#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9NPH3	uniprotkb:P01584	intact:EBI-525939|uniprotkb:O14915|uniprotkb:Q86WJ7|uniprotkb:B1NLD0|uniprotkb:D3DNW0|ensembl:ENSP00000072516|ensembl:ENSP00000390541|ensembl:ENSP00000401132|ensembl:ENSP00000412053	intact:EBI-1026290|uniprotkb:Q7RU01|uniprotkb:Q96HE5|uniprotkb:Q9UCT6|uniprotkb:Q53X59|uniprotkb:Q53XX2|uniprotkb:Q7M4S7|ensembl:ENSP00000263341	psi-mi:il1ap_human(display_long)|uniprotkb:IL1RAP(gene name)|psi-mi:IL1RAP(display_short)|uniprotkb:C3orf13(gene name synonym)|uniprotkb:IL1R3(gene name synonym)|uniprotkb:Interleukin-1 receptor 3(gene name synonym)	psi-mi:il1b_human(display_long)|uniprotkb:IL1B(gene name)|psi-mi:IL1B(display_short)|uniprotkb:IL1F2(gene name synonym)|uniprotkb:Catabolin(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Thomas et al. (2012)	pubmed:22426547|doi:10.1038/nsmb.2260|imex:IM-18094	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15975086|imex:IM-18094-1|dip:DIP-189820E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161400.1|refseq:NP_001161401.1|refseq:NP_001161402.1|refseq:NP_001161403.1|refseq:NP_002173.1|refseq:NP_608273.1|dip:DIP-33487N|ensembl:ENSG00000196083(gene)|ensembl:ENST00000072516(transcript)|ensembl:ENST00000412504(transcript)|ensembl:ENST00000439062(transcript)|ensembl:ENST00000447382(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|rcsb pdb:4DEP|reactome:R-HSA-1257604|reactome:R-HSA-388844|reactome:R-HSA-6811558|reactome:R-HSA-9014826|reactome:R-HSA-9014843|reactome:R-HSA-9020702	refseq:NP_000567.1|rcsb pdb:5R8O|rcsb pdb:5R8P|rcsb pdb:5R8Q|rcsb pdb:6I1B|rcsb pdb:6Y8I|rcsb pdb:6Y8M|rcsb pdb:7CHY|rcsb pdb:7CHZ|rcsb pdb:7I1B|rcsb pdb:9ILB|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5660668|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020702|reactome:R-HSA-9660826|ensembl:ENSG00000125538(gene)|ensembl:ENST00000263341(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001660"(fever generation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002711"(positive regulation of T cell mediated immunity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014805"(smooth muscle adaptation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035505"(positive regulation of myosin light chain kinase activity)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0070164"(negative regulation of adiponectin secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|rcsb pdb:1I1B|rcsb pdb:1IOB|rcsb pdb:1ITB|rcsb pdb:1L2H|rcsb pdb:1S0L|rcsb pdb:1T4Q|rcsb pdb:1TOO|rcsb pdb:1TP0|rcsb pdb:1TWE|rcsb pdb:1TWM|rcsb pdb:21BI|rcsb pdb:2I1B|rcsb pdb:2KH2|rcsb pdb:2NVH|rcsb pdb:31BI|rcsb pdb:3LTQ|rcsb pdb:3O4O|rcsb pdb:3POK|rcsb pdb:41BI|rcsb pdb:4DEP|rcsb pdb:4G6J|rcsb pdb:4G6M|rcsb pdb:4GAF|rcsb pdb:4GAI|rcsb pdb:4I1B|rcsb pdb:5BVP|rcsb pdb:5I1B|rcsb pdb:5MVZ|rcsb pdb:5R7W|rcsb pdb:5R85|rcsb pdb:5R86|rcsb pdb:5R87|rcsb pdb:5R88|rcsb pdb:5R89|rcsb pdb:5R8A|rcsb pdb:5R8B|rcsb pdb:5R8C|rcsb pdb:5R8D|rcsb pdb:5R8E|rcsb pdb:5R8F|rcsb pdb:5R8G|rcsb pdb:5R8H|rcsb pdb:5R8I|rcsb pdb:5R8J|rcsb pdb:5R8K|rcsb pdb:5R8L|rcsb pdb:5R8M|rcsb pdb:5R8N|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902680"(positive regulation of RNA biosynthetic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903597"(negative regulation of gap junction assembly)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|interpro:IPR003296(Interleukin-1, beta IL1B)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:1HIB|dip:DIP-474N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:G3A02KnaI98Ea4SzAFjUvCCnfnM9606	rogid:riBBjazKZOBrwdqj7YxrGiJtJAg9606	rigid:UTzq6pD8UKOASX5kbolSScbVvnY	false	sufficient binding region:21-350	sufficient binding region:117-269	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPH3	uniprotkb:P14778	intact:EBI-525939|uniprotkb:O14915|uniprotkb:Q86WJ7|uniprotkb:B1NLD0|uniprotkb:D3DNW0|ensembl:ENSP00000072516|ensembl:ENSP00000390541|ensembl:ENSP00000401132|ensembl:ENSP00000412053	intact:EBI-525905|uniprotkb:Q587I7|ensembl:ENSP00000386380	psi-mi:il1ap_human(display_long)|uniprotkb:IL1RAP(gene name)|psi-mi:IL1RAP(display_short)|uniprotkb:C3orf13(gene name synonym)|uniprotkb:IL1R3(gene name synonym)|uniprotkb:Interleukin-1 receptor 3(gene name synonym)	psi-mi:il1r1_human(display_long)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:IL1RT1(gene name synonym)|uniprotkb:IL1R1(gene name)|psi-mi:IL1R1(display_short)|uniprotkb:IL1R(gene name synonym)|uniprotkb:IL1RA(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Thomas et al. (2012)	pubmed:22426547|doi:10.1038/nsmb.2260|imex:IM-18094	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15975086|imex:IM-18094-1|dip:DIP-189820E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161400.1|refseq:NP_001161401.1|refseq:NP_001161402.1|refseq:NP_001161403.1|refseq:NP_002173.1|refseq:NP_608273.1|dip:DIP-33487N|ensembl:ENSG00000196083(gene)|ensembl:ENST00000072516(transcript)|ensembl:ENST00000412504(transcript)|ensembl:ENST00000439062(transcript)|ensembl:ENST00000447382(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|rcsb pdb:4DEP|reactome:R-HSA-1257604|reactome:R-HSA-388844|reactome:R-HSA-6811558|reactome:R-HSA-9014826|reactome:R-HSA-9014843|reactome:R-HSA-9020702	refseq:NP_000868.1|refseq:XP_005263987.1|refseq:XP_005263991.1|refseq:NP_001275635.1|refseq:XP_011509417.1|refseq:XP_011509418.1|refseq:XP_011509419.1|refseq:XP_011509420.1|ensembl:ENSG00000115594(gene)|ensembl:ENST00000410023(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1G0Y|rcsb pdb:1IRA|rcsb pdb:1ITB|rcsb pdb:4DEP|rcsb pdb:4GAF|reactome:R-HSA-6783783|reactome:R-HSA-9020702|reactome:R-HSA-9679191|dip:DIP-93N|refseq:NP_001307907.1|refseq:NP_001307909.1|refseq:NP_001307910.1|refseq:NP_001307911.1|refseq:NP_001307912.1|refseq:NP_001307913.1|refseq:NP_001307914.1|refseq:XP_016859478.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:G3A02KnaI98Ea4SzAFjUvCCnfnM9606	rogid:2qxcax5pAtmXBQudsAOyK1V2/Oo9606	rigid:UTzq6pD8UKOASX5kbolSScbVvnY	false	sufficient binding region:21-350	sufficient binding region:18-330	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPH3	uniprotkb:P01584	intact:EBI-525939|uniprotkb:O14915|uniprotkb:Q86WJ7|uniprotkb:B1NLD0|uniprotkb:D3DNW0|ensembl:ENSP00000072516|ensembl:ENSP00000390541|ensembl:ENSP00000401132|ensembl:ENSP00000412053	intact:EBI-1026290|uniprotkb:Q7RU01|uniprotkb:Q96HE5|uniprotkb:Q9UCT6|uniprotkb:Q53X59|uniprotkb:Q53XX2|uniprotkb:Q7M4S7|ensembl:ENSP00000263341	psi-mi:il1ap_human(display_long)|uniprotkb:IL1RAP(gene name)|psi-mi:IL1RAP(display_short)|uniprotkb:C3orf13(gene name synonym)|uniprotkb:IL1R3(gene name synonym)|uniprotkb:Interleukin-1 receptor 3(gene name synonym)	psi-mi:il1b_human(display_long)|uniprotkb:IL1B(gene name)|psi-mi:IL1B(display_short)|uniprotkb:IL1F2(gene name synonym)|uniprotkb:Catabolin(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Thomas et al. (2012)	pubmed:22426547|doi:10.1038/nsmb.2260|imex:IM-18094	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15975111|imex:IM-18094-2|dip:DIP-189820E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161400.1|refseq:NP_001161401.1|refseq:NP_001161402.1|refseq:NP_001161403.1|refseq:NP_002173.1|refseq:NP_608273.1|dip:DIP-33487N|ensembl:ENSG00000196083(gene)|ensembl:ENST00000072516(transcript)|ensembl:ENST00000412504(transcript)|ensembl:ENST00000439062(transcript)|ensembl:ENST00000447382(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|rcsb pdb:4DEP|reactome:R-HSA-1257604|reactome:R-HSA-388844|reactome:R-HSA-6811558|reactome:R-HSA-9014826|reactome:R-HSA-9014843|reactome:R-HSA-9020702	refseq:NP_000567.1|rcsb pdb:5R8O|rcsb pdb:5R8P|rcsb pdb:5R8Q|rcsb pdb:6I1B|rcsb pdb:6Y8I|rcsb pdb:6Y8M|rcsb pdb:7CHY|rcsb pdb:7CHZ|rcsb pdb:7I1B|rcsb pdb:9ILB|reactome:R-HSA-448706|reactome:R-HSA-5620971|reactome:R-HSA-5660668|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020702|reactome:R-HSA-9660826|ensembl:ENSG00000125538(gene)|ensembl:ENST00000263341(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001660"(fever generation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002711"(positive regulation of T cell mediated immunity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014805"(smooth muscle adaptation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035505"(positive regulation of myosin light chain kinase activity)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0070164"(negative regulation of adiponectin secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|rcsb pdb:1I1B|rcsb pdb:1IOB|rcsb pdb:1ITB|rcsb pdb:1L2H|rcsb pdb:1S0L|rcsb pdb:1T4Q|rcsb pdb:1TOO|rcsb pdb:1TP0|rcsb pdb:1TWE|rcsb pdb:1TWM|rcsb pdb:21BI|rcsb pdb:2I1B|rcsb pdb:2KH2|rcsb pdb:2NVH|rcsb pdb:31BI|rcsb pdb:3LTQ|rcsb pdb:3O4O|rcsb pdb:3POK|rcsb pdb:41BI|rcsb pdb:4DEP|rcsb pdb:4G6J|rcsb pdb:4G6M|rcsb pdb:4GAF|rcsb pdb:4GAI|rcsb pdb:4I1B|rcsb pdb:5BVP|rcsb pdb:5I1B|rcsb pdb:5MVZ|rcsb pdb:5R7W|rcsb pdb:5R85|rcsb pdb:5R86|rcsb pdb:5R87|rcsb pdb:5R88|rcsb pdb:5R89|rcsb pdb:5R8A|rcsb pdb:5R8B|rcsb pdb:5R8C|rcsb pdb:5R8D|rcsb pdb:5R8E|rcsb pdb:5R8F|rcsb pdb:5R8G|rcsb pdb:5R8H|rcsb pdb:5R8I|rcsb pdb:5R8J|rcsb pdb:5R8K|rcsb pdb:5R8L|rcsb pdb:5R8M|rcsb pdb:5R8N|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902680"(positive regulation of RNA biosynthetic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903597"(negative regulation of gap junction assembly)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|interpro:IPR003296(Interleukin-1, beta IL1B)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:1HIB|dip:DIP-474N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:G3A02KnaI98Ea4SzAFjUvCCnfnM9606	rogid:riBBjazKZOBrwdqj7YxrGiJtJAg9606	rigid:UTzq6pD8UKOASX5kbolSScbVvnY	false	sufficient binding region:21-350	sufficient binding region:117-269	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NPH3	uniprotkb:P14778	intact:EBI-525939|uniprotkb:O14915|uniprotkb:Q86WJ7|uniprotkb:B1NLD0|uniprotkb:D3DNW0|ensembl:ENSP00000072516|ensembl:ENSP00000390541|ensembl:ENSP00000401132|ensembl:ENSP00000412053	intact:EBI-525905|uniprotkb:Q587I7|ensembl:ENSP00000386380	psi-mi:il1ap_human(display_long)|uniprotkb:IL1RAP(gene name)|psi-mi:IL1RAP(display_short)|uniprotkb:C3orf13(gene name synonym)|uniprotkb:IL1R3(gene name synonym)|uniprotkb:Interleukin-1 receptor 3(gene name synonym)	psi-mi:il1r1_human(display_long)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:IL1RT1(gene name synonym)|uniprotkb:IL1R1(gene name)|psi-mi:IL1R1(display_short)|uniprotkb:IL1R(gene name synonym)|uniprotkb:IL1RA(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Thomas et al. (2012)	pubmed:22426547|doi:10.1038/nsmb.2260|imex:IM-18094	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15975111|imex:IM-18094-2|dip:DIP-189820E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161400.1|refseq:NP_001161401.1|refseq:NP_001161402.1|refseq:NP_001161403.1|refseq:NP_002173.1|refseq:NP_608273.1|dip:DIP-33487N|ensembl:ENSG00000196083(gene)|ensembl:ENST00000072516(transcript)|ensembl:ENST00000412504(transcript)|ensembl:ENST00000439062(transcript)|ensembl:ENST00000447382(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0016020"(membrane)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:3O4O|rcsb pdb:4DEP|reactome:R-HSA-1257604|reactome:R-HSA-388844|reactome:R-HSA-6811558|reactome:R-HSA-9014826|reactome:R-HSA-9014843|reactome:R-HSA-9020702	refseq:NP_000868.1|refseq:XP_005263987.1|refseq:XP_005263991.1|refseq:NP_001275635.1|refseq:XP_011509417.1|refseq:XP_011509418.1|refseq:XP_011509419.1|refseq:XP_011509420.1|ensembl:ENSG00000115594(gene)|ensembl:ENST00000410023(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1G0Y|rcsb pdb:1IRA|rcsb pdb:1ITB|rcsb pdb:4DEP|rcsb pdb:4GAF|reactome:R-HSA-6783783|reactome:R-HSA-9020702|reactome:R-HSA-9679191|dip:DIP-93N|refseq:NP_001307907.1|refseq:NP_001307909.1|refseq:NP_001307910.1|refseq:NP_001307911.1|refseq:NP_001307912.1|refseq:NP_001307913.1|refseq:NP_001307914.1|refseq:XP_016859478.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:G3A02KnaI98Ea4SzAFjUvCCnfnM9606	rogid:2qxcax5pAtmXBQudsAOyK1V2/Oo9606	rigid:UTzq6pD8UKOASX5kbolSScbVvnY	false	sufficient binding region:21-350	sufficient binding region:18-330	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)