#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q5FWF4	uniprotkb:P33991	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954665|imex:IM-25700-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/24	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	rigid:eRXlGezvu+bJDB4hW96wrWBD484	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P33993	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954665|imex:IM-25700-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/24	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	rigid:eRXlGezvu+bJDB4hW96wrWBD484	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P25205	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954665|imex:IM-25700-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/24	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rigid:eRXlGezvu+bJDB4hW96wrWBD484	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P12004	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954665|imex:IM-25700-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/24	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rigid:eRXlGezvu+bJDB4hW96wrWBD484	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P33991	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954716|imex:IM-25700-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	comment:PIP-box gln519ala,phe525ala,phe526ala construct abolishes association of PCNA but has no effect on association with MCM3 and MCM4	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/24	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	rigid:GcfjbQ3zyjrtcInCRtGygZ+lNes	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P25205	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954716|imex:IM-25700-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	comment:PIP-box gln519ala,phe525ala,phe526ala construct abolishes association of PCNA but has no effect on association with MCM3 and MCM4	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/24	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rigid:GcfjbQ3zyjrtcInCRtGygZ+lNes	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P12004	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954716|imex:IM-25700-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	-	comment:PIP-box gln519ala,phe525ala,phe526ala construct abolishes association of PCNA but has no effect on association with MCM3 and MCM4	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/24	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rigid:GcfjbQ3zyjrtcInCRtGygZ+lNes	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12004	uniprotkb:Q5FWF4	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13955302|imex:IM-25700-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	-	-	comment:PIP-box gln519ala,phe525ala,phe526ala construct abolishes association of PCNA but has no effect on association with MCM3 and MCM4	figure legend:supplemental fig 2B|comment:UV radiation does not change the interaction|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/27	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rigid:gMfdi5pEf/GWTxhtxeft0J0AXO8	false	-	flag tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P33991	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13955383|imex:IM-25700-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:2C-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/29	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	rigid:vuoPCZAPLQ/lvVvDQE/jbzfFg9I	false	flag tag:n-n|mutation:519-519,525-525,526-526	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5FWF4	uniprotkb:P25205	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13955383|imex:IM-25700-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:2C-2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2017/03/24	2017/03/29	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rigid:vuoPCZAPLQ/lvVvDQE/jbzfFg9I	false	flag tag:n-n|mutation:519-519,525-525,526-526	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12004	uniprotkb:Q5FWF4	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954680|imex:IM-25700-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	-	-	-	figure legend:5C- F|comment:Colocalize in DNA damage-induced foci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2017/03/24	2017/03/24	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rigid:gMfdi5pEf/GWTxhtxeft0J0AXO8	false	-	yellow fluorescent protein tag:n-n|mutation decreasing interaction strength:632-632,519-519,525-525,526-526	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-4399559	uniprotkb:Q5FWF4	dip:DIP-24261N	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13955183|imex:IM-25700-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	-	no-uniprot-update:|comment:Used antibody recognizes conjugated but not free ubiquitin	-	figure legend:2F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2017/03/24	2017/03/27	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rigid:6X8KOqT0vxfMz2BT2IhVpveKtSs	false	-	yellow fluorescent protein tag:n-n	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P12004	uniprotkb:Q5FWF4	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13955226|imex:IM-25700-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	-	-	-	figure legend:5D, supplemental fig 5C|comment:Colocalize in untreated and in DNA damage-induced foci with comparable efficiencies|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2017/03/24	2017/03/27	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rigid:gMfdi5pEf/GWTxhtxeft0J0AXO8	false	-	yellow fluorescent protein tag:n-n|sufficient binding region:961..961-1056..1056	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P12004	uniprotkb:Q5FWF4	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13955247|imex:IM-25700-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	-	-	-	figure legend:5D, supplemental fig 5C|comment:Colocalize in DNA damage-induced foci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2017/03/24	2017/03/27	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rigid:gMfdi5pEf/GWTxhtxeft0J0AXO8	false	-	yellow fluorescent protein tag:n-n|mutation:525-525,526-526,519-519	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P12004	uniprotkb:Q5FWF4	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13955266|imex:IM-25700-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	-	-	-	figure legend:5D, supplemental fig 5C|comment:Colocalize in DNA damage-induced foci|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u2-os)|taxid:9606(Human U2-OS osteosarcoma cell line)	-	2017/03/24	2017/03/27	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rigid:gMfdi5pEf/GWTxhtxeft0J0AXO8	false	-	yellow fluorescent protein tag:n-n|mutation:632-632	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P12004	uniprotkb:Q5FWF4	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	intact:EBI-13954615|ensembl:ENSP00000264159|uniprotkb:B3KYA1|uniprotkb:B4E375|uniprotkb:B5MDI3|uniprotkb:D3DP76|uniprotkb:E9PBP0|uniprotkb:Q53SM1|uniprotkb:Q6P2C4|uniprotkb:Q8N1P4|uniprotkb:Q9H0E8	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:zrab3_human(display_long)|uniprotkb:ZRANB3(gene name)|psi-mi:ZRANB3(display_short)|uniprotkb:Annealing helicase 2(gene name synonym)|uniprotkb:Zinc finger Ran-binding domain-containing protein 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weston et al. (2012)	pubmed:22759634|imex:IM-25700	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13954697|imex:IM-25700-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	ensembl:ENSG00000121988(gene)|ensembl:ENST00000264159(transcript)|go:"GO:0004386"(helicase activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0009411"(response to UV)|go:"GO:0031297"(replication fork processing)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0036292"(DNA rewinding)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|refseq:NP_001273497.1|refseq:NP_115519.2|refseq:XP_005263866.1|refseq:XP_006712851.1|refseq:XP_011510260.1|refseq:XP_011510262.1|refseq:XP_011510265.1|go:"GO:0048478"(replication fork protection)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002711(HNH endonuclease)|interpro:IPR003615(HNH nuclease)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR036443|interpro:IPR038718|rcsb pdb:5MKW|rcsb pdb:5MLO|rcsb pdb:5MLW|rcsb pdb:5YD8	-	-	-	figure legend:2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/03/24	2017/03/29	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	rogid:14I6eWoNA5janXjGCtZTkf8VGRU9606	rigid:gMfdi5pEf/GWTxhtxeft0J0AXO8	false	his tag:?-?	biotin tag:?-?|sufficient binding region:510..510-533..533|mutation disrupting interaction strength:519-519,525-525,526-526	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0867"(tag visualisation by fluorescence)