#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70206	uniprotkb:Q99NH8	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982070|imex:IM-18055-1|dip:DIP-189698E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	rigid:15kaPYDCPe3N3mdNPm+7gIaOKzk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70206	uniprotkb:O54885	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	intact:EBI-15687058|ensembl:ENSMUSP00000032800|uniprotkb:O88603	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:tyobp_mouse(display_long)|uniprotkb:Tyrobp(gene name)|psi-mi:Tyrobp(display_short)|uniprotkb:Dap12(gene name synonym)|uniprotkb:Karap(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982070|imex:IM-18055-1|dip:DIP-189698E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	ensembl:ENSMUSG00000030579(gene)|ensembl:ENSMUST00000032800(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001204"(regulation of osteoclast development)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-391160|reactome:R-MMU-416700|reactome:R-MMU-6798695|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|refseq:NP_035792.1|dip:DIP-29746N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rogid:Bkz67c2d2L0IQ2pEFgplF4bw/9M10090	rigid:15kaPYDCPe3N3mdNPm+7gIaOKzk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70206	uniprotkb:P97333	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982070|imex:IM-18055-1|dip:DIP-189698E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rigid:15kaPYDCPe3N3mdNPm+7gIaOKzk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70206	uniprotkb:Q99NH8	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982089|imex:IM-18055-2|dip:DIP-189699E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	rigid:Qkv76ob5hTa8YZD93w3DeNX0AHY	false	flag tag:c-c	v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P70206	uniprotkb:P97333	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982089|imex:IM-18055-2|dip:DIP-189699E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rigid:Qkv76ob5hTa8YZD93w3DeNX0AHY	false	flag tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97333	uniprotkb:P70206	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982111|imex:IM-18055-3|dip:DIP-189701E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rigid:iDYf8Js/rr1MG1MAwCVENmdmSoM	false	-	flag tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70206	uniprotkb:Q99NH8	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982130|imex:IM-18055-4|dip:DIP-189699E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	rigid:Qkv76ob5hTa8YZD93w3DeNX0AHY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70206	uniprotkb:P97333	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982130|imex:IM-18055-4|dip:DIP-189699E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rigid:Qkv76ob5hTa8YZD93w3DeNX0AHY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99NH8	uniprotkb:P70206	intact:EBI-15982016|ensembl:ENSMUSP00000024791|uniprotkb:Q8CGK4|uniprotkb:Q8CIA6|uniprotkb:Q99NH9|uniprotkb:Q9JL34	intact:EBI-771260|uniprotkb:Q5DTR0|uniprotkb:B2RQP7|ensembl:ENSMUSP00000063066|ensembl:ENSMUSP00000131840	psi-mi:trem2_mouse(display_long)|uniprotkb:Trem2(gene name)|psi-mi:Trem2(display_short)|uniprotkb:Trem2a(gene name synonym)|uniprotkb:Trem2b(gene name synonym)|uniprotkb:Trem2c(gene name synonym)|uniprotkb:Triggering receptor expressed on monocytes 2(gene name synonym)	psi-mi:plxa1_mouse(display_long)|uniprotkb:Plxna1(gene name)|psi-mi:Plxna1(display_short)|uniprotkb:Kiaa4053(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hayashi et al. (2012)	pubmed:22522930|doi:10.1038/nature11000|imex:IM-18055	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15982148|imex:IM-18055-5|dip:DIP-189700E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000023992(gene)|ensembl:ENSMUST00000024791(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0002931"(response to ischemia)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007613"(memory)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010822"(positive regulation of mitochondrion organization)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0010891"(negative regulation of sequestering of triglyceride)|go:"GO:0010983"(positive regulation of high-density lipoprotein particle clearance)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019209"(kinase activator activity)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032499"(detection of peptidoglycan)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034151"(regulation of toll-like receptor 6 signaling pathway)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0050866"(negative regulation of cell activation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070269"(pyroptosis)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035176"(social behavior)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045728"(respiratory burst after phagocytosis)|go:"GO:0045960"(positive regulation of complement activation, classical pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048678"(response to axon injury)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0070345"(negative regulation of fat cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070392"(detection of lipoteichoic acid)|go:"GO:0070891"(lipoteichoic acid binding)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071640"(regulation of macrophage inflammatory protein 1 alpha production)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098657"(import into cell)|go:"GO:0110089"(regulation of hippocampal neuron apoptotic process)|go:"GO:0120035"(regulation of plasma membrane bounded cell projection organization)|go:"GO:0120146"(sulfatide binding)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:0150062"(complement-mediated synapse pruning)|go:"GO:0150076"(neuroinflammatory response)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900226"(negative regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901076"(positive regulation of engulfment of apoptotic cell)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1901980"(positive regulation of inward rectifier potassium channel activity)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902531"(regulation of intracellular signal transduction)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903082"(positive regulation of C-C chemokine receptor CCR7 signaling pathway)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:1904093"(negative regulation of autophagic cell death)|go:"GO:1904141"(positive regulation of microglial cell migration)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904951"(positive regulation of establishment of protein localization)|go:"GO:1905291"(positive regulation of CAMKK-AMPK signaling cascade)|go:"GO:1905581"(positive regulation of low-density lipoprotein particle clearance)|go:"GO:1905805"(excitatory synapse pruning)|go:"GO:1905808"(positive regulation of synapse pruning)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000350"(positive regulation of CD40 signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-MMU-198933|reactome:R-MMU-2172127|reactome:R-MMU-2424491|reactome:R-MMU-416700|refseq:NP_001259007.1|refseq:NP_112544.1|dip:DIP-59896N	refseq:NP_032907.1|dip:DIP-29745N|go:"GO:0016020"(membrane)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0097485"(neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1990138"(neuron projection extension)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR013548(Plexin cytoplasmic region)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016201(Plexin-like fold)|interpro:IPR031148|interpro:IPR036352|interpro:IPR041019|interpro:IPR041362|interpro:IPR042744|mint:P70206|rcsb pdb:3RYT|rcsb pdb:5L56|rcsb pdb:5L59|rcsb pdb:5L5C|rcsb pdb:5L7N|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-416700|reactome:R-MMU-9696273|ensembl:ENSMUSG00000030084(gene)|ensembl:ENSMUST00000049845(transcript)|ensembl:ENSMUST00000163139(transcript)|go:"GO:0002116"(semaphorin receptor complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014910"(regulation of smooth muscle cell migration)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:GryhnogotbUPy3+Xd/ty/3ibKZ010090	rogid:AgCACazq+fYBgTGYIAKk2hRbPEw10090	rigid:Jhub/aQK5aU6WuFtaw3k9k4y1a4	false	v5 tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)