#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99JA0	uniprotkb:Q9JHR7	intact:EBI-15984908|ensembl:ENSMUSP00000032906	intact:EBI-15984868	psi-mi:calca_mouse(display_long)|uniprotkb:Calca(gene name)|psi-mi:Calca(display_short)|uniprotkb:Calc(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)	psi-mi:ide_mouse(display_long)|uniprotkb:Ide(gene name)|psi-mi:Ide(display_short)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Kim et al. (2012)	pubmed:22586115|doi:10.1073/pnas.1203195109|imex:IM-20670	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15984960|imex:IM-20670-1|dip:DIP-190286E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030669(gene)|ensembl:ENSMUST00000032906(transcript)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR015476(Calcitonin gene related peptide)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|refseq:NP_001029126.1|refseq:NP_001276373.1|refseq:XP_011239962.1|dip:DIP-60043N	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010815"(bradykinin catabolic process)|go:"GO:0010992"(ubiquitin recycling)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0019885"(antigen processing and presentation of endogenous peptide antigen via MHC class I)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0031626"(beta-endorphin binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042447"(hormone catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0043559"(insulin binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|reactome:R-MMU-5689880|reactome:R-MMU-9033241|dip:DIP-60044N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:7gRYRH3tS9dWeL8u6H2U2ZxDtxU10090	rogid:1bBj9xStEfEdIPg/V+W2eXmDeFU10090	rigid:0qEbuekKIflhnNQPNnXNvEEh7qE	false	sufficient binding region:83-119	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14735-1	uniprotkb:Q99JA0	intact:EBI-15607031|ensembl:ENSP00000265986	intact:EBI-15984908|ensembl:ENSMUSP00000032906	psi-mi:p14735-1(display_long)|uniprotkb:IDE(gene name)|psi-mi:IDE(display_short)|uniprotkb:Abeta-degrading protease(gene name synonym)|uniprotkb:Insulin protease(gene name synonym)|uniprotkb:Insulysin(gene name synonym)	psi-mi:calca_mouse(display_long)|uniprotkb:Calca(gene name)|psi-mi:Calca(display_short)|uniprotkb:Calc(gene name synonym)|uniprotkb:Alpha-type CGRP(gene name synonym)|uniprotkb:Calcitonin gene-related peptide I(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Kim et al. (2012)	pubmed:22586115|doi:10.1073/pnas.1203195109|imex:IM-20670	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15984979|imex:IM-20670-2|dip:DIP-190287E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2556886(isoform-parent)|ensembl:ENSG00000119912(gene)|ensembl:ENST00000265986(transcript)	ensembl:ENSMUSG00000030669(gene)|ensembl:ENSMUST00000032906(transcript)|go:"GO:0001976"(nervous system process involved in regulation of systemic arterial blood pressure)|go:"GO:0001984"(artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007631"(feeding behavior)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0009408"(response to heat)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0031716"(calcitonin receptor binding)|go:"GO:0042311"(vasodilation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048265"(response to pain)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001693(Calcitonin-like)|interpro:IPR015476(Calcitonin gene related peptide)|interpro:IPR018360|interpro:IPR021116|interpro:IPR021117|refseq:NP_001029126.1|refseq:NP_001276373.1|refseq:XP_011239962.1|dip:DIP-60043N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:dwngN3kUOExC5qapSgF01YhBNAM9606	rogid:7gRYRH3tS9dWeL8u6H2U2ZxDtxU10090	rigid:JmQVgTL/FehKvywgdsDmhgJiZNY	false	-	sufficient binding region:83-119	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)