#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q77YG0 uniprotkb:Q9NRW3 intact:EBI-15731903|uniprotkb:A0A076PX61 intact:EBI-1044593|uniprotkb:Q5JZ92|uniprotkb:Q7Z2N7|uniprotkb:Q96F12|uniprotkb:B2R884|ensembl:ENSP00000355340 psi-mi:q77yg0_9hiv1(display_long)|uniprotkb:vif(gene name)|psi-mi:vif(display_short)|uniprotkb:SOR protein(gene name synonym) psi-mi:abc3c_human(display_long)|uniprotkb:APOBEC1-like(gene name synonym)|uniprotkb:Phorbolin I(gene name synonym)|uniprotkb:APOBEC3C(gene name)|psi-mi:APOBEC3C(display_short)|uniprotkb:APOBEC1L(gene name synonym)|uniprotkb:PBI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kitamura et al. (2012) pubmed:23001005|doi:10.1038/nsmb.2378|imex:IM-18566 taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16014151|imex:IM-18566-1|dip:DIP-190008E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|refseq:NP_057851.1|dip:DIP-46350N refseq:NP_055323.2|ensembl:ENSG00000244509(gene)|ensembl:ENST00000361441(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004126"(cytidine deaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009972"(cytidine deamination)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016554"(cytidine to uridine editing)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0047844"(deoxycytidine deaminase activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0070383"(DNA cytosine deamination)|go:"GO:0080111"(DNA demethylation)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|rcsb pdb:3VM8|rcsb pdb:3VOW|reactome:R-HSA-72200|reactome:R-HSA-75094|dip:DIP-48919N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:zZCNRTNfMY5QKW+P8XLzdnYg3EA11676 rogid:ux+DxCCQm60aF6LNr1Q4atd5ZFU9606 rigid:W7y8Hb29ugF+IisHGrq3Cm0HYEc false mutation:146-146,145-145,144-144 his tag:c-c|mutation decreasing interaction strength:75-75|mutation decreasing interaction strength:76-76|mutation decreasing interaction strength:79-79|mutation decreasing interaction strength:80-80|mutation decreasing interaction strength:80-80,79-79|mutation decreasing interaction strength:81-81|mutation disrupting interaction strength:86-86|mutation decreasing interaction strength:106-106|mutation disrupting interaction strength:111-111|mutation decreasing interaction strength:141-141|mutation decreasing interaction strength:141-141 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8IUX4 uniprotkb:Q77YG0 intact:EBI-11306991|uniprotkb:Q7Z2N2|uniprotkb:B0QYD4|uniprotkb:Q45F03|uniprotkb:Q6ICH3|uniprotkb:Q7Z2N5|ensembl:ENSP00000309749 intact:EBI-15731903|uniprotkb:A0A076PX61 psi-mi:abc3f_human(display_long)|uniprotkb:APOBEC3F(gene name)|psi-mi:APOBEC3F(display_short)|uniprotkb:Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F(gene name synonym) psi-mi:q77yg0_9hiv1(display_long)|uniprotkb:vif(gene name)|psi-mi:vif(display_short)|uniprotkb:SOR protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kitamura et al. (2012) pubmed:23001005|doi:10.1038/nsmb.2378|imex:IM-18566 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16014209|imex:IM-18566-2|dip:DIP-190009E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001006667.1|refseq:NP_660341.2|ensembl:ENSG00000128394(gene)|ensembl:ENST00000308521(transcript)|go:"GO:0000932"(P-body)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003723"(RNA binding)|go:"GO:0004126"(cytidine deaminase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016553"(base conversion or substitution editing)|go:"GO:0016554"(cytidine to uridine editing)|go:"GO:0030895"(apolipoprotein B mRNA editing enzyme complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0047844"(deoxycytidine deaminase activity)|go:"GO:0048525"(negative regulation of viral process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070383"(DNA cytosine deamination)|go:"GO:0080111"(DNA demethylation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|rcsb pdb:3WUS|rcsb pdb:4IOU|rcsb pdb:4J4J|rcsb pdb:5HX4|rcsb pdb:5HX5|rcsb pdb:5W2M|rcsb pdb:6NIL|refseq:XP_016884132.1|dip:DIP-59966N go:"GO:0003723"(RNA binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|refseq:NP_057851.1|dip:DIP-46350N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:UQApMs/hHRGAKejbOlOwc2tVp+Q9606 rogid:zZCNRTNfMY5QKW+P8XLzdnYg3EA11676 rigid:lKivyO3FAzeNOV10p6PmSoJbdfo false his tag:c-c|mutation disrupting interaction strength:263-263,262-262|mutation decreasing interaction strength:255-255|mutation decreasing interaction strength:258-258|mutation decreasing interaction strength:259-259|mutation decreasing interaction strength:264-264|mutation decreasing interaction strength:269-269|mutation decreasing interaction strength:289-289|mutation decreasing interaction strength:290-290|mutation decreasing interaction strength:294-294|mutation decreasing interaction strength:324-324|mutation decreasing interaction strength:324-324 mutation:146-146,145-145,144-144 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B2CML4 uniprotkb:Q77YG0 intact:EBI-16014266 intact:EBI-15731903|uniprotkb:A0A076PX61 psi-mi:b2cml4_human(display_long)|uniprotkb:APOBEC3DE(gene name)|psi-mi:APOBEC3DE(display_short)|uniprotkb:hCG_41704(orf name) psi-mi:q77yg0_9hiv1(display_long)|uniprotkb:vif(gene name)|psi-mi:vif(display_short)|uniprotkb:SOR protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kitamura et al. (2012) pubmed:23001005|doi:10.1038/nsmb.2378|imex:IM-18566 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11676(9hiv1)|taxid:11676(Human immunodeficiency virus 1) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16014280|imex:IM-18566-3|dip:DIP-190010E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0008270"(zinc ion binding)|go:"GO:0016787"(hydrolase activity)|interpro:IPR002125(CMP/dCMP deaminase, zinc-binding)|interpro:IPR016192(APOBEC/CMP deaminase, zinc-binding)|interpro:IPR016193(Cytidine deaminase-like)|refseq:NP_689639.2|dip:DIP-59967N go:"GO:0003723"(RNA binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|refseq:NP_057851.1|dip:DIP-46350N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:ElSbe2neB7aZmOn9dP1GBpeK/dc9606 rogid:zZCNRTNfMY5QKW+P8XLzdnYg3EA11676 rigid:zk2whWTLO3Vuh1vtoGacxzUhuCw false his tag:c-c|mutation disrupting interaction strength:268-268|mutation disrupting interaction strength:271-271|mutation decreasing interaction strength:272-272|mutation disrupting interaction strength:276-276,275-275|mutation decreasing interaction strength:277-277|mutation disrupting interaction strength:282-282|mutation decreasing interaction strength:302-302|mutation disrupting interaction strength:303-303|mutation disrupting interaction strength:307-307|mutation disrupting interaction strength:337-337|mutation decreasing interaction strength:337-337 mutation:146-146,145-145,144-144 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)