#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43318	uniprotkb:Q9UKE5	intact:EBI-358684|uniprotkb:O43317|uniprotkb:O43319|uniprotkb:Q9NZ70|uniprotkb:Q9NTR3|uniprotkb:E1P523|uniprotkb:Q5TDN2|uniprotkb:Q5TDN3|uniprotkb:B2RE27|uniprotkb:Q5TDT7|ensembl:ENSP00000358335	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:m3k7_human(display_long)|uniprotkb:MAP3K7(gene name)|psi-mi:MAP3K7(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009006|imex:IM-21062-3|dip:DIP-190691E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003179.1|refseq:NP_663304.1|refseq:NP_663305.1|refseq:NP_663306.1|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSG00000135341(gene)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|ensembl:ENST00000369329(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43318|rcsb pdb:2EVA|rcsb pdb:2YIY|rcsb pdb:4GS6|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5V5N|rcsb pdb:7NTH|rcsb pdb:7NTI|reactome:R-HSA-1169091|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-4086398|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27523N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:U/W3xH9XPl6BIdCcfrw1gG/+n7Y9606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:tWiMVReobpasqsrXRlas9oub8G0	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03230	uniprotkb:Q9UKE5	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16008968|imex:IM-21062-1|dip:DIP-190688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:MQ9SZZBSD0W2KsHpwgl94mpQWMU	false	ha tag:n-n|sufficient binding region:187-386	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P03230	uniprotkb:Q9UKE5	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16008989|imex:IM-21062-2|dip:DIP-190688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:MQ9SZZBSD0W2KsHpwgl94mpQWMU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03230	uniprotkb:Q9NYJ8	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-358708|uniprotkb:O94838|uniprotkb:Q6I9W8|uniprotkb:Q76N06|uniprotkb:Q9UFP7|uniprotkb:E1P5A0|uniprotkb:B2RCC4|ensembl:ENSP00000356426|ensembl:ENSP00000445752|ensembl:ENSP00000490618	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:tab2_human(display_long)|uniprotkb:TAB2(gene name)|psi-mi:TAB2(display_short)|uniprotkb:KIAA0733(gene name synonym)|uniprotkb:MAP3K7IP2(gene name synonym)|uniprotkb:TAK1-binding protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009027|imex:IM-21062-4|dip:DIP-190695E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	refseq:NP_055908.1|refseq:NP_001278963.1|refseq:NP_001278964.1|refseq:XP_011533935.1|ensembl:ENST00000637181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000538427(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR036443|interpro:IPR041911|mint:Q9NYJ8|rcsb pdb:2DAE|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1|reactome:R-HSA-1251985|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|ensembl:ENST00000367456(transcript)|ensembl:ENSG00000055208(gene)|refseq:XP_016866080.1|refseq:XP_016866081.1|dip:DIP-27525N	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:hMWL5GobXJSsm8ToWVBF/ZwPX3M9606	rigid:hNBOQq8qYAt1USRggCQ4EKEtocs	false	-	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKE5	uniprotkb:P03230	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009088|imex:IM-21062-7|dip:DIP-190692E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	psi-mi:"MI:0465"(dip)	-	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rigid:fP0JW+vmfxn0HFurcKFVuNlxVpc	false	flag tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKE5	uniprotkb:Q9NYJ8	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	intact:EBI-358708|uniprotkb:O94838|uniprotkb:Q6I9W8|uniprotkb:Q76N06|uniprotkb:Q9UFP7|uniprotkb:E1P5A0|uniprotkb:B2RCC4|ensembl:ENSP00000356426|ensembl:ENSP00000445752|ensembl:ENSP00000490618	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:tab2_human(display_long)|uniprotkb:TAB2(gene name)|psi-mi:TAB2(display_short)|uniprotkb:KIAA0733(gene name synonym)|uniprotkb:MAP3K7IP2(gene name synonym)|uniprotkb:TAK1-binding protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009088|imex:IM-21062-7|dip:DIP-190692E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	refseq:NP_055908.1|refseq:NP_001278963.1|refseq:NP_001278964.1|refseq:XP_011533935.1|ensembl:ENST00000637181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000538427(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR036443|interpro:IPR041911|mint:Q9NYJ8|rcsb pdb:2DAE|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1|reactome:R-HSA-1251985|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|ensembl:ENST00000367456(transcript)|ensembl:ENSG00000055208(gene)|refseq:XP_016866080.1|refseq:XP_016866081.1|dip:DIP-27525N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rogid:hMWL5GobXJSsm8ToWVBF/ZwPX3M9606	rigid:fP0JW+vmfxn0HFurcKFVuNlxVpc	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03230	uniprotkb:Q9UKE5	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009071|imex:IM-21062-6|dip:DIP-190688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:MQ9SZZBSD0W2KsHpwgl94mpQWMU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y4K3	uniprotkb:Q9UKE5	intact:EBI-359276|uniprotkb:Q8NEH5|uniprotkb:A6NKI7|uniprotkb:A8KAB3|ensembl:ENSP00000337853|ensembl:ENSP00000433623|uniprotkb:D3DR16	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:traf6_human(display_long)|uniprotkb:TRAF6(gene name)|psi-mi:TRAF6(display_short)|uniprotkb:RNF85(gene name synonym)|uniprotkb:Interleukin-1 signal transducer(gene name synonym)|uniprotkb:RING finger protein 85(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009046|imex:IM-21062-5|dip:DIP-190689E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004611.1|refseq:NP_665802.1|ensembl:ENSG00000175104(gene)|ensembl:ENST00000348124(transcript)|ensembl:ENST00000526995(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:Q9Y4K3|rcsb pdb:1LB4|rcsb pdb:1LB5|go:"GO:0070534"(protein K63-linked ubiquitination)|rcsb pdb:1LB6|rcsb pdb:2ECI|rcsb pdb:2JMD|rcsb pdb:3HCS|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:4Z8M|rcsb pdb:5ZUJ|rcsb pdb:6A33|go:"GO:0070555"(response to interleukin-1)|rcsb pdb:7L3L|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-205043|go:"GO:0071222"(cellular response to lipopolysaccharide)|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-2871837|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975163|reactome:R-HSA-975871|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|dip:DIP-27515N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:m0TTXwlrtXnnjXWbg0MsEULlq0I9606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:7K+lCb5yf1YHdvepHPJxABB8Ve4	false	sufficient binding region:310-522|his tag:n-n	sufficient binding region:306-1017|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12933	uniprotkb:Q9UKE5	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009110|imex:IM-21062-8|dip:DIP-190690E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:KuMvO92CrOh/axX+YXbyFtw6D4A	false	sufficient binding region:311-501|his tag:n-n	sufficient binding region:306-1017|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14920	uniprotkb:Q9UKE5	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009157|imex:IM-21062-10|dip:DIP-190696E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:ZGDLgfykT8gPM5dBEPN3Qi0y5I0	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03230	uniprotkb:Q9UKE5	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009135|imex:IM-21062-9|dip:DIP-190688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:MQ9SZZBSD0W2KsHpwgl94mpQWMU	false	necessary binding region:371-386|mutation disrupting interaction strength:384-384	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4K3	uniprotkb:Q9UKE5	intact:EBI-359276|uniprotkb:Q8NEH5|uniprotkb:A6NKI7|uniprotkb:A8KAB3|ensembl:ENSP00000337853|ensembl:ENSP00000433623|uniprotkb:D3DR16	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:traf6_human(display_long)|uniprotkb:TRAF6(gene name)|psi-mi:TRAF6(display_short)|uniprotkb:RNF85(gene name synonym)|uniprotkb:Interleukin-1 signal transducer(gene name synonym)|uniprotkb:RING finger protein 85(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009178|imex:IM-21062-11|dip:DIP-190689E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004611.1|refseq:NP_665802.1|ensembl:ENSG00000175104(gene)|ensembl:ENST00000348124(transcript)|ensembl:ENST00000526995(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:Q9Y4K3|rcsb pdb:1LB4|rcsb pdb:1LB5|go:"GO:0070534"(protein K63-linked ubiquitination)|rcsb pdb:1LB6|rcsb pdb:2ECI|rcsb pdb:2JMD|rcsb pdb:3HCS|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:4Z8M|rcsb pdb:5ZUJ|rcsb pdb:6A33|go:"GO:0070555"(response to interleukin-1)|rcsb pdb:7L3L|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-205043|go:"GO:0071222"(cellular response to lipopolysaccharide)|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-2871837|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975163|reactome:R-HSA-975871|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|dip:DIP-27515N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:m0TTXwlrtXnnjXWbg0MsEULlq0I9606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:7K+lCb5yf1YHdvepHPJxABB8Ve4	false	flag tag:n-n	ha tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UKE5	uniprotkb:P03230	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009199|imex:IM-21062-12|dip:DIP-190697E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	psi-mi:"MI:0465"(dip)	-	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rigid:ZAgJaVJUna5N0MRgGVy9WJZ2Dfs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UKE5	uniprotkb:O14920	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	intact:EBI-81266|uniprotkb:O75327|uniprotkb:B4E0U4|uniprotkb:B4DZ30|ensembl:ENSP00000430684	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:ikkb_human(display_long)|uniprotkb:IKBKB(gene name)|psi-mi:IKBKB(display_short)|uniprotkb:IKKB(gene name synonym)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009199|imex:IM-21062-12|dip:DIP-190697E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	refseq:NP_001177649.1|refseq:NP_001547.1|interpro:IPR000626(Ubiquitin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR029071|interpro:IPR041185|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|mint:O14920|rcsb pdb:3BRT|rcsb pdb:3BRV|rcsb pdb:4E3C|rcsb pdb:4KIK|reactome:R-HSA-1169091|reactome:R-HSA-1236974|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-1810476|reactome:R-HSA-202424|reactome:R-HSA-209543|reactome:R-HSA-209560|ensembl:ENSG00000104365(gene)|ensembl:ENST00000520810(transcript)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002479"(antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009615"(response to virus)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|reactome:R-HSA-445989|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5602636|reactome:R-HSA-5603027|reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5684264|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-975144|reactome:R-HSA-2871837|go:"GO:0019901"(protein kinase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903140"(regulation of establishment of endothelial barrier)|refseq:NP_001229707.1|dip:DIP-27527N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rogid:Za/bWjmPFaKOGVvQ00rtBfikvhI9606	rigid:ZAgJaVJUna5N0MRgGVy9WJZ2Dfs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UKE5	uniprotkb:Q9NYJ8	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	intact:EBI-358708|uniprotkb:O94838|uniprotkb:Q6I9W8|uniprotkb:Q76N06|uniprotkb:Q9UFP7|uniprotkb:E1P5A0|uniprotkb:B2RCC4|ensembl:ENSP00000356426|ensembl:ENSP00000445752|ensembl:ENSP00000490618	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:tab2_human(display_long)|uniprotkb:TAB2(gene name)|psi-mi:TAB2(display_short)|uniprotkb:KIAA0733(gene name synonym)|uniprotkb:MAP3K7IP2(gene name synonym)|uniprotkb:TAK1-binding protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009199|imex:IM-21062-12|dip:DIP-190697E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	refseq:NP_055908.1|refseq:NP_001278963.1|refseq:NP_001278964.1|refseq:XP_011533935.1|ensembl:ENST00000637181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000538427(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR036443|interpro:IPR041911|mint:Q9NYJ8|rcsb pdb:2DAE|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1|reactome:R-HSA-1251985|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|ensembl:ENST00000367456(transcript)|ensembl:ENSG00000055208(gene)|refseq:XP_016866080.1|refseq:XP_016866081.1|dip:DIP-27525N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rogid:hMWL5GobXJSsm8ToWVBF/ZwPX3M9606	rigid:ZAgJaVJUna5N0MRgGVy9WJZ2Dfs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UKE5	uniprotkb:O43318	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	intact:EBI-358684|uniprotkb:O43317|uniprotkb:O43319|uniprotkb:Q9NZ70|uniprotkb:Q9NTR3|uniprotkb:E1P523|uniprotkb:Q5TDN2|uniprotkb:Q5TDN3|uniprotkb:B2RE27|uniprotkb:Q5TDT7|ensembl:ENSP00000358335	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:m3k7_human(display_long)|uniprotkb:MAP3K7(gene name)|psi-mi:MAP3K7(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009199|imex:IM-21062-12|dip:DIP-190697E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	refseq:NP_003179.1|refseq:NP_663304.1|refseq:NP_663305.1|refseq:NP_663306.1|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSG00000135341(gene)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|ensembl:ENST00000369329(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43318|rcsb pdb:2EVA|rcsb pdb:2YIY|rcsb pdb:4GS6|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5V5N|rcsb pdb:7NTH|rcsb pdb:7NTI|reactome:R-HSA-1169091|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-4086398|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27523N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rogid:U/W3xH9XPl6BIdCcfrw1gG/+n7Y9606	rigid:ZAgJaVJUna5N0MRgGVy9WJZ2Dfs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UKE5	uniprotkb:Q9Y4K3	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	intact:EBI-359276|uniprotkb:Q8NEH5|uniprotkb:A6NKI7|uniprotkb:A8KAB3|ensembl:ENSP00000337853|ensembl:ENSP00000433623|uniprotkb:D3DR16	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:traf6_human(display_long)|uniprotkb:TRAF6(gene name)|psi-mi:TRAF6(display_short)|uniprotkb:RNF85(gene name synonym)|uniprotkb:Interleukin-1 signal transducer(gene name synonym)|uniprotkb:RING finger protein 85(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009199|imex:IM-21062-12|dip:DIP-190697E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	refseq:NP_004611.1|refseq:NP_665802.1|ensembl:ENSG00000175104(gene)|ensembl:ENST00000348124(transcript)|ensembl:ENST00000526995(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:Q9Y4K3|rcsb pdb:1LB4|rcsb pdb:1LB5|go:"GO:0070534"(protein K63-linked ubiquitination)|rcsb pdb:1LB6|rcsb pdb:2ECI|rcsb pdb:2JMD|rcsb pdb:3HCS|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:4Z8M|rcsb pdb:5ZUJ|rcsb pdb:6A33|go:"GO:0070555"(response to interleukin-1)|rcsb pdb:7L3L|reactome:R-HSA-1257604|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-205043|go:"GO:0071222"(cellular response to lipopolysaccharide)|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-2871837|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975110|reactome:R-HSA-975138|reactome:R-HSA-975144|reactome:R-HSA-975155|reactome:R-HSA-975163|reactome:R-HSA-975871|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|dip:DIP-27515N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rogid:m0TTXwlrtXnnjXWbg0MsEULlq0I9606	rigid:ZAgJaVJUna5N0MRgGVy9WJZ2Dfs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03230	uniprotkb:Q13114	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-357631|uniprotkb:Q12990|uniprotkb:Q13076|uniprotkb:Q13947|uniprotkb:Q6AZX1|uniprotkb:Q9UNL1|ensembl:ENSP00000376500|ensembl:ENSP00000454207|uniprotkb:B7Z8C4	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:traf3_human(display_long)|uniprotkb:TRAF3(gene name)|psi-mi:TRAF3(display_short)|uniprotkb:CAP1(gene name synonym)|uniprotkb:CRAF1(gene name synonym)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:CD40-binding protein(gene name synonym)|uniprotkb:LMP1-associated protein 1(gene name synonym)|uniprotkb:CAP-1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009241|imex:IM-21062-14|dip:DIP-75911E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	ensembl:ENSG00000131323(gene)|ensembl:ENST00000392745(transcript)|ensembl:ENST00000560371(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|refseq:NP_001186356.1|refseq:NP_003291.2|refseq:NP_663777.1|refseq:NP_663778.1|go:"GO:0007165"(signal transduction)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q13114|go:"GO:0042981"(regulation of apoptotic process)|rcsb pdb:1FLK|rcsb pdb:1FLL|rcsb pdb:1L0A|rcsb pdb:1RF3|rcsb pdb:1ZMS|rcsb pdb:2ECY|rcsb pdb:2GKW|rcsb pdb:1KZZ|refseq:XP_011535420.1|reactome:R-HSA-5668541|reactome:R-HSA-5676594|reactome:R-HSA-5689896|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-5602571|refseq:XP_016877106.1|refseq:XP_016877107.1|dip:DIP-6222N	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:9Tjx/USypDBBrPVyFOsLzM/bwzA9606	rigid:IISSEwFJun6x6bF+19VpBacVY9E	false	ha tag:n-n|sufficient binding region:187-386	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NYJ8	uniprotkb:Q9UKE5	intact:EBI-358708|uniprotkb:O94838|uniprotkb:Q6I9W8|uniprotkb:Q76N06|uniprotkb:Q9UFP7|uniprotkb:E1P5A0|uniprotkb:B2RCC4|ensembl:ENSP00000356426|ensembl:ENSP00000445752|ensembl:ENSP00000490618	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:tab2_human(display_long)|uniprotkb:TAB2(gene name)|psi-mi:TAB2(display_short)|uniprotkb:KIAA0733(gene name synonym)|uniprotkb:MAP3K7IP2(gene name synonym)|uniprotkb:TAK1-binding protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 2(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009220|imex:IM-21062-13|dip:DIP-190693E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055908.1|refseq:NP_001278963.1|refseq:NP_001278964.1|refseq:XP_011533935.1|ensembl:ENST00000637181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000538427(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR036443|interpro:IPR041911|mint:Q9NYJ8|rcsb pdb:2DAE|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1|reactome:R-HSA-1251985|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|ensembl:ENST00000367456(transcript)|ensembl:ENSG00000055208(gene)|refseq:XP_016866080.1|refseq:XP_016866081.1|dip:DIP-27525N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:hMWL5GobXJSsm8ToWVBF/ZwPX3M9606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:0Ksw9kC6j1TvAVsvRu1N/bMsWVQ	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O43318	uniprotkb:Q9UKE5	intact:EBI-358684|uniprotkb:O43317|uniprotkb:O43319|uniprotkb:Q9NZ70|uniprotkb:Q9NTR3|uniprotkb:E1P523|uniprotkb:Q5TDN2|uniprotkb:Q5TDN3|uniprotkb:B2RE27|uniprotkb:Q5TDT7|ensembl:ENSP00000358335	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:m3k7_human(display_long)|uniprotkb:MAP3K7(gene name)|psi-mi:MAP3K7(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009262|imex:IM-21062-15|dip:DIP-190691E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003179.1|refseq:NP_663304.1|refseq:NP_663305.1|refseq:NP_663306.1|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSG00000135341(gene)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|ensembl:ENST00000369329(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43318|rcsb pdb:2EVA|rcsb pdb:2YIY|rcsb pdb:4GS6|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5V5N|rcsb pdb:7NTH|rcsb pdb:7NTI|reactome:R-HSA-1169091|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-4086398|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27523N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	comment:Deletion of region 1017-1360 decreased the interaction rate/strength.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:U/W3xH9XPl6BIdCcfrw1gG/+n7Y9606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:tWiMVReobpasqsrXRlas9oub8G0	false	flag tag:n-n	ha tag:n-n|sufficient binding region:1017-1360	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03230	uniprotkb:Q9UKE5	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009305|imex:IM-21062-17|dip:DIP-190688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:MQ9SZZBSD0W2KsHpwgl94mpQWMU	false	ha tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12933	uniprotkb:Q9UKE5	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-1051794|intact:EBI-1762540|uniprotkb:O60298|uniprotkb:Q8WUY7|uniprotkb:Q9UKD8|uniprotkb:Q9UKD9|uniprotkb:Q9UKE0|uniprotkb:Q9UKE1|uniprotkb:Q9UKE2|uniprotkb:Q9UKE3|uniprotkb:Q9UKE4|intact:EBI-1968916|uniprotkb:A8K4U1|uniprotkb:D3DNQ6|uniprotkb:A7E2A3|ensembl:ENSP00000399511	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:tnik_human(display_long)|uniprotkb:TNIK(gene name)|psi-mi:TNIK(display_short)|uniprotkb:KIAA0551(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009286|imex:IM-21062-16|dip:DIP-190690E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	refseq:NP_001155032.1|refseq:NP_001155033.1|refseq:NP_001155034.1|refseq:NP_001155035.1|refseq:NP_001155036.1|refseq:NP_001155037.1|refseq:NP_001155038.1|refseq:NP_055843.1|dip:DIP-37562N|ensembl:ENSG00000154310(gene)|ensembl:ENST00000436636(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030033"(microvillus assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9UKE5|rcsb pdb:2X7F|rcsb pdb:5AX9|rcsb pdb:5CWZ|rcsb pdb:5D7A|rcsb pdb:6RA5|rcsb pdb:6RA7|reactome:R-HSA-2559580	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:b+FNQZpz2ZX+wcVH9wuqOgZQ/cE9606	rigid:KuMvO92CrOh/axX+YXbyFtw6D4A	false	-	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03230	uniprotkb:O43318	intact:EBI-6973030|uniprotkb:Q777A4|intact:MINT-1509916	intact:EBI-358684|uniprotkb:O43317|uniprotkb:O43319|uniprotkb:Q9NZ70|uniprotkb:Q9NTR3|uniprotkb:E1P523|uniprotkb:Q5TDN2|uniprotkb:Q5TDN3|uniprotkb:B2RE27|uniprotkb:Q5TDT7|ensembl:ENSP00000358335	psi-mi:lmp1_ebvb9(display_long)|uniprotkb:LMP1(gene name)|psi-mi:LMP1(display_short)|uniprotkb:BNLF1(orf name)|uniprotkb:Protein p63(gene name synonym)	psi-mi:m3k7_human(display_long)|uniprotkb:MAP3K7(gene name)|psi-mi:MAP3K7(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shkoda et al. (2011)	pubmed:22904686|doi:10.1371/journal.pbio.1001376|imex:IM-21062	taxid:10377(ebvb9)|taxid:10377("Epstein-Barr virus (strain B95-8) (HHV-4)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16009326|imex:IM-21062-18|dip:DIP-190694E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019087"(transformation of host cell by virus)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0033644"(host cell membrane)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039547"(suppression by virus of host TRAF activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039652"(induction by virus of host NF-kappaB cascade)|interpro:IPR007961(Herpesvirus latent membrane 1)|rcsb pdb:1CZY|refseq:YP_401722.1|mint:P03230|dip:DIP-29603N|dip:DIP-43767N	refseq:NP_003179.1|refseq:NP_663304.1|refseq:NP_663305.1|refseq:NP_663306.1|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSG00000135341(gene)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|ensembl:ENST00000369329(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002753"(cytoplasmic pattern recognition receptor signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O43318|rcsb pdb:2EVA|rcsb pdb:2YIY|rcsb pdb:4GS6|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5V5N|rcsb pdb:7NTH|rcsb pdb:7NTI|reactome:R-HSA-1169091|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-4086398|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27523N	psi-mi:"MI:0465"(dip)	crc64:1E19446E857DB8A3|comment:mint|comment:homomint|function:The latent membrane protein has transforming activity	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:BnKAPmlZEaISOXfVyDdDiOICwgs10377	rogid:U/W3xH9XPl6BIdCcfrw1gG/+n7Y9606	rigid:5tTPTW47+0ppY2q1kgLAwBw6AWw	false	-	flag tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)