.2|dip:DIP-31126N|ensembl:ENSG00000172795(gene)|ensembl:ENST00000389063(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0016896"(exoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030054"(cell junction)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR007722(Dcp2, box A)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR036189|interpro:IPR044099|rcsb pdb:5MP0|rcsb pdb:5QOH|rcsb pdb:5QOI|rcsb pdb:5QOJ|rcsb pdb:5QOK|rcsb pdb:5QOL|rcsb pdb:5QOM|rcsb pdb:5QON|rcsb pdb:5QOO|rcsb pdb:5QOP|rcsb pdb:5QOQ|rcsb pdb:5QOR|rcsb pdb:5QOS|rcsb pdb:5QOT|rcsb pdb:5QOU|rcsb pdb:5QOV|rcsb pdb:5QOW|rcsb pdb:5QOX|rcsb pdb:5QOY|rcsb pdb:5QOZ|rcsb pdb:5QP0|rcsb pdb:5QP1|rcsb pdb:5QP2|rcsb pdb:5QP3|rcsb pdb:5QP4|rcsb pdb:5QP5|rcsb pdb:5QP6|rcsb pdb:5QP7|rcsb pdb:5QP8|rcsb pdb:5QP9|rcsb pdb:5QPA|rcsb pdb:5QPB|rcsb pdb:5QPC|reactome:R-HSA-380994|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604 ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2018/09/18 rogid:3Bo/mLVHBcFZ4VmRqgvE2PWTw+Y9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rigid:dUJ0gbvJGV8vt4mUy3AtEcjp0UM false flag tag:n-n - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q8IU60 uniprotkb:Q9NPJ4-1 intact:EBI-521577|uniprotkb:Q6P2D4|uniprotkb:Q7Z5W5|uniprotkb:Q8NBG5|uniprotkb:C9J778|ensembl:ENSP00000373715 intact:EBI-16018718|ensembl:ENSP00000334840|ensembl:ENSP00000363592|ensembl:ENSP00000497590 psi-mi:dcp2_human(display_long)|uniprotkb:Nucleoside diphosphate-linked moiety X motif 20(gene name synonym)|uniprotkb:DCP2(gene name)|psi-mi:DCP2(display_short)|uniprotkb:NUDT20(gene name synonym)|uniprotkb:mRNA-decapping enzyme 2(gene name synonym) psi-mi:q9npj4-1(display_long)|uniprotkb:PNRC2(gene name)|psi-mi:PNRC2(display_short)|uniprotkb:HSPC208(orf name) psi-mi:"MI:0096"(pull down) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16018818|imex:IM-20600-5|dip:DIP-190153E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001229306.1|refseq:NP_689837.2|dip:DIP-31126N|ensembl:ENSG00000172795(gene)|ensembl:ENST00000389063(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0004534"(5'-3' exoribonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0016896"(exoribonuclease activity, producing 5'-phosphomonoesters)|go:"GO:0030054"(cell junction)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0050072"("m7G(5')pppN diphosphatase activity")|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0071044"(histone mRNA catabolic process)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR007722(Dcp2, box A)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR036189|interpro:IPR044099|rcsb pdb:5MP0|rcsb pdb:5QOH|rcsb pdb:5QOI|rcsb pdb:5QOJ|rcsb pdb:5QOK|rcsb pdb:5QOL|rcsb pdb:5QOM|rcsb pdb:5QON|rcsb pdb:5QOO|rcsb pdb:5QOP|rcsb pdb:5QOQ|rcsb pdb:5QOR|rcsb pdb:5QOS|rcsb pdb:5QOT|rcsb pdb:5QOU|rcsb pdb:5QOV|rcsb pdb:5QOW|rcsb pdb:5QOX|rcsb pdb:5QOY|rcsb pdb:5QOZ|rcsb pdb:5QP0|rcsb pdb:5QP1|rcsb pdb:5QP2|rcsb pdb:5QP3|rcsb pdb:5QP4|rcsb pdb:5QP5|rcsb pdb:5QP6|rcsb pdb:5QP7|rcsb pdb:5QP8|rcsb pdb:5QP9|rcsb pdb:5QPA|rcsb pdb:5QPB|rcsb pdb:5QPC|reactome:R-HSA-380994|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604 ensembl:ENSG00000189266(gene)|ensembl:ENST00000334351(transcript)|ensembl:ENST00000374468(transcript)|ensembl:ENST00000647887(transcript)|intact:EBI-726549(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2018/09/18 rogid:3Bo/mLVHBcFZ4VmRqgvE2PWTw+Y9606 rogid:95yy4wkOEjSuRUGby7OanMTNtCk9606 rigid:gZ6X0bThRSfnyZ5KCfZ37uYCr2M false glutathione s tranferase tag:n-n|sufficient binding region:1-245 sufficient binding region:1-121|his tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9NPI6 uniprotkb:Q9NPJ4-1 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-16018718|ensembl:ENSP00000334840|ensembl:ENSP00000363592|ensembl:ENSP00000497590 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:q9npj4-1(display_long)|uniprotkb:PNRC2(gene name)|psi-mi:PNRC2(display_short)|uniprotkb:HSPC208(orf name) psi-mi:"MI:0018"(two hybrid) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16018845|imex:IM-20600-6|dip:DIP-190152E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N ensembl:ENSG00000189266(gene)|ensembl:ENST00000334351(transcript)|ensembl:ENST00000374468(transcript)|ensembl:ENST00000647887(transcript)|intact:EBI-726549(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/07 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:95yy4wkOEjSuRUGby7OanMTNtCk9606 rigid:9VS3Uw25VhecwLwPB0JND+kdBec false - mutation disrupting interaction strength:114-114|mutation disrupting interaction strength:109-109|mutation decreasing interaction strength:108-108 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NPI6 uniprotkb:Q9NPJ4-1 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-16018718|ensembl:ENSP00000334840|ensembl:ENSP00000363592|ensembl:ENSP00000497590 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:q9npj4-1(display_long)|uniprotkb:PNRC2(gene name)|psi-mi:PNRC2(display_short)|uniprotkb:HSPC208(orf name) psi-mi:"MI:0226"(ion exchange chromatography) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16018871|imex:IM-20600-7|dip:DIP-190152E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N ensembl:ENSG00000189266(gene)|ensembl:ENST00000334351(transcript)|ensembl:ENST00000374468(transcript)|ensembl:ENST00000647887(transcript)|intact:EBI-726549(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:95yy4wkOEjSuRUGby7OanMTNtCk9606 rigid:9VS3Uw25VhecwLwPB0JND+kdBec false sufficient binding region:1-130 sufficient binding region:1-121 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NPI6 uniprotkb:Q9NPJ4-1 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 intact:EBI-16018718|ensembl:ENSP00000334840|ensembl:ENSP00000363592|ensembl:ENSP00000497590 psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:q9npj4-1(display_long)|uniprotkb:PNRC2(gene name)|psi-mi:PNRC2(display_short)|uniprotkb:HSPC208(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lai et al. (2012) pubmed:23085078|doi:10.1016/j.str.2012.09.009|imex:IM-20600 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16018892|imex:IM-20600-8|dip:DIP-190152E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N ensembl:ENSG00000189266(gene)|ensembl:ENST00000334351(transcript)|ensembl:ENST00000374468(transcript)|ensembl:ENST00000647887(transcript)|intact:EBI-726549(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2018/09/18 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 rogid:95yy4wkOEjSuRUGby7OanMTNtCk9606 rigid:9VS3Uw25VhecwLwPB0JND+kdBec false - mutation disrupting interaction strength:114-114|mutation decreasing interaction strength:108-108|myc tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)