#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9EQD0	uniprotkb:Q5NCP0	intact:EBI-7938232|uniprotkb:G5E8F0|uniprotkb:Q8CHK9|uniprotkb:Q8BMR2|intact:MINT-1783095|uniprotkb:O08975|ensembl:ENSMUSP00000067783|ensembl:ENSMUSP00000111828	intact:EBI-16006983|ensembl:ENSMUSP00000090476|ensembl:ENSMUSP00000130685|uniprotkb:B2KGH3|uniprotkb:Q6DI76|uniprotkb:Q8BME0|uniprotkb:Q8C191|uniprotkb:Q8K0X4	psi-mi:fzd5_mouse(display_long)|uniprotkb:Fzd5(gene name)|psi-mi:Fzd5(display_short)	psi-mi:rnf43_mouse(display_long)|uniprotkb:Rnf43(gene name)|psi-mi:Rnf43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Koo et al. (2012)	pubmed:22895187|doi:10.1038/nature11308|imex:IM-18078	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16007021|imex:IM-18078-1|dip:DIP-189768E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036124.1|refseq:NP_073558.2|dip:DIP-41260N|ensembl:ENSMUSG00000045005(gene)|ensembl:ENSMUST00000063982(transcript)|ensembl:ENSMUST00000116133(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001944"(vasculature development)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR037441|reactome:R-MMU-4086398|reactome:R-MMU-4608870|reactome:R-MMU-4641262|reactome:R-MMU-4641263|reactome:R-MMU-5140745	ensembl:ENSMUSG00000034177(gene)|ensembl:ENSMUST00000092800(transcript)|ensembl:ENSMUST00000165679(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|reactome:R-MMU-4641263|refseq:NP_766036.2|refseq:XP_011247146.1|dip:DIP-59915N|refseq:XP_006532764.1	psi-mi:"MI:0465"(dip)	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:O3uI77ElZ4+6mCkb8gfIfqe6+jE10090	rogid:E6hJhhnAlAPNThB1x/FbS0Nal4c10090	rigid:SwVY8k5mQe4DCpAOK5MRw2LO6C8	false	v5 tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9EQD0	uniprotkb:P62991	intact:EBI-7938232|uniprotkb:G5E8F0|uniprotkb:Q8CHK9|uniprotkb:Q8BMR2|intact:MINT-1783095|uniprotkb:O08975|ensembl:ENSMUSP00000067783|ensembl:ENSMUSP00000111828	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:fzd5_mouse(display_long)|uniprotkb:Fzd5(gene name)|psi-mi:Fzd5(display_short)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0096"(pull down)	Koo et al. (2012)	pubmed:22895187|doi:10.1038/nature11308|imex:IM-18078	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16007042|imex:IM-18078-2|dip:DIP-189769E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001036124.1|refseq:NP_073558.2|dip:DIP-41260N|ensembl:ENSMUSG00000045005(gene)|ensembl:ENSMUST00000063982(transcript)|ensembl:ENSMUST00000116133(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001525"(angiogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001944"(vasculature development)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031076"(embryonic camera-type eye development)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043204"(perikaryon)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0060061"(Spemann organizer formation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:1901382"(regulation of chorionic trophoblast cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR037441|reactome:R-MMU-4086398|reactome:R-MMU-4608870|reactome:R-MMU-4641262|reactome:R-MMU-4641263|reactome:R-MMU-5140745	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	psi-mi:"MI:0465"(dip)	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in yolk sac angiogenesis and in placental vascularization. Binds to Wnt2, Wnt10B, Wnt5A, but not to Wnt2B or Wnt4	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:O3uI77ElZ4+6mCkb8gfIfqe6+jE10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rigid:AIFnTiDWjhVdm7/PeV/cUVr52OM	false	v5 tag:n-n	his tag:0-0	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)