#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49021	uniprotkb:Q9V475	intact:EBI-266295|uniprotkb:O44380|uniprotkb:Q8I037|uniprotkb:Q95U67|uniprotkb:Q9VQR6|uniprotkb:Q9VQR7|intact:EBI-3407510|uniprotkb:M9MRE9|uniprotkb:A4V040|uniprotkb:B7Z007|uniprotkb:B7Z008|uniprotkb:C9QPB7|uniprotkb:Q1WWF5|uniprotkb:Q59E16|intact:EBI-9944820|ensemblmetazoa:FBpp0077256|ensemblmetazoa:FBpp0305454	intact:EBI-109873|ensemblmetazoa:FBpp0291366|ensemblmetazoa:FBpp0291367|ensemblmetazoa:FBpp0291368	psi-mi:tim_drome(display_long)|uniprotkb:tim(gene name)|psi-mi:tim(display_short)|uniprotkb:CG3234(orf name)	psi-mi:q9v475_drome(display_long)|uniprotkb:CG11861(gene name synonym)|uniprotkb:CG31829(gene name synonym)|uniprotkb:Cul3(gene name)|psi-mi:Cul3(display_short)|uniprotkb:Cul-3(gene name synonym)|uniprotkb:cul-3(gene name synonym)|uniprotkb:gft(gene name synonym)|uniprotkb:CG42616(orf name)|uniprotkb:"BG:DS07851.2"(gene name synonym)|uniprotkb:CUL-3(gene name synonym)|uniprotkb:CUL3(gene name synonym)|uniprotkb:Cullin3(gene name synonym)|uniprotkb:DMcul-3(gene name synonym)|uniprotkb:Dmel\CG42616(gene name synonym)|uniprotkb:br34(gene name synonym)|uniprotkb:cul3(gene name synonym)|uniprotkb:dCul-3(gene name synonym)|uniprotkb:dCul3(gene name synonym)|uniprotkb:guftagu(gene name synonym)|uniprotkb:"l(2)06430"(gene name synonym)|uniprotkb:"l(2)35Cd"(gene name synonym)|uniprotkb:"l(2)br34"(gene name synonym)|uniprotkb:l35Cd(gene name synonym)|uniprotkb:mds(gene name synonym)|uniprotkb:Dmel_CG42616(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Grima et al. (2011)	pubmed:22879814|doi:10.1371/journal.pbio.1001367|imex:IM-18048	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16005494|imex:IM-18048-1|dip:DIP-189666E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722914.3|flybase:FBgn0014396|refseq:NP_722912.3|refseq:NP_722913.3|refseq:NP_001014463.2|refseq:NP_001033872.2|refseq:NP_001137780.2|refseq:NP_001137781.2|refseq:NP_001188686.2|dip:DIP-29425N|ensemblmetazoa:FBgn0014396(gene)|ensemblmetazoa:FBtr0077567(transcript)|ensemblmetazoa:FBtr0333256(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007617"(mating behavior)|go:"GO:0007620"(copulation)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009648"(photoperiodism)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0043111"(replication fork arrest)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0046957"(negative phototaxis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048478"(replication fork protection)|go:"GO:0048512"(circadian behavior)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR006906(Timeless protein)|interpro:IPR007725(Timeless C-terminal)|reactome:R-DME-432395|reactome:R-DME-432490|reactome:R-DME-432501|reactome:R-DME-432553|reactome:R-DME-432620|reactome:R-DME-538898	refseq:NP_523573.1|refseq:NP_723907.1|refseq:NP_723908.2|flybase:FBgn0261268|dip:DIP-29549N|ensemblmetazoa:FBgn0261268(gene)|ensemblmetazoa:FBtr0302156(transcript)|ensemblmetazoa:FBtr0302157(transcript)|ensemblmetazoa:FBtr0302158(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007291"(sperm individualization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007423"(sensory organ development)|go:"GO:0007476"(imaginal disc-derived wing morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030431"(sleep)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0048813"(dendrite morphogenesis)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-DME-216167	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:wdN/j17nXo6XpfHUGGSo5zYNhog7227	rogid:FdSkVuXrUqWZ/sUgajntxvW8pd07227	rigid:G40QIoB266fXvhiw8MfWYSiFfnM	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9VDE3	uniprotkb:P49021	intact:EBI-91763|ensemblmetazoa:FBpp0083434|ensemblmetazoa:FBpp0306059	intact:EBI-266295|uniprotkb:O44380|uniprotkb:Q8I037|uniprotkb:Q95U67|uniprotkb:Q9VQR6|uniprotkb:Q9VQR7|intact:EBI-3407510|uniprotkb:M9MRE9|uniprotkb:A4V040|uniprotkb:B7Z007|uniprotkb:B7Z008|uniprotkb:C9QPB7|uniprotkb:Q1WWF5|uniprotkb:Q59E16|intact:EBI-9944820|ensemblmetazoa:FBpp0077256|ensemblmetazoa:FBpp0305454	psi-mi:q9vde3_drome(display_long)|uniprotkb:slmb(gene name)|psi-mi:slmb(display_short)|uniprotkb:beta-TrCP(gene name synonym)|uniprotkb:"BcDNA:GM02031"(gene name synonym)|uniprotkb:Beta-TRCP1(gene name synonym)|uniprotkb:Dmel\CG3412(gene name synonym)|uniprotkb:FBXW1(gene name synonym)|uniprotkb:"MENE (3R)-B"(gene name synonym)|uniprotkb:"MENE(3R)-B"(gene name synonym)|uniprotkb:SLIMB(gene name synonym)|uniprotkb:SLMB(gene name synonym)|uniprotkb:Slimb(gene name synonym)|uniprotkb:Slmb(gene name synonym)|uniprotkb:beta-TRCP(gene name synonym)|uniprotkb:betaTrCP(gene name synonym)|uniprotkb:crd(gene name synonym)|uniprotkb:ica(gene name synonym)|uniprotkb:"l(3)00295"(gene name synonym)|uniprotkb:shv(gene name synonym)|uniprotkb:slimb(gene name synonym)|uniprotkb:wel(gene name synonym)|uniprotkb:Dmel_CG3412(orf name)|uniprotkb:CG3412(orf name)	psi-mi:tim_drome(display_long)|uniprotkb:tim(gene name)|psi-mi:tim(display_short)|uniprotkb:CG3234(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Grima et al. (2011)	pubmed:22879814|doi:10.1371/journal.pbio.1001367|imex:IM-18048	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16005513|imex:IM-18048-2|dip:DIP-189667E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0283468|refseq:NP_524430.1|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045849"(negative regulation of nurse cell apoptotic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060623"(regulation of chromosome condensation)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:2000114"(regulation of establishment of cell polarity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|ensemblmetazoa:FBgn0283468(gene)|ensemblmetazoa:FBtr0084032(transcript)|ensemblmetazoa:FBtr0333931(transcript)|go:"GO:0006508"(proteolysis)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007293"(germarium-derived egg chamber formation)|go:"GO:0007304"(chorion-containing eggshell formation)|go:"GO:0007309"(oocyte axis specification)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030707"(ovarian follicle cell development)|go:"GO:0030708"(germarium-derived female germ-line cyst encapsulation)|go:"GO:0030713"(ovarian follicle cell stalk formation)|go:"GO:0030720"(oocyte localization involved in germarium-derived egg chamber formation)|go:"GO:0030727"(germarium-derived female germ-line cyst formation)|refseq:NP_001262801.1|dip:DIP-22524N	refseq:NP_722914.3|flybase:FBgn0014396|refseq:NP_722912.3|refseq:NP_722913.3|refseq:NP_001014463.2|refseq:NP_001033872.2|refseq:NP_001137780.2|refseq:NP_001137781.2|refseq:NP_001188686.2|dip:DIP-29425N|ensemblmetazoa:FBgn0014396(gene)|ensemblmetazoa:FBtr0077567(transcript)|ensemblmetazoa:FBtr0333256(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003053"(circadian regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007617"(mating behavior)|go:"GO:0007620"(copulation)|go:"GO:0007622"(rhythmic behavior)|go:"GO:0008062"(eclosion rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009648"(photoperiodism)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0043111"(replication fork arrest)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0046957"(negative phototaxis)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048478"(replication fork protection)|go:"GO:0048512"(circadian behavior)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0071482"(cellular response to light stimulus)|go:"GO:2000678"(negative regulation of transcription regulatory region DNA binding)|interpro:IPR006906(Timeless protein)|interpro:IPR007725(Timeless C-terminal)|reactome:R-DME-432395|reactome:R-DME-432490|reactome:R-DME-432501|reactome:R-DME-432553|reactome:R-DME-432620|reactome:R-DME-538898	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:4WM8B/xRk+ezxr9VCBG/jw6fwYw7227	rogid:wdN/j17nXo6XpfHUGGSo5zYNhog7227	rigid:tsRyVpg+tx+9Wn7wnD1dDhmSnOE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)