#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P56528	uniprotkb:P56528	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Hara-Yokoyama et al. (2012)	pubmed:22863568|doi:10.1016/j.str.2012.06.017|imex:IM-18041	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16002983|imex:IM-18041-1|dip:DIP-189643E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	psi-mi:"MI:0465"(dip)	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rigid:fXYGJrOkSGxOoZ/aOp6y+87ZB7Q	false	sufficient binding region:48-288|mutation disrupting interaction strength:68-68	sufficient binding region:48-288|mutation disrupting interaction strength:68-68	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56528	uniprotkb:P56528	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Hara-Yokoyama et al. (2012)	pubmed:22863568|doi:10.1016/j.str.2012.06.017|imex:IM-18041	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16003025|imex:IM-18041-3|dip:DIP-189643E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	psi-mi:"MI:0465"(dip)	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rigid:fXYGJrOkSGxOoZ/aOp6y+87ZB7Q	false	sufficient binding region:48-288|mutation disrupting interaction strength:68-68	sufficient binding region:48-288|mutation disrupting interaction strength:68-68	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56528	uniprotkb:P56528	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Hara-Yokoyama et al. (2012)	pubmed:22863568|doi:10.1016/j.str.2012.06.017|imex:IM-18041	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16003047|imex:IM-18041-4|dip:DIP-189643E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	psi-mi:"MI:0465"(dip)	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/07	2017/08/10	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rigid:fXYGJrOkSGxOoZ/aOp6y+87ZB7Q	false	sufficient binding region:48-288|mutation:223-223,213-213,124-124,104-104	sufficient binding region:48-288|mutation:223-223,213-213,124-124,104-104	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P56528	uniprotkb:P56528	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hara-Yokoyama et al. (2012)	pubmed:22863568|doi:10.1016/j.str.2012.06.017|imex:IM-18041	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16003004|imex:IM-18041-2|dip:DIP-189643E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	psi-mi:"MI:0465"(dip)	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	-	2017/08/07	2017/08/10	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rigid:iw5Tl3sM0ar8k4SQiVJSdPV055Q	false	myc tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P56528	uniprotkb:P56528	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	intact:EBI-8401721|intact:MINT-4090243|uniprotkb:Q8BFY8|ensembl:ENSMUSP00000030964	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:cd38_mouse(display_long)|uniprotkb:2'-phospho-ADP-ribosyl cyclase(gene name synonym)|uniprotkb:2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:2'-phospho-cyclic-ADP-ribose transferase(gene name synonym)|uniprotkb:ADP-ribosyl cyclase 1(gene name synonym)|uniprotkb:Cd38(gene name)|psi-mi:Cd38(display_short)|uniprotkb:Cyclic ADP-ribose hydrolase 1(gene name synonym)|uniprotkb:NIM-R5 antigen(gene name synonym)|uniprotkb:I-19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Hara-Yokoyama et al. (2012)	pubmed:22863568|doi:10.1016/j.str.2012.06.017|imex:IM-18041	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16003071|imex:IM-18041-5|dip:DIP-189643E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	refseq:NP_031672.2|dip:DIP-59864N|ensembl:ENSMUSG00000029084(gene)|ensembl:ENSMUST00000030964(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003953"(NAD+ nucleosidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007565"(female pregnancy)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0016798"(hydrolase activity, acting on glycosyl bonds)|go:"GO:0016849"(phosphorus-oxygen lyase activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032570"(response to progesterone)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR003193("ADP-ribosyl cyclase (CD38/157)")|interpro:IPR033567|mint:P56528|rcsb pdb:2EG9|reactome:R-MMU-196807	psi-mi:"MI:0465"(dip)	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	function:Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rogid:LDdsGyDTvN6KlRnxq6J2ipT+3Nc10090	rigid:fXYGJrOkSGxOoZ/aOp6y+87ZB7Q	false	sufficient binding region:48-288|mutation disrupting interaction strength:68-68	sufficient binding region:48-288|mutation disrupting interaction strength:68-68	-	0	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)