#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06786	uniprotkb:P06786	intact:EBI-19352|uniprotkb:D6W191|ensemblfungi:YNL088W	intact:EBI-19352|uniprotkb:D6W191|ensemblfungi:YNL088W	psi-mi:top2_yeast(display_long)|uniprotkb:TOP2(gene name)|psi-mi:TOP2(display_short)|uniprotkb:TOR3(gene name synonym)|uniprotkb:YNL088W(locus name)|uniprotkb:N2244(orf name)|uniprotkb:DNA topoisomerase II(gene name synonym)	psi-mi:top2_yeast(display_long)|uniprotkb:TOP2(gene name)|psi-mi:TOP2(display_short)|uniprotkb:TOR3(gene name synonym)|uniprotkb:YNL088W(locus name)|uniprotkb:N2244(orf name)|uniprotkb:DNA topoisomerase II(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Schmidt et al. (2012)	pubmed:23022727|doi:10.1038/nsmb.2388|imex:IM-18611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015363|imex:IM-18611-1|dip:DIP-2616E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005032|ensemblfungi:YNL088W(gene)|ensemblfungi:YNL088W_mRNA(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031055"(chromatin remodeling at centromere)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097046"(replication fork progression beyond termination site)|go:"GO:0097047"(DNA replication termination region)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|rcsb pdb:1BGW|rcsb pdb:1BJT|rcsb pdb:1PVG|rcsb pdb:1QZR|rcsb pdb:2RGR|rcsb pdb:3L4J|rcsb pdb:3L4K|rcsb pdb:4GFH|reactome:R-SCE-4615885|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|refseq:NP_014311.3|dip:DIP-2300N|mint:P06786	sgd:S000005032|ensemblfungi:YNL088W(gene)|ensemblfungi:YNL088W_mRNA(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031055"(chromatin remodeling at centromere)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097046"(replication fork progression beyond termination site)|go:"GO:0097047"(DNA replication termination region)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|rcsb pdb:1BGW|rcsb pdb:1BJT|rcsb pdb:1PVG|rcsb pdb:1QZR|rcsb pdb:2RGR|rcsb pdb:3L4J|rcsb pdb:3L4K|rcsb pdb:4GFH|reactome:R-SCE-4615885|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|refseq:NP_014311.3|dip:DIP-2300N|mint:P06786	psi-mi:"MI:0465"(dip)	crc64:0E29EB8B89AA1387	crc64:0E29EB8B89AA1387	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/07	2017/08/10	rogid:XKHvaF2HxChXbspQofpg5T6iZ+g559292	rogid:XKHvaF2HxChXbspQofpg5T6iZ+g559292	rigid:5ukv/CUy1VJnGcndIPO7mvRN6AY	false	sufficient binding region:1-1177	sufficient binding region:1-1177	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06786	uniprotkb:P06786	intact:EBI-19352|uniprotkb:D6W191|ensemblfungi:YNL088W	intact:EBI-19352|uniprotkb:D6W191|ensemblfungi:YNL088W	psi-mi:top2_yeast(display_long)|uniprotkb:TOP2(gene name)|psi-mi:TOP2(display_short)|uniprotkb:TOR3(gene name synonym)|uniprotkb:YNL088W(locus name)|uniprotkb:N2244(orf name)|uniprotkb:DNA topoisomerase II(gene name synonym)	psi-mi:top2_yeast(display_long)|uniprotkb:TOP2(gene name)|psi-mi:TOP2(display_short)|uniprotkb:TOR3(gene name synonym)|uniprotkb:YNL088W(locus name)|uniprotkb:N2244(orf name)|uniprotkb:DNA topoisomerase II(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schmidt et al. (2012)	pubmed:23022727|doi:10.1038/nsmb.2388|imex:IM-18611	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16015382|imex:IM-18611-2|dip:DIP-2616E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	sgd:S000005032|ensemblfungi:YNL088W(gene)|ensemblfungi:YNL088W_mRNA(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031055"(chromatin remodeling at centromere)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097046"(replication fork progression beyond termination site)|go:"GO:0097047"(DNA replication termination region)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|rcsb pdb:1BGW|rcsb pdb:1BJT|rcsb pdb:1PVG|rcsb pdb:1QZR|rcsb pdb:2RGR|rcsb pdb:3L4J|rcsb pdb:3L4K|rcsb pdb:4GFH|reactome:R-SCE-4615885|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|refseq:NP_014311.3|dip:DIP-2300N|mint:P06786	sgd:S000005032|ensemblfungi:YNL088W(gene)|ensemblfungi:YNL088W_mRNA(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0003677"(DNA binding)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006265"(DNA topological change)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0009303"(rRNA transcription)|go:"GO:0031055"(chromatin remodeling at centromere)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0097046"(replication fork progression beyond termination site)|go:"GO:0097047"(DNA replication termination region)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|interpro:IPR020568|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|rcsb pdb:1BGW|rcsb pdb:1BJT|rcsb pdb:1PVG|rcsb pdb:1QZR|rcsb pdb:2RGR|rcsb pdb:3L4J|rcsb pdb:3L4K|rcsb pdb:4GFH|reactome:R-SCE-4615885|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|refseq:NP_014311.3|dip:DIP-2300N|mint:P06786	psi-mi:"MI:0465"(dip)	crc64:0E29EB8B89AA1387	crc64:0E29EB8B89AA1387	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/07	2017/08/10	rogid:XKHvaF2HxChXbspQofpg5T6iZ+g559292	rogid:XKHvaF2HxChXbspQofpg5T6iZ+g559292	rigid:5ukv/CUy1VJnGcndIPO7mvRN6AY	false	sufficient binding region:1-1177	sufficient binding region:1-1177	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)