#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q61088	uniprotkb:P62991	intact:EBI-7987880|intact:MINT-1779328|ensembl:ENSMUSP00000049852	intact:EBI-413074|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q62317|uniprotkb:Q64223|uniprotkb:Q8VCH1|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9CXY4|uniprotkb:Q9CZM0|uniprotkb:Q9D1R5|uniprotkb:Q9D8D9|uniprotkb:Q9ET23|uniprotkb:Q9ET24|uniprotkb:Q9Z0H9|dip:DIP-29742N	psi-mi:fzd4_mouse(display_long)|uniprotkb:Fzd4(gene name)|psi-mi:Fzd4(display_short)	psi-mi:ubiq_mouse(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982833|imex:IM-18053-2|dip:DIP-189686E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032081.3|dip:DIP-41623N|reactome:R-MMU-4608870|reactome:R-MMU-4641263|reactome:R-MMU-5099900|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-4086398|ensembl:ENSMUSG00000049791(gene)|ensembl:ENSMUST00000058755(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001553"(luteinization)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030947"(regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061301"(cerebellum vasculature morphogenesis)|go:"GO:0061304"(retinal blood vessel morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0110135"(Norrin signaling pathway)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026551|interpro:IPR036790|interpro:IPR041765|go:"GO:0035426"(extracellular matrix-cell signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042701"(progesterone secretion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)	interpro:IPR000626(Ubiquitin)|refseq:NP_001029037.1|refseq:NP_035794.1|refseq:NP_075626.1|refseq:NP_077239.1|refseq:XP_001481004.1|go:"GO:0005515"(protein binding)|ensembl:ENSMUSG00000019505|ensembl:ENSMUSG00000020460|ensembl:ENSMUSG00000058838|ensembl:ENSMUSG00000068240|ensembl:ENSMUSG00000055553|interpro:IPR019954|interpro:IPR019956|interpro:IPR019955|ensembl:ENSMUSG00000008348|go:"GO:0005634"(nucleus)|rcsb pdb:2ZNV|ipi:IPI00750889|refseq:XP_889611.1|rcsb pdb:3A1Q|rcsb pdb:3A9J|rcsb pdb:3A9K	psi-mi:"MI:0465"(dip)	comment:mint|function:Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:IMze54UHJy045NV/Gryg5DOH9xY10090	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10090	rigid:1gRXIAYpgC12M5g4khT1pnHNypY	false	myc tag:n-n	ha tag:0-0	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75581	uniprotkb:Q9ULT6	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982814|imex:IM-18053-1|dip:DIP-189688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:bKJ/uaUwilwYK57yTxdvqloLWc0	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9ULT6	uniprotkb:Q2MKA7	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982974|imex:IM-18053-9|dip:DIP-189691E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rigid:1uXPwHiVWDkH92g15LniA5hx+pE	false	myc tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9ULT6	uniprotkb:Q9BXB1	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	intact:EBI-10965764|uniprotkb:Q9NYD1|uniprotkb:Q8N537|uniprotkb:A6NCH3|uniprotkb:G5E9B3|ensembl:ENSP00000368516	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:lgr4_human(display_long)|uniprotkb:LGR4(gene name)|psi-mi:LGR4(display_short)|uniprotkb:G-protein coupled receptor 48(gene name synonym)|uniprotkb:GPR48(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982974|imex:IM-18053-9|dip:DIP-189691E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	refseq:NP_060960.2|refseq:NP_001333361.1|dip:DIP-59894N|ensembl:ENSG00000205213(gene)|ensembl:ENST00000379214(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0030282"(bone mineralization)|go:"GO:0030539"(male genitalia development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046849"(bone remodeling)|go:"GO:0048565"(digestive tract development)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0072202"(cell differentiation involved in metanephros development)|go:"GO:0072224"(metanephric glomerulus development)|go:"GO:0072282"(metanephric nephron tubule morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR032675|rcsb pdb:4KT1|rcsb pdb:4QXE|rcsb pdb:4QXF|reactome:R-HSA-4641263	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rogid:DdjBg8b15PTB1xY4ZS+F0s0woo49606	rigid:1uXPwHiVWDkH92g15LniA5hx+pE	false	myc tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60353	uniprotkb:Q9ULT6	intact:EBI-8754490|uniprotkb:B4DRN0|uniprotkb:Q6N0A5|uniprotkb:Q6P9C3|uniprotkb:Q8WXR9|ensembl:ENSP00000351605|ensembl:ENSP00000429055	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:fzd6_human(display_long)|uniprotkb:FZD6(gene name)|psi-mi:FZD6(display_short)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982915|imex:IM-18053-6|dip:DIP-189689E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304725.1|refseq:NP_001158087.1|refseq:NP_001158088.1|refseq:NP_003497.2|ensembl:ENSG00000164930(gene)|ensembl:ENST00000358755(transcript)|ensembl:ENST00000522566(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001942"(hair follicle development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904693"(midbrain morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026543|interpro:IPR036790|interpro:IPR041770|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4086400|reactome:R-HSA-4641263|reactome:R-HSA-5340588|dip:DIP-59893N	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:vBccj/vFYRExa+isZOvQLQXm4409606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:p2hSjX8U9czfFW8DRhBFY3qJeA8	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61091	uniprotkb:Q9ULT6	intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982934|imex:IM-18053-7|dip:DIP-189687E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:v8Mm8hv2lwgITm6DEpUUMNdTK78	false	myc tag:n-n	ha tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O60353	uniprotkb:Q9ULT6	intact:EBI-8754490|uniprotkb:B4DRN0|uniprotkb:Q6N0A5|uniprotkb:Q6P9C3|uniprotkb:Q8WXR9|ensembl:ENSP00000351605|ensembl:ENSP00000429055	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:fzd6_human(display_long)|uniprotkb:FZD6(gene name)|psi-mi:FZD6(display_short)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982955|imex:IM-18053-8|dip:DIP-189689E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001304725.1|refseq:NP_001158087.1|refseq:NP_001158088.1|refseq:NP_003497.2|ensembl:ENSG00000164930(gene)|ensembl:ENST00000358755(transcript)|ensembl:ENST00000522566(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001942"(hair follicle development)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035880"(embryonic nail plate morphogenesis)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0048105"(establishment of body hair planar orientation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904693"(midbrain morphogenesis)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR026543|interpro:IPR036790|interpro:IPR041770|reactome:R-HSA-373080|reactome:R-HSA-4086398|reactome:R-HSA-4086400|reactome:R-HSA-4641263|reactome:R-HSA-5340588|dip:DIP-59893N	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:vBccj/vFYRExa+isZOvQLQXm4409606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:p2hSjX8U9czfFW8DRhBFY3qJeA8	false	-	ha tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P27467	uniprotkb:Q61091	intact:EBI-2899665|ensembl:ENSMUSP00000010044	intact:EBI-6171689|ensembl:ENSMUSP00000039660|uniprotkb:A2RTK9	psi-mi:wnt3a_mouse(display_long)|uniprotkb:Wnt3a(gene name)|psi-mi:Wnt3a(display_short)|uniprotkb:Wnt-3a(gene name synonym)	psi-mi:fzd8_mouse(display_long)|uniprotkb:Fzd8(gene name)|psi-mi:Fzd8(display_short)	psi-mi:"MI:0096"(pull down)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982873|imex:IM-18053-4|dip:DIP-189693E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000009900(gene)|ensembl:ENSMUST00000010044(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021846"(cell proliferation in forebrain)|go:"GO:0021874"(Wnt signaling pathway involved in forebrain neuroblast division)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0022008"(neurogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003136"(negative regulation of heart induction by canonical Wnt signaling pathway)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030168"(platelet activation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030879"(mammary gland development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0030901"(midbrain development)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033278"(cell proliferation in midbrain)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048337"(positive regulation of mesodermal cell fate specification)|go:"GO:0048343"(paraxial mesodermal cell fate commitment)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048697"(positive regulation of collateral sprouting in absence of injury)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060923"(cardiac muscle cell fate commitment)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0061184"(positive regulation of dermatome development)|go:"GO:0061317"(canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment)|go:"GO:0062009"(secondary palate development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090676"(calcium ion transmembrane transport via low voltage-gated calcium channel)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904339"(negative regulation of dopaminergic neuron differentiation)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000081"(positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-MMU-201681|reactome:R-MMU-3238698|reactome:R-MMU-4641262|reactome:R-MMU-4641263|go:"GO:1901215"(negative regulation of neuron death)|refseq:NP_033548.1|dip:DIP-55954N	ensembl:ENSMUSG00000036904(gene)|ensembl:ENSMUST00000041080(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR017981|interpro:IPR020067|interpro:IPR036790|interpro:IPR041776|rcsb pdb:1IJY|rcsb pdb:4F0A|rcsb pdb:6TFB|rcsb pdb:6TFM|reactome:R-MMU-4608870|reactome:R-MMU-4641263|rcsb pdb:6AHY|refseq:NP_032084.2|dip:DIP-41258N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:8qMbzAMqZA12Q/4DcX5Qea3CdSQ10090	rogid:CBc7b1GULb5YzydnpCYV4uXaTmo10090	rigid:rlLSjl+uA/oCbUAeuMPtXdmf6wc	false	-	fc-igg tag:c-c|sufficient binding region:30-151	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75581	uniprotkb:Q9ULT6	intact:EBI-910915|ensembl:ENSP00000261349|ensembl:ENSP00000486315|uniprotkb:Q17RZ2	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:lrp6_human(display_long)|uniprotkb:LRP6(gene name)|psi-mi:LRP6(display_short)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982854|imex:IM-18053-3|dip:DIP-189688E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0014029"(neural crest formation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|ensembl:ENSG00000070018(gene)|ensembl:ENSG00000281324(gene)|ensembl:ENST00000261349(transcript)|ensembl:ENST00000628182(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0019210"(kinase inhibitor activity)|go:"GO:0019534"(toxin transmembrane transporter activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0021794"(thalamus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030901"(midbrain development)|go:"GO:0030917"(midbrain-hindbrain boundary development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0060535"(trachea cartilage morphogenesis)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044335"(canonical Wnt signaling pathway involved in neural crest cell differentiation)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0071936"(coreceptor activity involved in Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046849"(bone remodeling)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060026"(convergent extension)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060349"(bone morphogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090244"(Wnt signaling pathway involved in somitogenesis)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904928"(coreceptor activity involved in canonical Wnt signaling pathway)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904953"(Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990851"(Wnt-Frizzled-LRP5/6 complex)|go:"GO:1990909"(Wnt signalosome)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR017049(Low density lipoprotein receptor-related protein, 5/6)|interpro:IPR023415|interpro:IPR036055|mint:O75581|rcsb pdb:3S2K|rcsb pdb:3S8V|refseq:XP_006719141.1|refseq:NP_002327.2|dip:DIP-29884N|rcsb pdb:3S8Z|rcsb pdb:3S94|rcsb pdb:3SOB|rcsb pdb:3SOQ|rcsb pdb:3SOV|rcsb pdb:4A0P|rcsb pdb:4DG6|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:5AIR|rcsb pdb:5FWW|rcsb pdb:5GJE|rcsb pdb:6H15|rcsb pdb:6H16|rcsb pdb:6L6R|reactome:R-HSA-201681|reactome:R-HSA-3772470|reactome:R-HSA-4641262|reactome:R-HSA-4641263|reactome:R-HSA-5340588	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:MCGyqWGRjE0XbT9NW2U5OZGX2as9606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:bKJ/uaUwilwYK57yTxdvqloLWc0	false	-	ha tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BXB1	uniprotkb:Q9ULT6	intact:EBI-10965764|uniprotkb:Q9NYD1|uniprotkb:Q8N537|uniprotkb:A6NCH3|uniprotkb:G5E9B3|ensembl:ENSP00000368516	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:lgr4_human(display_long)|uniprotkb:LGR4(gene name)|psi-mi:LGR4(display_short)|uniprotkb:G-protein coupled receptor 48(gene name synonym)|uniprotkb:GPR48(gene name synonym)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982894|imex:IM-18053-5|dip:DIP-189692E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060960.2|refseq:NP_001333361.1|dip:DIP-59894N|ensembl:ENSG00000205213(gene)|ensembl:ENST00000379214(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001942"(hair follicle development)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008528"(G protein-coupled peptide receptor activity)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0016500"(protein-hormone receptor activity)|go:"GO:0030282"(bone mineralization)|go:"GO:0030539"(male genitalia development)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0036335"(intestinal stem cell homeostasis)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046849"(bone remodeling)|go:"GO:0048565"(digestive tract development)|go:"GO:0061290"(canonical Wnt signaling pathway involved in metanephric kidney development)|go:"GO:0072202"(cell differentiation involved in metanephros development)|go:"GO:0072224"(metanephric glomerulus development)|go:"GO:0072282"(metanephric nephron tubule morphogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2001013"(epithelial cell proliferation involved in renal tubule morphogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR002131(Glycoprotein hormone receptor)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR032675|rcsb pdb:4KT1|rcsb pdb:4QXE|rcsb pdb:4QXF|reactome:R-HSA-4641263	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:DdjBg8b15PTB1xY4ZS+F0s0woo49606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:+zUEMDwaw7yxtwzfeY3L96lXMwE	false	ha tag:c-c	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q2MKA7	uniprotkb:Q9ULT6	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982998|imex:IM-18053-10|dip:DIP-189690E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:yG/hCC7kXBiN+dRiOaC09tWRavo	false	green fluorescent protein tag:c-c	sufficient binding region:1-256|mutation disrupting interaction strength:103-103|fc-igg tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q2MKA7	uniprotkb:Q9ULT6	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hao et al. (2012)	pubmed:22575959|doi:10.1038/nature11019|imex:IM-18053	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15983024|imex:IM-18053-11|dip:DIP-189690E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rigid:yG/hCC7kXBiN+dRiOaC09tWRavo	false	green fluorescent protein tag:c-c	myc tag:n-n|mutation disrupting interaction strength:103-103	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)