#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0DJ88	uniprotkb:Q9UHR4	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	psi-mi:esfu2_eco57(display_long)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010619|imex:IM-18539-2|dip:DIP-189954E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006891(EspF protein)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0009405"(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|go:"GO:0005576"(extracellular region)|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:WARX33S3/G5CXG922GIjofxveNc83334	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rigid:mtJleX3K0ofqu5BzImyQsN15Y2U	false	mutation decreasing interaction strength:300-300|sufficient binding region:292-311	sufficient binding region:339-402	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:Q9UHR4	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:"MI:0096"(pull down)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010595|imex:IM-18539-1|dip:DIP-188133E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rigid:rcWbX7hL7jqluFb3hy624s8rC6k	false	mutation increasing interaction strength:215-215|myc tag:?-?	biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P0DJ88	uniprotkb:Q9UHR4	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	psi-mi:esfu2_eco57(display_long)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010684|imex:IM-18539-5|dip:DIP-189954E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006891(EspF protein)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0009405"(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|go:"GO:0005576"(extracellular region)|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/08/07	2017/08/10	rogid:WARX33S3/G5CXG922GIjofxveNc83334	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rigid:mtJleX3K0ofqu5BzImyQsN15Y2U	false	sufficient binding region:292-314|mutation disrupting interaction strength:300-300	sufficient binding region:339-402	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHR4	uniprotkb:P0DJ88	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:esfu2_eco57(display_long)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010707|imex:IM-18539-6|dip:DIP-189954E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	interpro:IPR006891(EspF protein)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0009405"(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|go:"GO:0005576"(extracellular region)|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:WARX33S3/G5CXG922GIjofxveNc83334	rigid:mtJleX3K0ofqu5BzImyQsN15Y2U	false	sufficient binding region:339-402	sufficient binding region:268-314	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0DJ88	uniprotkb:Q9UHR4	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	psi-mi:esfu2_eco57(display_long)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010728|imex:IM-18539-7|dip:DIP-189954E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR006891(EspF protein)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0009405"(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|go:"GO:0005576"(extracellular region)|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	psi-mi:"MI:0465"(dip)	caution:This sequence has been withdrawn from Uniprot.	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:WARX33S3/G5CXG922GIjofxveNc83334	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rigid:mtJleX3K0ofqu5BzImyQsN15Y2U	false	sufficient binding region:292-311	sufficient binding region:339-402	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:Q9UHR4	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010749|imex:IM-18539-8|dip:DIP-188133E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rigid:rcWbX7hL7jqluFb3hy624s8rC6k	false	mutation increasing interaction strength:215-215|sufficient binding region:207-226	sufficient binding region:339-402	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00401	uniprotkb:P0DJ88	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:esfu2_eco57(display_long)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010663|imex:IM-18539-4|dip:DIP-189955E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	interpro:IPR006891(EspF protein)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0009405"(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|go:"GO:0005576"(extracellular region)|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	rogid:WARX33S3/G5CXG922GIjofxveNc83334	rigid:K7O+53K+01aZdpgvY+bLxj4GtBg	false	sufficient binding region:207-270	sufficient binding region:268-314	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12929	uniprotkb:Q9UHR4	intact:EBI-375576|uniprotkb:A6NMC3|ensembl:ENSP00000281172|ensembl:ENSP00000441867|ensembl:ENSP00000442388|ensembl:ENSP00000494689|ensembl:ENSP00000494842|ensembl:ENSP00000495722|ensembl:ENSP00000495824|ensembl:ENSP00000495956|ensembl:ENSP00000496406|ensembl:ENSP00000496516|uniprotkb:Q8N6J0|uniprotkb:B4DX66|uniprotkb:A8K6W2|uniprotkb:A8KA66	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	psi-mi:eps8_human(display_long)|uniprotkb:EPS8(gene name)|psi-mi:EPS8(display_short)	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010642|imex:IM-18539-3|dip:DIP-188133E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000645775(transcript)|ensembl:ENST00000646828(transcript)|ensembl:ENSG00000151491(gene)|ensembl:ENST00000646918(transcript)|ensembl:ENST00000647087(transcript)|ensembl:ENST00000647224(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010458"(exit from mitosis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0030426"(growth cone)|go:"GO:0030832"(regulation of actin filament length)|go:"GO:0031267"(small GTPase binding)|ensembl:ENST00000281172(transcript)|ensembl:ENST00000543523(transcript)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032420"(stereocilium)|go:"GO:0032426"(stereocilium tip)|ensembl:ENST00000543612(transcript)|ensembl:ENST00000642278(transcript)|ensembl:ENST00000644374(transcript)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR030222|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q12929|rcsb pdb:2E8M|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_004438.3|dip:DIP-32859N	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ulBgb+4uZ7XrN4bLogRtd9I5AbY9606	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rigid:rcWbX7hL7jqluFb3hy624s8rC6k	false	sufficient binding region:207-226	sufficient binding region:339-402	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHR4	uniprotkb:P0DJ88	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-10039462|uniprotkb:Q8X2D5|uniprotkb:P0DJ89	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:esfu2_eco57(display_long)|uniprotkb:"espF(U)"(gene name)|psi-mi:"espF(U)"(display_short)|uniprotkb:tccP(gene name synonym)|uniprotkb:EspF-like protein encoded on prophage U(gene name synonym)|uniprotkb:Tir-cytoskeleton coupling protein TccP(gene name synonym)|uniprotkb:ECs2715(locus name)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010774|imex:IM-18539-9|dip:DIP-189956E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	interpro:IPR006891(EspF protein)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0009405"(obsolete pathogenesis)|refseq:NP_310742.1|refseq:WP_010917831.1|go:"GO:0005576"(extracellular region)|rcsb pdb:2K42|rcsb pdb:2KXC|rcsb pdb:2LNH|dip:DIP-59949N	psi-mi:"MI:0465"(dip)	-	caution:This sequence has been withdrawn from Uniprot.	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:WARX33S3/G5CXG922GIjofxveNc83334	rigid:85QC/LEYyHENzA6bSubemaH9OnE	false	sufficient binding region:339-402	sufficient binding region:268-314	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UHR4	uniprotkb:O00401	intact:EBI-2483278|ensembl:ENSP00000005260|uniprotkb:A4D268|uniprotkb:Q75L21|uniprotkb:Q75L22|uniprotkb:Q96CV4|uniprotkb:Q9H5F5|uniprotkb:Q9Y2M8	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	psi-mi:bi2l1_human(display_long)|uniprotkb:BAIAP2L1(gene name)|psi-mi:BAIAP2L1(display_short)|uniprotkb:IRTKS(gene name synonym)|uniprotkb:Insulin receptor tyrosine kinase substrate(gene name synonym)	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Aitio et al. (2012)	pubmed:22921828|doi:10.1016/j.str.2012.07.015|imex:IM-18539	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16010774|imex:IM-18539-9|dip:DIP-189956E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000006453(gene)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000005260(transcript)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0009617"(response to bacterium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030060|interpro:IPR035592|interpro:IPR036028|rcsb pdb:2KXC|rcsb pdb:2LNH|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9035034|refseq:NP_061330.2|ensembl:ENSP00000005260|dip:DIP-53820N	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ig7xSOv8h6Y4vYE0/n228+ZLWaM9606	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	rigid:85QC/LEYyHENzA6bSubemaH9OnE	false	sufficient binding region:339-402	sufficient binding region:207-270	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)