#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14788	uniprotkb:O00300	intact:EBI-7404021|intact:MINT-8247611|uniprotkb:Q96Q17|uniprotkb:Q9P2Q3|uniprotkb:O14723|ensembl:ENSP00000381775	intact:EBI-15481185|ensembl:ENSP00000297350|uniprotkb:B2R9A8|uniprotkb:O60236|uniprotkb:Q53FX6|uniprotkb:Q9UHP4	psi-mi:tnf11_human(display_long)|uniprotkb:TNFSF11(gene name)|psi-mi:TNFSF11(display_short)|uniprotkb:OPGL(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:RANKL(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)|uniprotkb:TRANCE(gene name synonym)	psi-mi:tr11b_human(display_long)|uniprotkb:OCIF(gene name synonym)|uniprotkb:OPG(gene name synonym)|uniprotkb:TNFRSF11B(gene name)|psi-mi:TNFRSF11B(display_short)|uniprotkb:Osteoclastogenesis inhibitory factor(gene name synonym)|uniprotkb:Osteoprotegerin(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Luan et al. (2012)	pubmed:22664871|imex:IM-25812	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15481533|wwpdb:3urf|imex:IM-25812-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533582.1|refseq:NP_143026.1|refseq:NP_003692.1|refseq:XP_016876292.1|ensembl:ENSG00000120659(gene)|ensembl:ENST00000398795(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0036035"(osteoclast development)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051466"(positive regulation of corticotropin-releasing hormone secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904616"(regulation of actin binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|rcsb pdb:3URF|rcsb pdb:5BNQ|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)	ensembl:ENSG00000164761(gene)|ensembl:ENST00000297350(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042489"(negative regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0043627"(response to estrogen)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046685"(response to arsenic-containing substance)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR017371(Tumour necrosis factor receptor superfamily member 11B)|interpro:IPR022323|rcsb pdb:3URF|reactome:R-HSA-5669034|go:"GO:0030198"(extracellular matrix organization)|refseq:NP_002537.3	-	comment:mint|comment:homomint	-	figure legend:Table 1|3d-resolution:2.7A|3d-r-factors:Rwork = 0.202  Rfree = 0.251|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/25	2017/07/10	rogid:ckHu030pHQr694G3Eyrl8HmHFqM9606	rogid:a/nQCb6uXfcHd5Q4cbaRlF3/shY9606	rigid:Gu25YxUU64efAkbgr1TiFRvypjo	false	sufficient binding region:162-317	sufficient binding region:22-186(IPR001368)|his tag:c-c	3	3	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14788	uniprotkb:O00300	intact:EBI-7404021|intact:MINT-8247611|uniprotkb:Q96Q17|uniprotkb:Q9P2Q3|uniprotkb:O14723|ensembl:ENSP00000381775	intact:EBI-15481185|ensembl:ENSP00000297350|uniprotkb:B2R9A8|uniprotkb:O60236|uniprotkb:Q53FX6|uniprotkb:Q9UHP4	psi-mi:tnf11_human(display_long)|uniprotkb:TNFSF11(gene name)|psi-mi:TNFSF11(display_short)|uniprotkb:OPGL(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:RANKL(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)|uniprotkb:TRANCE(gene name synonym)	psi-mi:tr11b_human(display_long)|uniprotkb:OCIF(gene name synonym)|uniprotkb:OPG(gene name synonym)|uniprotkb:TNFRSF11B(gene name)|psi-mi:TNFRSF11B(display_short)|uniprotkb:Osteoclastogenesis inhibitory factor(gene name synonym)|uniprotkb:Osteoprotegerin(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Luan et al. (2012)	pubmed:22664871|imex:IM-25812	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15481557|imex:IM-25812-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533582.1|refseq:NP_143026.1|refseq:NP_003692.1|refseq:XP_016876292.1|ensembl:ENSG00000120659(gene)|ensembl:ENST00000398795(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0036035"(osteoclast development)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051466"(positive regulation of corticotropin-releasing hormone secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904616"(regulation of actin binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|rcsb pdb:3URF|rcsb pdb:5BNQ|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)	ensembl:ENSG00000164761(gene)|ensembl:ENST00000297350(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042489"(negative regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0043627"(response to estrogen)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046685"(response to arsenic-containing substance)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR017371(Tumour necrosis factor receptor superfamily member 11B)|interpro:IPR022323|rcsb pdb:3URF|reactome:R-HSA-5669034|go:"GO:0030198"(extracellular matrix organization)|refseq:NP_002537.3	-	comment:mint|comment:homomint	-	figure legend:Figure 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.5x10^-10(molar)	2017/05/25	2017/07/10	rogid:ckHu030pHQr694G3Eyrl8HmHFqM9606	rogid:a/nQCb6uXfcHd5Q4cbaRlF3/shY9606	rigid:Gu25YxUU64efAkbgr1TiFRvypjo	false	sufficient binding region:162-317	sufficient binding region:22-186(IPR001368)|his tag:c-c|mutation with no effect:78-79|mutation decreasing interaction strength:116-116	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14788	uniprotkb:O00300	intact:EBI-7404021|intact:MINT-8247611|uniprotkb:Q96Q17|uniprotkb:Q9P2Q3|uniprotkb:O14723|ensembl:ENSP00000381775	intact:EBI-15481185|ensembl:ENSP00000297350|uniprotkb:B2R9A8|uniprotkb:O60236|uniprotkb:Q53FX6|uniprotkb:Q9UHP4	psi-mi:tnf11_human(display_long)|uniprotkb:TNFSF11(gene name)|psi-mi:TNFSF11(display_short)|uniprotkb:OPGL(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:RANKL(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)|uniprotkb:TRANCE(gene name synonym)	psi-mi:tr11b_human(display_long)|uniprotkb:OCIF(gene name synonym)|uniprotkb:OPG(gene name synonym)|uniprotkb:TNFRSF11B(gene name)|psi-mi:TNFRSF11B(display_short)|uniprotkb:Osteoclastogenesis inhibitory factor(gene name synonym)|uniprotkb:Osteoprotegerin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Luan et al. (2012)	pubmed:22664871|imex:IM-25812	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15481584|imex:IM-25812-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533582.1|refseq:NP_143026.1|refseq:NP_003692.1|refseq:XP_016876292.1|ensembl:ENSG00000120659(gene)|ensembl:ENST00000398795(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0036035"(osteoclast development)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051466"(positive regulation of corticotropin-releasing hormone secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904616"(regulation of actin binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|rcsb pdb:3URF|rcsb pdb:5BNQ|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)	ensembl:ENSG00000164761(gene)|ensembl:ENST00000297350(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042489"(negative regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0043627"(response to estrogen)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046685"(response to arsenic-containing substance)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR017371(Tumour necrosis factor receptor superfamily member 11B)|interpro:IPR022323|rcsb pdb:3URF|reactome:R-HSA-5669034|go:"GO:0030198"(extracellular matrix organization)|refseq:NP_002537.3	-	comment:mint|comment:homomint	-	figure legend:Figure 5C -LHS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/25	2017/07/10	rogid:ckHu030pHQr694G3Eyrl8HmHFqM9606	rogid:a/nQCb6uXfcHd5Q4cbaRlF3/shY9606	rigid:Gu25YxUU64efAkbgr1TiFRvypjo	false	sufficient binding region:162-317|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:223-223|mutation disrupting interaction strength:257-257|mutation decreasing interaction strength:241-241	sufficient binding region:22-186(IPR001368)|his tag:c-c	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:O14788	uniprotkb:Q9Y6Q6	intact:EBI-7404021|intact:MINT-8247611|uniprotkb:Q96Q17|uniprotkb:Q9P2Q3|uniprotkb:O14723|ensembl:ENSP00000381775	intact:EBI-525675|ensembl:ENSP00000465500|uniprotkb:I4EC39|uniprotkb:I4EC36|uniprotkb:I4EC38|uniprotkb:I7JE63|uniprotkb:N0GVH0|uniprotkb:Q59EP9	psi-mi:tnf11_human(display_long)|uniprotkb:TNFSF11(gene name)|psi-mi:TNFSF11(display_short)|uniprotkb:OPGL(gene name synonym)|uniprotkb:Osteoclast differentiation factor(gene name synonym)|uniprotkb:Osteoprotegerin ligand(gene name synonym)|uniprotkb:RANKL(gene name synonym)|uniprotkb:Receptor activator of nuclear factor kappa-B ligand(gene name synonym)|uniprotkb:TNF-related activation-induced cytokine(gene name synonym)|uniprotkb:TRANCE(gene name synonym)	psi-mi:tnr11_human(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:TNFRSF11A(gene name)|psi-mi:TNFRSF11A(display_short)|uniprotkb:RANK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Luan et al. (2012)	pubmed:22664871|imex:IM-25812	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-15481617|imex:IM-25812-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011533582.1|refseq:NP_143026.1|refseq:NP_003692.1|refseq:XP_016876292.1|ensembl:ENSG00000120659(gene)|ensembl:ENST00000398795(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002158"(osteoclast proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0036035"(osteoclast development)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044691"(tooth eruption)|go:"GO:0045453"(bone resorption)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051466"(positive regulation of corticotropin-releasing hormone secretion)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1904616"(regulation of actin binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR017355(Tumour necrosis factor ligand superfamily member, 10/11)|rcsb pdb:3URF|rcsb pdb:5BNQ|reactome:R-HSA-5668541|reactome:R-HSA-5669034|reactome:R-HSA-5676594|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)	refseq:NP_001257878.1|refseq:NP_001257879.1|refseq:NP_001265197.1|refseq:NP_003830.1|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|mint:Q9Y6Q6|rcsb pdb:1LB5|reactome:R-HSA-5668541|reactome:R-HSA-5676594|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|ensembl:ENSG00000141655(gene)|ensembl:ENST00000586569(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|refseq:NP_001257880.1	-	comment:mint|comment:homomint	-	figure legend:Figure 5C -RHS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/25	2017/07/10	rogid:ckHu030pHQr694G3Eyrl8HmHFqM9606	rogid:MfAijsRPOfdjCfKTkrV196sCZzw9606	rigid:EP9VTFpuUGi2Kj4e9LIa6vQGiPk	false	sufficient binding region:162-317|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:223-223|mutation disrupting interaction strength:257-257|mutation decreasing interaction strength:241-241	sufficient binding region:30-196(IPR034040)|his tag:c-c	1	1	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)