#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15823	uniprotkb:P30729	intact:EBI-15185013|uniprotkb:Q63215	intact:EBI-15989078|uniprotkb:Q62610	psi-mi:ada1b_rat(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:Adra1b(gene name)|psi-mi:Adra1b(display_short)	psi-mi:drd4_rat(display_long)|uniprotkb:Drd4(gene name)|psi-mi:Drd4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989124|imex:IM-18045-3|dip:DIP-189649E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001987"(vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009725"(response to hormone)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035265"(organ growth)|dip:DIP-59867N|rgd:2054|reactome:R-RNO-390696|reactome:R-RNO-416476|reactome:R-RNO-416482	go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0043025"(neuronal cell body)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007614"(short-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0009648"(photoperiodism)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|reactome:R-RNO-418594|reactome:R-RNO-390651|rgd:2522|dip:DIP-59866N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:v5AffHemwsOIgS5BgARd8tuHy8E10116	rogid:wcVk4kjTciJQG2eLwHI7Wj0ttzw10116	rigid:Ut+1HBrPBTg6vZv6B95gfzdPW48	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P21917	uniprotkb:P35368	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-490017|uniprotkb:B0LPE1|ensembl:ENSP00000306662	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:ada1b_human(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:ADRA1B(gene name)|psi-mi:ADRA1B(display_short)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989057|imex:IM-18045-2|dip:DIP-189646E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	refseq:NP_000670.1|ensembl:ENSG00000170214(gene)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000306675(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35368|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|dip:DIP-33399N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:labDfm9SIECH7JTHtwNoHTMuSS09606	rigid:dNethzroBdrfxyij2w01E+zdGTs	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21917	uniprotkb:P35368	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-490017|uniprotkb:B0LPE1|ensembl:ENSP00000306662	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:ada1b_human(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:ADRA1B(gene name)|psi-mi:ADRA1B(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989038|imex:IM-18045-1|dip:DIP-189646E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	refseq:NP_000670.1|ensembl:ENSG00000170214(gene)|go:"GO:0007267"(cell-cell signaling)|ensembl:ENST00000306675(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P35368|reactome:R-HSA-390696|reactome:R-HSA-416476|reactome:R-HSA-416482|dip:DIP-33399N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:labDfm9SIECH7JTHtwNoHTMuSS09606	rigid:dNethzroBdrfxyij2w01E+zdGTs	false	yellow fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15823	uniprotkb:P30729	intact:EBI-15185013|uniprotkb:Q63215	intact:EBI-15989078|uniprotkb:Q62610	psi-mi:ada1b_rat(display_long)|uniprotkb:Alpha-1B adrenoreceptor(gene name synonym)|uniprotkb:Adra1b(gene name)|psi-mi:Adra1b(display_short)	psi-mi:drd4_rat(display_long)|uniprotkb:Drd4(gene name)|psi-mi:Drd4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989141|imex:IM-18045-4|dip:DIP-189649E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043627"(response to estrogen)|go:"GO:0045818"(negative regulation of glycogen catabolic process)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0150099"(neuron-glial cell signaling)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001115(Adrenergic receptor, alpha-1B)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0001975"(response to amphetamine)|go:"GO:0001987"(vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004937"(alpha1-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007512"(adult heart development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009725"(response to hormone)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035265"(organ growth)|dip:DIP-59867N|rgd:2054|reactome:R-RNO-390696|reactome:R-RNO-416476|reactome:R-RNO-416482	go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0043025"(neuronal cell body)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007614"(short-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0009648"(photoperiodism)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|reactome:R-RNO-418594|reactome:R-RNO-390651|rgd:2522|dip:DIP-59866N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:v5AffHemwsOIgS5BgARd8tuHy8E10116	rogid:wcVk4kjTciJQG2eLwHI7Wj0ttzw10116	rigid:Ut+1HBrPBTg6vZv6B95gfzdPW48	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P21917	uniprotkb:P08588	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989194|imex:IM-18045-7|dip:DIP-189647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rigid:tZe0y1h9Se4aYhwG1byTckiQ1Kk	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21917	uniprotkb:P08588	intact:EBI-8592297|ensembl:ENSP00000176183|ensembl:ENSP00000478431|uniprotkb:B0M0J7|intact:MINT-8090293|uniprotkb:Q8NGM5|uniprotkb:Q7Z7Q5	intact:EBI-991009|uniprotkb:Q9UKG7|uniprotkb:Q9UKG8|ensembl:ENSP00000358301|uniprotkb:B0LPE2|uniprotkb:Q5T5Y4	psi-mi:drd4_human(display_long)|uniprotkb:DRD4(gene name)|psi-mi:DRD4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:adrb1_human(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:ADRB1(gene name)|psi-mi:ADRB1(display_short)|uniprotkb:ADRB1R(gene name synonym)|uniprotkb:B1AR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989175|imex:IM-18045-6|dip:DIP-189647E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000069696(gene)|ensembl:ENSG00000276825(gene)|ensembl:ENST00000176183(transcript)|ensembl:ENST00000611962(transcript)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035176"(social behavior)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0048511"(rhythmic process)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0051586"(positive regulation of dopamine uptake involved in synaptic transmission)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:5WIU|rcsb pdb:5WIV|reactome:R-HSA-390651|reactome:R-HSA-418594|refseq:NP_000788.2|dip:DIP-59865N	refseq:NP_000675.1|ensembl:ENSG00000043591(gene)|ensembl:ENST00000369295(transcript)|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0009409"(response to cold)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042596"(fear response)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2LSQ|rcsb pdb:7BTS|rcsb pdb:7BU6|rcsb pdb:7BU7|rcsb pdb:7BVQ|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821|dip:DIP-36294N	psi-mi:"MI:0465"(dip)	comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2019/04/15	rogid:sGcOjmtZEUo56Z1ZijXGzwNRMFw9606	rogid:WwGqJMzG+4OiJNDRpX2GJ/HPV449606	rigid:tZe0y1h9Se4aYhwG1byTckiQ1Kk	false	yellow fluorescent protein tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P18090	uniprotkb:P30729	intact:EBI-991303	intact:EBI-15989078|uniprotkb:Q62610	psi-mi:adrb1_rat(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)	psi-mi:drd4_rat(display_long)|uniprotkb:Drd4(gene name)|psi-mi:Drd4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989158|imex:IM-18045-5|dip:DIP-189648E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2059|refseq:NP_036833.1|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2FF9|dip:DIP-36293N|reactome:R-RNO-390696	go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0043025"(neuronal cell body)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007614"(short-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0009648"(photoperiodism)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|reactome:R-RNO-418594|reactome:R-RNO-390651|rgd:2522|dip:DIP-59866N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:Wq/dp2QYU3qvPFECl9JP7oSUGTE10116	rogid:wcVk4kjTciJQG2eLwHI7Wj0ttzw10116	rigid:WR7VPiR6m3bmgsTGZe7gtF61ySs	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P18090	uniprotkb:P30729	intact:EBI-991303	intact:EBI-15989078|uniprotkb:Q62610	psi-mi:adrb1_rat(display_long)|uniprotkb:Beta-1 adrenoreceptor(gene name synonym)|uniprotkb:Adrb1(gene name)|psi-mi:Adrb1(display_short)|uniprotkb:Adrb1r(gene name synonym)	psi-mi:drd4_rat(display_long)|uniprotkb:Drd4(gene name)|psi-mi:Drd4(display_short)|uniprotkb:"D(2C) dopamine receptor"(gene name synonym)|uniprotkb:Dopamine D4 receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	González et al. (2011)	pubmed:22723743|doi:10.1371/journal.pbio.1001347|imex:IM-18045	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15989215|imex:IM-18045-8|dip:DIP-189648E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2059|refseq:NP_036833.1|go:"GO:0001996"(positive regulation of heart rate by epinephrine-norepinephrine)|go:"GO:0001997"(positive regulation of the force of heart contraction by epinephrine-norepinephrine)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0003061"(positive regulation of the force of heart contraction by norepinephrine)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004940"(beta1-adrenergic receptor activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007613"(memory)|go:"GO:0009409"(response to cold)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0016020"(membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031649"(heat generation)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042596"(fear response)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045187"(regulation of circadian sleep/wake cycle, sleep)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0099579"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0106071"(positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900135"(positive regulation of renin secretion into blood stream)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000507(Adrenergic receptor, beta 1)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2FF9|dip:DIP-36293N|reactome:R-RNO-390696	go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043679"(axon terminus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000929(Dopamine receptor)|interpro:IPR002185(Dopamine D4 receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|go:"GO:0043025"(neuronal cell body)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001591"(dopamine neurotransmitter receptor activity, coupled via Gi/Go)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004952"(dopamine neurotransmitter receptor activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007614"(short-term memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0009648"(photoperiodism)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034776"(response to histamine)|go:"GO:0035240"(dopamine binding)|go:"GO:0042053"(regulation of dopamine metabolic process)|go:"GO:0042596"(fear response)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|reactome:R-RNO-418594|reactome:R-RNO-390651|rgd:2522|dip:DIP-59866N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	-	2017/08/07	2017/08/10	rogid:Wq/dp2QYU3qvPFECl9JP7oSUGTE10116	rogid:wcVk4kjTciJQG2eLwHI7Wj0ttzw10116	rigid:WR7VPiR6m3bmgsTGZe7gtF61ySs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)