#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3U182	uniprotkb:P29994-1	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-15683709	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:p29994-1(display_long)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:SISIIABC(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2012)	pubmed:22495310|doi:10.1038/nature10988|imex:IM-18054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15980711|imex:IM-18054-1|dip:DIP-189694E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	intact:EBI-8614640(isoform-parent)	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:L1I4Symxn2ABLg8esgd/caebF5810116	rigid:k01W1WmxzfksEmTuuFbWoK7qXn0	false	flag tag:n-n|sufficient binding region:1-240|necessary binding region:1-50	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3U182	uniprotkb:P29994-1	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-15683709	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:p29994-1(display_long)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:SISIIABC(isoform synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2012)	pubmed:22495310|doi:10.1038/nature10988|imex:IM-18054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15980762|imex:IM-18054-3|dip:DIP-189694E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	intact:EBI-8614640(isoform-parent)	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:L1I4Symxn2ABLg8esgd/caebF5810116	rigid:k01W1WmxzfksEmTuuFbWoK7qXn0	false	ha tag:n-n	flag tag:n-n|sufficient binding region:1-2274	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3U182	uniprotkb:P11881	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-541478|uniprotkb:P20943|uniprotkb:Q99LG5|ensembl:ENSMUSP00000032192	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:itpr1_mouse(display_long)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate-binding protein P400(gene name synonym)|uniprotkb:Purkinje cell protein 1(gene name synonym)|uniprotkb:Protein PCD-6(gene name synonym)|uniprotkb:Itpr1(gene name)|psi-mi:Itpr1(display_short)|uniprotkb:Insp3r(gene name synonym)|uniprotkb:Pcd6(gene name synonym)|uniprotkb:Pcp1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	pubmed:22495310|doi:10.1038/nature10988|imex:IM-18054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15980785|imex:IM-18054-4|dip:DIP-189696E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	refseq:NP_034715.3|refseq:XP_006505693.1|refseq:XP_006505699.1|refseq:XP_006505700.1|dip:DIP-32243N|refseq:XP_017176897.1|refseq:XP_017176899.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0098794"(postsynapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|mint:P11881|rcsb pdb:1N4K|rcsb pdb:1XZZ|rcsb pdb:5GUG|rcsb pdb:5X9Z|rcsb pdb:5XA0|rcsb pdb:5XA1|reactome:R-MMU-114508|reactome:R-MMU-139853|reactome:R-MMU-381676|reactome:R-MMU-418457|reactome:R-MMU-5578775|reactome:R-MMU-983695|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097421"(liver regeneration)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|go:"GO:0098793"(presynapse)|ensembl:ENSMUSG00000030102(gene)|ensembl:ENSMUST00000032192(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:O+LA4/Acwos+RNtyqL3IgAe/kkk10090	rigid:O9OXmfcOpmih5c4iDT/VphmyLtA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U182	uniprotkb:P63328	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2012)	pubmed:22495310|doi:10.1038/nature10988|imex:IM-18054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15980802|imex:IM-18054-5|dip:DIP-189695E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	comment:Deletion of region 249-258 decreased the interaction rate/strength.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	rigid:G/iuNFw5RvQ0ygbKuQwdNPYpvUA	false	flag tag:n-n|mutation decreasing interaction strength:619-619,618-618,616-616,614-614|sufficient binding region:180-692|mutation disrupting interaction strength:618-619,616-616,614-614,249-258	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3U182	uniprotkb:P63328	intact:EBI-8018890|uniprotkb:Q8BH09|intact:UNK-5915295|uniprotkb:Q3TA52|ensembl:ENSMUSP00000029545	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:crtc2_mouse(display_long)|uniprotkb:Torc2(gene name synonym)|uniprotkb:Crtc2(gene name)|psi-mi:Crtc2(display_short)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Wang et al. (2012)	pubmed:22495310|doi:10.1038/nature10988|imex:IM-18054	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15980736|imex:IM-18054-2|dip:DIP-189695E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083157.1|dip:DIP-46162N|ensembl:ENSMUSG00000027936(gene)|ensembl:ENSMUST00000029545(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|rcsb pdb:5ZK1|rcsb pdb:5ZKO	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	psi-mi:"MI:0465"(dip)	function:"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells"|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:z8OUduQtKaV/y3vfRQjySLCKopg10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	rigid:G/iuNFw5RvQ0ygbKuQwdNPYpvUA	false	flag tag:n-n|mutation disrupting interaction strength:618-619,616-616,614-614,249-258	ha tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q14643	uniprotkb:Q53ET0	intact:EBI-465548|ensembl:ENSP00000497605|uniprotkb:Q14660|uniprotkb:Q99897|uniprotkb:E7EPX7|uniprotkb:E9PDE9	intact:EBI-1181987|uniprotkb:Q7Z3X7|uniprotkb:Q6UUV8|uniprotkb:Q8N332|ensembl:ENSP00000357622	psi-mi:itpr1_human(display_long)|uniprotkb:ITPR1(gene name)|psi-mi:ITPR1(display_short)|uniprotkb:INSP3R1(gene name synonym)|uniprotkb:Type 1 inositol 1,4,5-trisphosphate receptor(gene name synonym)|uniprotkb:IP3 receptor isoform 1(gene name synonym)	psi-mi:crtc2_human(display_long)|uniprotkb:TORC2(gene name synonym)|uniprotkb:Transducer of regulated cAMP response element-binding protein 2(gene name synonym)|uniprotkb:CRTC2(gene name)|psi-mi:CRTC2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Wang et al. (2012)	pubmed:22495310|doi:10.1038/nature10988|imex:IM-18054	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15980837|imex:IM-18054-6|dip:DIP-189697E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000150995(gene)|ensembl:ENST00000649015(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050849"(negative regulation of calcium-mediated signaling)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|go:"GO:0098695"(inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels)|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-418457|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_001093422.2|refseq:NP_002213.5|refseq:XP_011531985.1|dip:DIP-29714N|refseq:NP_001161744.1	refseq:NP_859066.1|ensembl:ENSP00000357622|ensembl:ENSG00000160741(gene)|ensembl:ENST00000368633(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043970"(histone H3-K9 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|interpro:IPR024783|interpro:IPR024784|interpro:IPR024785|interpro:IPR024786|mint:Q53ET0|rcsb pdb:4HTM|reactome:R-HSA-2151201|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-29950N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:54BRt783vU5D9fCHNO5uFJy1N7I9606	rogid:p/QkUoueS1+KCLb0il8SMt8JwQM9606	rigid:0+KBumB0RO9xcC9OEfzWnjtSES8	false	-	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)