#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0CW72 uniprotkb:P09603 intact:EBI-2620133|uniprotkb:Q777A5 intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3 psi-mi:barf1_ebvg(display_long)|uniprotkb:BARF1(gene name)|psi-mi:BARF1(display_short)|uniprotkb:33 kDa early protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Shim et al. (2012) pubmed:22826234|doi:10.1073/pnas.1205309109|imex:IM-20697 taxid:10376(ebvg)|taxid:10376("Epstein-Barr virus (strain B95-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16001586|imex:IM-20697-1|dip:DIP-190343E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_401719.1|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4FA8|dip:DIP-60066N ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:D3ADKUsYpDVqDM/mOMUXstVGHw410376 rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606 rigid:UMWe+HIzVrJAUcbpdsQkvmoEij0 false sufficient binding region:19-221 sufficient binding region:36-182 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0CW72 uniprotkb:P09603 intact:EBI-2620133|uniprotkb:Q777A5 intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3 psi-mi:barf1_ebvg(display_long)|uniprotkb:BARF1(gene name)|psi-mi:BARF1(display_short)|uniprotkb:33 kDa early protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Shim et al. (2012) pubmed:22826234|doi:10.1073/pnas.1205309109|imex:IM-20697 taxid:10376(ebvg)|taxid:10376("Epstein-Barr virus (strain B95-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16001607|imex:IM-20697-2|dip:DIP-190343E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_401719.1|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4FA8|dip:DIP-60066N ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:D3ADKUsYpDVqDM/mOMUXstVGHw410376 rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606 rigid:UMWe+HIzVrJAUcbpdsQkvmoEij0 false sufficient binding region:19-221 sufficient binding region:36-182 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P09581 uniprotkb:P09603 intact:EBI-6305373|ensembl:ENSMUSP00000025523|ensembl:ENSMUSP00000110923|uniprotkb:Q3U3P1|uniprotkb:Q9DBH9 intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3 psi-mi:csf1r_mouse(display_long)|uniprotkb:Csf1r(gene name)|psi-mi:Csf1r(display_short)|uniprotkb:Csfmr(gene name synonym)|uniprotkb:Fms(gene name synonym)|uniprotkb:CSF-1 receptor(gene name synonym)|uniprotkb:Proto-oncogene c-Fms(gene name synonym) psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Shim et al. (2012) pubmed:22826234|doi:10.1073/pnas.1205309109|imex:IM-20697 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16001628|imex:IM-20697-3|dip:DIP-187848E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-MMU-449836|rcsb pdb:4EXP|ensembl:ENSMUSG00000024621(gene)|ensembl:ENSMUST00000025523(transcript)|ensembl:ENSMUST00000115268(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002931"(response to ischemia)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005011"(macrophage colony-stimulating factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021772"(olfactory bulb development)|go:"GO:0021879"(forebrain neuron differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032944"(regulation of mononuclear cell proliferation)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0036006"(cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990682"(CSF1-CSF1R complex)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR030658|interpro:IPR036179|rcsb pdb:3EJJ|dip:DIP-46415N|refseq:XP_006525647.1|refseq:XP_006525648.1|refseq:XP_006525649.1|refseq:NP_001032948.2|refseq:XP_017173299.1 ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:jWzzruMZt6wnD2QFpQ4/aov3vlU10090 rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606 rigid:mF8umfUqbG/Z2ECjPkmvMtwQrPk false sufficient binding region:20-511 sufficient binding region:36-182 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0CW72 uniprotkb:P09603 intact:EBI-2620133|uniprotkb:Q777A5 intact:EBI-2872294|ensembl:ENSP00000327513|ensembl:ENSP00000358817|uniprotkb:Q14806|uniprotkb:Q5VVF4|uniprotkb:Q14086|uniprotkb:A8K6J5|uniprotkb:Q13130|uniprotkb:Q9UQR8|uniprotkb:Q5VVF3 psi-mi:barf1_ebvg(display_long)|uniprotkb:BARF1(gene name)|psi-mi:BARF1(display_short)|uniprotkb:33 kDa early protein(gene name synonym)|uniprotkb:p33(gene name synonym) psi-mi:csf1_human(display_long)|uniprotkb:CSF1(gene name)|psi-mi:CSF1(display_short)|uniprotkb:Lanimostim(gene name synonym) psi-mi:"MI:0065"(isothermal titration calorimetry) Shim et al. (2012) pubmed:22826234|doi:10.1073/pnas.1205309109|imex:IM-20697 taxid:10376(ebvg)|taxid:10376("Epstein-Barr virus (strain B95-8)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16001649|imex:IM-20697-4|dip:DIP-190343E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:YP_401719.1|go:"GO:0005576"(extracellular region)|go:"GO:0042802"(identical protein binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:4FA8|dip:DIP-60066N ensembl:ENSG00000184371(gene)|ensembl:ENST00000329608(transcript)|ensembl:ENST00000369802(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002931"(response to ischemia)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0005125"(cytokine activity)|go:"GO:0005157"(macrophage colony-stimulating factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010743"(regulation of macrophage derived foam cell differentiation)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0038145"(macrophage colony-stimulating factor signaling pathway)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042117"(monocyte activation)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045087"(innate immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060611"(mammary gland fat development)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902228"(positive regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1905523"(positive regulation of macrophage migration)|interpro:IPR008001(Macrophage colony stimulating factor-1)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1HMC|rcsb pdb:3UEZ|rcsb pdb:3UF2|rcsb pdb:4ADF|rcsb pdb:4FA8|rcsb pdb:4WRL|rcsb pdb:4WRM|rcsb pdb:5LXF|reactome:R-HSA-381426|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8957275|go:"GO:1990682"(CSF1-CSF1R complex)|refseq:NP_000748.3|refseq:NP_757349.1|refseq:NP_757351.1|refseq:NP_757350.1|dip:DIP-41860N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:D3ADKUsYpDVqDM/mOMUXstVGHw410376 rogid:YSg7hoJM9d3lvDoswhhVkvt0D8I9606 rigid:UMWe+HIzVrJAUcbpdsQkvmoEij0 false sufficient binding region:19-221 sufficient binding region:36-182 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)