#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53420	chembl target:CHEMBL1907598	intact:EBI-2432581|uniprotkb:A8MTZ1|uniprotkb:Q53RW9|uniprotkb:Q53S42|uniprotkb:Q53WR1|ensembl:ENSP00000379866	intact:EBI-2550735|reactome:R-HSA-210216|matrixdb:MULT_16_human|wwpdb:3ije|wwpdb:4g1e|wwpdb:1U8C|wwpdb:1jv2|wwpdb:1m1x|wwpdb:4g1m|signor:SIGNOR-C177	psi-mi:co4a4_human(display_long)|uniprotkb:COL4A4(gene name)|psi-mi:COL4A4(display_short)	psi-mi:intg_av_b3_human(display_short)|psi-mi:CHEMBL1907598(display_long)|intact:alphav-beta3 integrin complex(complex synonym)|intact:alpha-v/beta-3 integrin complex(complex synonym)|intact:Integrin alphav-beta3 complex(complex recommended name)|intact:"ITGAV:ITGB3"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Brassart-Pasco et al. (2011)	pubmed:22539938|imex:IM-25769	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0917"(matrixdb)	intact:EBI-15099973|imex:IM-25769-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	refseq:NP_000083.3|refseq:XP_005246338.1|reactome:R-HSA-2022090|reactome:R-HSA-216083|reactome:R-HSA-2214320|reactome:R-HSA-2243919|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-419037|reactome:R-HSA-8948216|ensembl:ENSG00000081052(gene)|ensembl:ENST00000396625(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005587"(collagen type IV trimer)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032836"(glomerular basement membrane development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR016187(C-type lectin fold)|interpro:IPR036954|mint:P53420|rcsb pdb:5NB1|rcsb pdb:6WKU|reactome:R-HSA-1442490|reactome:R-HSA-1474244|reactome:R-HSA-1650814|reactome:R-HSA-186797	go:"GO:0034683"(integrin alphav-beta3 complex)|pubmed:19693543(see-also)|pubmed:12297042(see-also)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|intact:EBI-1039821(exp-evidence)|complex portal:CPX-1795(complex-primary)|evidence ontology:"ECO:0000353"	-	-	curated-complex:Cell adhesion, bi-directional signaling receptor which functions as a link between the extra-cellular matrix and the cytoskeleton. Receptor for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor which its binds via the sequence R-G-D in the ligand.|complex-properties:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. The ligand-binding site forms in a region at the intersection of the integrin alpha-chain beta-propeller and the betaI domain, with the alpha chain being central in determining ligand specificity.|complex-assembly:Heterodimer	figure legend:Fig 7C|comment:"The NC1 a4(IV) domain bound to the  immobilized avb3 integrin and formed a stable complex that was dissociated upon addition of 10 mM EDTA, demonstrating that the binding was dependent upon divalent cations"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:148.0x10^-9 ~9.54(molar)	2017/06/09	2017/06/09	rogid:33OBK6m4LBya+l/OQQ1JYlvFx109606	-	-	false	his tag:n-n|sufficient binding region:1458-1690	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)