#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O35235-1	uniprotkb:O35235-1	intact:EBI-15890886|ensembl:ENSMUSP00000022592	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015832|imex:IM-18599-1|dip:DIP-190054E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/07	2017/08/10	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:y54Z1CRtb9SG28Xu24RfA7gRCM8	false	sufficient binding region:162-316	sufficient binding region:162-316	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35305	uniprotkb:O35235-1	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015850|imex:IM-18599-2|dip:DIP-188121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:i4ywqFZctL9NJvryst9My52nv4810090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:gysElnU5AHMMqiW+O+Ju4WqfNVs	false	sufficient binding region:1-198	sufficient binding region:162-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08712	uniprotkb:O35235-1	intact:EBI-16015871|ensembl:ENSMUSP00000078705|uniprotkb:O70202	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tr11b_mouse(display_long)|uniprotkb:Tnfrsf11b(gene name)|psi-mi:Tnfrsf11b(display_short)|uniprotkb:Ocif(gene name synonym)|uniprotkb:Opg(gene name synonym)|uniprotkb:Osteoclastogenesis inhibitory factor(gene name synonym)|uniprotkb:Osteoprotegerin(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015912|imex:IM-18599-3|dip:DIP-190055E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000063727(gene)|ensembl:ENSMUST00000079772(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042489"(negative regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0043627"(response to estrogen)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046685"(response to arsenic-containing substance)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022323|rcsb pdb:4E4D|reactome:R-MMU-5669034|interpro:IPR017371(Tumour necrosis factor receptor superfamily member 11B)|refseq:NP_032790.3|dip:DIP-59980N	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4rKi+Rkv6jQ5314IN+vo389+94g10090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:BunWUA//c5zbAsw+QzPx1iqOplM	false	sufficient binding region:22-197	sufficient binding region:162-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35305	uniprotkb:O35235-1	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015934|imex:IM-18599-4|dip:DIP-188121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:i4ywqFZctL9NJvryst9My52nv4810090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:gysElnU5AHMMqiW+O+Ju4WqfNVs	false	sufficient binding region:1-198	sufficient binding region:162-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08712	uniprotkb:O35235-1	intact:EBI-16015871|ensembl:ENSMUSP00000078705|uniprotkb:O70202	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tr11b_mouse(display_long)|uniprotkb:Tnfrsf11b(gene name)|psi-mi:Tnfrsf11b(display_short)|uniprotkb:Ocif(gene name synonym)|uniprotkb:Opg(gene name synonym)|uniprotkb:Osteoclastogenesis inhibitory factor(gene name synonym)|uniprotkb:Osteoprotegerin(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015955|imex:IM-18599-5|dip:DIP-190055E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000063727(gene)|ensembl:ENSMUST00000079772(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042489"(negative regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0043627"(response to estrogen)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046685"(response to arsenic-containing substance)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022323|rcsb pdb:4E4D|reactome:R-MMU-5669034|interpro:IPR017371(Tumour necrosis factor receptor superfamily member 11B)|refseq:NP_032790.3|dip:DIP-59980N	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4rKi+Rkv6jQ5314IN+vo389+94g10090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:BunWUA//c5zbAsw+QzPx1iqOplM	false	sufficient binding region:22-191|mutation increasing interaction strength:117-117	sufficient binding region:162-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O35305	uniprotkb:O35235-1	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0969"(bio-layer interferometry)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015979|imex:IM-18599-6|dip:DIP-188121E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:i4ywqFZctL9NJvryst9My52nv4810090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:gysElnU5AHMMqiW+O+Ju4WqfNVs	false	sufficient binding region:1-198	sufficient binding region:162-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08712	uniprotkb:O35235-1	intact:EBI-16015871|ensembl:ENSMUSP00000078705|uniprotkb:O70202	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tr11b_mouse(display_long)|uniprotkb:Tnfrsf11b(gene name)|psi-mi:Tnfrsf11b(display_short)|uniprotkb:Ocif(gene name synonym)|uniprotkb:Opg(gene name synonym)|uniprotkb:Osteoclastogenesis inhibitory factor(gene name synonym)|uniprotkb:Osteoprotegerin(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16016001|imex:IM-18599-7|dip:DIP-190055E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000063727(gene)|ensembl:ENSMUST00000079772(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042489"(negative regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0043627"(response to estrogen)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046685"(response to arsenic-containing substance)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022323|rcsb pdb:4E4D|reactome:R-MMU-5669034|interpro:IPR017371(Tumour necrosis factor receptor superfamily member 11B)|refseq:NP_032790.3|dip:DIP-59980N	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4rKi+Rkv6jQ5314IN+vo389+94g10090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:BunWUA//c5zbAsw+QzPx1iqOplM	false	sufficient binding region:22-197	sufficient binding region:162-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08712	uniprotkb:O35235-1	intact:EBI-16015871|ensembl:ENSMUSP00000078705|uniprotkb:O70202	intact:EBI-15890886|ensembl:ENSMUSP00000022592	psi-mi:tr11b_mouse(display_long)|uniprotkb:Tnfrsf11b(gene name)|psi-mi:Tnfrsf11b(display_short)|uniprotkb:Ocif(gene name synonym)|uniprotkb:Opg(gene name synonym)|uniprotkb:Osteoclastogenesis inhibitory factor(gene name synonym)|uniprotkb:Osteoprotegerin(gene name synonym)	psi-mi:o35235-1(display_long)|uniprotkb:Tnfsf11(gene name)|psi-mi:Tnfsf11(display_short)|uniprotkb:Opgl(gene name synonym)|uniprotkb:Rankl(gene name synonym)|uniprotkb:Trance(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nelson et al. (2012)	pubmed:23039992|doi:10.1016/j.str.2012.08.030|imex:IM-18599	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16016022|imex:IM-18599-8|dip:DIP-190055E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000063727(gene)|ensembl:ENSMUST00000079772(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042489"(negative regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0043627"(response to estrogen)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046685"(response to arsenic-containing substance)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022323|rcsb pdb:4E4D|reactome:R-MMU-5669034|interpro:IPR017371(Tumour necrosis factor receptor superfamily member 11B)|refseq:NP_032790.3|dip:DIP-59980N	intact:EBI-6924911(isoform-parent)|ensembl:ENSMUSG00000022015(gene)|ensembl:ENSMUST00000022592(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4rKi+Rkv6jQ5314IN+vo389+94g10090	rogid:DyiTxQtT5e6m1nFIN7uABxC+XuA10090	rigid:BunWUA//c5zbAsw+QzPx1iqOplM	false	sufficient binding region:22-191|mutation increasing interaction strength:117-117|mutation increasing interaction strength:117-117	sufficient binding region:162-316	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)